LLPS-Hos-a256
GRIN2D

▼ OVERVIEW


Status: Reviewed
Protein Name: Glutamate receptor ionotropic, NMDA 2D
Gene Name: GRIN2D, GluN2D, NMDAR2D
Ensembl Gene: ENSG00000105464.3
Ensembl Protein: ENSP00000263269.2
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others


▼ PROPERTY



▼ Classification


Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION


Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:9489750).

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MRGAGGPRGP  RGPAKMLLLL  ALACASPFPE  EAPGPGGAGG  PGGGLGGARP  LNVALVFSGP  60
61    AYAAEAARLG  PAVAAAVRSP  GLDVRPVALV  LNGSDPRSLV  LQLCDLLSGL  RVHGVVFEDD  120
121   SRAPAVAPIL  DFLSAQTSLP  IVAVHGGAAL  VLTPKEKGST  FLQLGSSTEQ  QLQVIFEVLE  180
181   EYDWTSFVAV  TTRAPGHRAF  LSYIEVLTDG  SLVGWEHRGA  LTLDPGAGEA  VLSAQLRSVS  240
241   AQIRLLFCAR  EEAEPVFRAA  EEAGLTGSGY  VWFMVGPQLA  GGGGSGAPGE  PPLLPGGAPL  300
301   PAGLFAVRSA  GWRDDLARRV  AAGVAVVARG  AQALLRDYGF  LPELGHDCRA  QNRTHRGESL  360
361   HRYFMNITWD  NRDYSFNEDG  FLVNPSLVVI  SLTRDRTWEV  VGSWEQQTLR  LKYPLWSRYG  420
421   RFLQPVDDTQ  HLTVATLEER  PFVIVEPADP  ISGTCIRDSV  PCRSQLNRTH  SPPPDAPRPE  480
481   KRCCKGFCID  ILKRLAHTIG  FSYDLYLVTN  GKHGKKIDGV  WNGMIGEVFY  QRADMAIGSL  540
541   TINEERSEIV  DFSVPFVETG  ISVMVARSNG  TVSPSAFLEP  YSPAVWVMMF  VMCLTVVAVT  600
601   VFIFEYLSPV  GYNRSLATGK  RPGGSTFTIG  KSIWLLWALV  FNNSVPVENP  RGTTSKIMVL  660
661   VWAFFAVIFL  ASYTANLAAF  MIQEEYVDTV  SGLSDRKFQR  PQEQYPPLKF  GTVPNGSTEK  720
721   NIRSNYPDMH  SYMVRYNQPR  VEEALTQLKA  GKLDAFIYDA  AVLNYMARKD  EGCKLVTIGS  780
781   GKVFATTGYG  IALHKGSRWK  RPIDLALLQF  LGDDEIEMLE  RLWLSGICHN  DKIEVMSSKL  840
841   DIDNMAGVFY  MLLVAMGLSL  LVFAWEHLVY  WRLRHCLGPT  HRMDFLLAFS  RGMYSCCSAE  900
901   AAPPPAKPPP  PPQPLPSPAY  PAPRPAPGPA  PFVPRERASV  DRWRRTKGAG  PPGGAGLADG  960
961   FHRYYGPIEP  QGLGLGLGEA  RAAPRGAAGR  PLSPPAAQPP  QKPPPSYFAI  VRDKEPAEPP  1020
1021  AGAFPGFPSP  PAPPAAAATA  VGPPLCRLAF  EDESPPAPAR  WPRSDPESQP  LLGPGAGGAG  1080
