LLPS-Hos-a116
RAP1GAP
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Human cortex | 23071613 |
▼ FUNCTION
| GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000471600.6 | ENSP00000431364.1 |
| Ensembl | ENST00000374765.8 | ENSP00000363897.4 |
| Ensembl | ENST00000542643.6 | ENSP00000441661.1 |
| Ensembl | ENST00000290101.8 | ENSP00000290101.5 |
| Ensembl | ENST00000374763.6 | ENSP00000363895.2 |
| Ensembl | ENST00000447293.5 | ENSP00000392717.1 |
| Ensembl | ENST00000374761.6 | ENSP00000363893.2 |
| Ensembl | ENST00000495204.5 | ENSP00000434033.2 |
| Ensembl | ENST00000317967.11 | ENSP00000315420.7 |
| UniProt | P47736, RPGP1_HUMAN, J3QSS6, O75062, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51 | |
| GeneBank | AB003930, CH471134, M64788, AB007943, BC054490, AL359815 | BAA32319.3, EAW94981.1, AAA60252.1, AAH54490.1, EAW94980.1, BAA83674.1 |
| RefSeq | NM_001145657.1, NM_001145658.1, NM_002885.2, XM_005245955.3, XM_017001970.1, XM_017001973.1, XM_017001984.1, XM_017001986.1, XM_017001987.1, XM_017001988.1 | NP_001139129.1, NP_001139130.1, NP_002876.2, XP_005246012.2, XP_016857459.1, XP_016857462.1, XP_016857473.1, XP_016857475.1, XP_016857476.1, XP_016857477.1 |
| Entrez | 5909 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MIEKMQGSRM DEQRCSFPPP LKTEEDYIPY PSVHEVLGRE GPFPLILLPQ FGGYWIEGTN 60 61 HEITSIPETE PLQSPTTKVK LECNPTARIY RKHFLGKEHF NYYSLDAALG HLVFSLKYDV 120 121 IGDQEHLRLL LRTKCRTYHD VIPISCLTEF PNVVQMAKLV CEDVNVDRFY PVLYPKASRL 180 181 IVTFDEHVIS NNFKFGVIYQ KLGQTSEEEL FSTNEESPAF VEFLEFLGQK VKLQDFKGFR 240 241 GGLDVTHGQT GTESVYCNFR NKEIMFHVST KLPYTEGDAQ QLQRKRHIGN DIVAVVFQDE 300 301 NTPFVPDMIA SNFLHAYVVV QAEGGGPDGP LYKVSVTARD DVPFFGPPLP DPAVFRKGPE 360 361 FQEFLLTKLI NAEYACYKAE KFAKLEERTR AALLETLYEE LHIHSQSMMG LGGDEDKMEN 420 421 GSGGGGFFES FKRVIRSRSQ SMDAMGLSNK KPNTVSTSHS GSFAPNNPDL AKAAGISLLI 480 481 PGKSASRFGR RGSAIGIGTV EEVVVRGAAG SGGCLHALFS ARSQDGGHIG DVAPLPPGQA 540 541 PGRAGWSGGS SDGTQHLLWG LSLIVPGKSP TRKKSGPFGS RRSSAIGIEN IQEVQEKRES 600 601 PPAGQKTPDS GHVSQEPKSE NSSTQSSPEM PTTKNRAETA AQRAEALKDF SRSSSSASSF 660 661 ASVVEETEGV DGEDTGLESV SSSGTPHKRD SFIYSTWLED SVSTTSGGSS PGPSRSPHPD 720 721 AGKLGDPACP EIKIQLEASE QHMPQLGC 748 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGCGGCC GGAAGCGCAG CTTCACCTTC