LLPS-Hos-a1051
ROBO2

▼ OVERVIEW


Status: Unreviewed
Protein Name: Roundabout homolog 2
Gene Name: ROBO2, KIAA1568
Ensembl Gene: ENSG00000185008.17
Ensembl Protein: ENSP00000480344.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client
PDB: 6IAA (A) More


▼ PROPERTY



▼ Classification


Condensates:
CondensateEvidenceOrthologs
Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION


Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MSLLMFTQLL  LCGFLYVRVD  GSRLRQEDFP  PRIVEHPSDV  IVSKGEPTTL  NCKAEGRPTP  60
61    TIEWYKDGER  VETDKDDPRS  HRMLLPSGSL  FFLRIVHGRR  SKPDEGSYVC  VARNYLGEAV  120
121   SRNASLEVAL  LRDDFRQNPT  DVVVAAGEPA  ILECQPPRGH  PEPTIYWKKD  KVRIDDKEER  180
181   ISIRGGKLMI  SNTRKSDAGM  YTCVGTNMVG  ERDSDPAELT  VFERPTFLRR  PINQVVLEEE  240
241   AVEFRCQVQG  DPQPTVRWKK  DDADLPRGRY  DIKDDYTLRI  KKTMSTDEGT  YMCIAENRVG  300
301   KMEASATLTV  RAPPQFVVRP  RDQIVAQGRT  VTFPCETKGN  PQPAVFWQKE  GSQNLLFPNQ  360
361   PQQPNSRCSV  SPTGDLTITN  IQRSDAGYYI  CQALTVAGSI  LAKAQLEVTD  VLTDRPPPII  420
421   LQGPANQTLA  VDGTALLKCK  ATGDPLPVIS  WLKEGFTFPG  RDPRATIQEQ  GTLQIKNLRI  480
481   SDTGTYTCVA  TSSSGETSWS  AVLDVTESGA  TISKNYDLSD  LPGPPSKPQV  TDVTKNSVTL  540
541   SWQPGTPGTL  PASAYIIEAF  SQSVSNSWQT  VANHVKTTLY  TVRGLRPNTI  YLFMVRAINP  600
601   QGLSDPSPMS  DPVRTQDISP  PAQGVDHRQV  QKELGDVLVR  LHNPVVLTPT  TVQVTWTVDR  660
661   QPQFIQGYRV  MYRQTSGLQA  TSSWQNLDAK  VPTERSAVLV  NLKKGVTYEI  KVRPYFNEFQ  720
721   GMDSESKTVR  TTEEAPSAPP  QSVTVLTVGS  YNSTSISVSW  DPPPPDHQNG  IIQEYKIWCL  780
781   GNETRFHINK  TVDAAIRSVI  IGGLFPGIQY  RVEVAASTSA  GVGVKSEPQP  IIIGRRNEVV  840
841   ITENNNSITE  QITDVVKQPA  FIAGIGGACW  VILMGFSIWL  YWRRKKRKGL  SNYAVTFQRG  900
901   DGGLMSNGSR  PGLLNAGDPS  YPWLADSWPA  TSLPVNNSNS  GPNEIGNFGR  GDVLPPVPGQ  960
961   GDKTATMLSD  GAIYSSIDFT  TKTSYNSSSQ  ITQATPYATT  QILHSNSIHE  LAVDLPDPQW  1020
1021  KSSIQQKTDL  MGFGYSLPDQ  NKGNNGGKGG  KKKKNKNSSK  PQKNNGSTWA  NVPLPPPPVQ  1080
1081  PLPGTELEHY  AVEQQENGYD  SDSWCPPLPV  QTYLHQGLED  ELEEDDDRVP  TPPVRGVASS  1140
1141  PAISFGQQST  ATLTPSPREE  MQPMLQAHLD  ELTRAYQFDI  AKQTWHIQSN  NQPPQPPVPP  1200
1201  LGYVSGALIS  DLETDVADDD  ADDEEEALEI  PRPLRALDQT  PGSSMDNLDS  SVTGSMVNGW  1260
1261  GSASDEDRNF  SSHRSSVGSS  SDGSIFASGS  FAQALVAAAD  KAGFRLDGTS  LTRTGKAFTS  1320
1321  SQRPRPTSPF  STDSNTSAAL  SQSQRPRPTK  KHKGGRMDQQ  PALPHRREGM  TDEEALVPYS  1380
1381  KPSFPSPGGH  SSSGTASSKG  STGPRKTEVL  RAGHQRNASD  LLDIGYMGSN  SQGQFTGEL  1439
Nucleotide CDS Sequence (FASTA)
1     ATGAGTCTGC  TGATGTTTAC  ACAACTACTG  CTCTGTGGAT  TTTTATATGT  TCGGGTTGAT  60
61    GGATCGCGTC  TTCGCCAGGA  GGACTTTCCC  CCGCGGATTG  TGGAGCATCC  TTCCGATGTC  120
121   ATCGTCTCTA  AGGGCGAGCC  CACGACTCTG  AACTGCAAGG  CGGAGGGCCG  GCCAACGCCC  180
181   ACCATTGAGT  GGTACAAAGA  TGGGGAGCGA  GTGGAGACTG  ACAAGGACGA  TCCCCGGTCC  240
