LLPS-Hos-a188
NEFH

▼ OVERVIEW

Status: Reviewed
Protein Name: Neurofilament heavy polypeptide
Gene Name: NEFH, KIAA0845, NFH
Ensembl Gene: ENSG00000100285.9
Ensembl Protein: ENSP00000311997.6
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MMSFGGADAL  LGAPFAPLHG  GGSLHYALAR  KGGAGGTRSA  AGSSSGFHSW  TRTSVSSVSA  60
61    SPSRFRGAGA  ASSTDSLDTL  SNGPEGCMVA  VATSRSEKEQ  LQALNDRFAG  YIDKVRQLEA  120
121   HNRSLEGEAA  ALRQQQAGRS  AMGELYEREV  REMRGAVLRL  GAARGQLRLE  QEHLLEDIAH  180
181   VRQRLDDEAR  QREEAEAAAR  ALARFAQEAE  AARVDLQKKA  QALQEECGYL  RRHHQEEVGE  240
241   LLGQIQGSGA  AQAQMQAETR  DALKCDVTSA  LREIRAQLEG  HAVQSTLQSE  EWFRVRLDRL  300
301   SEAAKVNTDA  MRSAQEEITE  YRRQLQARTT  ELEALKSTKD  SLERQRSELE  DRHQADIASY  360
361   QEAIQQLDAE  LRNTKWEMAA  QLREYQDLLN  VKMALDIEIA  AYRKLLEGEE  CRIGFGPIPF  420
421   SLPEGLPKIP  SVSTHIKVKS  EEKIKVVEKS  EKETVIVEEQ  TEETQVTEEV  TEEEEKEAKE  480
481   EEGKEEEGGE  EEEAEGGEEE  TKSPPAEEAA  SPEKEAKSPV  KEEAKSPAEA  KSPEKEEAKS  540
541   PAEVKSPEKA  KSPAKEEAKS  PPEAKSPEKE  EAKSPAEVKS  PEKAKSPAKE  EAKSPAEAKS  600
601   PEKAKSPVKE  EAKSPAEAKS  PVKEEAKSPA  EVKSPEKAKS  PTKEEAKSPE  KAKSPEKEEA  660
661   KSPEKAKSPV  KAEAKSPEKA  KSPVKAEAKS  PEKAKSPVKE  EAKSPEKAKS  PVKEEAKSPE  720
721   KAKSPVKEEA  KTPEKAKSPV  KEEAKSPEKA  KSPEKAKTLD  VKSPEAKTPA  KEEARSPADK  780
781   FPEKAKSPVK  EEVKSPEKAK  SPLKEDAKAP  EKEIPKKEEV  KSPVKEEEKP  QEVKVKEPPK  840
841   KAEEEKAPAT  PKTEEKKDSK  KEEAPKKEAP  KPKVEEKKEP  AVEKPKESKV  EAKKEEAEDK  900
901   KKVPTPEKEA  PAKVEVKEDA  KPKEKTEVAK  KEPDDAKAKE  PSKPAEKKEA  APEKKDTKEE  960
961   KAKKPEEKPK  TEAKAKEDDK  TLSKEPSKPK  AEKAEKSSST  DQKDSKPPEK  ATEDKAAKGK  1020
Nucleotide CDS Sequence (FASTA)
1     ATGATGAGCT  TCGGCGGCGC  GGACGCGCTG  CTGGGCGCCC  CGTTCGCGCC  GCTGCATGGC  60
61    GGCGGCAGCC  TCCACTACGC  GCTAGCCCGA  AAGGGTGGCG  CAGGCGGGAC  GCGCTCCGCC  120
121   GCTGGCTCCT  CCAGCGGCTT  CCACTCGTGG  ACACGGACGT  CCGTGAGCTC  CGTGTCCGCC  180
181   TCGCCCAGCC  GCTTCCGTGG  CGCAGGCGCC  GCCTCAAGCA  CCGACTCGCT  GGACACGCTG  240
241   AGCAACGGGC  CGGAGGGCTG  CATGGTGGCG  GTGGCCACCT  CACGCAGTGA  GAAGGAGCAG  300
301   CTGCAGGCGC  TGAACGACCG  CTTCGCCGGG  TACATCGACA  AGGTGCGGCA  GCTGGAGGCG  360
361   CACAACCGCA  GCCTGGAGGG  CGAGGCTGCG  GCGCTGCGGC  AGCAGCAGGC  GGGCCGCTCC  420
421   GCTATGGGCG  AGCTGTACGA  GCGCGAGGTC  CGCGAGATGC  GCGGCGCGGT  GCTGCGCCTG  480
