LLPS-Hos-a184
SH3BP1

▼ OVERVIEW

Status: Reviewed
Protein Name: SH3 domain-binding protein 1
Gene Name: SH3BP1
Ensembl Gene: ENSG00000100092.22
Ensembl Protein: ENSP00000498037.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others
PDB: 4J9F (A, B) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MMKRQLHRMR  QLAQTGSLGR  TPETAEFLGE  DLLQVEQRLE  PAKRAAHNIH  KRLQACLQGQ  60
61    SGADMDKRVK  KLPLMALSTT  MAESFKELDP  DSSMGKALEM  SCAIQNQLAR  ILAEFEMTLE  120
121   RDVLQPLSRL  SEEELPAILK  HKKSLQKLVS  DWNTLKSRLS  QATKNSGSSQ  GLGGSPGSHS  180
181   HTTMANKVET  LKEEEEELKR  KVEQCRDEYL  ADLYHFVTKE  DSYANYFIRL  LEIQADYHRR  240
241   SLSSLDTALA  ELRENHGQAD  HSPSMTATHF  PRVYGVSLAT  HLQELGREIA  LPIEACVMML  300
301   LSEGMKEEGL  FRLAAGASVL  KRLKQTMASD  PHSLEEFCSD  PHAVAGALKS  YLRELPEPLM  360
361   TFDLYDDWMR  AASLKEPGAR  LQALQEVCSR  LPPENLSNLR  YLMKFLARLA  EEQEVNKMTP  420
421   SNIAIVLGPN  LLWPPEKEGD  QAQLDAASVS  SIQVVGVVEA  LIQSADTLFP  GDINFNVSGL  480
481   FSAVTLQDTV  SDRLASEELP  STAVPTPATT  PAPAPAPAPA  PAPALASAAT  KERTESEVPP  540
541   RPASPKVTRS  PPETAAPVED  MARRTKRPAP  ARPTMPPPQV  SGSRSSPPAP  PLPPGSGSPG  600
601   TPQALPRRLV  GSSLRAPTVP  PPLPPTPPQP  ARRQSRRSPA  SPSPASPGPA  SPSPVSLSNP  660
661   AQVDLGAATA  EGGAPEAISG  VPTPPAIPPQ  PRPRSLASET  N  701
Nucleotide CDS Sequence (FASTA)
1     ATGATGAAGA  GGCAGCTGCA  CCGCATGCGG  CAGCTGGCCC  AGACGGGCAG  CTTGGGACGC  60
61    ACCCCGGAGA  CCGCTGAGTT  CCTGGGTGAG  GACCTGCTGC  AGGTAGAACA  GCGGCTGGAG  120
121   CCGGCCAAGC  GGGCAGCCCA  CAACATCCAC  AAGCGGCTGC  AGGCCTGTCT  GCAGGGCCAG  180
181   AGCGGGGCAG  ACATGGACAA  GCGGGTGAAG  AAGCTTCCCC  TCATGGCTCT  GTCCACCACG  240
241   ATGGCTGAGA  GCTTCAAGGA  GCTGGACCCT  GATTCCAGCA  TGGGGAAGGC  CTTGGAGATG  300
301   AGCTGTGCCA  TCCAGAATCA  GCTGGCCCGC  ATCCTGGCCG  AGTTTGAGAT  GACCCTGGAG  360
361   AGGGACGTCC  TGCAGCCACT  CAGCAGGCTG  AGTGAGGAGG  AGCTGCCAGC  CATCCTCAAA  420
421   CACAAGAAAA  GCCTCCAGAA  GCTCGTGTCC  GACTGGAACA  CACTCAAGAG  CAGGCTCAGT  480
481   CAGGCAACCA  AGAATTCAGG  CAGCAGTCAA  GGCCTAGGAG  GCAGCCCGGG  TAGTCACAGC  540
541   CATACGACCA  TGGCCAACAA  GGTGGAGACG  CTGAAGGAGG  AGGAGGAGGA  GCTGAAGAGG  600
601   AAAGTGGAGC  AATGCAGGGA  CGAGTACTTG  GCTGACCTGT  ACCACTTTGT  TACCAAGGAG  660
661   GACTCCTATG  CCAACTACTT  CATTCGTCTC  CTGGAGATTC  AGGCCGATTA  CCATCGCAGG  720
721   TCACTGAGCT  CGCTGGACAC  AGCCCTGGCT  GAGCTGAGGG  AGAACCACGG  CCAAGCAGAC  780
781   CACTCCCCTT  CGATGACAGC  CACCCACTTC  CCCAGGGTGT  ATGGGGTGTC  GCTGGCAACC  840
841   CACCTGCAAG  AGCTGGGCCG  GGAGATTGCC  CTGCCCATCG  AGGCCTGCGT  CATGATGCTG  900
901   CTTTCTGAGG  GCATGAAGGA  AGAGGGTCTC  TTCCGTCTGG  CTGCTGGGGC  CTCGGTGCTG  960
961   AAGCGTCTCA  AGCAGACAAT  GGCCTCGGAC  CCCCACAGCC  TGGAGGAGTT  CTGCTCCGAC  1020
1021  CCGCACGCTG  TGGCAGGTGC  CCTCAAGTCC  TATCTGCGGG  AGCTGCCAGA  GCCTCTGATG  1080
1081  ACCTTCGACC  TCTATGATGA  CTGGATGAGG  GCAGCCAGCC  TGAAGGAGCC  AGGGGCCCGG  1140
1141  CTGCAGGCCC  TCCAAGAGGT  GTGCAGCCGC  CTACCCCCCG  AGAACCTCAG  CAACCTCAGG  1200
1201  TACCTGATGA  AGTTCCTGGC  ACGGCTGGCC  GAGGAGCAGG  AGGTGAACAA  GATGACACCC  1260
1261  AGCAACATCG  CCATAGTCCT  GGGACCCAAC  TTGCTGTGGC  CACCTGAGAA  AGAAGGCACA  1320
1321  GAGCCAGCCA  GAGAGTTGGG  GTCACAAACC  CTTTGCTGA  1359

