LLPS-Hos-a212
SYP

▼ OVERVIEW

Status: Reviewed
Protein Name: Synaptophysin; Major synaptic vesicle protein p38
Gene Name: SYP
Ensembl Gene: ENSG00000102003.10
Ensembl Protein: ENSP00000420774.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLLLADMDVV  NQLVAGGQFR  VVKEPLGFVK  VLQWVFAIFA  FATCGSYSGE  LQLSVDCANK  60
61    TESDLSIEVE  FEYPFRLHQV  YFDAPTCRGG  TTKVFLVGDY  SSSAEFFVTV  AVFAFLYSMG  120
121   ALATYIFLQN  KYRENNKGPM  LDFLATAVFA  FMWLVSSSAW  AKGLSDVKMA  TDPENIIKEM  180
181   PVCRQTGNTC  KELRDPVTSG  LNTSVVFGFL  NLVLWVGNLW  FVFKETGWAA  PFLRAPPGAP  240
241   EKQPAPGDAY  GDAGYGQGPG  GYGPQDSYGP  QGGYQPDYGQ  PAGSGGSGYG  PQGDYGQQGY  300
301   GPQGAPTSFS  NQM  313
Nucleotide CDS Sequence (FASTA)
1     ATGCTGCTGC  TGGCGGACAT  GGACGTGGTG  AATCAGCTGG  TGGCTGGGGG  TCAGTTCCGG  60
61    GTGGTCAAGG  AGCCCCTCGG  CTTTGTGAAG  GTGCTGCAAT  GGGTCTTCGC  CATCTTCGCC  120
121   TTTGCCACAT  GCGGCAGCTA  CAGTGGGGAG  CTCCAGCTGA  GCGTGGATTG  TGCCAACAAG  180
181   ACCGAGAGTG  ACCTCAGCAT  CGAGGTCGAG  TTCGAGTACC  CCTTCAGGCT  GCACCAAGTG  240
241   TACTTTGATG  CACCCACCTG  CCGAGGGGGC  ACCACCAAGG  TCTTCTTAGT  TGGGGACTAC  300
301   TCCTCGTCAG  CCGAATTCTT  TGTCACCGTG  GCCGTGTTTG  CCTTCCTCTA  CTCCATGGGG  360
361   GCTCTGGCCA  CCTACATCTT  CCTGCAGAAC  AAGTACCGAG  AGAATAACAA  AGGGCCCATG  420
421   CTGGACTTTC  TGGCCACGGC  TGTGTTCGCC  TTCATGTGGC  TAGTTAGCTC  ATCGGCATGG  480
481   GCCAAGGGGC  TGTCAGATGT  GAAGATGGCC  ACAGACCCAG  AGAACATTAT  CAAGGAGATG  540
541   CCTGTCTGCC  GCCAGACAGG  GAACACATGC  AAGGAGCTGA  GAGACCCTGT  GACCTCGGGA  600
601   CTCAACACCT  CGGTGGTGTT  CGGCTTCCTG  AACCTGGTGC  TCTGGGTCGG  CAACCTGTGG  660
661   TTCGTGTTTA  AGGAGACAGG  CTGGGCCGCC  CCGTTCCTGC  GCGCGCCTCC  CGGCGCCCCC  720
721   GAGAAACAAC  CGGCACCCGG  GGACGCCTAC  GGCGATGCAG  GCTACGGGCA  GGGCCCCGGC  780
781   GGGTACGGGC  CCCAGGATTC  CTACGGGCCT  CAGGGCGGCT  ACCAGCCTGA  CTATGGTCAA  840
841   CCAGCCGGCA  GCGGTGGCAG  TGGCTACGGG  CCTCAGGGCG  ACTATGGGCA  GCAAGGCTAC  900
901   GGCCCGCAGG  GTGCACCCAC  CTCCTTCTCC  AATCAGATGT  AG  942

▼ KEYWORD

ID
Family
Alternative splicing
Calcium
Cell junction
Complete proteome
Cytoplasmic vesicle
Disease mutation
Glycoprotein
Membrane
Mental retardation
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Synapse
Synaptosome
Transmembrane
Transmembrane helix
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cell junction
Cellular Component
Excitatory synapse
Cellular Component
Integral component of synaptic vesicle membrane
Cellular Component
Neuromuscular junction
Cellular Component
Neuron projection
Cellular Component
Perinuclear region of cytoplasm
Cellular Component
Presynaptic active zone
Cellular Component
Presynaptic membrane
Cellular Component
Schaffer collateral - CA1 synapse
Cellular Component
Synaptic vesicle
Cellular Component
Synaptic vesicle membrane
Cellular Component
Terminal bouton
Molecular Function
Cholesterol binding
Molecular Function
Identical protein binding
Molecular Function
Protein self-association
Molecular Function
SH2 domain binding
Molecular Function
Syntaxin-1 binding
Biological Process
Cellular response to organic substance
Biological Process
Endocytosis
Biological Process
Regulation of long-term neuronal synaptic plasticity
Biological Process
Regulation of opioid receptor signaling pathway
Biological Process
Regulation of short-term neuronal synaptic plasticity
Biological Process
Regulation of synaptic vesicle exocytosis
Biological Process
Synaptic vesicle endocytosis
Biological Process
Synaptic vesicle maturation
Biological Process
Synaptic vesicle membrane organization

