LLPS-Hos-a114
GPC4
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Glypican-4; K-glypican |
| Gene Name: | GPC4, UNQ474/PRO937 |
| Ensembl Gene: | ENSG00000076716.8 |
| Ensembl Protein: | ENSP00000359864.3 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000370828.3 | ENSP00000359864.3 |
| UniProt | O75487, GPC4_HUMAN, B2R6J7, B4E2C0, Q6ZMA6, Q96L43, Q9NU08, Q9UJN1, Q9UPD9 | |
| GeneBank | AY358507, AY052833, AL034400, AF030186, AK312605, AL109623, BC017166, AF064826, CH471107, AK304207 | AAQ88871.1, BAG35494.1, AAC31899.1, AAH17166.1, AAC69991.1, AAL11018.1, EAX11772.1, BAG65082.1 |
| RefSeq | NM_001448.2 | NP_001439.2 |
| Entrez | 2239 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MARFGLPALL CTLAVLSAAL LAAELKSKSC SEVRRLYVSK GFNKNDAPLH EINGDHLKIC 60 61 PQGSTCCSQE MEEKYSLQSK DDFKSVVSEQ CNHLQAVFAS RYKKFDEFFK ELLENAEKSL 120 121 NDMFVKTYGH LYMQNSELFK DLFVELKRYY VVGNVNLEEM LNDFWARLLE RMFRLVNSQY 180 181 HFTDEYLECV SKYTEQLKPF GDVPRKLKLQ VTRAFVAART FAQGLAVAGD VVSKVSVVNP 240 241 TAQCTHALLK MIYCSHCRGL VTVKPCYNYC SNIMRGCLAN QGDLDFEWNN FIDAMLMVAE 300 301 RLEGPFNIES VMDPIDVKIS DAIMNMQDNS VQVSQKVFQG CGPPKPLPAG RISRSISESA 360 361 FSARFRPHHP EERPTTAAGT SLDRLVTDVK EKLKQAKKFW SSLPSNVCND ERMAAGNGNE 420 421 DDCWNGKGKS RYLFAVTGNG LANQGNNPEV QVDTSKPDIL ILRQIMALRV MTSKMKNAYN 480 481 GNDVDFFDIS DESSGEGSGS GCEYQQCPSE FDYNATDHAG KSANEKADSA GVRPGAQAYL 540 541 LTVFCILFLV MQREWR 556 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCACGGT TCGGCTTGCC CGCGCTTCTC TGCACCCTGG CAGTGCTCAG CGCCGCGCTG 60 61 CTGGCTGCCG AGCTCAAGTC GAAAAGTTGC TCGGAAGTGC GACGTCTTTA CGTGTCCAAA 120 121 GGCTTCAACA AGAACGATGC CCCCCTCCAC GAGATCAACG GTGATCATTT GAAGATCTGT 180 181 CCCCAGGGTT CTACCTGCTG CTCTCAAGAG ATGGAGGAGA AGTACAGCCT GCAAAGTAAA 240 241 GATGATTTCA AAAGTGTGGT CAGCGAACAG TGCAATCATT TGCAAGCTGT CTTTGCTTCA 300 301 CGTTACAAGA AGTTTGATGA ATTCTTCAAA GAACTACTTG AAAATGCAGA GAAATCCCTG 360 361 AATGATATGT TTGTGAAGAC ATATGGCCAT TTATACATGC AAAATTCTGA GCTATTTAAA 420 421 GATCTCTTCG TAGAGTTGAA ACGTTACTAC GTGGTGGGAA ATGTGAACCT GGAAGAAATG 480 481 CTAAATGACT TCTGGGCTCG CCTCCTGGAG CGGATGTTCC GCCTGGTGAA CTCCCAGTAC 540 541 CACTTTACAG ATGAGTATCT GGAATGTGTG AGCAAGTATA CGGAGCAGCT GAAGCCCTTC 600 601 GGAGATGTCC CTCGCAAATT GAAGCTCCAG GTTACTCGTG CTTTTGTAGC AGCCCGTACT 660 661 TTCGCTCAAG GCTTAGCGGT TGCGGGAGAT GTCGTGAGCA AGGTCTCCGT GGTAAACCCC 720 721 ACAGCCCAGT GTACCCATGC CCTGTTGAAG ATGATCTACT GCTCCCACTG CCGGGGTCTC 780 781 GTGACTGTGA AGCCATGTTA CAACTACTGC TCAAACATCA TGAGAGGCTG TTTGGCCAAC 840 841 CAAGGGGATC TCGATTTTGA ATGGAACAAT TTCATAGATG CTATGCTGAT GGTGGCAGAG 900 901 AGGCTAGAGG GTCCTTTCAA CATTGAATCG GTCATGGATC CCATCGATGT GAAGATTTCT 960 961 GATGCTATTA TGAACATGCA GGATAATAGT GTTCAAGTGT CTCAGAAGGT TTTCCAGGGA 1020 1021 TGTGGACCCC CCAAGCCCCT CCCAGCTGGA CGAATTTCTC GTTCCATCTC TGAAAGTGCC 1080 1081 TTCAGTGCTC