241   CACAGGATGC  TTCTGCCCAG  CGGATCCTTA  TTCTTCTTGC  GCATCGTGCA  CGGGCGCAGG  300
301   AGTAAACCTG  ATGAAGGAAG  CTACGTTTGT  GTTGCGAGGA  ACTATCTTGG  TGAAGCAGTG  360
361   AGTCGAAATG  CGTCTCTGGA  AGTGGCATTG  TTACGAGATG  ACTTCCGACA  AAACCCCACA  420
421   GATGTTGTAG  TGGCAGCTGG  AGAGCCTGCA  ATCCTGGAGT  GCCAGCCTCC  CCGGGGACAC  480
481   CCAGAACCCA  CCATCTACTG  GAAAAAAGAC  AAAGTTCGAA  TTGATGACAA  GGAAGAAAGA  540
541   ATAAGTATCC  GTGGTGGAAA  ACTGATGATC  TCCAATACCA  GGAAAAGTGA  TGCAGGGATG  600
601   TATACTTGTG  TTGGTACCAA  TATGGTGGGA  GAAAGGGACA  GTGACCCAGC  AGAGCTGACT  660
661   GTCTTTGAAC  GACCCACATT  TCTCAGGAGG  CCAATTAACC  AGGTGGTACT  GGAGGAAGAA  720
721   GCTGTAGAAT  TTCGTTGTCA  AGTCCAAGGA  GATCCTCAAC  CAACTGTGAG  GTGGAAAAAG  780
781   GATGATGCAG  ACTTGCCAAG  AGGAAGGTAT  GACATCAAAG  ACGATTACAC  ACTAAGAATT  840
841   AAAAAGACCA  TGAGTACAGA  TGAAGGCACC  TATATGTGTA  TTGCTGAGAA  TCGGGTTGGA  900
901   AAAATGGAAG  CCTCTGCTAC  ACTCACCGTC  CGAGCTCCCC  CACAGTTTGT  GGTTCGGCCA  960
961   AGAGATCAGA  TTGTTGCTCA  AGGTCGAACA  GTGACATTTC  CCTGTGAAAC  TAAAGGAAAC  1020
1021  CCACAGCCAG  CTGTTTTTTG  GCAGAAAGAA  GGCAGCCAGA  ACCTACTTTT  CCCAAACCAA  1080
1081  CCCCAGCAGC  CCAACAGTAG  ATGCTCAGTG  TCACCAACTG  GAGACCTCAC  AATCACCAAC  1140
1141  ATTCAACGTT  CCGACGCGGG  TTACTACATC  TGCCAGGCTT  TAACTGTGGC  AGGAAGCATT  1200
1201  TTAGCAAAAG  CTCAACTGGA  GGTTACTGAT  GTTTTGACAG  ATAGACCTCC  ACCTATAATT  1260
1261  CTACAAGGCC  CAGCCAACCA  AACGCTGGCA  GTGGATGGTA  CAGCGTTACT  GAAATGTAAA  1320
1321  GCCACTGGTG  ATCCTCTTCC  TGTAATTAGC  TGGTTAAAGG  AGGGATTTAC  TTTTCCGGGT  1380
1381  AGAGATCCAA  GAGCAACAAT  TCAAGAGCAA  GGCACACTGC  AGATTAAGAA  TTTACGGATT  1440
1441  TCTGATACTG  GCACTTATAC  TTGTGTGGCT  ACAAGTTCAA  GTGGAGAGAC  TTCCTGGAGT  1500
1501  GCAGTGCTGG  ATGTGACAGA  GTCTGGAGCA  ACAATCAGTA  AAAACTATGA  TTTAAGTGAC  1560
1561  CTGCCAGGGC  CACCATCCAA  ACCGCAGGTC  ACTGATGTTA  CTAAGAACAG  TGTCACCTTG  1620
1621  TCCTGGCAGC  CAGGTACCCC  TGGAACCCTT  CCAGCAAGTG  CATATATCAT  TGAGGCTTTC  1680
1681  AGCCAATCAG  TGAGCAACAG  CTGGCAGACC  GTGGCAAACC  ATGTAAAGAC  CACCCTCTAT  1740
1741  ACTGTAAGAG  GACTGCGGCC  CAATACAATC  TACTTATTCA  TGGTCAGAGC  GATCAACCCC  1800
1801  CAAGGTCTCA  GTGACCCAAG  TCCCATGTCA  GATCCTGTGC  GCACACAAGA  TATCAGCCCA  1860
1861  CCAGCACAAG  GAGTGGACCA  CAGGCAAGTG  CAGAAAGAGC  TAGGAGATGT  CCTTGTCCGT  1920
1921  CTTCATAATC  CAGTTGTGCT  GACTCCCACC  ACGGTTCAGG  TCACATGGAC  GGTTGATCGC  1980
1981  CAACCCCAGT  TTATCCAAGG  CTACCGAGTG  ATGTATCGTC  AGACTTCAGG  TCTGCAGGCG  2040
2041  ACATCTTCGT  GGCAGAATTT  AGATGCCAAA  GTCCCGACTG  AACGAAGTGC  TGTCTTAGTC  2100
2101  AACCTGAAAA  AGGGGGTGAC  TTATGAAATT  AAAGTACGGC  CATATTTTAA  TGAGTTCCAA  2160
2161  GGAATGGATA  GTGAATCTAA  AACGGTTCGT  ACTACTGAAG  AAGCCCCAAG  TGCCCCACCA  2220
2221  CAGTCTGTCA  CTGTACTGAC  AGTTGGAAGC  TACAATAGCA  CAAGTATTAG  TGTTTCCTGG  2280
