LLPS-Hos-a256
GRIN2D
▼ OVERVIEW
Status: | Reviewed |
Protein Name: | Glutamate receptor ionotropic, NMDA 2D |
Gene Name: | GRIN2D, GluN2D, NMDAR2D |
Ensembl Gene: | ENSG00000105464.3 |
Ensembl Protein: | ENSP00000263269.2 |
Organism: | Homo sapiens |
Taxa ID: | 9606 |
LLPS Type: | Others |
▼ PROPERTY
▼ Classification
Condensates:
Condensate | Description | Tissue/Cell | PMIDs |
---|---|---|---|
Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Human cortex | 23071613 |
▼ FUNCTION
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:9489750). |
▼ CROSS REFERENCE
Database | Nucleotide ID | Protein ID |
---|---|---|
Ensembl | ENST00000263269.3 | ENSP00000263269.2 |
UniProt | O15399, NMDE4_HUMAN | |
GeneBank | AC008403, U77783, AC011527 | AAC15910.1 |
RefSeq | NM_000836.2, XM_011526872.1 | NP_000827.2, XP_011525174.1 |
Entrez | 2906 |
▼ SEQUENCE
Protein Sequence (FASTA) |
---|
1 MRGAGGPRGP RGPAKMLLLL ALACASPFPE EAPGPGGAGG PGGGLGGARP LNVALVFSGP 60 61 AYAAEAARLG PAVAAAVRSP GLDVRPVALV LNGSDPRSLV LQLCDLLSGL RVHGVVFEDD 120 121 SRAPAVAPIL DFLSAQTSLP IVAVHGGAAL VLTPKEKGST FLQLGSSTEQ QLQVIFEVLE 180 181 EYDWTSFVAV TTRAPGHRAF LSYIEVLTDG SLVGWEHRGA LTLDPGAGEA VLSAQLRSVS 240 241 AQIRLLFCAR EEAEPVFRAA EEAGLTGSGY VWFMVGPQLA GGGGSGAPGE PPLLPGGAPL 300 301 PAGLFAVRSA GWRDDLARRV AAGVAVVARG AQALLRDYGF LPELGHDCRA QNRTHRGESL 360 361 HRYFMNITWD NRDYSFNEDG FLVNPSLVVI SLTRDRTWEV VGSWEQQTLR LKYPLWSRYG 420 421 RFLQPVDDTQ HLTVATLEER PFVIVEPADP ISGTCIRDSV PCRSQLNRTH SPPPDAPRPE 480 481 KRCCKGFCID ILKRLAHTIG FSYDLYLVTN GKHGKKIDGV WNGMIGEVFY QRADMAIGSL 540 541 TINEERSEIV DFSVPFVETG ISVMVARSNG TVSPSAFLEP YSPAVWVMMF VMCLTVVAVT 600 601 VFIFEYLSPV GYNRSLATGK RPGGSTFTIG KSIWLLWALV FNNSVPVENP RGTTSKIMVL 660 661 VWAFFAVIFL ASYTANLAAF MIQEEYVDTV SGLSDRKFQR PQEQYPPLKF GTVPNGSTEK 720 721 NIRSNYPDMH SYMVRYNQPR VEEALTQLKA GKLDAFIYDA AVLNYMARKD EGCKLVTIGS 780 781 GKVFATTGYG IALHKGSRWK RPIDLALLQF LGDDEIEMLE RLWLSGICHN DKIEVMSSKL 840 841 DIDNMAGVFY MLLVAMGLSL LVFAWEHLVY WRLRHCLGPT HRMDFLLAFS RGMYSCCSAE 900 901 AAPPPAKPPP PPQPLPSPAY PAPRPAPGPA PFVPRERASV DRWRRTKGAG PPGGAGLADG 960 961 FHRYYGPIEP QGLGLGLGEA RAAPRGAAGR PLSPPAAQPP QKPPPSYFAI VRDKEPAEPP 1020 1021 AGAFPGFPSP PAPPAAAATA VGPPLCRLAF EDESPPAPAR WPRSDPESQP LLGPGAGGAG 1080 1081 GTGGAGGGAP AAPPPCRAAP PPCPYLDLEP SPSDSEDSES LGGASLGGLE PWWFADFPYP 1140 1141 YAERLGPPPG RYWSVDKLGG WRAGSWDYLP PRSGPAAWHC RHCASLELLP PPRHLSCSHD 1200 1201 GLDGGWWAPP PPPWAAGPLP RRRARCGCPR SHPHRPRASH RTPAAAAPHH HRHRRAAGGW 1260 1261 DLPPPAPTSR SLEDLSSCPR AAPARRLTGP SRHARRCPHA AHWGPPLPTA SHRRHRGGDL 1320 1321 GTRRGSAHFS SLESEV 1336 |