481   GGCGCGGCGC  GCGGTCAGCT  ACGCCTGGAG  CAGGAGCACC  TGCTCGAGGA  CATCGCGCAC  540
541   GTGCGCCAGC  GCCTAGACGA  CGAGGCCCGG  CAGCGAGAGG  AGGCCGAGGC  GGCGGCCCGC  600
601   GCGCTGGCGC  GCTTCGCGCA  GGAGGCCGAG  GCGGCGCGCG  TGGACCTGCA  GAAGAAGGCG  660
661   CAGGCGCTGC  AGGAGGAGTG  CGGCTACCTG  CGGCGCCACC  ACCAGGAAGA  GGTGGGCGAG  720
721   CTGCTCGGCC  AGATCCAGGG  CTCCGGCGCC  GCGCAGGCGC  AGATGCAGGC  CGAGACGCGC  780
781   GACGCCCTGA  AGTGCGACGT  GACGTCGGCG  CTGCGCGAGA  TTCGCGCGCA  GCTTGAAGGC  840
841   CACGCGGTGC  AGAGCACGCT  GCAGTCCGAG  GAGTGGTTCC  GAGTGAGGCT  GGACCGACTG  900
901   TCGGAGGCAG  CCAAGGTGAA  CACAGACGCT  ATGCGCTCAG  CGCAGGAGGA  GATAACTGAG  960
961   TACCGGCGTC  AGCTGCAGGC  CAGGACCACA  GAGCTGGAGG  CACTGAAAAG  CACCAAGGAC  1020
1021  TCACTGGAGA  GGCAGCGCTC  TGAGCTGGAG  GACCGTCATC  AGGCCGACAT  TGCCTCCTAC  1080
1081  CAGGAAGCCA  TTCAGCAGCT  GGACGCTGAG  CTGAGGAACA  CCAAGTGGGA  GATGGCCGCC  1140
1141  CAGCTGCGAG  AATACCAGGA  CCTGCTCAAT  GTCAAGATGG  CTCTGGATAT  AGAGATAGCC  1200
1201  GCTTACAGAA  AACTCCTGGA  AGGTGAAGAG  TGTCGGATTG  GCTTTGGCCC  AATTCCTTTC  1260
1261  TCGCTTCCAG  AAGGACTCCC  CAAAATTCCC  TCTGTGTCCA  CTCACATAAA  GGTGAAAAGC  1320
1321  GAAGAGAAGA  TCAAAGTGGT  GGAGAAGTCT  GAGAAAGAAA  CTGTGATTGT  GGAGGAACAG  1380
1381  ACAGAGGAGA  CCCAAGTGAC  TGAAGAAGTG  ACTGAAGAAG  AGGAGAAAGA  GGCCAAAGAG  1440
1441  GAGGAGGGCA  AGGAGGAAGA  AGGGGGTGAA  GAAGAGGAGG  CAGAAGGGGG  AGAAGAAGAA  1500
1501  ACAAAGTCTC  CCCCAGCAGA  AGAGGCTGCA  TCCCCAGAGA  AGGAAGCCAA  GTCACCAGTA  1560
1561  AAGGAAGAGG  CAAAGTCACC  GGCTGAGGCC  AAGTCCCCAG  AGAAGGAGGA  AGCAAAATCC  1620
1621  CCAGCCGAAG  TCAAGTCCCC  TGAGAAGGCC  AAGTCTCCAG  CAAAGGAAGA  GGCAAAGTCA  1680
1681  CCGCCTGAGG  CCAAGTCCCC  AGAGAAGGAG  GAAGCAAAAT  CTCCAGCTGA  GGTCAAGTCC  1740
1741  CCCGAGAAGG  CCAAGTCCCC  AGCAAAGGAA  GAGGCAAAGT  CACCGGCTGA  GGCCAAGTCT  1800
1801  CCAGAGAAGG  CCAAGTCCCC  AGTGAAGGAA  GAAGCAAAGT  CACCGGCTGA  GGCCAAGTCC  1860
1861  CCAGTGAAGG  AAGAAGCAAA  ATCTCCAGCT  GAGGTCAAGT  CCCCGGAAAA  GGCCAAGTCT  1920
1921  CCAACGAAGG  AGGAAGCAAA  GTCCCCTGAG  AAGGCCAAGT  CCCCAGAGAA  GGAAGAGGCC  1980
1981  AAGTCCCCTG  AGAAGGCCAA  GTCCCCAGTG  AAGGCAGAAG  CAAAGTCCCC  TGAGAAGGCC  2040
2041  AAGTCCCCAG  TGAAGGCAGA  AGCAAAGTCC  CCTGAGAAGG  CCAAGTCCCC  AGTGAAGGAA  2100
2101  GAAGCAAAGT  CCCCTGAGAA  GGCCAAGTCC  CCAGTGAAGG  AAGAAGCAAA  GTCCCCTGAG  2160
2161  AAGGCCAAGT  CCCCAGTGAA  GGAAGAAGCA  AAGACCCCCG  AGAAGGCCAA  GTCCCCAGTG  2220