2281  GATCCTCCTC  CTCCAGATCA  CCAGAATGGA  ATTATCCAAG  AATACAAGAT  CTGGTGTCTA  2340
2341  GGAAATGAAA  CGCGATTCCA  TATCAACAAA  ACTGTGGATG  CAGCCATTCG  GTCCGTAATA  2400
2401  ATTGGTGGAT  TATTCCCAGG  TATTCAATAC  CGGGTAGAGG  TTGCAGCTAG  TACCAGTGCA  2460
2461  GGGGTTGGAG  TAAAGAGTGA  GCCACAGCCA  ATAATAATCG  GGAGACGCAA  TGAAGTTGTC  2520
2521  ATTACTGAAA  ACAATAACAG  CATAACTGAG  CAAATCACTG  ATGTGGTGAA  GCAACCAGCC  2580
2581  TTTATAGCTG  GTATTGGTGG  TGCCTGCTGG  GTAATTCTGA  TGGGTTTTAG  CATATGGTTG  2640
2641  TATTGGCGAA  GAAAGAAGAG  GAAGGGACTC  AGTAATTATG  CTGTTACGTT  TCAAAGAGGA  2700
2701  GATGGAGGAC  TAATGAGCAA  TGGAAGCCGT  CCAGGTCTTC  TCAATGCTGG  TGATCCCAGC  2760
2761  TATCCATGGC  TTGCTGATTC  TTGGCCAGCC  ACGAGCTTGC  CAGTAAATAA  TAGCAACAGT  2820
2821  GGCCCAAATG  AGATTGGAAA  TTTTGGCCGT  GGAGATGTGC  TGCCACCAGT  TCCAGGCCAA  2880
2881  GGGGATAAAA  CAGCAACGAT  GCTCTCAGAT  GGAGCCATTT  ATAGTAGCAT  TGACTTCACT  2940
2941  ACCAAAACCA  GTTACAACAG  TTCCAGCCAA  ATAACACAGG  CTACCCCATA  TGCCACGACA  3000
3001  CAGATCTTGC  ATTCCAACAG  CATACATGAA  TTGGCTGTCG  ATCTGCCTGA  TCCACAATGG  3060
3061  AAAAGCTCAA  TTCAGCAAAA  AACAGATCTG  ATGGGATTTG  GTTATTCTCT  ACCTGATCAG  3120
3121  AACAAAGGTA  ACAATGGTGG  GAAAGGTGGA  AAAAAGAAGA  AAAATAAAAA  CTCTTCTAAA  3180
3181  CCACAGAAAA  ACAATGGATC  CACTTGGGCC  AATGTCCCTC  TACCTCCCCC  CCCAGTCCAG  3240
3241  CCCCTTCCTG  GCACGGAGCT  GGAACACTAT  GCAGTGGAAC  AACAAGAAAA  TGGCTATGAC  3300
3301  AGTGATAGCT  GGTGCCCACC  ATTGCCAGTA  CAAACTTACT  TACACCAAGG  TCTGGAAGAT  3360
3361  GAACTGGAAG  AAGATGATGA  TAGGGTCCCA  ACACCTCCTG  TTCGAGGCGT  GGCTTCTTCT  3420
3421  CCTGCTATCT  CCTTTGGACA  GCAGTCCACT  GCAACTCTTA  CTCCATCCCC  ACGGGAAGAG  3480
3481  ATGCAACCCA  TGCTGCAGGC  TCACCTGGAT  GAGTTGACAA  GAGCCTATCA  GTTTGATATA  3540
3541  GCAAAACAAA  CATGGCACAT  TCAAAGCAAT  AATCAACCTC  CACAGCCTCC  AGTTCCACCG  3600
3601  TTAGGTTATG  TGTCTGGAGC  CTTGATTTCT  GATTTGGAAA  CGGATGTTGC  AGATGATGAT  3660
3661  GCCGACGACG  AAGAGGAAGC  TTTAGAAATC  CCCAGGCCCC  TGAGAGCACT  GGACCAGACT  3720
3721  CCTGGATCCA  GCATGGACAA  TCTAGACAGC  TCTGTGACAG  GTTCAATGGT  AAATGGATGG  3780
3781  GGCTCTGCAT  CTGATGAGGA  TCGTAACTTT  TCTAGTCATA  GATCTAGTGT  AGGTAGCTCC  3840
3841  TCAGATGGCT  CTATCTTTGC  CAGCGGCAGT  TTTGCACAAG  CACTGGTGGC  AGCAGCAGAT  3900
3901  AAAGCTGGTT  TTAGGCTGGA  TGGAACCAGC  CTTACAAGAA  CAGGAAAAGC  CTTTACCTCC  3960
3961  TCTCAAAGAC  CTCGACCTAC  CAGCCCATTT  TCTACTGACA  GTAACACCAG  TGCAGCCCTG  4020
4021  AGTCAAAGTC  AGAGGCCTCG  GCCCACTAAA  AAACACAAGG  GAGGGCGGAT  GGACCAACAA  4080
4081  CCAGCATTGC  CTCATCGAAG  GGAAGGAATG  ACAGATGAGG  AGGCCTTGGT  GCCCTATAGC  4140
4141  AAGCCCAGTT  TCCCATCTCC  AGGTGGCCAC  AGCTCATCAG  GAACAGCTTC  TTCTAAGGGA  4200
4201  TCCACTGGAC  CTAGGAAAAC  CGAGGTGTTG  AGAGCAGGCC  ACCAGCGCAA  TGCCAGCGAC  4260
4261  CTTCTTGACA  TAGGATATAT  GGGCTCCAAC  AGTCAAGGAC  AGTTTACAGG  TGAATTATAG  4320