1081  GTGGAGGGAP  AAPPPCRAAP  PPCPYLDLEP  SPSDSEDSES  LGGASLGGLE  PWWFADFPYP  1140
1141  YAERLGPPPG  RYWSVDKLGG  WRAGSWDYLP  PRSGPAAWHC  RHCASLELLP  PPRHLSCSHD  1200
1201  GLDGGWWAPP  PPPWAAGPLP  RRRARCGCPR  SHPHRPRASH  RTPAAAAPHH  HRHRRAAGGW  1260
1261  DLPPPAPTSR  SLEDLSSCPR  AAPARRLTGP  SRHARRCPHA  AHWGPPLPTA  SHRRHRGGDL  1320
1321  GTRRGSAHFS  SLESEV  1336
Nucleotide CDS Sequence (FASTA)
1     ATGCGCGGCG  CCGGTGGCCC  CCGCGGCCCT  CGGGGCCCCG  CTAAGATGCT  GCTGCTGCTG  60
61    GCGCTGGCCT  GCGCCAGCCC  GTTCCCGGAG  GAGGCGCCGG  GGCCGGGCGG  GGCCGGTGGG  120
121   CCCGGCGGCG  GCCTCGGCGG  GGCGCGGCCG  CTCAACGTGG  CGCTCGTGTT  CTCGGGGCCC  180
181   GCGTACGCGG  CCGAGGCGGC  ACGCCTGGGC  CCGGCCGTGG  CGGCGGCGGT  GCGCAGCCCG  240
241   GGCCTAGACG  TGCGGCCCGT  GGCGCTGGTG  CTCAACGGCT  CGGACCCGCG  CAGCCTCGTG  300
301   CTGCAGCTCT  GCGACCTGCT  GTCGGGGTTG  CGCGTGCACG  GCGTGGTCTT  CGAAGACGAC  360
361   TCGCGCGCGC  CCGCCGTCGC  GCCCATCCTC  GACTTCCTGT  CGGCGCAGAC  CTCGCTGCCC  420
421   ATCGTGGCCG  TGCACGGCGG  CGCCGCGCTC  GTGCTCACGC  CCAAGGAGAA  GGGCTCCACC  480
481   TTCCTGCAGC  TGGGCTCTTC  CACCGAGCAA  CAGCTTCAGG  TCATCTTTGA  GGTGCTGGAG  540
541   GAGTATGACT  GGACGTCCTT  TGTAGCCGTG  ACCACTCGTG  CCCCTGGCCA  CCGGGCCTTC  600
601   CTGTCCTACA  TTGAGGTGCT  GACTGACGGT  AGTCTGGTGG  GCTGGGAGCA  CCGCGGAGCG  660
661   CTGACGCTGG  ACCCTGGGGC  GGGCGAGGCC  GTGCTCAGTG  CCCAGCTCCG  CAGTGTCAGC  720
721   GCGCAGATCC  GCCTGCTCTT  CTGCGCCCGA  GAGGAGGCCG  AGCCCGTGTT  CCGCGCAGCT  780
781   GAGGAGGCTG  GCCTCACTGG  ATCTGGCTAC  GTCTGGTTCA  TGGTGGGGCC  CCAGCTGGCT  840
841   GGAGGCGGGG  GCTCTGGGGC  CCCTGGTGAG  CCCCCTCTTC  TGCCAGGAGG  CGCCCCCCTG  900
901   CCTGCCGGGC  TGTTTGCAGT  GCGCTCGGCT  GGCTGGCGGG  ATGACCTGGC  TCGGCGAGTG  960
961   GCAGCTGGCG  TGGCCGTAGT  GGCCAGAGGT  GCCCAGGCCC  TGCTGCGTGA  TTATGGTTTC  1020
1021  CTTCCTGAGC  TCGGCCACGA  CTGTCGCGCC  CAGAACCGCA  CCCACCGCGG  CGAGAGTCTG  1080
1081  CATAGGTACT  TCATGAACAT  CACGTGGGAT  AACCGGGATT  ACTCCTTCAA  TGAGGACGGC  1140
