LLPS-Hos-a1164
MTFP1
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Mitochondrial fission process protein 1; Mitochondrial 18 kDa protein; MTP18 |
| Gene Name: | MTFP1, MTP18, HSPC242, My022 |
| Ensembl Gene: | ENSG00000242114.5 |
| Ensembl Protein: | ENSP00000266263.5 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000266263.9 | ENSP00000266263.5 |
| Ensembl | ENST00000407550.3 | ENSP00000383926.3 |
| Ensembl | ENST00000355143.8 | ENSP00000347267.4 |
| Ensembl | ENST00000629597.2 | ENSP00000487369.1 |
| Ensembl | ENST00000412752.5 | ENSP00000393954.1 |
| UniProt | Q9UDX5, MTFP1_HUMAN, A6NFQ5, Q9H3K1, Q9P0N6 | |
| GeneBank | CR456345, BC030989, BC038831, AF151076, AF060924, AC004832, BC009300, BC046132, BC014446, BC001608 | AAH46132.1, AAH14446.1, CAG30231.1, AAH09300.1, AAF19257.1, AAH30989.1, AAF36162.1, AAG43136.1, AAH38831.1, AAH01608.1 |
| RefSeq | NM_001003704.2, NM_016498.4 | NP_001003704.1, NP_057582.2 |
| Entrez | 51537 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSEPQPRGAE RDLYRDTWVR YLGYANEVGE AFRSLVPAAV VWLSYGVASS YVLADAIDKG 60 61 KKAGEVPSPE AGRSARVTVA VVDTFVWQAL ASVAIPGFTI NRVCAASLYV LGTATRWPLA 120 121 VRKWTTTALG LLTIPIIIHP IDRSVDFLLD SSLRKLYPTV GKPSSS 166 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCAGAGC CGCAGCCGCG GGGCGCAGAG CGCGATCTCT ACCGGGACAC GTGGGTGCGA 60 61 TACCTGGGCT ATGCCAATGA GGTGGGCGAG GCTTTCCGCT CTCTTGTGCC AGCGGCGGTG 120 121 GTGTGGCTGA GCTATGGCGT GGCCAGCTCC TACGTGCTGG CGGATGCCAT TGACAAAGGC 180 181 AAGAAGGCTG GAGAGGTGCC CAGCCCTGAA GCAGGCCGCA GCGCCAGGGT GACTGTGGCT 240 241 GTGGTGGACA CCTTTGTATG GCAGGCTCTA GCCTCTGTGG CCATTCCGGG CTTCACCATC 300 301 AACCGCGTGT GTGCTGCCTC TCTCTATGTC CTGGGCACTG CCACCCGCTG GCCCCTGGCT 360 361 GTCCGCAAGT GGACCACCAC CGCGCTTGGG CTGTTGACCA TCCCCATCAT TATCCACCCC 420 421 ATTGACAGGT CGGTGGATTT CCTCCTGGAC TCCAGCCTGC GCAAGCTCTA CCCAACAGTG 480 481 GGGAAGCCCA GCTCCTCCTG A 501 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Integral component of membrane | |
Cellular Component | Mitochondrial inner membrane | |
Cellular Component | Mitochondrion | |
Biological Process | Apoptotic process | |
Biological Process | Mitochondrial fission | |
Biological Process | Response to muscle activity |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Disease | ||||
| OMIM | DisGeNET | ActiveDriverDB | ||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | RaftProt | |||
| Localization | ||||
| COMPARTMENTS | ||||