Nucleotide CDS Sequence (FASTA) |
1 ATGCGCGGCG CCGGTGGCCC CCGCGGCCCT CGGGGCCCCG CTAAGATGCT GCTGCTGCTG 60 61 GCGCTGGCCT GCGCCAGCCC GTTCCCGGAG GAGGCGCCGG GGCCGGGCGG GGCCGGTGGG 120 121 CCCGGCGGCG GCCTCGGCGG GGCGCGGCCG CTCAACGTGG CGCTCGTGTT CTCGGGGCCC 180 181 GCGTACGCGG CCGAGGCGGC ACGCCTGGGC CCGGCCGTGG CGGCGGCGGT GCGCAGCCCG 240 241 GGCCTAGACG TGCGGCCCGT GGCGCTGGTG CTCAACGGCT CGGACCCGCG CAGCCTCGTG 300 301 CTGCAGCTCT GCGACCTGCT GTCGGGGTTG CGCGTGCACG GCGTGGTCTT CGAAGACGAC 360 361 TCGCGCGCGC CCGCCGTCGC GCCCATCCTC GACTTCCTGT CGGCGCAGAC CTCGCTGCCC 420 421 ATCGTGGCCG TGCACGGCGG CGCCGCGCTC GTGCTCACGC CCAAGGAGAA GGGCTCCACC 480 481 TTCCTGCAGC TGGGCTCTTC CACCGAGCAA CAGCTTCAGG TCATCTTTGA GGTGCTGGAG 540 541 GAGTATGACT GGACGTCCTT TGTAGCCGTG ACCACTCGTG CCCCTGGCCA CCGGGCCTTC 600 601 CTGTCCTACA TTGAGGTGCT GACTGACGGT AGTCTGGTGG GCTGGGAGCA CCGCGGAGCG 660 661 CTGACGCTGG ACCCTGGGGC GGGCGAGGCC GTGCTCAGTG CCCAGCTCCG CAGTGTCAGC 720 721 GCGCAGATCC GCCTGCTCTT CTGCGCCCGA GAGGAGGCCG AGCCCGTGTT CCGCGCAGCT 780 781 GAGGAGGCTG GCCTCACTGG ATCTGGCTAC GTCTGGTTCA TGGTGGGGCC CCAGCTGGCT 840 841 GGAGGCGGGG GCTCTGGGGC CCCTGGTGAG CCCCCTCTTC TGCCAGGAGG CGCCCCCCTG 900 901 CCTGCCGGGC TGTTTGCAGT GCGCTCGGCT GGCTGGCGGG ATGACCTGGC TCGGCGAGTG 960 961 GCAGCTGGCG TGGCCGTAGT GGCCAGAGGT GCCCAGGCCC TGCTGCGTGA TTATGGTTTC 1020 1021 CTTCCTGAGC TCGGCCACGA CTGTCGCGCC CAGAACCGCA CCCACCGCGG CGAGAGTCTG 1080 1081 CATAGGTACT TCATGAACAT CACGTGGGAT AACCGGGATT ACTCCTTCAA TGAGGACGGC 1140 1141 TTCCTAGTGA ACCCCTCCCT GGTGGTCATC TCCCTCACCA GAGACAGGAC GTGGGAGGTG 1200 1201 GTGGGCAGCT GGGAGCAGCA GACGCTCCGC CTCAAGTACC CGCTGTGGTC CCGCTATGGT 1260 1261 CGCTTCCTGC AGCCAGTGGA CGACACGCAG CACCTCACGG TGGCCACGCT GGAGGAAAGG 1320 1321 CCGTTTGTCA TCGTGGAGCC TGCAGACCCT ATCAGCGGCA CCTGCATCCG AGACTCCGTC 1380 1381 CCCTGCCGGA GCCAGCTCAA CCGAACCCAC AGCCCTCCAC CGGATGCCCC CCGCCCGGAA 1440 1441 AAGCGCTGCT GCAAGGGTTT CTGCATCGAC ATTCTGAAGC GGCTGGCGCA TACCATCGGC 1500 1501 TTCAGCTACG ACCTCTACCT GGTCACCAAT GGCAAGCACG GAAAGAAGAT CGATGGCGTC 1560 1561 TGGAACGGCA TGATCGGGGA GGTGTTCTAC CAGCGCGCAG ACATGGCCAT CGGCTCCCTC 1620 1621 ACCATCAACG AGGAGCGCTC CGAGATCGTG GACTTCTCCG TCCCCTTCGT GGAGACCGGC 1680 1681 ATCAGCGTCA TGGTGGCGCG CAGCAATGGC ACGGTGTCCC CCTCGGCCTT CCTCGAGCCC 1740 1741 TACAGCCCCG CCGTGTGGGT GATGATGTTC GTCATGTGCC TCACTGTGGT CGCCGTCACT 1800 1801 GTTTTCATCT TCGAGTACCT CAGTCCTGTT GGTTACAACC