LLPS-Hos-a458
OMG

▼ OVERVIEW

Status: Reviewed
Protein Name: Oligodendrocyte-myelin glycoprotein
Gene Name: OMG, OMGP
Ensembl Gene: ENSG00000126861.4
Ensembl Protein: ENSP00000247271.4
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEYQILKMSL  CLFILLFLTP  GILCICPLQC  ICTERHRHVD  CSGRNLSTLP  SGLQENIIHL  60
61    NLSYNHFTDL  HNQLTQYTNL  RTLDISNNRL  ESLPAHLPRS  LWNMSAANNN  IKLLDKSDTA  120
121   YQWNLKYLDV  SKNMLEKVVL  IKNTLRSLEV  LNLSSNKLWT  VPTNMPSKLH  IVDLSNNSLT  180
181   QILPGTLINL  TNLTHLYLHN  NKFTFIPDQS  FDQLFQLQEI  TLYNNRWSCD  HKQNITYLLK  240
241   WMMETKAHVI  GTPCSTQISS  LKEHNMYPTP  SGFTSSLFTV  SGMQTVDTIN  SLSVVTQPKV  300
301   TKIPKQYRTK  ETTFGATLSK  DTTFTSTDKA  FVPYPEDTST  ETINSHEAAA  ATLTIHLQDG  360
361   MVTNTSLTSS  TKSSPTPMTL  SITSGMPNNF  SEMPQQSTTL  NLWREETTTN  VKTPLPSVAN  420
421   AWKVNASFLL  LLNVVVMLAV  440
Nucleotide CDS Sequence (FASTA)
1     ATGGAATATC  AGATATTGAA  AATGTCTCTC  TGCCTGTTCA  TCCTTCTGTT  TCTCACACCT  60
61    GGTATTTTAT  GCATTTGTCC  TCTCCAATGT  ATATGCACAG  AGAGGCACAG  GCATGTGGAC  120
121   TGTTCAGGCA  GAAACTTGTC  TACATTACCA  TCTGGACTGC  AAGAGAATAT  TATACATTTA  180
181   AACCTGTCTT  ATAACCACTT  TACTGATCTG  CATAACCAGT  TAACCCAATA  TACCAATCTG  240
241   AGGACCCTGG  ACATTTCAAA  CAACAGGCTT  GAAAGCCTGC  CTGCTCACTT  ACCTCGGTCT  300
301   CTGTGGAACA  TGTCTGCTGC  TAACAACAAC  ATTAAACTTC  TTGACAAATC  TGATACTGCT  360
361   TATCAGTGGA  ATCTTAAATA  TCTGGATGTT  TCTAAGAACA  TGCTGGAAAA  GGTTGTCCTC  420
421   ATTAAAAATA  CACTAAGAAG  TCTCGAGGTT  CTCAACCTCA  GTAGTAACAA  ACTTTGGACA  480
481   GTTCCAACCA  ACATGCCCTC  CAAACTACAT  ATCGTGGACC  TGTCTAATAA  TTCTTTGACA  540
541   CAAATTCTTC  CAGGTACATT  AATAAACCTG  ACAAATCTCA  CACATCTTTA  CCTGCACAAC  600
601   AATAAGTTCA  CATTCATTCC  AGACCAATCT  TTTGACCAAC  TCTTTCAGTT  GCAAGAGATA  660
661   ACCCTTTACA  ATAACAGGTG  GTCATGTGAC  CACAAACAAA  ACATTACTTA  CTTACTGAAG  720
721   TGGATGATGG  AAACAAAAGC  CCATGTGATA  GGGACTCCAT  GTTCTACCCA  AATATCATCT  780
781   TTAAAGGAAC  ATAACATGTA  TCCCACACCT  TCTGGATTTA  CCTCAAGCTT  ATTCACTGTA  840
841   AGTGGGATGC  AGACAGTGGA  CACCATTAAC  TCTCTGAGTG  TGGTAACTCA  ACCCAAAGTG  900
901   ACCAAAATAC  CCAAACAATA  TCGAACAAAG  GAAACAACGT  TTGGTGCCAC  TCTAAGCAAA  960
961   GACACCACCT  TTACTAGCAC  TGATAAGGCT  TTTGTGCCCT  ATCCAGAAGA  TACATCCACA  1020
1021  GAGACTATCA  ATTCACATGA  AGCAGCAGCT  GCAACTCTAA  CTATTCATCT  CCAAGATGGA  1080
1081  ATGGTCACAA  ACACAAGCCT  CACTAGCTCA  ACAAAATCAT  CCCCAACACC  CATGACCCTA  1140
1141  AGTATCACTA  GTGGCATGCC  AAATAATTTC  TCTGAAATGC  CTCAACAAAG  CACAACCCTT  1200
1201  AACTTATGGA  GGGAAGAGAC  AACCACAAAT  GTAAAGACTC  CATTACCTTC  TGTGGCAAAT  1260
1261  GCTTGGAAAG  TAAATGCTTC  ATTTCTCTTA  TTGCTCAATG  TTGTGGTCAT  GCTGGCTGTC  1320
1321  TGA  1323