2221  AAGGAAGAAG  CTAAGTCCCC  AGAGAAGGCC  AAGTCCCCAG  AGAAGGCCAA  GACTCTTGAT  2280
2281  GTGAAGTCTC  CAGAAGCCAA  GACTCCAGCG  AAGGAGGAAG  CAAGGTCCCC  TGCAGACAAA  2340
2341  TTCCCTGAAA  AGGCCAAAAG  CCCTGTCAAG  GAGGAGGTCA  AGTCCCCAGA  GAAGGCGAAA  2400
2401  TCTCCCCTGA  AGGAGGATGC  CAAGGCCCCT  GAGAAGGAGA  TCCCAAAAAA  GGAAGAGGTG  2460
2461  AAGTCCCCAG  TGAAGGAGGA  GGAGAAGCCC  CAGGAGGTGA  AAGTCAAAGA  GCCCCCAAAG  2520
2521  AAGGCAGAGG  AAGAGAAAGC  CCCTGCCACA  CCAAAAACAG  AGGAGAAGAA  GGACAGCAAG  2580
2581  AAAGAGGAGG  CACCCAAGAA  GGAGGCTCCA  AAGCCCAAGG  TGGAGGAGAA  GAAGGAACCT  2640
2641  GCTGTCGAAA  AGCCCAAAGA  ATCCAAAGTT  GAAGCCAAGA  AGGAAGAGGC  TGAAGATAAG  2700
2701  AAAAAAGTCC  CCACCCCAGA  GAAGGAGGCT  CCTGCCAAGG  TGGAGGTGAA  GGAAGACGCT  2760
2761  AAACCCAAAG  AAAAGACAGA  GGTAGCCAAG  AAGGAACCAG  ATGATGCCAA  GGCCAAGGAA  2820
2821  CCCAGCAAAC  CAGCAGAGAA  GAAGGAGGCA  GCACCGGAGA  AAAAAGACAC  CAAGGAGGAG  2880
2881  AAGGCCAAGA  AGCCTGAGGA  GAAACCCAAG  ACAGAGGCCA  AAGCCAAGGA  AGATGACAAG  2940
2941  ACCCTCTCAA  AAGAGCCTAG  CAAGCCTAAG  GCAGAAAAGG  CTGAAAAATC  CTCCAGCACA  3000
3001  GACCAAAAAG  ACAGCAAGCC  TCCAGAGAAG  GCCACAGAAG  ACAAGGCCGC  CAAGGGGAAG  3060
3061  TAA  3063

▼ KEYWORD

ID
Family
Alternative splicing
Amyotrophic lateral sclerosis
Charcot-Marie-Tooth disease
Coiled coil
Complete proteome
Cytoplasm
Disease mutation
Intermediate filament
Neurodegeneration
Neuropathy
Phosphoprotein
Polymorphism
Reference proteome
Repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Axon
Cellular Component
Cytoplasm
Cellular Component
Cytoskeleton
Cellular Component
Neurofibrillary tangle
Cellular Component
Neurofilament
Cellular Component
Postsynaptic density
Cellular Component
Postsynaptic intermediate filament cytoskeleton
Cellular Component
Schaffer collateral - CA1 synapse
Molecular Function
Dynein complex binding
Molecular Function
Kinesin binding
Molecular Function
Microtubule binding
Molecular Function
Protein binding, bridging
Molecular Function
Protein kinase binding
Molecular Function
Structural constituent of cytoskeleton
Molecular Function
Structural constituent of postsynaptic intermediate filament cytoskeleton
Biological Process
Axon development
Biological Process
Axonogenesis
Biological Process
Cell projection assembly
Biological Process
Cellular response to leukemia inhibitory factor