GCAGCCTGGC CACGGGCAAG 1860 1861 CGCCCTGGCG GTTCAACCTT CACCATTGGG AAATCCATCT GGCTGCTCTG GGCCCTGGTG 1920 1921 TTCAATAATT CGGTGCCCGT GGAGAACCCC CGGGGAACCA CCAGCAAAAT CATGGTGCTG 1980 1981 GTGTGGGCCT TCTTCGCCGT CATCTTCCTC GCCAGCTACA CAGCCAACCT GGCCGCCTTC 2040 2041 ATGATCCAGG AGGAGTACGT GGATACTGTG TCTGGGCTCA GTGACCGCAA GTTCCAGAGG 2100 2101 CCCCAGGAGC AGTACCCGCC CCTGAAGTTT GGGACCGTGC CCAACGGCTC CACGGAGAAG 2160 2161 AACATCCGCA GCAACTATCC CGACATGCAC AGCTACATGG TGCGCTACAA CCAGCCCCGC 2220 2221 GTAGAGGAAG CGCTCACTCA GCTCAAGGCA GGGAAGCTGG ACGCCTTCAT CTACGATGCT 2280 2281 GCAGTGCTCA ATTACATGGC CCGCAAGGAC GAGGGCTGCA AGCTTGTCAC CATCGGCTCC 2340 2341 GGCAAGGTCT TCGCCACGAC AGGCTATGGC ATCGCCCTGC ACAAGGGCTC CCGCTGGAAG 2400 2401 CGGCCCATCG ACCTGGCGTT GCTGCAGTTC CTGGGGGATG ATGAGATCGA GATGCTGGAG 2460 2461 CGGCTGTGGC TCTCTGGGAT CTGCCACAAT GACAAAATCG AGGTGATGAG CAGCAAGCTG 2520 2521 GACATCGACA ACATGGCGGG CGTCTTCTAC ATGCTCCTGG TGGCCATGGG CCTGTCCCTG 2580 2581 CTGGTCTTCG CCTGGGAGCA CCTGGTGTAC TGGCGCCTGC GGCACTGCCT GGGGCCCACC 2640 2641 CACCGCATGG ACTTCCTGCT GGCCTTCTCC AGGGGCATGT ACAGCTGCTG CAGCGCTGAG 2700 2701 GCCGCCCCAC CGCCCGCCAA GCCCCCGCCG CCGCCACAGC CCCTGCCCAG CCCCGCGTAC 2760 2761 CCCGCGCCGC GGCCGGCTCC CGGGCCCGCA CCTTTCGTGC CCCGCGAGCG CGCCTCAGTG 2820 2821 GACCGCTGGC GCCGGACCAA GGGCGCGGGG CCGCCGGGGG GCGCGGGCCT GGCCGACGGC 2880 2881 TTCCACCGCT ACTACGGCCC CATCGAGCCG CAGGGCCTAG GCCTCGGCCT GGGCGAAGCG 2940 2941 CGCGCGGCAC CGCGGGGCGC AGCCGGGCGC CCGCTGTCCC CGCCGGCCGC TCAGCCCCCG 3000 3001 CAGAAGCCGC CGCCCTCCTA TTTCGCCATC GTACGCGACA AGGAGCCAGC CGAGCCCCCC 3060 3061 GCCGGCGCCT TCCCCGGCTT CCCGTCGCCG CCCGCGCCCC CCGCCGCCGC GGCCACCGCC 3120 3121 GTCGGGCCGC CACTCTGCCG CTTGGCCTTC GAGGACGAGA GCCCGCCGGC GCCCGCGCGG 3180 3181 TGGCCGCGCT CGGACCCCGA GAGCCAACCC CTGCTGGGGC CAGGCGCGGG CGGCGCGGGG 3240 3241 GGCACGGGGG GCGCAGGCGG AGGAGCCCCG GCCGCTCCGC CCCCGTGCCG CGCCGCGCCG 3300 3301 CCCCCGTGCC CTTACCTCGA TCTCGAGCCG TCGCCGTCGG ACTCGGAGGA CTCGGAGAGC 3360 3361 CTGGGCGGCG CGTCGCTGGG CGGCCTGGAG CCCTGGTGGT TCGCCGACTT CCCTTACCCG 3420 3421 TATGCCGAGC GCCTCGGGCC GCCGCCCGGC CGCTACTGGT CGGTCGACAA GCTCGGGGGC 3480 3481 TGGCGCGCCG GGAGCTGGGA CTACCTGCCC CCGCGCAGCG GTCCGGCCGC CTGGCACTGT 3540 3541 CGGCACTGCG CCAGCCTGGA GCTGCTGCCG CCGCCGCGCC ATCTCAGCTG CTCGCACGAT 3600 3601 GGCCTGGACG GCGGCTGGTG GGCGCCACCG CCTCCACCCT GGGCCGCCGG GCCCCTGCCC 3660 3661 CGACGCCGGG CCCGCTGCGG GTGCCCGCGG TCGCACCCGC ACCGCCCGCG GGCCTCGCAC 3720 3721 CGCACGCCCG CCGCCGCCGC GCCCCACCAC CACAGGCACC GGCGCGCCGC TGGGGGCTGG 3780 3781 GACCTCCCGC CGCCCGCGCC CACCTCGCGC TCGCTCGAGG ACCTCAGCTC GTGCCCTCGC 3840 3841 GCCGCCCCTG CGCGCAGGCT TACCGGGCCC TCCCGCCACG CTCGCAGGTG TCCGCACGCC 3900 3901 GCGCACTGGG GGCCGCCGCT GCCCACAGCT TCCCACCGGA GACACCGGGG CGGGGACCTG 3960 3961 GGCACCCGCA GGGGCTCGGC GCACTTCTCT AGCCTCGAGT CCGAGGTATG A 4011 |