GCTTCAGACC ACATCACCCC GAGGAACGCC CAACCACAGC AGCTGGCACT 1140 1141 AGTTTGGACC GACTGGTTAC TGATGTCAAG GAGAAACTGA AACAGGCCAA GAAATTCTGG 1200 1201 TCCTCCCTTC CGAGCAACGT TTGCAACGAT GAGAGGATGG CTGCAGGAAA CGGCAATGAG 1260 1261 GATGACTGTT GGAATGGGAA AGGCAAAAGC AGGTACCTGT TTGCAGTGAC AGGAAATGGA 1320 1321 TTAGCCAACC AGGGCAACAA CCCAGAGGTC CAGGTTGACA CCAGCAAACC AGACATACTG 1380 1381 ATCCTTCGTC AAATCATGGC TCTTCGAGTG ATGACCAGCA AGATGAAGAA TGCATACAAT 1440 1441 GGGAACGACG TGGACTTCTT TGATATCAGT GATGAAAGTA GTGGAGAAGG AAGTGGAAGT 1500 1501 GGCTGTGAGT ATCAGCAGTG CCCTTCAGAG TTTGACTACA ATGCCACTGA CCATGCTGGG 1560 1561 AAGAGTGCCA ATGAGAAAGC CGACAGTGCT GGTGTCCGTC CTGGGGCACA GGCCTACCTC 1620 1621 CTCACTGTCT TCTGCATCTT GTTCCTGGTT ATGCAGAGAG AGTGGAGATA A 1671 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Anchored component of presynaptic membrane | |
Cellular Component | Cell surface | |
Cellular Component | Collagen-containing extracellular matrix | |
Cellular Component | External side of plasma membrane | |
Cellular Component | Extracellular exosome | |
Cellular Component | Extracellular region | |
Cellular Component | Glutamatergic synapse | |
Cellular Component | Golgi lumen | |
Cellular Component | Lysosomal lumen | |
Cellular Component | Nucleus | |
Cellular Component | Plasma membrane | |
Cellular Component | Synapse | |
Molecular Function | Coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway | |
Biological Process | Cell migration | |
Biological Process | Glycosaminoglycan biosynthetic process | |
Biological Process | Glycosaminoglycan catabolic process | |
Biological Process | Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane | |
Biological Process | Regulation of presynapse assembly | |
Biological Process | Regulation of protein localization to membrane | |
Biological Process | Regulation of signal transduction | |
Biological Process | Retinoid metabolic process | |
Biological Process | Synaptic membrane adhesion |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | CellMarker | RaftProt | ||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-a113 | Pan troglodytes | 100.0 | 0.0 | 1165 |
| LLPS-Pap-a111 | Pan paniscus | 100.0 | 0.0 | 1165 |
| LLPS-Gog-a114 | Gorilla gorilla | 99.64 | 0.0 | 1163 |
| LLPS-Mam-a112 | Macaca mulatta | 99.6 | 0.0 | 1052 |
| LLPS-Mal-a112 | Mandrillus leucophaeus | 99.1 | 0.0 | 1154 |
| LLPS-Man-a114 | Macaca nemestrina | 99.1 | 0.0 | 1154 |
| LLPS-Paa-a115 | Papio anubis | 99.1 | 0.0 | 1154 |
| LLPS-Chs-a115 | Chlorocebus sabaeus | 99.1 | 0.0 | 1154 |
| LLPS-Maf-a115 | Macaca fascicularis | 99.1 | 0.0 | 1154 |
| LLPS-Cea-a116 | Cercocebus atys | 98.74 | 0.0 | 1151 |
| LLPS-Aon-a116 | Aotus nancymaae | 98.56 | 0.0 | 1154 |
| LLPS-Rhb-a115 | Rhinopithecus bieti | 98.43 | 0.0 | 1059 |
| LLPS-Caj-a112 | Callithrix jacchus | 98.38 | 0.0 | 1152 |