▼ KEYWORD

ID
Family
Cell adhesion
Cell membrane
Complete proteome
Direct protein sequencing
Glycoprotein
GPI-anchor
Leucine-rich repeat
Lipoprotein
Membrane
Polymorphism
Reference proteome
Repeat
Signal

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Anchored component of membrane
Cellular Component
Plasma membrane
Biological Process
Cell adhesion
Biological Process
Negative regulation of axonogenesis
Biological Process
Neuron projection regeneration

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-a450Pan troglodytes99.550.0894
LLPS-Pap-a450Pan paniscus99.550.0894
LLPS-Gog-a445Gorilla gorilla98.640.0887
LLPS-Poa-a445Pongo abelii98.640.0886
LLPS-Mal-a445Mandrillus leucophaeus98.180.0878
LLPS-Cea-a453Cercocebus atys98.180.0878
LLPS-Maf-a453Macaca fascicularis98.180.0878
LLPS-Man-a452Macaca nemestrina98.180.0878
LLPS-Mam-a449Macaca mulatta98.180.0878
LLPS-Paa-a452Papio anubis97.950.0876
LLPS-Rhb-a447Rhinopithecus bieti97.950.0875
LLPS-Nol-a442Nomascus leucogenys97.950.0880
LLPS-Aon-a455Aotus nancymaae97.50.0873
LLPS-Chs-a448Chlorocebus sabaeus97.50.0872
LLPS-Cas-a404Carlito syrichta96.360.0858
LLPS-Caf-a442Canis familiaris95.910.0832
LLPS-Urm-a415Ursus maritimus95.680.0831
LLPS-Aim-a441Ailuropoda melanoleuca95.450.0830
LLPS-Ict-a449Ictidomys tridecemlineatus94.770.0840
LLPS-Bot-a457Bos taurus94.770.0820
LLPS-Mup-a446Mustela putorius furo94.550.0849
LLPS-Otg-a450Otolemur garnettii94.320.0817
LLPS-Fec-a451Felis catus94.310.0817
LLPS-Dio-a442Dipodomys ordii94.090.0807
LLPS-Sus-a456Sus scrofa93.880.0805
LLPS-Eqc-a456Equus caballus93.860.0814
LLPS-Ova-a443Ovis aries93.850.0809
LLPS-Myl-a428Myotis lucifugus93.640.0818
LLPS-Cap-a449Cavia porcellus92.270.0831
LLPS-Fud-a437Fukomys damarensis91.360.0821
LLPS-Orc-a433Oryctolagus cuniculus90.910.0793
LLPS-Loa-a439Loxodonta africana90.910.0790
LLPS-Mea-a419Mesocricetus auratus90.890.0815
LLPS-Ran-a452Rattus norvegicus89.520.0803
LLPS-Mum-a455Mus musculus88.840.0798
LLPS-Sah-a417Sarcophilus harrisii70.290.0595
LLPS-Ora-a386Ornithorhynchus anatinus64.550.0529
LLPS-Lac-a402Latimeria chalumnae62.658e-110340
LLPS-Gaga-a407Gallus gallus57.532e-166484
LLPS-Anp-a375Anas platyrhynchos57.012e-164479
LLPS-Icp-a396Ictalurus punctatus56.891e-77249
LLPS-Meg-a377Meleagris gallopavo56.494e-165481
LLPS-Asm-a390Astyanax mexicanus54.97e-87281
LLPS-Leo-a398Lepisosteus oculatus54.222e-86274
LLPS-Orn-a396Oreochromis niloticus53.655e-80263
LLPS-Xim-a405Xiphophorus maculatus53.368e-87278
LLPS-Tag-a392Taeniopygia guttata53.054e-143424
LLPS-Scf-a375Scleropages formosus52.07e-28117
LLPS-Fia-a397Ficedula albicollis50.931e-131395