LLPS-Hos-a1039
TM2D3
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | TM2 domain-containing protein 3; Beta-amyloid-binding protein-like protein 2; BBP-like protein 2 |
| Gene Name: | TM2D3, BLP2 |
| Ensembl Gene: | ENSG00000184277.12 |
| Ensembl Protein: | ENSP00000402179.2 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Human cortex | 23071613 |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000428002.6 | ENSP00000402179.2 |
| Ensembl | ENST00000558677.5 | ENSP00000456921.1 |
| Ensembl | ENST00000560013.5 | ENSP00000453503.1 |
| Ensembl | ENST00000561373.1 | ENSP00000452823.1 |
| Ensembl | ENST00000333202.7 | ENSP00000330433.3 |
| Ensembl | ENST00000347970.7 | ENSP00000327584.3 |
| Ensembl | ENST00000558129.5 | ENSP00000453990.1 |
| Ensembl | ENST00000559107.5 | ENSP00000454131.1 |
| UniProt | Q9BRN9, TM2D3_HUMAN, B2RDK9, Q9H046, Q9H651 | |
| GeneBank | AK315584, CH471101, AK026257, AF353992, BC008873, AC090164, BC006150, AL512689 | BAG37956.1, BAB15415.1, CAC21647.1, AAH06150.1, AAH08873.1, AAK35066.1, EAX02315.1 |
| RefSeq | NM_025141.3, NM_078474.2 | NP_079417.2, NP_510883.2 |
| Entrez | 80213 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAGGVLPLRG LRALCRVLLF LSQFCILSGG EQSQALAQSI KDPGPTRTFT VVPRAAESTE 60 61 IPPYVMKCPS NGLCSRLPAD CIDCTTNFSC TYGKPVTFDC AVKPSVTCVD QDFKSQKNFI 120 121 INMTCRFCWQ LPETDYECTN STSCMTVSCP RQRYPANCTV RDHVHCLGNR TFPKMLYCNW 180 181 TGGYKWSTAL ALSITLGGFG ADRFYLGQWR EGLGKLFSFG GLGIWTLIDV LLIGVGYVGP 240 241 ADGSLYI 247 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGGAG GGGTGCTCCC GCTGAGGGGC CTCCGCGCCT TGTGTCGCGT GCTGCTCTTC 60 61 CTCTCGCAGT TCTGCATTCT GTCGGGCGGT GAGCAATCGC AGGCGCTGGC TCAGTCAATA 120 121 AAGGATCCGG GCCCAACACG CACATTCACA GTAGTTCCCA GGGCAGCAGA AAGTACTGAA 180 181 ATCCCACCTT ATGTGATGAA GTGTCCGAGC AATGGTTTGT GTAGCAGGCT TCCTGCAGAC 240 241 TGTATAGACT GCACAACAAA TTTCTCCTGT ACCTATGGGA AGCCTGTCAC TTTTGACTGT 300 301 GCAGTGAAAC CATCTGTTAC CTGTGTTGAT CAAGACTTCA AATCCCAAAA GAACTTCATC 360 361 ATTAACATGA CTTGCAGATT TTGCTGGCAG CTTCCTGAAA CAGATTACGA GTGTACCAAC 420 421 TCCACCAGCT GCATGACGGT GTCCTGTCCT CGGCAGCGCT ACCCTGCCAA CTGCACGGTG 480 481 CGGGACCACG TCCACTGCTT GGGTAACCGT ACTTTTCCCA AAATGCTATA TTGCAATTGG 540 541 ACTGGAGGCT ATAAGTGGTC TACGGCTCTG GCTCTAAGCA TCACCCTCGG TGGGTTTGGA 600 601 GCAGACCGTT TCTACCTGGG CCAGTGGCGG GAAGGCCTCG GCAAGCTCTT CAGCTTCGGT 660 661 GGCCTGGGAA TATGGACGCT GATAGACGTC CTGCTCATTG GAGTTGGCTA TGTTGGACCA 720 721 GCAGATGGCT CTTTGTACAT TTAG 744 |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Domain | ||||
| LCR-eXXXplorer | CDD | |||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mal-a999 | Mandrillus leucophaeus | 99.54 | 2e-158 | 448 |
| LLPS-Chs-a1012 | Chlorocebus sabaeus | 99.19 | 1e-180 | 505 |
| LLPS-Man-a1023 | Macaca nemestrina | 99.19 | 1e-180 | 505 |
| LLPS-Maf-a1018 | Macaca fascicularis | 99.19 | 1e-180 | 505 |
| LLPS-Pap-a994 | Pan paniscus | 99.18 | 2e-178 | 499 |
| LLPS-Pat-a1025 | Pan troglodytes | 98.79 | 2e-180 | 504 |
| LLPS-Cea-a1018 | Cercocebus atys | 98.79 | 3e-180 | 504 |
| LLPS-Rhb-a1009 | Rhinopithecus bieti | 98.79 | 2e-180 | 504 |
| LLPS-Poa-a994 | Pongo abelii | 98.44 | 1e-137 | 394 |
| LLPS-Gog-a1010 | Gorilla gorilla | 98.38 | 2e-179 | 502 |
| LLPS-Paa-a1022 | Papio anubis | 97.98 | 1e-179 | 502 |