▼ KEYWORD


ID
Family
3D-structure
Alternative splicing
Chemotaxis
Chromosomal rearrangement
Complete proteome
Developmental protein
Differentiation
Disease mutation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Neurogenesis
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Axolemma
Cellular Component
Cell surface
Cellular Component
Extracellular exosome
Cellular Component
Integral component of membrane
Cellular Component
Plasma membrane
Molecular Function
Axon guidance receptor activity
Molecular Function
Identical protein binding
Biological Process
Aorta development
Biological Process
Aortic valve morphogenesis
Biological Process
Apoptotic process involved in luteolysis
Biological Process
Axon guidance
Biological Process
Axon midline choice point recognition
Biological Process
Brain development
Biological Process
Cellular response to hormone stimulus
Biological Process
Central nervous system development
Biological Process
Endocardial cushion formation
Biological Process
Homophilic cell adhesion via plasma membrane adhesion molecules
Biological Process
Metanephros development
Biological Process
Negative regulation of negative chemotaxis
Biological Process
Negative regulation of synapse assembly
Biological Process
Olfactory bulb interneuron development
Biological Process
Outflow tract septum morphogenesis
Biological Process
Positive regulation of axonogenesis
Biological Process
Positive regulation of Notch signaling pathway involved in heart induction
Biological Process
Pulmonary valve morphogenesis
Biological Process
Retinal ganglion cell axon guidance
Biological Process
Roundabout signaling pathway
Biological Process
Spinal cord development
Biological Process
Ureteric bud development
Biological Process
Ventricular septum morphogenesis