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-a205Pan troglodytes99.680.0637
LLPS-Pap-a205Pan paniscus99.680.0637
LLPS-Nol-a212Nomascus leucogenys99.680.0637
LLPS-Poa-a209Pongo abelii99.360.0634
LLPS-Mal-a206Mandrillus leucophaeus99.360.0634
LLPS-Cea-a209Cercocebus atys99.360.0634
LLPS-Chs-a208Chlorocebus sabaeus99.360.0634
LLPS-Caj-a205Callithrix jacchus99.360.0636
LLPS-Paa-a208Papio anubis99.360.0637
LLPS-Mam-a207Macaca mulatta99.360.0634
LLPS-Rhb-a204Rhinopithecus bieti99.360.0637
LLPS-Maf-a209Macaca fascicularis99.360.0634
LLPS-Man-a207Macaca nemestrina99.360.0634
LLPS-Gog-a206Gorilla gorilla99.040.0635
LLPS-Aon-a212Aotus nancymaae98.720.0633
LLPS-Dio-a205Dipodomys ordii96.810.0622
LLPS-Ict-a208Ictidomys tridecemlineatus96.490.0621
LLPS-Cas-a190Carlito syrichta96.380.0603
LLPS-Otg-a207Otolemur garnettii96.170.0616
LLPS-Cap-a207Cavia porcellus96.170.0612
LLPS-Eqc-a212Equus caballus96.170.0546
LLPS-Loa-a205Loxodonta africana95.487e-152434
LLPS-Fud-a205Fukomys damarensis95.020.0518
LLPS-Mum-a208Mus musculus94.90.0540
LLPS-Tut-a118Tursiops truncatus94.890.0537
LLPS-Mea-a193Mesocricetus auratus94.890.0542
LLPS-Aim-a203Ailuropoda melanoleuca94.570.0555
LLPS-Bot-a212Bos taurus94.250.0549
LLPS-Sus-a211Sus scrofa93.930.0548
LLPS-Ran-a209Rattus norvegicus93.663e-165470
LLPS-Fec-a208Felis catus93.290.0538
LLPS-Mup-a211Mustela putorius furo92.990.0538
LLPS-Caf-a208Canis familiaris92.110.0514
LLPS-Myl-a200Myotis lucifugus91.670.0558
LLPS-Mod-a199Monodelphis domestica78.677e-151434
LLPS-Anc-a195Anolis carolinensis70.967e-143415
LLPS-Xet-a185Xenopus tropicalis70.754e-150433
LLPS-Scf-a178Scleropages formosus69.581e-144419
LLPS-Dar-a184Danio rerio68.934e-142412
LLPS-Pof-a185Poecilia formosa66.993e-137400
LLPS-Orn-a182Oreochromis niloticus66.674e-141409
LLPS-Xim-a190Xiphophorus maculatus66.023e-141410
LLPS-Lac-a192Latimeria chalumnae65.533e-135395
LLPS-Asm-a179Astyanax mexicanus65.371e-136398
LLPS-Scm-a175Scophthalmus maximus65.372e-137400
LLPS-Icp-a190Ictalurus punctatus65.159e-138401
LLPS-Orl-a182Oryzias latipes65.051e-134393
LLPS-Gaa-a183Gasterosteus aculeatus64.49e-135393
LLPS-Ten-a180Tetraodon nigroviridis63.782e-135395
LLPS-Tar-a178Takifugu rubripes63.162e-131385
LLPS-Tag-a189Taeniopygia guttata61.921e-113338
LLPS-Meg-a181Meleagris gallopavo61.923e-112335
LLPS-Anp-a188Anas platyrhynchos61.574e-113337
LLPS-Gaga-a194Gallus gallus61.491e-125372
LLPS-Fia-a189Ficedula albicollis61.199e-114339
LLPS-Leo-a183Lepisosteus oculatus60.72e-129380
LLPS-Pes-a188Pelodiscus sinensis59.248e-80251
LLPS-Sah-a201Sarcophilus harrisii59.226e-108324
LLPS-Ova-a206Ovis aries58.779e-118350
LLPS-Urm-a196Ursus maritimus58.012e-102310
LLPS-Orc-a203Oryctolagus cuniculus58.017e-102308