| LLPS-Mam-a1006 | Macaca mulatta | 96.94 | 1e-138 | 397 |
| LLPS-Aon-a1024 | Aotus nancymaae | 96.36 | 1e-176 | 495 |
| LLPS-Nol-a991 | Nomascus leucogenys | 94.44 | 4e-165 | 466 |
| LLPS-Aim-a971 | Ailuropoda melanoleuca | 93.86 | 7e-159 | 450 |
| LLPS-Mup-a981 | Mustela putorius furo | 93.67 | 3e-163 | 461 |
| LLPS-Caj-a1009 | Callithrix jacchus | 93.63 | 2e-170 | 479 |
| LLPS-Caf-a1000 | Canis familiaris | 93.12 | 5e-171 | 481 |
| LLPS-Ict-a1006 | Ictidomys tridecemlineatus | 92.64 | 2e-156 | 444 |
| LLPS-Ere-a258 | Erinaceus europaeus | 91.67 | 3e-148 | 422 |
| LLPS-Fec-a1018 | Felis catus | 91.09 | 1e-158 | 449 |
| LLPS-Urm-a907 | Ursus maritimus | 91.07 | 2e-150 | 429 |
| LLPS-Mea-a973 | Mesocricetus auratus | 90.65 | 7e-162 | 457 |
| LLPS-Sus-a1020 | Sus scrofa | 90.48 | 7e-166 | 468 |
| LLPS-Bot-a1020 | Bos taurus | 90.32 | 9e-145 | 416 |
| LLPS-Fud-a975 | Fukomys damarensis | 89.88 | 2e-157 | 446 |
| LLPS-Otg-a1005 | Otolemur garnettii | 88.66 | 3e-157 | 446 |
| LLPS-Tut-a531 | Tursiops truncatus | 88.26 | 1e-156 | 444 |
| LLPS-Eqc-a1019 | Equus caballus | 86.49 | 9e-163 | 460 |
| LLPS-Cap-a1013 | Cavia porcellus | 84.82 | 1e-155 | 442 |
| LLPS-Loa-a990 | Loxodonta africana | 84.17 | 6e-146 | 418 |
| LLPS-Ova-a982 | Ovis aries | 84.13 | 4e-151 | 430 |
| LLPS-Dio-a978 | Dipodomys ordii | 83.78 | 5e-153 | 436 |
| LLPS-Tag-a872 | Taeniopygia guttata | 83.16 | 4e-116 | 339 |
| LLPS-Anp-a805 | Anas platyrhynchos | 82.99 | 6e-118 | 344 |
| LLPS-Mum-a1023 | Mus musculus | 82.38 | 2e-154 | 439 |
| LLPS-Orc-a947 | Oryctolagus cuniculus | 82.16 | 3e-144 | 413 |
| LLPS-Meg-a807 | Meleagris gallopavo | 80.18 | 2e-124 | 362 |
| LLPS-Lac-a885 | Latimeria chalumnae | 78.92 | 9e-92 | 276 |
| LLPS-Fia-a892 | Ficedula albicollis | 78.3 | 6e-119 | 347 |
| LLPS-Myl-a943 | Myotis lucifugus | 78.02 | 9e-97 | 289 |
| LLPS-Mod-a974 | Monodelphis domestica | 77.96 | 7e-134 | 387 |
| LLPS-Pes-a869 | Pelodiscus sinensis | 76.96 | 6e-119 | 348 |
| LLPS-Gaga-a912 | Gallus gallus | 76.52 | 5e-131 | 380 |
| LLPS-Ora-a835 | Ornithorhynchus anatinus | 75.98 | 7e-139 | 400 |
| LLPS-Scf-a857 | Scleropages formosus | 72.68 | 2e-99 | 297 |
| LLPS-Ten-a836 | Tetraodon nigroviridis | 70.98 | 2e-95 | 288 |
| LLPS-Cis-a205 | Ciona savignyi | 70.0 | 5e-32 | 120 |
| LLPS-Orl-a869 | Oryzias latipes | 68.93 | 1e-98 | 298 |
| LLPS-Xim-a887 | Xiphophorus maculatus | 68.93 | 4e-96 | 291 |
| LLPS-Anc-a917 | Anolis carolinensis | 68.6 | 7e-119 | 348 |
| LLPS-Pof-a878 | Poecilia formosa | 68.45 | 8e-96 | 290 |
| LLPS-Xet-a866 | Xenopus tropicalis | 68.15 | 4e-119 | 349 |
| LLPS-Asm-a878 | Astyanax mexicanus | 68.06 | 2e-91 | 279 |
| LLPS-Ran-a1015 | Rattus norvegicus | 67.94 | 5e-105 | 313 |
| LLPS-Scm-a845 | Scophthalmus maximus | 66.99 | 2e-94 | 287 |
| LLPS-Leo-a875 | Lepisosteus oculatus | 66.06 | 7e-101 | 303 |
| LLPS-Orn-a877 | Oreochromis niloticus | 66.06 | 8e-99 | 298 |
| LLPS-Icp-a886 | Ictalurus punctatus | 65.85 | 2e-92 | 280 |
| LLPS-Dar-a887 | Danio rerio | 62.79 | 1e-93 | 284 |
| LLPS-Gaa-a856 | Gasterosteus aculeatus | 62.3 | 1e-101 | 305 |
| LLPS-Tar-a840 | Takifugu rubripes | 61.4 | 5e-91 | 279 |
| LLPS-Drm-a210 | Drosophila melanogaster | 51.35 | 2e-56 | 190 |
| LLPS-Cii-a244 | Ciona intestinalis | 51.32 | 7e-12 | 67.8 |