1141  TTCCTAGTGA  ACCCCTCCCT  GGTGGTCATC  TCCCTCACCA  GAGACAGGAC  GTGGGAGGTG  1200
1201  GTGGGCAGCT  GGGAGCAGCA  GACGCTCCGC  CTCAAGTACC  CGCTGTGGTC  CCGCTATGGT  1260
1261  CGCTTCCTGC  AGCCAGTGGA  CGACACGCAG  CACCTCACGG  TGGCCACGCT  GGAGGAAAGG  1320
1321  CCGTTTGTCA  TCGTGGAGCC  TGCAGACCCT  ATCAGCGGCA  CCTGCATCCG  AGACTCCGTC  1380
1381  CCCTGCCGGA  GCCAGCTCAA  CCGAACCCAC  AGCCCTCCAC  CGGATGCCCC  CCGCCCGGAA  1440
1441  AAGCGCTGCT  GCAAGGGTTT  CTGCATCGAC  ATTCTGAAGC  GGCTGGCGCA  TACCATCGGC  1500
1501  TTCAGCTACG  ACCTCTACCT  GGTCACCAAT  GGCAAGCACG  GAAAGAAGAT  CGATGGCGTC  1560
1561  TGGAACGGCA  TGATCGGGGA  GGTGTTCTAC  CAGCGCGCAG  ACATGGCCAT  CGGCTCCCTC  1620
1621  ACCATCAACG  AGGAGCGCTC  CGAGATCGTG  GACTTCTCCG  TCCCCTTCGT  GGAGACCGGC  1680
1681  ATCAGCGTCA  TGGTGGCGCG  CAGCAATGGC  ACGGTGTCCC  CCTCGGCCTT  CCTCGAGCCC  1740
1741  TACAGCCCCG  CCGTGTGGGT  GATGATGTTC  GTCATGTGCC  TCACTGTGGT  CGCCGTCACT  1800
1801  GTTTTCATCT  TCGAGTACCT  CAGTCCTGTT  GGTTACAACC  GCAGCCTGGC  CACGGGCAAG  1860
1861  CGCCCTGGCG  GTTCAACCTT  CACCATTGGG  AAATCCATCT  GGCTGCTCTG  GGCCCTGGTG  1920
1921  TTCAATAATT  CGGTGCCCGT  GGAGAACCCC  CGGGGAACCA  CCAGCAAAAT  CATGGTGCTG  1980
1981  GTGTGGGCCT  TCTTCGCCGT  CATCTTCCTC  GCCAGCTACA  CAGCCAACCT  GGCCGCCTTC  2040
2041  ATGATCCAGG  AGGAGTACGT  GGATACTGTG  TCTGGGCTCA  GTGACCGCAA  GTTCCAGAGG  2100
2101  CCCCAGGAGC  AGTACCCGCC  CCTGAAGTTT  GGGACCGTGC  CCAACGGCTC  CACGGAGAAG  2160
2161  AACATCCGCA  GCAACTATCC  CGACATGCAC  AGCTACATGG  TGCGCTACAA  CCAGCCCCGC  2220
2221  GTAGAGGAAG  CGCTCACTCA  GCTCAAGGCA  GGGAAGCTGG  ACGCCTTCAT  CTACGATGCT  2280
2281  GCAGTGCTCA  ATTACATGGC  CCGCAAGGAC  GAGGGCTGCA  AGCTTGTCAC  CATCGGCTCC  2340
2341  GGCAAGGTCT  TCGCCACGAC  AGGCTATGGC  ATCGCCCTGC  ACAAGGGCTC  CCGCTGGAAG  2400
2401  CGGCCCATCG  ACCTGGCGTT  GCTGCAGTTC  CTGGGGGATG  ATGAGATCGA  GATGCTGGAG  2460
2461  CGGCTGTGGC  TCTCTGGGAT  CTGCCACAAT  GACAAAATCG  AGGTGATGAG  CAGCAAGCTG  2520
2521  GACATCGACA  ACATGGCGGG  CGTCTTCTAC  ATGCTCCTGG  TGGCCATGGG  CCTGTCCCTG  2580
