LLPS-Hos-a205
SNTA1

▼ OVERVIEW

Status: Reviewed
Protein Name: Alpha-1-syntrophin; 59 kDa dystrophin-associated protein A1 acidic component 1; Pro-TGF-alpha cytoplasmic domain-interacting protein 1; TACIP1; Syntrophin-1
Gene Name: SNTA1, SNT1
Ensembl Gene: ENSG00000101400.5
Ensembl Protein: ENSP00000217381.2
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MASGRRAPRT  GLLELRAGAG  SGAGGERWQR  VLLSLAEDVL  TVSPADGDPG  PEPGAPREQE  60
61    PAQLNGAAEP  GAGPPQLPEA  LLLQRRRVTV  RKADAGGLGI  SIKGGRENKM  PILISKIFKG  120
121   LAADQTEALF  VGDAILSVNG  EDLSSATHDE  AVQVLKKTGK  EVVLEVKYMK  DVSPYFKNST  180
181   GGTSVGWDSP  PASPLQRQPS  SPGPTPRNFS  EAKHMSLKMA  YVSKRCTPND  PEPRYLEICS  240
241   ADGQDTLFLR  AKDEASARSW  ATAIQAQVNT  LTPRVKDELQ  ALLAATSTAG  SQDIKQIGWL  300
301   TEQLPSGGTA  PTLALLTEKE  LLLYLSLPET  REALSRPART  APLIATRLVH  SGPSKGSVPY  360
361   DAELSFALRT  GTRHGVDTHL  FSVESPQELA  AWTRQLVDGC  HRAAEGVQEV  STACTWNGRP  420
421   CSLSVHIDKG  FTLWAAEPGA  ARAVLLRQPF  EKLQMSSDDG  ASLLFLDFGG  AEGEIQLDLH  480
481   SCPKTIVFII  HSFLSAKVTR  LGLLA  505
Nucleotide CDS Sequence (FASTA)
1     ATGGCGTCCG  GCAGGCGCGC  CCCGCGCACC  GGGCTGCTGG  AGCTGCGCGC  CGGGGCGGGC  60
61    TCGGGGGCCG  GCGGCGAGCG  ATGGCAGCGG  GTGCTGCTGA  GTCTGGCGGA  GGACGTGCTG  120
121   ACCGTGAGCC  CCGCCGACGG  CGACCCTGGT  CCCGAGCCCG  GCGCTCCGCG  GGAGCAGGAG  180
181   CCCGCGCAGC  TCAACGGCGC  CGCGGAGCCG  GGCGCCGGGC  CCCCGCAGCT  GCCAGAGGCG  240
241   CTACTGCTCC  AGCGGCGCCG  CGTGACGGTG  CGCAAGGCCG  ACGCCGGTGG  GCTGGGCATC  300
301   AGCATCAAAG  GCGGCCGGGA  GAACAAGATG  CCTATTCTCA  TTTCCAAGAT  CTTCAAGGGA  360
361   TTGGCAGCTG  ACCAGACAGA  GGCCCTTTTT  GTGGGGGATG  CCATCCTGTC  TGTGAATGGG  420
421   GAAGACTTGT  CCTCTGCTAC  CCATGATGAG  GCGGTGCAGG  TCCTCAAGAA  GACAGGCAAG  480
481   GAGGTGGTGC  TGGAGGTCAA  GTATATGAAG  GACGTCTCAC  CGTATTTCAA  GAACTCTACT  540
541   GGTGGGACCT  CGGTCGGCTG  GGACTCACCT  CCTGCCTCAC  CCCTTCAGCG  GCAGCCTTCC  600
601   TCCCCTGGCC  CCACACCCCG  GAACTTCAGC  GAGGCCAAAC  ACATGTCCTT  GAAGATGGCA  660
661   TATGTCTCGA  AGAGGTGCAC  CCCCAATGAC  CCGGAGCCCA  GGTATCTGGA  GATCTGCTCG  720
721   GCAGATGGTC  AAGACACCCT  CTTCCTGAGG  GCCAAGGATG  AGGCTAGTGC  GAGGTCGTGG  780
781   GCGACTGCCA  TCCAAGCCCA  GGTCAATACT  CTGACGCCGC  GGGTCAAGGA  TGAGCTGCAG  840
841   GCACTGTTGG  CAGCCACCAG  CACAGCTGGG  AGCCAGGACA  TCAAGCAGAT  TGGCTGGCTA  900
901   ACTGAGCAGC  TGCCCAGTGG  GGGCACAGCC  CCCACCCTGG  CCCTGCTAAC  TGAAAAGGAA  960
961   CTGCTCCTCT  ACTTGTCTCT  CCCCGAGACC  CGCGAGGCCC  TGAGCCGGCC  AGCCCGTACT  1020
1021  GCCCCACTCA  TCGCCACCAG  ACTGGTGCAC  TCAGGCCCCT  CCAAGGGCTC  AGTGCCCTAC  1080
1081  GATGCAGAGC  TCTCTTTTGC  CCTGCGCACG  GGCACGCGTC  ACGGTGTGGA  CACTCACCTG  1140
1141  TTCAGCGTGG  AGTCACCGCA  GGAGCTGGCT  GCCTGGACCC  GCCAGCTTGT  GGATGGCTGT  1200
1201  CACCGGGCCG  CCGAGGGTGT  GCAGGAGGTG  TCTACAGCCT  GCACGTGGAA  TGGGCGTCCC  1260
1261  TGCAGCCTGT  CTGTGCACAT  CGACAAGGGC  TTCACACTGT  GGGCGGCTGA  GCCAGGTGCA  1320
1321  GCCCGAGCTG  TGCTCCTGCG  ACAGCCCTTC  GAGAAGCTGC  AGATGTCTTC  AGATGACGGT  1380
1381  GCCAGTCTCC  TTTTCCTGGA  TTTTGGAGGT  GCTGAAGGCG  AGATCCAGCT  GGACCTGCAC  1440
1441  TCGTGTCCCA  AAACCATAGT  CTTCATCATC  CACTCCTTCC  TGTCGGCCAA  AGTCACCCGC  1500
1501  CTCGGGCTGT  TGGCCTAG  1518

