DrLLPS - Data resource of LLPS

Overview
Property
Classification
Function
Cross Reference
Sequence
GO
Annotation
Orthology
TOP

LLPS-Hos-a391
NDUFB3

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3; Complex I-B12; CI-B12; NADH-ubiquinone oxidoreductase B12 subunit
Gene Name:	NDUFB3
Ensembl Gene:	ENSG00000119013.8
Ensembl Protein:	ENSP00000407336.1
Organism:	Homo sapiens
Taxa ID:	9606
LLPS Type:	Client

PDB: 5XTD (A, B, C, E, F, G, H, I, J, K, L, M, N, O, P, Q, S, T, U, V, W, Y, Z, a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, r, s, u, v, w) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Postsynaptic density	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Mus musculus	LLPS-Mum-a390	Q9CQZ6	Client	Postsynaptic density	81.40	4e-47	154

▼ FUNCTION

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENST00000454214.1	ENSP00000407336.1
Ensembl	ENST00000450023.5	ENSP00000401834.1
Ensembl	ENST00000433898.5	ENSP00000410600.1
Ensembl	ENST00000237889.8	ENSP00000237889.4
UniProt		O43676, NDUB3_HUMAN, Q6IB80
GeneBank	AF035839, CH471063, AF047183, AC007272, BC018183, CR456924	AAC15590.1, AAX88972.1, CAG33205.1, AAH18183.1, AAC04268.1, EAW70233.1
RefSeq	NM_001257102.1, NM_002491.2, XM_011511230.2, XM_017004186.1	NP_001244031.1, NP_002482.1, XP_011509532.1, XP_016859675.1
Entrez	4709

▼ SEQUENCE

Protein Sequence (FASTA)
1 MAHEHGHEHG HHKMELPDYR QWKIEGTPLE TIQKKLAAKG LRDPWGRNEA WRYMGGFAKS 60 61 VSFSDVFFKG FKWGFAAFVV AVGAEYYLES LNKDKKHH 98
Nucleotide CDS Sequence (FASTA)
1 ATGGCCCATG AACATGGACA TGAGCATGGA CATCATAAAA TGGAACTTCC AGATTATAGA 60 61 CAATGGAAGA TAGAAGGGAC ACCATTAGAA ACTATCCAGA AGAAGCTGGC TGCAAAAGGG 120 121 CTAAGGGATC CATGGGGCCG CAATGAAGCT TGGAGATACA TGGGTGGCTT TGCAAAGAGT 180 181 GTTTCCTTTT CTGATGTATT CTTTAAAGGA TTCAAATGGG GATTTGCTGC ATTTGTGGTA 240 241 GCTGTAGGAG CTGAATATTA CCTGGAGTCC CTGAATAAAG ATAAGAAGCA TCACTGA 297

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0007	Acetylation
KW-0181	Complete proteome
KW-0225	Disease mutation
KW-0249	Electron transport
KW-0472	Membrane
KW-0488	Methylation
KW-0496	Mitochondrion
KW-0999	Mitochondrion inner membrane
KW-1274	Primary mitochondrial disease
KW-1185	Reference proteome
KW-0679	Respiratory chain
KW-0812	Transmembrane
KW-1133	Transmembrane helix
KW-0813	Transport

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0016021	Cellular Component	Integral component of membrane
GO:0005743	Cellular Component	Mitochondrial inner membrane
GO:0005747	Cellular Component	Mitochondrial respiratory chain complex I
GO:0008137	Molecular Function	NADH dehydrogenase (ubiquinone) activity
GO:0006120	Biological Process	Mitochondrial electron transport, NADH to ubiquinone
GO:0032981	Biological Process	Mitochondrial respiratory chain complex I assembly

