LLPS-Hos-a280
SFXN3

▼ OVERVIEW

Status: Reviewed
Protein Name: Sideroflexin-3
Gene Name: SFXN3
Ensembl Gene: ENSG00000107819.13
Ensembl Protein: ENSP00000377103.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MESKMGELPL  DINIQEPRWD  QSTFLGRARH  FFTVTDPRNL  LLSGAQLEAS  RNIVQNYRAG  60
61    VVTPGITEDQ  LWRAKYVYDS  AFHPDTGEKV  VLIGRMSAQV  PMNMTITGCM  LTFYRKTPTV  120
121   VFWQWVNQSF  NAIVNYSNRS  GDTPITVRQL  GTAYVSATTG  AVATALGLKS  LTKHLPPLVG  180
181   RFVPFAAVAA  ANCINIPLMR  QRELQVGIPV  ADEAGQRLGY  SVTAAKQGIF  QVVISRICMA  240
241   IPAMAIPPLI  MDTLEKKDFL  KRRPWLGAPL  QVGLVGFCLV  FATPLCCALF  PQKSSIHISN  300
301   LEPELRAQIH  EQNPSVEVVY  YNKGL  325
Nucleotide CDS Sequence (FASTA)
1     ATGGAAAGCA  AAATGGGTGA  ATTGCCTTTA  GACATCAACA  TCCAGGAACC  TCGCTGGGAC  60
61    CAAAGTACTT  TCCTGGGCAG  AGCCCGGCAC  TTTTTCACTG  TTACTGATCC  TCGAAATCTG  120
121   CTGCTGTCCG  GGGCACAGCT  GGAAGCTTCT  CGGAACATCG  TGCAGAACTA  CAGGGCCGGC  180
181   GTGGTGACCC  CAGGGATCAC  CGAGGACCAG  CTGTGGAGGG  CCAAGTATGT  GTATGACTCC  240
241   GCCTTCCATC  CGGACACAGG  GGAGAAGGTG  GTCCTGATTG  GCCGCATGTC  AGCCCAGGTG  300
301   CCCATGAACA  TGACCATCAC  TGGCTGCATG  CTCACATTCT  ACAGGAAGAC  CCCAACCGTG  360
361   GTGTTCTGGC  AGTGGGTGAA  TCAGTCCTTC  AATGCCATTG  TTAACTACTC  CAACCGCAGT  420
421   GGTGACACTC  CCATCACTGT  GAGGCAGCTG  GGGACAGCCT  ATGTGAGTGC  CACCACTGGA  480
481   GCTGTGGCCA  CGGCCCTGGG  ACTCAAATCC  CTCACCAAGC  ACCTGCCCCC  CTTGGTCGGC  540
541   AGATTTGTGC  CCTTTGCAGC  AGTGGCAGCT  GCCAACTGCA  TCAACATCCC  CCTGATGAGG  600
601   CAGAGAGAGC  TGCAGGTGGG  CATCCCGGTG  GCTGATGAGG  CAGGTCAGAG  GCTTGGCTAC  660
661   TCGGTGACTG  CAGCCAAGCA  GGGAATCTTC  CAGGTGGTGA  TTTCAAGAAT  CTGCATGGCG  720
721   ATTCCTGCCA  TGGCCATCCC  ACCACTGATC  ATGGACACTC  TGGAGAAGAA  AGACTTCCTG  780
781   AAGCGCCGCC  CCTGGCTGGG  GGCACCCCTG  CAGGTGGGAC  TGGTGGGCTT  CTGCCTGGTA  840
841   TTTGCAACCC  CCCTGTGCTG  TGCCCTATTC  CCCCAGAAGA  GCTCCATACA  CATAAGCAAC  900
901   CTGGAACCAG  AGCTGAGAGC  TCAGATCCAT  GAGCAAAACC  CCAGCGTTGA  AGTGGTCTAC  960
961   TACAACAAGG  GGCTTTGA  978

▼ KEYWORD

ID
Family
Acetylation
Amino-acid transport
Complete proteome
Membrane
Mitochondrion
One-carbon metabolism
Reference proteome
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Integral component of membrane
Cellular Component
Mitochondrial membrane
Cellular Component
Mitochondrion
Molecular Function
Serine transmembrane transporter activity
Biological Process
Mitochondrial transmembrane transport
Biological Process
One-carbon metabolic process
Biological Process
Serine import into mitochondrion

