DrLLPS - Data resource of LLPS

LLPS-Hos-a328
SNX3

▼ OVERVIEW


Status:	Reviewed
Protein Name:	Sorting nexin-3; Protein SDP3
Gene Name:	SNX3
Ensembl Gene:	ENSG00000112335.14
Ensembl Protein:	ENSP00000357975.2
Organism:	Homo sapiens
Taxa ID:	9606
LLPS Type:	Client

PDB: 5F0M (A, B, C, D) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Postsynaptic density	"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."	Human cortex	23071613

▼ FUNCTION

Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs (PubMed:20482551).

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENST00000368979.6	ENSP00000357975.2
Ensembl	ENST00000426155.6	ENSP00000401779.2
Ensembl	ENST00000230085.12	ENSP00000230085.8
Ensembl	ENST00000349379.5	ENSP00000296991.7
UniProt		O60493, SNX3_HUMAN, A8K0B1, E1P5E4, E1P5E5, O60718, Q4TT29, Q4TT31, Q5JXJ7, Q5JXJ8, Q96AP9, Q9C0J5, Q9NU45
GeneBank	BC014580, CH471051, BC015179, AF062483, AL078596, AB047360, BC008444, BT007114, BC016863, CR456898, Z98742, AK289476, AF034546	CAG33179.1, EAW48378.1, AAC16040.1, EAW48381.1, BAF82165.1, BAB32649.1, EAW48382.1, AAH16863.1, AAH14580.1, AAP35778.1, AAC16018.1, AAH15179.1, EAW48379.1, AAH08444.1
RefSeq	NM_001300929.1, NM_003795.5, NM_152827.3	NP_001287858.1, NP_003786.1, NP_690040.1
Entrez	8724

▼ SEQUENCE

Protein Sequence (FASTA)
1 MAETVADTRR LITKPQNLND AYGPPSNFLE IDVSNPQTVG VGRGRFTTYE IRVKTNLPIF 60 61 KLKESTVRRR YSDFEWLRSE LERESKVVVP PLPGKAFLRQ LPFRGDDGIF DDNFIEERKQ 120 121 GLEQFINKVA GHPLAQNERC LHMFLQDEII DKSYTPSKIR HA 162
Nucleotide CDS Sequence (FASTA)
1 ATGGCGGAGA CCGTGGCTGA CACCCGGCGG CTGATCACCA AGCCGCAGAA CCTGAATGAC 60 61 GCCTACGGAC CCCCCAGCAA CTTCCTCGAG ATCGATGTGA GCAACCCGCA AACGGTGGGG 120 121 GTCGGCCGGG GCCGCTTCAC CACTTACGAA ATCAGGGTCA AGACAAATCT TCCTATTTTC 180 181 AAGCTGAAAG AATCTACTGT TAGAAGAAGA TACAGTGACT TTGAATGGCT GCGAAGTGAA 240 241 TTAGAAAGAG AGAGCAAGGT CGTAGTTCCC CCGCTCCCTG GGAAAGCGTT TTTGCGTCAG 300 301 CTTCCTTTTA GAGGAGATGA TGGAATATTT GATGACAATT TTATTGAGGA AAGAAAACAA 360 361 GGGCTGGAGC AGTTTATAAA CAAGGTCGCT GGTCATCCTC TGGCACAGAA CGAACGTTGT 420 421 CTTCACATGT TTTTACAAGA TGAAATAATA GATAAAAGCT ATACTCCATC TAAAATAAGA 480 481 CATGCCTGA 489

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0007	Acetylation
KW-0025	Alternative splicing
KW-0160	Chromosomal rearrangement
KW-0181	Complete proteome
KW-0968	Cytoplasmic vesicle
KW-0903	Direct protein sequencing
KW-0967	Endosome
KW-1017	Isopeptide bond
KW-0446	Lipid-binding
KW-0488	Methylation
KW-1013	Microphthalmia
KW-0597	Phosphoprotein
KW-0653	Protein transport
KW-1185	Reference proteome
KW-0813	Transport
KW-0832	Ubl conjugation

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0030136	Cellular Component	Clathrin-coated vesicle
GO:0005737	Cellular Component	Cytoplasm
GO:0005829	Cellular Component	Cytosol
GO:0005769	Cellular Component	Early endosome
GO:0031901	Cellular Component	Early endosome membrane
GO:0032009	Cellular Component	Early phagosome
GO:0010008	Cellular Component	Endosome membrane
GO:0070062	Cellular Component	Extracellular exosome
GO:0080025	Molecular Function	Phosphatidylinositol-3,5-bisphosphate binding
GO:0032266	Molecular Function	Phosphatidylinositol-3-phosphate binding
GO:0070273	Molecular Function	Phosphatidylinositol-4-phosphate binding
GO:0010314	Molecular Function	Phosphatidylinositol-5-phosphate binding
GO:0019903	Molecular Function	Protein phosphatase binding
GO:0070676	Biological Process	Intralumenal vesicle formation
GO:0010324	Biological Process	Membrane invagination
GO:2000642	Biological Process	Negative regulation of early endosome to late endosome transport
GO:0050765	Biological Process	Negative regulation of phagocytosis
GO:0042177	Biological Process	Negative regulation of protein catabolic process
GO:0051224	Biological Process	Negative regulation of protein transport
GO:0046597	Biological Process	Negative regulation of viral entry into host cell
GO:0010976	Biological Process	Positive regulation of neuron projection development
GO:0016579	Biological Process	Protein deubiquitination
GO:0022615	Biological Process	Protein to membrane docking
GO:0015031	Biological Process	Protein transport
GO:0030111	Biological Process	Regulation of Wnt signaling pathway
GO:0009617	Biological Process	Response to bacterium
GO:0016055	Biological Process	Wnt signaling pathway

