LLPS-Hos-a1206
ATP5MF
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | ATP synthase subunit f, mitochondrial; ATP synthase membrane subunit f |
| Gene Name: | ATP5MF, ATP5J2, ATP5JL |
| Ensembl Gene: | ENSG00000241468.7 |
| Ensembl Protein: | ENSP00000377740.3 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000394186.3 | ENSP00000377740.3 |
| Ensembl | ENST00000488775.5 | ENSP00000418197.1 |
| Ensembl | ENST00000414062.5 | ENSP00000412149.1 |
| Ensembl | ENST00000449683.5 | ENSP00000407540.1 |
| Ensembl | ENST00000523680.1 | ENSP00000430398.1 |
| Ensembl | ENST00000292475.7 | ENSP00000292475.3 |
| Ensembl | ENST00000359832.8 | ENSP00000352890.4 |
| UniProt | P56134, ATPK_HUMAN, C9J8H9, F8W7V3, O76079, Q6IBB3, Q96L83, Q9BTI8 | |
| GeneBank | BC003678, CR542155, CH236956, AF047436, AC073063, CH471091, CR456891, AF088918, AY046911 | AAH03678.1, CAG46952.1, AAC39887.1, EAW76661.1, AAL06647.1, CAG33172.1, EAL23877.1, AAC34895.1 |
| RefSeq | NM_001003713.2, NM_001003714.2, NM_001039178.2, NM_004889.3 | NP_001003713.1, NP_001003714.1, NP_001034267.1, NP_004880.1 |
| Entrez | 9551 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MASVVGIFSH SSVSVPVKDK KLLEVKLGEL PSWILMRDFS PSGIFGAFQR GYYRYYNKYI 60 61 NVKKGSISGI TMVLACYVLF SYSFSYKHLK HERLRKYH 98 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGTCAG TTGGTGAGTG TCCGGCCCCA GTACCAGTGA AGGACAAGAA ACTTCTGGAG 60 61 GTCAAACTGG GGGAGCTGCC AAGCTGGATC TTGATGCGGG ACTTCAGTCC TAGTGGCATT 120 121 TTCGGAGCGT TTCAAAGAGG TTACTACCGG TACTACAACA AGTACATCAA TGTGAAGAAG 180 181 GGGAGCATCT CGGGGATTAC CATGGTGCTG GCATGCTACG TGCTCTTTAG CTACTCCTTT 240 241 TCCTACAAGC ATCTCAAGCA CGAGCGGCTC CGCAAATACC ACTGA 285 |
▼ KEYWORD
ID | Family |
Acetylation | |
Alternative splicing | |
ATP synthesis | |
CF(0) | |
Complete proteome | |
Hydrogen ion transport | |
Ion transport | |
Membrane | |
Mitochondrion | |
Mitochondrion inner membrane | |
Phosphoprotein | |
Reference proteome | |
Transmembrane | |
Transmembrane helix | |
Transport
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Integral component of membrane | |
Cellular Component | Mitochondrial inner membrane | |
Cellular Component | Mitochondrial proton-transporting ATP synthase complex | |
Cellular Component | Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) | |
Cellular Component | Mitochondrion | |
Cellular Component | Nucleus | |
Molecular Function | Transmembrane transporter activity | |
Biological Process | ATP biosynthetic process | |
Biological Process | Cristae formation | |
Biological Process | Mitochondrial ATP synthesis coupled proton transport | |
Biological Process | Proton transmembrane transport |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CORUM | CellMarker | RaftProt | ||
| Proteomics | ||||
| THPA | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| TCGA | ArrayExpress | TISSUES | BioXpress | THPA |