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Poa-a272Pongo abelii99.380.0664
LLPS-Pat-a272Pan troglodytes99.080.0671
LLPS-Gog-a271Gorilla gorilla99.080.0671
LLPS-Pap-a272Pan paniscus99.080.0665
LLPS-Rhb-a267Rhinopithecus bieti98.440.0657
LLPS-Cea-a276Cercocebus atys98.150.0665
LLPS-Maf-a276Macaca fascicularis98.150.0665
LLPS-Paa-a275Papio anubis98.150.0665
LLPS-Mam-a273Macaca mulatta98.150.0665
LLPS-Aon-a279Aotus nancymaae98.130.0656
LLPS-Chs-a273Chlorocebus sabaeus98.130.0655
LLPS-Mal-a267Mandrillus leucophaeus97.850.0664
LLPS-Man-a275Macaca nemestrina97.850.0664
LLPS-Otg-a277Otolemur garnettii96.270.0636
LLPS-Sus-a277Sus scrofa95.330.0631
LLPS-Caf-a274Canis familiaris94.720.0629
LLPS-Fec-a275Felis catus94.440.0635
LLPS-Cap-a273Cavia porcellus94.390.0624
LLPS-Fud-a269Fukomys damarensis94.390.0624
LLPS-Urm-a254Ursus maritimus94.080.0624
LLPS-Mup-a278Mustela putorius furo94.080.0620
LLPS-Eqc-a280Equus caballus94.080.0627
LLPS-Nol-a270Nomascus leucogenys93.850.0625
LLPS-Orc-a264Oryctolagus cuniculus93.830.0626
LLPS-Bot-a280Bos taurus93.810.0561
LLPS-Ict-a275Ictidomys tridecemlineatus93.770.0622
LLPS-Mum-a279Mus musculus93.770.0620
LLPS-Ova-a271Ovis aries93.770.0623
LLPS-Ran-a277Rattus norvegicus93.460.0620
LLPS-Cas-a252Carlito syrichta92.860.0613
LLPS-Mea-a254Mesocricetus auratus92.830.0609
LLPS-Dio-a269Dipodomys ordii92.520.0625
LLPS-Aim-a269Ailuropoda melanoleuca88.650.0583
LLPS-Anc-a257Anolis carolinensis78.370.0541
LLPS-Pes-a243Pelodiscus sinensis78.120.0530
LLPS-Anp-a235Anas platyrhynchos77.780.0530
LLPS-Xet-a243Xenopus tropicalis77.740.0530
LLPS-Sah-a263Sarcophilus harrisii77.50.0541
LLPS-Meg-a224Meleagris gallopavo77.50.0530
LLPS-Fia-a239Ficedula albicollis77.430.0530
LLPS-Tag-a239Taeniopygia guttata77.430.0532
LLPS-Mod-a264Monodelphis domestica77.190.0540
LLPS-Leo-a246Lepisosteus oculatus76.80.0517
LLPS-Lac-a249Latimeria chalumnae76.80.0518
LLPS-Asm-a239Astyanax mexicanus76.564e-175498
LLPS-Icp-a251Ictalurus punctatus76.230.0522
LLPS-Tut-a163Tursiops truncatus75.940.0516
LLPS-Ora-a237Ornithorhynchus anatinus75.945e-180510
LLPS-Dar-a249Danio rerio75.940.0513
LLPS-Loa-a269Loxodonta africana75.940.0523
LLPS-Caj-a272Callithrix jacchus75.620.0520
LLPS-Scf-a234Scleropages formosus75.550.0525
LLPS-Tar-a235Takifugu rubripes75.02e-178506
LLPS-Pof-a246Poecilia formosa74.697e-180509
LLPS-Orn-a245Oreochromis niloticus74.691e-179509
LLPS-Scm-a231Scophthalmus maximus74.698e-179507
LLPS-Orl-a241Oryzias latipes74.383e-179508
LLPS-Xim-a249Xiphophorus maculatus74.381e-179509
LLPS-Ten-a237Tetraodon nigroviridis74.381e-179509
LLPS-Gaa-a236Gasterosteus aculeatus73.759e-178504
LLPS-Myl-a263Myotis lucifugus72.044e-160460
LLPS-Gaga-a243Gallus gallus71.33e-179509
LLPS-Cis-a073Ciona savignyi61.714e-140409
LLPS-Cii-a084Ciona intestinalis60.325e-144419
LLPS-Ere-a067Erinaceus europaeus56.461e-59199
LLPS-Drm-a078Drosophila melanogaster54.047e-124367
LLPS-Cae-a053Caenorhabditis elegans52.314e-107324