GGGGCCTACG GCGGGGTGGA CAAGTCCTTC 60 61 ACTTCTCGCC GGAGTGTGTG GAGGAGCGAT GGGCAGAACC AGCACTTCCC TCAGGCACTA 120 121 GACCTGTCAC GAGTGAACTT AGTTCCCTCC TATACTCCTT CACTCTACCC TAAGAACACA 180 181 GATCTATTTG AGATGATTGA GAAGATGCAG GGAAGCAGGA TGGATGAACA ACGCTGCTCC 240 241 TTCCCGCCGC CCCTCAAAAC AGAGGAGGAC TACATTCCAT ACCCGAGCGT GCACGAGGTC 300 301 TTGGGGCGAG AAGGACCCTT CCCCCTCATC CTGCTGCCCC AGTTTGGGGG CTACTGGATT 360 361 GAGGGCACCA ACCACGAAAT CACCAGCATC CCCGAGACAG AGCCACTGCA GTCGCCCACA 420 421 ACCAAGGTGA AGCTCGAGTG CAACCCCACA GCCCGCATCT ACCGGAAGCA CTTTCTCGGC 480 481 AAGGAGCATT TCAATTACTA CTCACTGGAC GCTGCCCTCG GCCACCTTGT CTTCTCACTC 540 541 AAGTACGATG TCATCGGGGA CCAAGAGCAC CTGCGGCTGC TGCTCAGGAC CAAGTGCCGG 600 601 ACATACCATG ATGTCATCCC CATCTCCTGC CTCACCGAGT TCCCTAATGT TGTCCAGATG 660 661 GCAAAGTTGG TGTGTGAAGA CGTCAATGTG GATCGGTTCT ATCCTGTGCT CTACCCCAAG 720 721 GCTTCCCGGC TCATCGTCAC CTTTGACGAG CATGTCATCA GCAATAACTT CAAGTTTGGC 780 781 GTCATTTATC AGAAGCTTGG GCAGACCTCC GAGGAAGAAC TCTTCAGCAC CAATGAGGAA 840 841 AGTCCCGCTT TCGTGGAGTT CCTTGAATTT CTTGGCCAGA AGGTCAAACT GCAGGACTTT 900 901 AAGGGGTTCC GAGGAGGCCT GGACGTGACC CACGGGCAGA CGGGGACCGA ATCTGTGTAC 960 961 TGCAACTTCC GCAACAAGGA GATCATGTTT CACGTGTCCA CCAAGCTGCC ATACACGGAA 1020 1021 GGGGACGCCC AGCAGTTGCA GCGGAAGCGG CACATCGGGA ACGACATCGT GGCTGTGGTC 1080 1081 TTCCAGGATG AGAACACTCC TTTCGTGCCC GACATGATCG CGTCCAACTT CCTGCATGCC 1140 1141 TACGTCGTGG TGCAGGCTGA GGGCGGGGGC CCTGATGGCC CCCTCTACAA GGTCTCTGTC 1200 1201 ACTGCAAGAG ATGATGTGCC CTTCTTTGGA CCCCCCCTCC CGGACCCCGC TGTGTTCAGG 1260 1261 AAGGGGCCTG AGTTCCAGGA ATTTTTGCTG ACAAAGCTGA TCAATGCTGA ATATGCCTGC 1320 1321 TACAAGGCAG AGAAGTTTGC CAAACTGGAG GAGCGGACGC GGGCCGCCCT CCTGGAGACG 1380 1381 CTCTATGAGG AACTACACAT CCACAGCCAG TCCATGATGG GCTTGGGCGG CGACGAGGAC 1440 1441 AAGATGGAGA ATGGCAGTGG GGGCGGCGGC TTCTTTGAGT CTTTCAAGCG GGTCATCCGG 1500 1501 AGCCGCAGCC AGTCCATGGA TGCCATGGGG CTGAGCAACA AGAAGCCCAA CACCGTGTCC 1560 1561 ACCAGCCACA GCGGGAGCTT CGCGCCCAAC AACCCCGACC TGGCCAAGGC GGCTGGAATA 1620 1621 TCACTGATTG TCCCTGGGAA GAGCCCCACG AGGAAGAAGT CGGGCCCGTT CGGCTCCCGC 1680 1681 CGCAGCAGCG CCATTGGCAT CGAGAACATA CAGGAGGTGC AGGAGAAGAG GGAGAGCCCT 1740 1741 CCGGCTGGTC AGAAGACCCC AGACAGCGGG CACGTCTCAC AGGAGCCCAA GTCGGAGAAC 1800 1801 TCATCCACTC AGAGCTCCCC AGAGATGCCC ACGACCAAGA ACAGAGCGGA GACCGCAGCG 