| LLPS-Fud-a114 | Fukomys damarensis | 96.41 | 0.0 | 1020 |
| LLPS-Tut-a062 | Tursiops truncatus | 96.02 | 0.0 | 1012 |
| LLPS-Urm-a106 | Ursus maritimus | 95.77 | 0.0 | 885 |
| LLPS-Eqc-a118 | Equus caballus | 95.26 | 0.0 | 964 |
| LLPS-Mum-a116 | Mus musculus | 95.11 | 0.0 | 1038 |
| LLPS-Ict-a115 | Ictidomys tridecemlineatus | 94.78 | 0.0 | 1080 |
| LLPS-Sus-a116 | Sus scrofa | 94.6 | 0.0 | 1037 |
| LLPS-Caf-a111 | Canis familiaris | 94.42 | 0.0 | 1058 |
| LLPS-Dio-a110 | Dipodomys ordii | 94.24 | 0.0 | 1078 |
| LLPS-Aim-a112 | Ailuropoda melanoleuca | 94.24 | 0.0 | 1037 |
| LLPS-Cap-a116 | Cavia porcellus | 94.23 | 0.0 | 1049 |
| LLPS-Ova-a116 | Ovis aries | 94.04 | 0.0 | 963 |
| LLPS-Otg-a115 | Otolemur garnettii | 93.92 | 0.0 | 1092 |
| LLPS-Ere-a022 | Erinaceus europaeus | 93.82 | 0.0 | 995 |
| LLPS-Ran-a115 | Rattus norvegicus | 93.82 | 0.0 | 1028 |
| LLPS-Mea-a107 | Mesocricetus auratus | 93.79 | 0.0 | 1032 |
| LLPS-Bot-a118 | Bos taurus | 93.53 | 0.0 | 1035 |
| LLPS-Fec-a116 | Felis catus | 92.81 | 0.0 | 1040 |
| LLPS-Mup-a114 | Mustela putorius furo | 92.59 | 0.0 | 922 |
| LLPS-Myl-a111 | Myotis lucifugus | 92.56 | 0.0 | 978 |
| LLPS-Nol-a117 | Nomascus leucogenys | 88.47 | 0.0 | 882 |
| LLPS-Pes-a101 | Pelodiscus sinensis | 85.17 | 0.0 | 572 |
| LLPS-Ora-a101 | Ornithorhynchus anatinus | 83.06 | 0.0 | 937 |
| LLPS-Sah-a109 | Sarcophilus harrisii | 81.08 | 0.0 | 853 |
| LLPS-Tag-a104 | Taeniopygia guttata | 79.49 | 0.0 | 814 |
| LLPS-Mod-a107 | Monodelphis domestica | 79.46 | 0.0 | 892 |
| LLPS-Anp-a104 | Anas platyrhynchos | 78.3 | 0.0 | 815 |
| LLPS-Fia-a108 | Ficedula albicollis | 78.16 | 0.0 | 773 |
| LLPS-Meg-a100 | Meleagris gallopavo | 76.83 | 0.0 | 801 |
| LLPS-Lac-a105 | Latimeria chalumnae | 76.61 | 0.0 | 707 |
| LLPS-Orc-a109 | Oryctolagus cuniculus | 75.82 | 1e-98 | 305 |
| LLPS-Gaga-a105 | Gallus gallus | 75.04 | 0.0 | 845 |
| LLPS-Xet-a103 | Xenopus tropicalis | 72.97 | 0.0 | 803 |
| LLPS-Poa-a112 | Pongo abelii | 65.85 | 0.0 | 725 |
| LLPS-Orn-a103 | Oreochromis niloticus | 63.92 | 0.0 | 661 |
| LLPS-Xim-a108 | Xiphophorus maculatus | 63.92 | 0.0 | 665 |
| LLPS-Leo-a097 | Lepisosteus oculatus | 63.65 | 0.0 | 727 |
| LLPS-Scf-a101 | Scleropages formosus | 63.27 | 0.0 | 712 |
| LLPS-Pof-a106 | Poecilia formosa | 62.68 | 0.0 | 641 |
| LLPS-Ten-a103 | Tetraodon nigroviridis | 62.04 | 0.0 | 588 |
| LLPS-Tar-a098 | Takifugu rubripes | 62.03 | 0.0 | 666 |
| LLPS-Asm-a101 | Astyanax mexicanus | 62.02 | 0.0 | 645 |
| LLPS-Dar-a102 | Danio rerio | 60.5 | 0.0 | 616 |
| LLPS-Scm-a096 | Scophthalmus maximus | 59.86 | 0.0 | 674 |
| LLPS-Orl-a106 | Oryzias latipes | 59.19 | 0.0 | 627 |
| LLPS-Gaa-a102 | Gasterosteus aculeatus | 57.17 | 0.0 | 633 |
| LLPS-Icp-a109 | Ictalurus punctatus | 53.46 | 0.0 | 572 |