LLPS-Hos-a1105
SIRPA

▼ OVERVIEW

Status: Reviewed
Protein Name: Tyrosine-protein phosphatase non-receptor type substrate 1
Gene Name: SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Ensembl Gene: ENSG00000198053.11
Ensembl Protein: ENSP00000382941.4
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others
PDB: 6BIT (I, K, H) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEPAGPAPGR  LGPLLCLLLA  ASCAWSGVAG  EEELQVIQPD  KSVLVAAGET  ATLRCTATSL  60
61    IPVGPIQWFR  GAGPGRELIY  NQKEGHFPRV  TTVSDLTKRN  NMDFSIRIGN  ITPADAGTYY  120
121   CVKFRKGSPD  DVEFKSGAGT  ELSVRAKPSA  PVVSGPAARA  TPQHTVSFTC  ESHGFSPRDI  180
181   TLKWFKNGNE  LSDFQTNVDP  VGESVSYSIH  STAKVVLTRE  DVHSQVICEV  AHVTLQGDPL  240
241   RGTANLSETI  RVPPTLEVTQ  QPVRAENQVN  VTCQVRKFYP  QRLQLTWLEN  GNVSRTETAS  300
301   TVTENKDGTY  NWMSWLLVNV  SAHRDDVKLT  CQVEHDGQPA  VSKSHDLKVS  AHPKEQGSNT  360
361   AAENTGSNER  NIYIVVGVVC  TLLVALLMAA  LYLVRIRQKK  AQGSTSSTRL  HEPEKNAREI  420
421   TQVQSLDTND  ITYADLNLPK  GKKPAPQAAE  PNNHTEYASI  QTSPQPASED  TLTYADLDMV  480
481   HLNRTPKQPA  PKPEPSFSEY  ASVQVPRK  508
Nucleotide CDS Sequence (FASTA)
1     ATGGAGCCCG  CCGGCCCGGC  CCCCGGCCGC  CTCGGGCCGC  TGCTCTGCCT  GCTGCTCGCC  60
61    GCGTCCTGCG  CCTGGTCAGG  AGTGGCGGGT  GAGGAGGAGC  TGCAGGTGAT  TCAGCCTGAC  120
121   AAGTCCGTGT  TGGTTGCAGC  TGGAGAGACA  GCCACTCTGC  GCTGCACTGC  GACCTCTCTG  180
181   ATCCCTGTGG  GGCCCATCCA  GTGGTTCAGA  GGAGCTGGAC  CAGGCCGGGA  ATTAATCTAC  240
241   AATCAAAAAG  AAGGCCACTT  CCCCCGGGTA  ACAACTGTTT  CAGACCTCAC  AAAGAGAAAC  300
301   AACATGGACT  TTTCCATCCG  CATCGGTAAC  ATCACCCCAG  CAGATGCCGG  CACCTACTAC  360
361   TGTGTGAAGT  TCCGGAAAGG  GAGCCCCGAT  GACGTGGAGT  TTAAGTCTGG  AGCAGGCACT  420
421   GAGCTGTCTG  TGCGCGCCAA  ACCCTCTGCC  CCCGTGGTAT  CGGGCCCTGC  GGCGAGGGCC  480
481   ACACCTCAGC  ACACAGTGAG  CTTCACCTGC  GAGTCCCACG  GCTTCTCACC  CAGAGACATC  540
541   ACCCTGAAAT  GGTTCAAAAA  TGGGAATGAG  CTCTCAGACT  TCCAGACCAA  CGTGGACCCC  600
601   GTAGGAGAGA  GCGTGTCCTA  CAGCATCCAC  AGCACAGCCA  AGGTGGTGCT  GACCCGCGAG  660
661   GACGTTCACT  CTCAAGTCAT  CTGCGAGGTG  GCCCACGTCA  CCTTGCAGGG  GGACCCTCTT  720
721   CGTGGGACTG  CCAACTTGTC  TGAGACCATC  CGAGTTCCAC  CCACCTTGGA  GGTTACTCAA  780
781   CAGCCCGTGA  GGGCAGAGAA  CCAGGTGAAT  GTCACCTGCC  AGGTGAGGAA  GTTCTACCCC  840
841   CAGAGACTAC  AGCTGACCTG  GTTGGAGAAT  GGAAACGTGT  CCCGGACAGA  AACGGCCTCA  900
901   ACCGTTACAG  AGAACAAGGA  TGGTACCTAC  AACTGGATGA  GCTGGCTCCT  GGTGAATGTA  960
961   TCTGCCCACA  GGGATGATGT  GAAGCTCACC  TGCCAGGTGG  AGCATGACGG  GCAGCCAGCG  1020
1021  GTCAGCAAAA  GCCATGACCT  GAAGGTCTCA  GCCCACCCGA  AGGAGCAGGG  CTCAAATACC  1080
1081  GCCGCTGAGA  ACACTGGATC  TAATGAACGG  AACATCTATA  TTGTGGTGGG  TGTGGTGTGC  1140
1141  ACCTTGCTGG  TGGCCCTACT  GATGGCGGCC  CTCTACCTCG  TCCGAATCAG  ACAGAAGAAA  1200
1201  GCCCAGGGCT  CCACTTCTTC  TACAAGGTTG  CATGAGCCCG  AGAAGAATGC  CAGAGAAATA  1260
1261  ACACAGGACA  CAAATGATAT  CACATATGCA  GACCTGAACC  TGCCCAAGGG  GAAGAAGCCT  1320
1321  GCTCCCCAGG  CTGCGGAGCC  CAACAACCAC  ACGGAGTATG  CCAGCATTCA  GACCAGCCCG  1380
1381  CAGCCCGCGT  CGGAGGACAC  CCTCACCTAT  GCTGACCTGG  ACATGGTCCA  CCTCAACCGG  1440
1441  ACCCCCAAGC  AGCCGGCCCC  CAAGCCTGAG  CCGTCCTTCT  CAGAGTACGC  CAGCGTCCAG  1500
1501  GTCCCGAGGA  AGTGA  1515