▼ KEGG

hsa:4709

▼ ANNOTATION

Disorder
IUPred2A

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	PTMcode

Variation
dbSNP	VarCards	rSNPBase

Mutation
TCGA	ICGC	CGAP	IntOGen	BioMuta

Interaction
HINT	InWeb_IM	RISE	RAIN	Mentha
PINA	IID	MIST	DifferentialNET	RNAct

Disease
ClinVar	OMIM	DisGeNET	ActiveDriverDB

Drug
DrugBank	ECOdrug	DGIdb	CTD

Physicochemical
Compute pI/Mw	AAindex

Function
CORUM	CellMarker	RaftProt

Proteomics
THPA	HPM

Structure
PDB

Localization
COMPARTMENTS

Expression
TCGA	ICGC	COSMIC	GEO	ArrayExpress
TISSUES	BioXpress	THPA

Element
UTRdb	CircNet	miRTarBase	miRWalk	miRcode
RAID	microRNA.org	m6AVar

Methylation
TCGA	ICGC	MethyCancer

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Pat-a382	Pan troglodytes	100.0	2e-66	203
LLPS-Pap-a382	Pan paniscus	100.0	2e-66	203
LLPS-Gog-a379	Gorilla gorilla	100.0	2e-66	203
LLPS-Maf-a386	Macaca fascicularis	96.94	1e-63	196
LLPS-Mal-a377	Mandrillus leucophaeus	95.92	2e-54	172
LLPS-Cea-a386	Cercocebus atys	95.92	2e-54	172
LLPS-Man-a385	Macaca nemestrina	95.92	2e-54	172
LLPS-Paa-a385	Papio anubis	95.92	2e-54	172
LLPS-Mam-a381	Macaca mulatta	95.92	2e-54	172
LLPS-Nol-a379	Nomascus leucogenys	95.92	1e-54	173
LLPS-Poa-a380	Pongo abelii	94.62	4e-59	184
LLPS-Chs-a382	Chlorocebus sabaeus	93.88	5e-53	169
LLPS-Rhb-a379	Rhinopithecus bieti	92.86	6e-54	171
LLPS-Aon-a391	Aotus nancymaae	90.82	9e-54	171
LLPS-Caj-a383	Callithrix jacchus	89.8	4e-53	169
LLPS-Otg-a389	Otolemur garnettii	86.05	4e-49	159
LLPS-Orc-a370	Oryctolagus cuniculus	86.05	3e-48	157
LLPS-Sus-a389	Sus scrofa	84.69	2e-48	157
LLPS-Aim-a376	Ailuropoda melanoleuca	84.69	7e-49	159
LLPS-Eqc-a392	Equus caballus	84.69	6e-49	159
LLPS-Cas-a349	Carlito syrichta	83.67	8e-39	133
LLPS-Ova-a381	Ovis aries	83.67	1e-54	173
LLPS-Urm-a356	Ursus maritimus	83.51	1e-46	153
LLPS-Fud-a376	Fukomys damarensis	83.0	4e-54	172
LLPS-Bot-a391	Bos taurus	82.65	2e-54	173
LLPS-Ict-a383	Ictidomys tridecemlineatus	82.56	4e-46	152
LLPS-Caf-a381	Canis familiaris	81.63	3e-47	154
LLPS-Fec-a387	Felis catus	81.63	1e-46	153
LLPS-Tut-a227	Tursiops truncatus	81.63	2e-46	152
LLPS-Myl-a368	Myotis lucifugus	81.4	1e-46	153
LLPS-Mum-a390	Mus musculus	81.4	4e-47	154
LLPS-Cap-a385	Cavia porcellus	80.61	1e-53	171
LLPS-Loa-a377	Loxodonta africana	80.23	1e-45	150
LLPS-Ran-a387	Rattus norvegicus	79.07	2e-44	147
LLPS-Mea-a356	Mesocricetus auratus	74.42	7e-44	146
LLPS-Ora-a328	Ornithorhynchus anatinus	72.09	1e-38	132
LLPS-Ere-a102	Erinaceus europaeus	70.59	7e-17	75.5
LLPS-Xet-a337	Xenopus tropicalis	70.53	2e-41	139
LLPS-Lac-a342	Latimeria chalumnae	68.09	3e-40	137
LLPS-Leo-a342	Lepisosteus oculatus	67.74	2e-40	137
LLPS-Anc-a361	Anolis carolinensis	67.44	6e-35	123
LLPS-Ten-a325	Tetraodon nigroviridis	67.44	3e-38	131
LLPS-Mod-a370	Monodelphis domestica	67.27	2e-20	85.1
LLPS-Gaga-a346	Gallus gallus	66.28	2e-37	129
LLPS-Xim-a346	Xiphophorus maculatus	66.27	2e-37	129
LLPS-Scf-a322	Scleropages formosus	65.22	1e-38	132
LLPS-Pes-a340	Pelodiscus sinensis	65.12	4e-36	126
LLPS-Meg-a324	Meleagris gallopavo	65.12	5e-37	128
LLPS-Gaa-a327	Gasterosteus aculeatus	65.06	8e-37	128
LLPS-Pof-a342	Poecilia formosa	64.37	1e-37	130
LLPS-Tar-a329	Takifugu rubripes	63.92	9e-38	130
LLPS-Orl-a335	Oryzias latipes	63.86	9e-36	125
LLPS-Dar-a341	Danio rerio	63.16	2e-35	124
LLPS-Anp-a326	Anas platyrhynchos	62.79	6e-36	125
LLPS-Asm-a336	Astyanax mexicanus	61.73	5e-32	115
LLPS-Sah-a361	Sarcophilus harrisii	60.82	1e-33	120
LLPS-Tag-a337	Taeniopygia guttata	59.57	2e-37	129
LLPS-Fia-a336	Ficedula albicollis	58.14	3e-34	121
LLPS-Icp-a342	Ictalurus punctatus	55.56	5e-26	100

LLPS-Hos-a391NDUFB3

Protein Sequence

Nucleotide Sequence

LLPS-Hos-a391
NDUFB3