▼ KEYWORD

ID
Family
Actin-binding
Alternative splicing
Calcium
Calmodulin-binding
Cell junction
Cell membrane
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Long QT syndrome
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cell junction
Cellular Component
Cytoplasm
Cellular Component
Cytoskeleton
Cellular Component
Dystrophin-associated glycoprotein complex
Cellular Component
Neuromuscular junction
Cellular Component
Protein-containing complex
Cellular Component
Sarcolemma
Cellular Component
Synapse
Cellular Component
Syntrophin complex
Molecular Function
Actin binding
Molecular Function
ATPase binding
Molecular Function
Calmodulin binding
Molecular Function
Ion channel binding
Molecular Function
Nitric-oxide synthase binding
Molecular Function
PDZ domain binding
Molecular Function
Structural molecule activity
Biological Process
Muscle contraction
Biological Process
Negative regulation of peptidyl-cysteine S-nitrosylation
Biological Process
Regulation of heart rate
Biological Process
Regulation of sodium ion transmembrane transport
Biological Process
Regulation of ventricular cardiac muscle cell membrane repolarization
Biological Process
Ventricular cardiac muscle cell action potential

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-a198Pan troglodytes99.410.01015
LLPS-Pap-a198Pan paniscus99.070.0869
LLPS-Gog-a199Gorilla gorilla98.810.01007
LLPS-Aon-a205Aotus nancymaae97.820.0996
LLPS-Poa-a202Pongo abelii97.430.0994
LLPS-Caj-a198Callithrix jacchus96.830.0987
LLPS-Nol-a205Nomascus leucogenys96.830.0981
LLPS-Cea-a202Cercocebus atys96.240.0962
LLPS-Paa-a201Papio anubis96.240.0962
LLPS-Maf-a202Macaca fascicularis96.040.0958
LLPS-Rhb-a197Rhinopithecus bieti96.00.0767
LLPS-Mam-a200Macaca mulatta95.960.0757
LLPS-Chs-a201Chlorocebus sabaeus95.250.0954
LLPS-Mup-a204Mustela putorius furo94.260.0944
LLPS-Fec-a201Felis catus94.260.0944
LLPS-Aim-a196Ailuropoda melanoleuca94.080.0778
LLPS-Caf-a201Canis familiaris93.690.0760
LLPS-Eqc-a205Equus caballus93.660.0934
LLPS-Otg-a200Otolemur garnettii93.520.0916
LLPS-Myl-a193Myotis lucifugus93.280.0773
LLPS-Ova-a199Ovis aries93.270.0925
LLPS-Bot-a205Bos taurus93.270.0932
LLPS-Urm-a189Ursus maritimus93.010.0679
LLPS-Ran-a202Rattus norvegicus92.870.0930
LLPS-Loa-a198Loxodonta africana92.760.0858
LLPS-Orc-a196Oryctolagus cuniculus92.620.0891
LLPS-Cap-a200Cavia porcellus92.480.0910
LLPS-Fud-a198Fukomys damarensis92.010.0780
LLPS-Mum-a201Mus musculus91.750.0942
LLPS-Mal-a199Mandrillus leucophaeus88.890.0785
LLPS-Sus-a204Sus scrofa87.920.0866
LLPS-Man-a200Macaca nemestrina87.550.0932
LLPS-Dio-a198Dipodomys ordii83.970.0791
LLPS-Cas-a183Carlito syrichta82.610.0754
LLPS-Ict-a201Ictidomys tridecemlineatus80.490.0686
LLPS-Ora-a180Ornithorhynchus anatinus76.592e-166482
LLPS-Mea-a186Mesocricetus auratus76.490.0714
LLPS-Mod-a192Monodelphis domestica71.260.0684
LLPS-Tag-a184Taeniopygia guttata68.230.0549
LLPS-Fia-a185Ficedula albicollis68.130.0565
LLPS-Gaga-a189Gallus gallus68.120.0660
LLPS-Anc-a189Anolis carolinensis67.520.0684
LLPS-Xet-a179Xenopus tropicalis61.460.0580
LLPS-Lac-a187Latimeria chalumnae60.590.0601
LLPS-Leo-a177Lepisosteus oculatus59.760.0593
LLPS-Gaa-a177Gasterosteus aculeatus58.879e-168489
LLPS-Scf-a172Scleropages formosus58.420.0561
LLPS-Orl-a176Oryzias latipes56.920.0561
LLPS-Scm-a170Scophthalmus maximus56.690.0551
LLPS-Asm-a173Astyanax mexicanus56.520.0546
LLPS-Icp-a184Ictalurus punctatus55.930.0536
LLPS-Tar-a173Takifugu rubripes55.730.0552
LLPS-Ten-a175Tetraodon nigroviridis55.530.0553
LLPS-Orn-a177Oreochromis niloticus55.340.0550
LLPS-Xim-a184Xiphophorus maculatus54.740.0543
LLPS-Tut-a113Tursiops truncatus54.428e-159469
LLPS-Pof-a179Poecilia formosa54.150.0528
LLPS-Pes-a183Pelodiscus sinensis53.331e-144431
LLPS-Anp-a182Anas platyrhynchos53.293e-161474
LLPS-Cii-a066Ciona intestinalis50.591e-1687.4
LLPS-Cis-a058Ciona savignyi50.05e-1686.7