2581  CTGGTCTTCG  CCTGGGAGCA  CCTGGTGTAC  TGGCGCCTGC  GGCACTGCCT  GGGGCCCACC  2640
2641  CACCGCATGG  ACTTCCTGCT  GGCCTTCTCC  AGGGGCATGT  ACAGCTGCTG  CAGCGCTGAG  2700
2701  GCCGCCCCAC  CGCCCGCCAA  GCCCCCGCCG  CCGCCACAGC  CCCTGCCCAG  CCCCGCGTAC  2760
2761  CCCGCGCCGC  GGCCGGCTCC  CGGGCCCGCA  CCTTTCGTGC  CCCGCGAGCG  CGCCTCAGTG  2820
2821  GACCGCTGGC  GCCGGACCAA  GGGCGCGGGG  CCGCCGGGGG  GCGCGGGCCT  GGCCGACGGC  2880
2881  TTCCACCGCT  ACTACGGCCC  CATCGAGCCG  CAGGGCCTAG  GCCTCGGCCT  GGGCGAAGCG  2940
2941  CGCGCGGCAC  CGCGGGGCGC  AGCCGGGCGC  CCGCTGTCCC  CGCCGGCCGC  TCAGCCCCCG  3000
3001  CAGAAGCCGC  CGCCCTCCTA  TTTCGCCATC  GTACGCGACA  AGGAGCCAGC  CGAGCCCCCC  3060
3061  GCCGGCGCCT  TCCCCGGCTT  CCCGTCGCCG  CCCGCGCCCC  CCGCCGCCGC  GGCCACCGCC  3120
3121  GTCGGGCCGC  CACTCTGCCG  CTTGGCCTTC  GAGGACGAGA  GCCCGCCGGC  GCCCGCGCGG  3180
3181  TGGCCGCGCT  CGGACCCCGA  GAGCCAACCC  CTGCTGGGGC  CAGGCGCGGG  CGGCGCGGGG  3240
3241  GGCACGGGGG  GCGCAGGCGG  AGGAGCCCCG  GCCGCTCCGC  CCCCGTGCCG  CGCCGCGCCG  3300
3301  CCCCCGTGCC  CTTACCTCGA  TCTCGAGCCG  TCGCCGTCGG  ACTCGGAGGA  CTCGGAGAGC  3360
3361  CTGGGCGGCG  CGTCGCTGGG  CGGCCTGGAG  CCCTGGTGGT  TCGCCGACTT  CCCTTACCCG  3420
3421  TATGCCGAGC  GCCTCGGGCC  GCCGCCCGGC  CGCTACTGGT  CGGTCGACAA  GCTCGGGGGC  3480
3481  TGGCGCGCCG  GGAGCTGGGA  CTACCTGCCC  CCGCGCAGCG  GTCCGGCCGC  CTGGCACTGT  3540
3541  CGGCACTGCG  CCAGCCTGGA  GCTGCTGCCG  CCGCCGCGCC  ATCTCAGCTG  CTCGCACGAT  3600
3601  GGCCTGGACG  GCGGCTGGTG  GGCGCCACCG  CCTCCACCCT  GGGCCGCCGG  GCCCCTGCCC  3660
3661  CGACGCCGGG  CCCGCTGCGG  GTGCCCGCGG  TCGCACCCGC  ACCGCCCGCG  GGCCTCGCAC  3720
3721  CGCACGCCCG  CCGCCGCCGC  GCCCCACCAC  CACAGGCACC  GGCGCGCCGC  TGGGGGCTGG  3780
3781  GACCTCCCGC  CGCCCGCGCC  CACCTCGCGC  TCGCTCGAGG  ACCTCAGCTC  GTGCCCTCGC  3840
3841  GCCGCCCCTG  CGCGCAGGCT  TACCGGGCCC  TCCCGCCACG  CTCGCAGGTG  TCCGCACGCC  3900
3901  GCGCACTGGG  GGCCGCCGCT  GCCCACAGCT  TCCCACCGGA  GACACCGGGG  CGGGGACCTG  3960
3961  GGCACCCGCA  GGGGCTCGGC  GCACTTCTCT  AGCCTCGAGT  CCGAGGTATG  A  4011