▼ KEGG

hsa:8724

▼ ANNOTATION

Disorder
IUPred2A

Domain
SMART	Pfam	InterPro	CDD	PROSITE
Gene3D

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	HPRD
BioGRID	mUbiSiDa	PTMcode

Variation
dbSNP	VarCards	rSNPBase

Mutation
TCGA	ICGC	CGAP	IntOGen	BioMuta

Interaction
HINT	InWeb_IM	RISE	RAIN	Mentha
PINA	IID	iRefIndex	MIST	DifferentialNET
RNAct

Disease
OMIM	DisGeNET	ActiveDriverDB

Drug
DrugBank	CTD

Physicochemical
Compute pI/Mw	AAindex

Function
PIRSF	CellMarker	RaftProt

Proteomics
THPA	HPM

Structure
PDB	MMDB

Localization
COMPARTMENTS

Expression
TCGA	ICGC	COSMIC	GEO	ArrayExpress
TISSUES	BioXpress	THPA

Element
UTRdb	circBase	CircNet	miRTarBase	miRWalk
miRcode	RAID	microRNA.org

Methylation
TCGA	ICGC	MethyCancer

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Pat-a320	Pan troglodytes	100.0	1e-116	335
LLPS-Caf-a323	Canis familiaris	100.0	1e-116	335
LLPS-Cea-a324	Cercocebus atys	100.0	1e-116	335
LLPS-Fec-a324	Felis catus	100.0	1e-116	335
LLPS-Mum-a328	Mus musculus	100.0	1e-116	335
LLPS-Poa-a320	Pongo abelii	100.0	1e-116	335
LLPS-Tut-a192	Tursiops truncatus	100.0	1e-116	335
LLPS-Caj-a321	Callithrix jacchus	100.0	1e-116	335
LLPS-Ict-a322	Ictidomys tridecemlineatus	100.0	1e-116	335
LLPS-Aim-a313	Ailuropoda melanoleuca	100.0	1e-116	335
LLPS-Ova-a317	Ovis aries	100.0	1e-116	335
LLPS-Mup-a321	Mustela putorius furo	100.0	1e-116	335
LLPS-Cas-a295	Carlito syrichta	100.0	1e-116	335
LLPS-Myl-a307	Myotis lucifugus	100.0	9e-116	333
LLPS-Aon-a328	Aotus nancymaae	100.0	1e-116	335
LLPS-Sus-a326	Sus scrofa	100.0	1e-116	335
LLPS-Chs-a320	Chlorocebus sabaeus	100.0	1e-116	335
LLPS-Maf-a324	Macaca fascicularis	100.0	1e-116	335
LLPS-Orc-a311	Oryctolagus cuniculus	100.0	1e-116	335
LLPS-Pap-a319	Pan paniscus	100.0	1e-116	335
LLPS-Eqc-a329	Equus caballus	100.0	2e-114	337
LLPS-Man-a323	Macaca nemestrina	100.0	1e-116	335
LLPS-Paa-a323	Papio anubis	100.0	1e-116	335
LLPS-Mam-a320	Macaca mulatta	100.0	1e-116	335
LLPS-Mea-a299	Mesocricetus auratus	100.0	1e-116	335
LLPS-Bot-a328	Bos taurus	100.0	1e-116	335
LLPS-Loa-a316	Loxodonta africana	99.38	7e-116	334
LLPS-Nol-a318	Nomascus leucogenys	99.38	7e-116	334
LLPS-Ere-a084	Erinaceus europaeus	99.07	3e-73	224
LLPS-Mod-a308	Monodelphis domestica	98.77	2e-115	333
LLPS-Anc-a301	Anolis carolinensis	96.27	5e-113	327
LLPS-Mal-a314	Mandrillus leucophaeus	95.86	3e-96	283
LLPS-Gog-a319	Gorilla gorilla	94.08	4e-111	322
LLPS-Fia-a279	Ficedula albicollis	93.83	8e-111	321
LLPS-Pes-a286	Pelodiscus sinensis	93.83	6e-111	322
LLPS-Gaga-a288	Gallus gallus	93.83	8e-111	321
LLPS-Meg-a268	Meleagris gallopavo	93.52	1e-69	214
LLPS-Anp-a272	Anas platyrhynchos	92.66	6e-70	215
LLPS-Xet-a286	Xenopus tropicalis	90.74	3e-109	317
LLPS-Leo-a287	Lepisosteus oculatus	90.62	6e-106	309
LLPS-Orn-a286	Oreochromis niloticus	89.51	4e-107	312
LLPS-Orl-a282	Oryzias latipes	89.51	1e-106	310