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-a1037Pan troglodytes100.00.02963
LLPS-Pap-a1005Pan paniscus100.00.02963
LLPS-Gog-a1022Gorilla gorilla99.930.02962
LLPS-Mam-a1017Macaca mulatta99.170.02944
LLPS-Mal-a1009Mandrillus leucophaeus99.10.02942
LLPS-Paa-a1033Papio anubis99.10.02944
LLPS-Man-a1034Macaca nemestrina99.10.02942
LLPS-Cea-a1029Cercocebus atys99.030.02939
LLPS-Maf-a1028Macaca fascicularis99.030.02940
LLPS-Aon-a1036Aotus nancymaae98.960.02937
LLPS-Caj-a1021Callithrix jacchus98.890.02934
LLPS-Nol-a1003Nomascus leucogenys98.390.02392
LLPS-Fec-a1029Felis catus98.120.02915
LLPS-Chs-a1023Chlorocebus sabaeus98.030.01973
LLPS-Rhb-a1020Rhinopithecus bieti97.150.02637
LLPS-Sus-a1032Sus scrofa97.130.02509
LLPS-Bot-a1031Bos taurus96.890.02496
LLPS-Poa-a1006Pongo abelii95.930.02408
LLPS-Mup-a992Mustela putorius furo94.390.02373
LLPS-Eqc-a1031Equus caballus94.120.02485
LLPS-Gaga-a923Gallus gallus92.50.02242
LLPS-Otg-a1015Otolemur garnettii92.140.02305
LLPS-Dio-a989Dipodomys ordii91.710.02686
LLPS-Mea-a982Mesocricetus auratus90.390.02404
LLPS-Cap-a1025Cavia porcellus89.40.02559
LLPS-Fud-a986Fukomys damarensis88.830.02547
LLPS-Loa-a1000Loxodonta africana88.190.02292
LLPS-Caf-a1012Canis familiaris88.150.02284
LLPS-Fia-a902Ficedula albicollis88.00.02097
LLPS-Ora-a846Ornithorhynchus anatinus87.960.01902
LLPS-Orc-a955Oryctolagus cuniculus87.890.02284
LLPS-Aim-a983Ailuropoda melanoleuca87.840.02284
LLPS-Ova-a993Ovis aries87.830.02281
LLPS-Mum-a1036Mus musculus87.810.02508
LLPS-Myl-a952Myotis lucifugus87.30.02272
LLPS-Ict-a1016Ictidomys tridecemlineatus87.00.02469
LLPS-Ran-a1026Rattus norvegicus86.710.02337
LLPS-Urm-a918Ursus maritimus85.370.02303
LLPS-Mod-a984Monodelphis domestica83.790.02013
LLPS-Pes-a876Pelodiscus sinensis83.720.02073
LLPS-Tag-a883Taeniopygia guttata83.070.02061
LLPS-Meg-a816Meleagris gallopavo83.050.02072
LLPS-Anp-a814Anas platyrhynchos83.010.02070
LLPS-Lac-a892Latimeria chalumnae82.180.01908
LLPS-Anc-a927Anolis carolinensis81.850.02045
LLPS-Tar-a848Takifugu rubripes80.260.01884
LLPS-Xet-a877Xenopus tropicalis76.680.02064
LLPS-Scf-a865Scleropages formosus76.230.02094
LLPS-Scm-a854Scophthalmus maximus75.140.02057
LLPS-Xim-a896Xiphophorus maculatus74.60.02056
LLPS-Orn-a885Oreochromis niloticus73.60.02018
LLPS-Icp-a895Ictalurus punctatus73.460.02016
LLPS-Pof-a887Poecilia formosa72.270.01713
LLPS-Orl-a879Oryzias latipes71.490.01982
LLPS-Leo-a884Lepisosteus oculatus71.220.01934
LLPS-Asm-a887Astyanax mexicanus69.480.01987
LLPS-Dar-a895Danio rerio68.150.01798
LLPS-Gaa-a865Gasterosteus aculeatus63.370.01607
LLPS-Ten-a845Tetraodon nigroviridis62.190.01657