▼ KEYWORD


ID
Family
Calcium
Cell junction
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Epilepsy
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Magnesium
Membrane
Methylation
Phosphoprotein
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cell junction
Cellular Component
Integral component of plasma membrane
Cellular Component
NMDA selective glutamate receptor complex
Cellular Component
Plasma membrane
Cellular Component
Postsynaptic density membrane
Molecular Function
Glutamate-gated calcium ion channel activity
Molecular Function
Ionotropic glutamate receptor activity
Molecular Function
NMDA glutamate receptor activity
Biological Process
Adult locomotory behavior
Biological Process
Brain development
Biological Process
Calcium ion transmembrane import into cytosol
Biological Process
Excitatory chemical synaptic transmission
Biological Process
Excitatory postsynaptic potential
Biological Process
Long-term synaptic potentiation
Biological Process
Regulation of sensory perception of pain
Biological Process
Regulation of synaptic plasticity
Biological Process
Startle response

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mal-a247Mandrillus leucophaeus100.00.01541
LLPS-Man-a250Macaca nemestrina99.660.01649
LLPS-Chs-a249Chlorocebus sabaeus99.40.02663
LLPS-Dio-a245Dipodomys ordii99.250.01585
LLPS-Caj-a248Callithrix jacchus99.180.02657
LLPS-Gog-a247Gorilla gorilla99.00.02578
LLPS-Otg-a252Otolemur garnettii98.350.02628
LLPS-Loa-a247Loxodonta africana97.960.02192
LLPS-Caf-a250Canis familiaris97.870.02222
LLPS-Fec-a250Felis catus97.610.02615
LLPS-Bot-a255Bos taurus97.130.02564
LLPS-Cea-a251Cercocebus atys97.00.02046
LLPS-Cap-a249Cavia porcellus96.830.01557
LLPS-Sus-a254Sus scrofa96.710.02571
LLPS-Mum-a254Mus musculus96.630.02571
LLPS-Maf-a252Macaca fascicularis96.540.01433
LLPS-Mam-a250Macaca mulatta96.120.01572
LLPS-Ran-a252Rattus norvegicus95.280.02031
LLPS-Paa-a250Papio anubis94.350.02061
LLPS-Fud-a247Fukomys damarensis92.690.01516
LLPS-Aon-a255Aotus nancymaae92.530.01640
LLPS-Eqc-a254Equus caballus92.390.02531
LLPS-Ova-a247Ovis aries81.530.01201
LLPS-Pat-a248Pan troglodytes78.410.01882
LLPS-Asm-a217Astyanax mexicanus68.470.01120
LLPS-Gaa-a217Gasterosteus aculeatus67.320.01052
LLPS-Scf-a211Scleropages formosus64.520.01153
LLPS-Orn-a222Oreochromis niloticus63.790.01140
LLPS-Dar-a228Danio rerio63.720.01115
LLPS-Ten-a216Tetraodon nigroviridis63.680.01156
LLPS-Pof-a225Poecilia formosa63.150.01155
LLPS-Xet-a222Xenopus tropicalis59.690.01519
LLPS-Scm-a211Scophthalmus maximus59.260.01154
LLPS-Xim-a227Xiphophorus maculatus59.130.01151
LLPS-Icp-a229Ictalurus punctatus58.790.01159
LLPS-Lac-a230Latimeria chalumnae58.770.01494
LLPS-Cas-a232Carlito syrichta58.540.0930
LLPS-Myl-a240Myotis lucifugus58.10.0927
LLPS-Ora-a218Ornithorhynchus anatinus57.840.01027
LLPS-Sah-a240Sarcophilus harrisii57.710.0922
LLPS-Anc-a236Anolis carolinensis57.650.01413
LLPS-Mod-a239Monodelphis domestica57.350.01015
LLPS-Urm-a232Ursus maritimus56.720.0978
LLPS-Aim-a246Ailuropoda melanoleuca56.720.0978
LLPS-Mup-a255Mustela putorius furo56.60.0974
LLPS-Ict-a251Ictidomys tridecemlineatus56.60.0976
LLPS-Anp-a219Anas platyrhynchos56.070.01027
LLPS-Tag-a219Taeniopygia guttata55.720.01020
LLPS-Tut-a149Tursiops truncatus55.390.01020
LLPS-Cii-a079Ciona intestinalis51.531e-68239