LLPS-Tag-a280	Taeniopygia guttata	89.02	7e-97	286
LLPS-Scm-a271	Scophthalmus maximus	88.89	3e-106	309
LLPS-Asm-a280	Astyanax mexicanus	88.27	7e-105	306
LLPS-Dar-a287	Danio rerio	88.27	2e-104	305
LLPS-Xim-a292	Xiphophorus maculatus	88.27	5e-106	309
LLPS-Scf-a269	Scleropages formosus	87.82	2e-98	291
LLPS-Pof-a288	Poecilia formosa	87.73	5e-104	304
LLPS-Icp-a289	Ictalurus punctatus	87.04	8e-104	305
LLPS-Gaa-a278	Gasterosteus aculeatus	85.8	8e-103	301
LLPS-Fud-a317	Fukomys damarensis	85.71	3e-75	230
LLPS-Ten-a276	Tetraodon nigroviridis	84.57	6e-100	293
LLPS-Tar-a276	Takifugu rubripes	83.95	2e-101	297
LLPS-Urm-a296	Ursus maritimus	80.37	4e-60	191
LLPS-Lac-a290	Latimeria chalumnae	79.49	5e-91	271
LLPS-Ran-a325	Rattus norvegicus	79.38	2e-92	275
LLPS-Sah-a301	Sarcophilus harrisii	79.35	2e-90	269
LLPS-Otg-a326	Otolemur garnettii	79.01	1e-93	278
LLPS-Dio-a316	Dipodomys ordii	79.01	1e-93	278
LLPS-Cap-a322	Cavia porcellus	78.4	6e-91	271
LLPS-Rhb-a316	Rhinopithecus bieti	73.91	2e-80	244
LLPS-Drm-a088	Drosophila melanogaster	70.0	3e-81	246
LLPS-Cii-a098	Ciona intestinalis	69.18	2e-74	229
LLPS-Cis-a084	Ciona savignyi	68.83	7e-73	225
LLPS-Cae-a061	Caenorhabditis elegans	66.67	5e-76	233
LLPS-Scp-a016	Schizosaccharomyces pombe	53.73	8e-37	132
LLPS-Abg-a032	Absidia glauca	52.9	4e-40	141
LLPS-Scj-a016	Schizosaccharomyces japonicus	51.8	1e-38	136
LLPS-Asni-a019	Aspergillus niger	51.47	1e-38	137
LLPS-Scc-a013	Schizosaccharomyces cryophilus	51.41	3e-38	135
LLPS-Pytr-a016	Pyrenophora triticirepentis	51.41	4e-40	140
LLPS-Lem-a018	Leptosphaeria maculans	51.41	3e-39	140
LLPS-Pyt-a021	Pyrenophora teres	51.41	4e-40	140
LLPS-Zyt-a015	Zymoseptoria tritici	51.09	2e-33	124
LLPS-Spr-a022	Sporisorium reilianum	51.08	3e-35	134
LLPS-Nec-a023	Neurospora crassa	51.05	2e-40	141
LLPS-Cog-a013	Colletotrichum gloeosporioides	51.05	2e-40	141
LLPS-Cogr-a019	Colletotrichum graminicola	50.71	7e-39	137
LLPS-Beb-a017	Beauveria bassiana	50.71	1e-39	139
LLPS-Mao-a017	Magnaporthe oryzae	50.71	9e-39	137
LLPS-Yal-a021	Yarrowia lipolytica	50.7	1e-37	134
LLPS-Gag-a017	Gaeumannomyces graminis	50.37	4e-37	133
LLPS-Usm-a022	Ustilago maydis	50.36	6e-35	133
LLPS-Coo-a018	Colletotrichum orbiculare	50.35	1e-39	139
LLPS-Asfu-a017	Aspergillus fumigatus	50.35	7e-40	139
LLPS-Asf-a015	Aspergillus flavus	50.35	7e-40	139
LLPS-Fus-a020	Fusarium solani	50.35	1e-39	139
LLPS-Trv-a017	Trichoderma virens	50.35	3e-40	140
LLPS-Scs-a015	Sclerotinia sclerotiorum	50.35	4e-40	141
LLPS-Fuo-a015	Fusarium oxysporum	50.35	2e-39	139
LLPS-Ast-a019	Aspergillus terreus	50.35	7e-40	139
LLPS-Trr-a016	Trichoderma reesei	50.35	4e-40	140
LLPS-Nef-a017	Neosartorya fischeri	50.35	7e-40	139
LLPS-Asn-a020	Aspergillus nidulans	50.35	7e-40	139
LLPS-Aso-a016	Aspergillus oryzae	50.35	7e-40	139
LLPS-Fuv-a014	Fusarium verticillioides	50.35	2e-39	139

LLPS-Hos-a328SNX3

Protein Sequence

Nucleotide Sequence

LLPS-Hos-a328
SNX3