▼ KEYWORD
ID | Family |
Calcium | |
Cell junction | |
Cell membrane | |
Complete proteome | |
Disease mutation | |
Disulfide bond | |
Epilepsy | |
Glycoprotein | |
Ion channel | |
Ion transport | |
Ligand-gated ion channel | |
Magnesium | |
Membrane | |
Methylation | |
Phosphoprotein | |
Polymorphism | |
Postsynaptic cell membrane | |
Receptor | |
Reference proteome | |
Signal | |
Synapse | |
Transmembrane | |
Transmembrane helix | |
Transport
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell junction | |
Cellular Component | Integral component of plasma membrane | |
Cellular Component | NMDA selective glutamate receptor complex | |
Cellular Component | Plasma membrane | |
Cellular Component | Postsynaptic density membrane | |
Molecular Function | Glutamate-gated calcium ion channel activity | |
Molecular Function | Ionotropic glutamate receptor activity | |
Molecular Function | NMDA glutamate receptor activity | |
Biological Process | Adult locomotory behavior | |
Biological Process | Brain development | |
Biological Process | Calcium ion transmembrane import into cytosol | |
Biological Process | Excitatory chemical synaptic transmission | |
Biological Process | Excitatory postsynaptic potential | |
Biological Process | Long-term synaptic potentiation | |
Biological Process | Regulation of sensory perception of pain | |
Biological Process | Regulation of synaptic plasticity | |
Biological Process | Startle response |
▼ ANNOTATION
Disorder | ||||
IUPred2A |
Physicochemical | ||||
Compute pI/Mw | AAindex |
Localization | ||||
COMPARTMENTS |
Methylation | ||||
TCGA | ICGC | COSMIC | MethyCancer |
▼ ORTHOLOGY
DrLLPS ID | Organism | Identity | E-value | Score |
---|---|---|---|---|
LLPS-Mal-a247 | Mandrillus leucophaeus | 100.0 | 0.0 | 1541 |
LLPS-Man-a250 | Macaca nemestrina | 99.66 | 0.0 | 1649 |
LLPS-Chs-a249 | Chlorocebus sabaeus | 99.4 | 0.0 | 2663 |
LLPS-Dio-a245 | Dipodomys ordii | 99.25 | 0.0 | 1585 |
LLPS-Caj-a248 | Callithrix jacchus | 99.18 | 0.0 | 2657 |
LLPS-Gog-a247 | Gorilla gorilla | 99.0 | 0.0 | 2578 |
LLPS-Otg-a252 | Otolemur garnettii | 98.35 | 0.0 | 2628 |