1860 1861 CAGAGAGCAG AGGCGCTCAA GGACTTCTCC CGCTCCTCGT CCAGTGCCAG CAGCTTCGCC 1920 1921 AGCGTGGTGG AGGAGACGGA GGGTGTGGAC GGAGAGGACA CAGGCCTGGA GAGCGTGTCA 1980 1981 TCCTCAGGAA CACCCCACAA GCGGGACTCC TTCATCTATA GCACGTGGCT GGAGGACAGT 2040 2041 GTCAGCACCA CTAGTGGGGG CAGCTCCCCA GGCCCCTCTC GATCACCCCA CCCAGACGCC 2100 2101 GGCAAGTTGG GGGACCCTGC GTGTCCCGAG ATCAAGATCC AGCTGGAAGC ATCTGAGCAG 2160 2161 CACATGCCCC AGCTGGGCTG TTAG 2184 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Golgi membrane | |
Cellular Component | Membrane | |
Molecular Function | GTPase activator activity | |
Molecular Function | GTPase activity | |
Molecular Function | Protein homodimerization activity | |
Molecular Function | Ras GTPase binding | |
Biological Process | Axon guidance | |
Biological Process | Negative regulation of microvillus assembly | |
Biological Process | Positive regulation of GTPase activity | |
Biological Process | Regulation of GTPase activity | |
Biological Process | Regulation of small GTPase mediated signal transduction | |
Biological Process | Signal transduction |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | CellMarker | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | COSMIC | MethyCancer | |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mam-a114 | Macaca mulatta | 99.73 | 0.0 | 1539 |
| LLPS-Caf-a113 | Canis familiaris | 99.44 | 0.0 | 746 |
| LLPS-Pap-a113 | Pan paniscus | 98.12 | 0.0 | 1495 |
| LLPS-Fec-a118 | Felis catus | 97.86 | 0.0 | 1505 |
| LLPS-Gog-a116 | Gorilla gorilla | 97.49 | 0.0 | 1118 |
| LLPS-Caj-a114 | Callithrix jacchus | 97.31 | 0.0 | 1478 |
| LLPS-Orc-a111 | Oryctolagus cuniculus | 95.84 | 0.0 | 1058 |
| LLPS-Ora-a103 | Ornithorhynchus anatinus | 94.31 | 0.0 | 889 |
| LLPS-Mal-a113 | Mandrillus leucophaeus | 92.9 | 0.0 | 1000 |
| LLPS-Aon-a118 | Aotus nancymaae | 92.41 | 0.0 | 1397 |
| LLPS-Mea-a109 | Mesocricetus auratus | 92.34 | 0.0 | 996 |
| LLPS-Dio-a112 | Dipodomys ordii | 92.32 | 0.0 | 1004 |
| LLPS-Mum-a118 | Mus musculus | 91.96 | 0.0 | 993 |
| LLPS-Nol-a118 | Nomascus leucogenys | 91.84 | 0.0 | 1389 |
| LLPS-Ict-a117 | Ictidomys tridecemlineatus | 91.59 | 0.0 | 999 |
| LLPS-Fud-a116 | Fukomys damarensis | 91.59 | 0.0 | 1004 |
| LLPS-Bot-a120 | Bos taurus | 91.59 | 0.0 | 996 |