Biological Process
Microtubule cytoskeleton organization
Biological Process
Neurofilament bundle assembly
Biological Process
Neurofilament cytoskeleton organization
Biological Process
Peripheral nervous system neuron axonogenesis
Biological Process
Regulation of organelle transport along microtubule

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-a183Pan troglodytes99.510.01914
LLPS-Poa-a185Pongo abelii96.860.01623
LLPS-Paa-a186Papio anubis96.680.01846
LLPS-Gog-a184Gorilla gorilla94.650.01358
LLPS-Mam-a185Macaca mulatta94.360.01576
LLPS-Cea-a187Cercocebus atys93.740.01533
LLPS-Man-a185Macaca nemestrina93.460.01573
LLPS-Maf-a187Macaca fascicularis91.880.01500
LLPS-Aon-a189Aotus nancymaae91.80.01521
LLPS-Chs-a186Chlorocebus sabaeus91.250.01484
LLPS-Nol-a191Nomascus leucogenys89.980.01491
LLPS-Rhb-a184Rhinopithecus bieti89.440.01120
LLPS-Caj-a183Callithrix jacchus87.570.01458
LLPS-Ict-a185Ictidomys tridecemlineatus86.460.01409
LLPS-Pap-a183Pan paniscus86.270.01023
LLPS-Orc-a180Oryctolagus cuniculus83.630.01381
LLPS-Myl-a178Myotis lucifugus83.540.0635
LLPS-Aim-a180Ailuropoda melanoleuca83.460.01445
LLPS-Tut-a105Tursiops truncatus83.430.01347
LLPS-Mup-a188Mustela putorius furo81.960.01358
LLPS-Bot-a189Bos taurus81.40.01388
LLPS-Sus-a188Sus scrofa80.740.01279
LLPS-Ova-a184Ovis aries79.710.01300
LLPS-Caf-a185Canis familiaris79.180.01426
LLPS-Cas-a168Carlito syrichta77.750.0924
LLPS-Eqc-a190Equus caballus77.00.01363
LLPS-Cap-a186Cavia porcellus76.150.01360
LLPS-Ran-a186Rattus norvegicus75.980.01275
LLPS-Mum-a186Mus musculus75.090.01273
LLPS-Fud-a183Fukomys damarensis73.680.0906
LLPS-Sah-a179Sarcophilus harrisii65.370.0684
LLPS-Anp-a168Anas platyrhynchos64.754e-133419
LLPS-Mod-a177Monodelphis domestica64.530.01019
LLPS-Ere-a040Erinaceus europaeus64.250.0553
LLPS-Loa-a182Loxodonta africana64.250.01048
LLPS-Fia-a171Ficedula albicollis63.643e-122389
LLPS-Lac-a170Latimeria chalumnae57.864e-122386
LLPS-Gaga-a174Gallus gallus57.20.0703
LLPS-Xet-a166Xenopus tropicalis57.144e-132432
LLPS-Xim-a168Xiphophorus maculatus55.948e-142452
LLPS-Gaa-a162Gasterosteus aculeatus55.812e-141442
LLPS-Leo-a162Lepisosteus oculatus54.43e-110370
LLPS-Pof-a164Poecilia formosa52.035e-167514
LLPS-Tar-a158Takifugu rubripes51.461e-137447
LLPS-Pes-a168Pelodiscus sinensis50.68e-117379
LLPS-Meg-a161Meleagris gallopavo50.112e-123404