▼ KEYWORD

ID
Family
3D-structure
Alternative initiation
Alternative splicing
Cell junction
Cell projection
Complete proteome
Cytoplasm
GTPase activation
Nucleus
Phagocytosis
Phosphoprotein
Polymorphism
Reference proteome
SH3-binding
Tight junction

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Adherens junction
Cellular Component
Bicellular tight junction
Cellular Component
Cell leading edge
Cellular Component
Cytosol
Cellular Component
Lamellipodium
Cellular Component
Nucleus
Cellular Component
Phagocytic cup
Molecular Function
GTPase activator activity
Molecular Function
Rac GTPase binding
Molecular Function
Semaphorin receptor binding
Molecular Function
SH3 domain binding
Biological Process
Actin filament organization
Biological Process
Cell junction assembly
Biological Process
Cell migration
Biological Process
Establishment of epithelial cell apical/basal polarity
Biological Process
Filopodium assembly
Biological Process
Negative regulation of small GTPase mediated signal transduction
Biological Process
Phagocytosis, engulfment
Biological Process
Positive regulation of GTPase activity
Biological Process
Regulation of actin cytoskeleton organization
Biological Process
Regulation of actin filament depolymerization
Biological Process
Regulation of blood vessel endothelial cell migration
Biological Process
Ruffle assembly
Biological Process
Semaphorin-plexin signaling pathway

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-a180Pan troglodytes99.140.01396
LLPS-Pap-a180Pan paniscus99.140.01396
LLPS-Mal-a181Mandrillus leucophaeus97.430.01367
LLPS-Rhb-a181Rhinopithecus bieti97.220.01202
LLPS-Maf-a184Macaca fascicularis96.740.01358
LLPS-Gog-a181Gorilla gorilla96.530.01060
LLPS-Mam-a182Macaca mulatta96.340.01362
LLPS-Cea-a184Cercocebus atys96.20.01361
LLPS-Paa-a183Papio anubis95.920.01355
LLPS-Chs-a183Chlorocebus sabaeus95.920.01357
LLPS-Poa-a181Pongo abelii95.350.0969
LLPS-Aon-a185Aotus nancymaae94.580.01155
LLPS-Nol-a188Nomascus leucogenys93.880.01295
LLPS-Caj-a180Callithrix jacchus93.580.01097
LLPS-Man-a182Macaca nemestrina91.820.01088
LLPS-Cas-a165Carlito syrichta91.570.0996
LLPS-Sus-a184Sus scrofa89.810.0728
LLPS-Otg-a184Otolemur garnettii88.250.0830
LLPS-Ova-a181Ovis aries87.730.01033
LLPS-Caf-a181Canis familiaris87.340.01015
LLPS-Aim-a177Ailuropoda melanoleuca87.20.0999
LLPS-Bot-a187Bos taurus87.160.01043
LLPS-Fec-a183Felis catus87.020.01023
LLPS-Tut-a103Tursiops truncatus86.990.0954
LLPS-Ict-a182Ictidomys tridecemlineatus86.590.01040
LLPS-Eqc-a187Equus caballus86.260.01034
LLPS-Myl-a174Myotis lucifugus85.630.01050
LLPS-Cap-a184Cavia porcellus83.210.0996
LLPS-Fud-a179Fukomys damarensis83.210.0969
LLPS-Mum-a184Mus musculus83.00.01016
LLPS-Mup-a184Mustela putorius furo82.140.0930
LLPS-Ran-a183Rattus norvegicus81.60.01013
LLPS-Orc-a177Oryctolagus cuniculus79.920.0769
LLPS-Loa-a179Loxodonta africana76.640.0783
LLPS-Ora-a165Ornithorhynchus anatinus74.373e-140422
LLPS-Tag-a165Taeniopygia guttata66.810.0583
LLPS-Fia-a168Ficedula albicollis66.040.0650
LLPS-Sah-a175Sarcophilus harrisii65.260.0776
LLPS-Gaga-a171Gallus gallus63.210.0627
LLPS-Pes-a164Pelodiscus sinensis62.690.0739
LLPS-Anc-a173Anolis carolinensis61.110.0674
LLPS-Meg-a158Meleagris gallopavo60.560.0655
LLPS-Mod-a173Monodelphis domestica59.090.0717
LLPS-Asm-a155Astyanax mexicanus53.652e-166503
LLPS-Scf-a158Scleropages formosus53.521e-162492
LLPS-Ten-a159Tetraodon nigroviridis52.898e-160489
LLPS-Dar-a161Danio rerio52.753e-161490
LLPS-Pof-a161Poecilia formosa51.999e-162492
LLPS-Xim-a166Xiphophorus maculatus51.783e-162494
LLPS-Leo-a159Lepisosteus oculatus51.487e-153474
LLPS-Scm-a151Scophthalmus maximus50.72e-156479
LLPS-Dio-a179Dipodomys ordii50.654e-149462
LLPS-Icp-a167Ictalurus punctatus50.212e-154476
LLPS-Tar-a154Takifugu rubripes50.02e-151469