| LLPS-Loa-a112 | Loxodonta africana | 91.4 | 0.0 | 1001 |
| LLPS-Chs-a117 | Chlorocebus sabaeus | 91.18 | 0.0 | 1378 |
| LLPS-Rhb-a117 | Rhinopithecus bieti | 90.91 | 0.0 | 1374 |
| LLPS-Pat-a115 | Pan troglodytes | 90.39 | 0.0 | 1087 |
| LLPS-Cas-a108 | Carlito syrichta | 90.37 | 0.0 | 1328 |
| LLPS-Sus-a118 | Sus scrofa | 89.78 | 0.0 | 1347 |
| LLPS-Eqc-a120 | Equus caballus | 89.65 | 0.0 | 1342 |
| LLPS-Mup-a116 | Mustela putorius furo | 89.57 | 0.0 | 1354 |
| LLPS-Maf-a117 | Macaca fascicularis | 89.52 | 0.0 | 1330 |
| LLPS-Man-a116 | Macaca nemestrina | 89.52 | 0.0 | 1330 |
| LLPS-Paa-a117 | Papio anubis | 89.52 | 0.0 | 1330 |
| LLPS-Cea-a118 | Cercocebus atys | 89.25 | 0.0 | 1325 |
| LLPS-Cap-a118 | Cavia porcellus | 88.9 | 0.0 | 1344 |
| LLPS-Poa-a114 | Pongo abelii | 88.79 | 0.0 | 934 |
| LLPS-Ran-a117 | Rattus norvegicus | 88.1 | 0.0 | 1338 |
| LLPS-Ova-a118 | Ovis aries | 87.72 | 0.0 | 1320 |
| LLPS-Sah-a110 | Sarcophilus harrisii | 86.94 | 0.0 | 937 |
| LLPS-Urm-a107 | Ursus maritimus | 84.52 | 0.0 | 1140 |
| LLPS-Lac-a107 | Latimeria chalumnae | 74.63 | 0.0 | 1086 |
| LLPS-Leo-a098 | Lepisosteus oculatus | 72.92 | 0.0 | 1055 |
| LLPS-Ten-a104 | Tetraodon nigroviridis | 71.93 | 0.0 | 739 |
| LLPS-Orn-a104 | Oreochromis niloticus | 70.98 | 0.0 | 968 |
| LLPS-Dar-a103 | Danio rerio | 70.85 | 0.0 | 1029 |
| LLPS-Pes-a102 | Pelodiscus sinensis | 70.02 | 0.0 | 729 |
| LLPS-Orl-a107 | Oryzias latipes | 69.91 | 0.0 | 1002 |
| LLPS-Fia-a109 | Ficedula albicollis | 69.29 | 0.0 | 723 |
| LLPS-Tag-a105 | Taeniopygia guttata | 69.29 | 0.0 | 723 |
| LLPS-Anc-a112 | Anolis carolinensis | 69.08 | 0.0 | 726 |
| LLPS-Xim-a109 | Xiphophorus maculatus | 69.0 | 0.0 | 962 |
| LLPS-Scm-a097 | Scophthalmus maximus | 68.93 | 0.0 | 935 |
| LLPS-Pof-a107 | Poecilia formosa | 68.73 | 0.0 | 958 |
| LLPS-Meg-a101 | Meleagris gallopavo | 68.27 | 0.0 | 712 |
| LLPS-Gaa-a103 | Gasterosteus aculeatus | 68.03 | 0.0 | 948 |
| LLPS-Gaga-a106 | Gallus gallus | 67.49 | 0.0 | 713 |
| LLPS-Tar-a099 | Takifugu rubripes | 67.48 | 0.0 | 875 |
| LLPS-Asm-a102 | Astyanax mexicanus | 66.62 | 0.0 | 991 |
| LLPS-Scf-a102 | Scleropages formosus | 66.62 | 0.0 | 966 |
| LLPS-Icp-a110 | Ictalurus punctatus | 65.33 | 0.0 | 973 |
| LLPS-Drm-a033 | Drosophila melanogaster | 53.16 | 3e-148 | 467 |