▼ KEYWORD

ID
Family
3D-structure
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
SH3-binding
Signal
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cell surface
Cellular Component
Extracellular exosome
Cellular Component
Ficolin-1-rich granule membrane
Cellular Component
Integral component of plasma membrane
Cellular Component
Membrane
Cellular Component
Plasma membrane
Cellular Component
Tertiary granule membrane
Molecular Function
Cell-cell adhesion mediator activity
Molecular Function
GTPase regulator activity
Molecular Function
Protein antigen binding
Molecular Function
Protein binding involved in heterotypic cell-cell adhesion
Molecular Function
Protein phosphatase binding
Molecular Function
Protein tyrosine kinase binding
Molecular Function
SH3 domain binding
Biological Process
Cell adhesion
Biological Process
Cell migration
Biological Process
Cellular response to hydrogen peroxide
Biological Process
Cellular response to interferon-gamma
Biological Process
Cellular response to interleukin-1
Biological Process
Cellular response to interleukin-12
Biological Process
Cellular response to lipopolysaccharide
Biological Process
Leukocyte migration
Biological Process
Monocyte extravasation
Biological Process
Negative regulation of chemokine (C-C motif) ligand 5 production
Biological Process
Negative regulation of cytokine production involved in inflammatory response
Biological Process
Negative regulation of ERK1 and ERK2 cascade
Biological Process
Negative regulation of I-kappaB phosphorylation
Biological Process
Negative regulation of inflammatory response
Biological Process
Negative regulation of interferon-beta production
Biological Process
Negative regulation of interleukin-6 production
Biological Process
Negative regulation of JNK cascade
Biological Process
Negative regulation of macrophage inflammatory protein 1 alpha production
Biological Process
Negative regulation of nitric oxide biosynthetic process
Biological Process
Negative regulation of phagocytosis
Biological Process
Negative regulation of protein phosphorylation
Biological Process
Negative regulation of tumor necrosis factor production
Biological Process
Neutrophil degranulation
Biological Process
Positive regulation of cell-cell adhesion
Biological Process
Positive regulation of phagocytosis
Biological Process
Positive regulation of T cell activation
Biological Process
Regulation of gene expression
Biological Process
Regulation of interferon-gamma production
Biological Process
Regulation of interleukin-1 beta production
Biological Process
Regulation of interleukin-6 production
Biological Process
Regulation of nitric oxide biosynthetic process
Biological Process
Regulation of tumor necrosis factor production

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gog-a1073Gorilla gorilla98.620.01043
LLPS-Pat-a1092Pan troglodytes98.230.01031
LLPS-Pap-a1054Pan paniscus98.030.01030
LLPS-Poa-a1057Pongo abelii94.290.0936
LLPS-Nol-a1051Nomascus leucogenys93.670.0919
LLPS-Cea-a1084Cercocebus atys92.130.0914
LLPS-Maf-a1077Macaca fascicularis92.130.0915
LLPS-Chs-a1072Chlorocebus sabaeus91.930.0909
LLPS-Rhb-a1071Rhinopithecus bieti91.930.0902
LLPS-Man-a1088Macaca nemestrina91.340.0904
LLPS-Paa-a1084Papio anubis91.340.0899
LLPS-Caj-a1076Callithrix jacchus89.960.0889
LLPS-Mal-a1062Mandrillus leucophaeus87.050.0855
LLPS-Cap-a1076Cavia porcellus81.519e-58202
LLPS-Cas-a913Carlito syrichta81.220.0578
LLPS-Mam-a1066Macaca mulatta81.150.0600
LLPS-Caf-a1062Canis familiaris77.540.0768
LLPS-Mup-a1040Mustela putorius furo76.950.0758
LLPS-Fud-a1031Fukomys damarensis76.820.0738
LLPS-Otg-a1065Otolemur garnettii76.770.0744
LLPS-Ova-a1039Ovis aries76.620.0732
LLPS-Bot-a1084Bos taurus76.620.0733
LLPS-Fec-a1081Felis catus76.520.0760
LLPS-Aon-a1088Aotus nancymaae76.230.0689
LLPS-Orc-a999Oryctolagus cuniculus76.080.0726
LLPS-Sus-a1085Sus scrofa75.780.0714
LLPS-Aim-a1025Ailuropoda melanoleuca75.730.0761
LLPS-Ict-a1065Ictidomys tridecemlineatus75.088e-179515
LLPS-Urm-a958Ursus maritimus74.16e-173502
LLPS-Dio-a1041Dipodomys ordii73.369e-107326
LLPS-Loa-a1051Loxodonta africana70.960.0670
LLPS-Eqc-a1085Equus caballus70.657e-180521
LLPS-Myl-a998Myotis lucifugus68.240.0667
LLPS-Mum-a1090Mus musculus65.890.0640
LLPS-Ran-a1081Rattus norvegicus65.760.0632
LLPS-Mea-a1032Mesocricetus auratus64.948e-153449
LLPS-Ere-a274Erinaceus europaeus57.27e-90284
LLPS-Mod-a1032Monodelphis domestica51.919e-168493
LLPS-Sah-a967Sarcophilus harrisii51.732e-166491