LLPS-Loa-a247 | Loxodonta africana | 97.96 | 0.0 | 2192 |
LLPS-Caf-a250 | Canis familiaris | 97.87 | 0.0 | 2222 |
LLPS-Fec-a250 | Felis catus | 97.61 | 0.0 | 2615 |
LLPS-Bot-a255 | Bos taurus | 97.13 | 0.0 | 2564 |
LLPS-Cea-a251 | Cercocebus atys | 97.0 | 0.0 | 2046 |
LLPS-Cap-a249 | Cavia porcellus | 96.83 | 0.0 | 1557 |
LLPS-Sus-a254 | Sus scrofa | 96.71 | 0.0 | 2571 |
LLPS-Mum-a254 | Mus musculus | 96.63 | 0.0 | 2571 |
LLPS-Maf-a252 | Macaca fascicularis | 96.54 | 0.0 | 1433 |
LLPS-Mam-a250 | Macaca mulatta | 96.12 | 0.0 | 1572 |
LLPS-Ran-a252 | Rattus norvegicus | 95.28 | 0.0 | 2031 |
LLPS-Paa-a250 | Papio anubis | 94.35 | 0.0 | 2061 |
LLPS-Fud-a247 | Fukomys damarensis | 92.69 | 0.0 | 1516 |
LLPS-Aon-a255 | Aotus nancymaae | 92.53 | 0.0 | 1640 |
LLPS-Eqc-a254 | Equus caballus | 92.39 | 0.0 | 2531 |
LLPS-Ova-a247 | Ovis aries | 81.53 | 0.0 | 1201 |
LLPS-Pat-a248 | Pan troglodytes | 78.41 | 0.0 | 1882 |
LLPS-Asm-a217 | Astyanax mexicanus | 68.47 | 0.0 | 1120 |
LLPS-Gaa-a217 | Gasterosteus aculeatus | 67.32 | 0.0 | 1052 |
LLPS-Scf-a211 | Scleropages formosus | 64.52 | 0.0 | 1153 |
LLPS-Orn-a222 | Oreochromis niloticus | 63.79 | 0.0 | 1140 |
LLPS-Dar-a228 | Danio rerio | 63.72 | 0.0 | 1115 |
LLPS-Ten-a216 | Tetraodon nigroviridis | 63.68 | 0.0 | 1156 |
LLPS-Pof-a225 | Poecilia formosa | 63.15 | 0.0 | 1155 |
LLPS-Xet-a222 | Xenopus tropicalis | 59.69 | 0.0 | 1519 |
LLPS-Scm-a211 | Scophthalmus maximus | 59.26 | 0.0 | 1154 |
LLPS-Xim-a227 | Xiphophorus maculatus | 59.13 | 0.0 | 1151 |
LLPS-Icp-a229 | Ictalurus punctatus | 58.79 | 0.0 | 1159 |
LLPS-Lac-a230 | Latimeria chalumnae | 58.77 | 0.0 | 1494 |
LLPS-Cas-a232 | Carlito syrichta | 58.54 | 0.0 | 930 |
LLPS-Myl-a240 | Myotis lucifugus | 58.1 | 0.0 | 927 |
LLPS-Ora-a218 | Ornithorhynchus anatinus | 57.84 | 0.0 | 1027 |
LLPS-Sah-a240 | Sarcophilus harrisii | 57.71 | 0.0 | 922 |
LLPS-Anc-a236 | Anolis carolinensis | 57.65 | 0.0 | 1413 |
LLPS-Mod-a239 | Monodelphis domestica | 57.35 | 0.0 | 1015 |
LLPS-Urm-a232 | Ursus maritimus | 56.72 | 0.0 | 978 |
LLPS-Aim-a246 | Ailuropoda melanoleuca | 56.72 | 0.0 | 978 |
LLPS-Mup-a255 | Mustela putorius furo | 56.6 | 0.0 | 974 |
LLPS-Ict-a251 | Ictidomys tridecemlineatus | 56.6 | 0.0 | 976 |
LLPS-Anp-a219 | Anas platyrhynchos | 56.07 | 0.0 | 1027 |
LLPS-Tag-a219 | Taeniopygia guttata | 55.72 | 0.0 | 1020 |
LLPS-Tut-a149 | Tursiops truncatus | 55.39 | 0.0 | 1020 |
LLPS-Cii-a079 | Ciona intestinalis | 51.53 | 1e-68 | 239 |