LLPS-Hos-a103
MGLL
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000494830.1 | ENSP00000417489.1 |
| Ensembl | ENST00000496306.5 | ENSP00000417060.1 |
| Ensembl | ENST00000434178.6 | ENSP00000402798.2 |
| Ensembl | ENST00000453507.6 | ENSP00000404146.2 |
| Ensembl | ENST00000487473.5 | ENSP00000420125.1 |
| Ensembl | ENST00000493611.1 | ENSP00000417689.1 |
| Ensembl | ENST00000648300.1 | ENSP00000497905.1 |
| Ensembl | ENST00000398101.7 | ENSP00000381173.3 |
| Ensembl | ENST00000484451.1 | ENSP00000419340.1 |
| Ensembl | ENST00000398104.5 | ENSP00000381176.1 |
| Ensembl | ENST00000265052.9 | ENSP00000265052.5 |
| UniProt | Q99685, MGLL_HUMAN, B3KRC2, B7Z9D1, Q6IBG9, Q96AA5 | |
| GeneBank | CR456835, CH471052, AC117480, AC023593, U67963, BC006230, AK091314, AJ270950, BX640777, AK304844, BC000551, AK315529 | CAE45873.1, AAH00551.1, AAH06230.1, EAW79331.1, CAG33116.1, AAB39616.1, EAW79330.1, CAC43316.1, BAG52334.1, BAH14267.1, BAG37910.1 |
| RefSeq | NM_001003794.2, NM_001256585.1, NM_007283.6 | NP_001003794.1, NP_001243514.1, NP_009214.1 |
| Entrez | 11343 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 METGPEDPSS MPEESSPRRT PQSIPYQDLP HLVNADGQYL FCRYWKPTGT PKALIFVSHG 60 61 AGEHSGRYEE LARMLMGLDL LVFAHDHVGH GQSEGERMVV SDFHVFVRDV LQHVDSMQKD 120 121 YPGLPVFLLG HSMGGAIAIL TAAERPGHFA GMVLISPLVL ANPESATTFK VLAAKVLNLV 180 181 LPNLSLGPID SSVLSRNKTE VDIYNSDPLI CRAGLKVCFG IQLLNAVSRV ERALPKLTVP 240 241 FLLLQGSADR LCDSKGAYLL MELAKSQDKT LKIYEGAYHV LHKELPEVTN SVFHEINMWV 300 301 SQRTATAGTA SPP 313 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAAACAG GACCTGAAGA CCCTTCCAGC ATGCCAGAGG AAAGTTCCCC CAGGCGGACC 60 61 CCGCAGAGCA TTCCCTACCA GGACCTCCCT CACCTGGTCA ATGCAGACGG ACAGTACCTC 120 121 TTCTGCAGGT ACTGGAAACC CACAGGCACA CCCAAGGCCC TCATCTTTGT GTCCCATGGA 180 181 GCCGGAGAGC ACAGTGGCCG CTATGAAGAG CTGGCTCGGA TGCTGATGGG GCTGGACCTG 240 241 CTGGTGTTCG CCCACGACCA TGTTGGCCAC GGACAGAGCG AAGGGGAGAG GATGGTAGTG 300 301 TCTGACTTCC ACGTTTTCGT CAGGGATGTG TTGCAGCATG TGGATTCCAT GCAGAAAGAC 360 361 TACCCTGGGC TTCCTGTCTT CCTTCTGGGC CACTCCATGG GAGGCGCCAT CGCCATCCTC 420 421 ACGGCCGCAG AGAGGCCGGG CCACTTCGCC GGCATGGTAC TCATTTCGCC TCTGGTTCTT 480 481 GCCAATCCTG AATCTGCAAC AACTTTCAAG GTCCTTGCTG CGAAAGTGCT CAACCTTGTG 540 541 CTGCCAAACT TGTCCCTCGG GCCCATCGAC TCCAGCGTGC TCTCTCGGAA TAAGACAGAG 600 601 GTCGACATTT ATAACTCAGA CCCCCTGATC TGCCGGGCAG GGCTGAAGGT GTGCTTCGGC 660 661 ATCCAACTGC TGAATGCCGT CTCACGGGTG GAGCGCGCCC TCCCCAAGCT GACTGTGCCC 720 721 TTCCTGCTGC TCCAGGGCTC TGCCGATCGC CTATGTGACA GCAAAGGGGC CTACCTGCTC 780 781 ATGGAGTTAG CCAAGAGCCA GGACAAGACT CTCAAGATTT ATGAAGGTGC CTACCATGTT 840 841 CTCCACAAGG AGCTTCCTGA AGTCACCAAC TCCGTCTTCC ATGAAATAAA CATGTGGGTC 900 901 TCTCAAAGGA CAGCCACGGC AGGAACTGCG TCCCCACCCT GA 942 |
▼ KEYWORD
ID | Family |
3D-structure | |
Alternative splicing | |
Complete proteome | |
Cytoplasm | |
Fatty acid biosynthesis | |
Fatty acid metabolism | |
Hydrolase | |
Lipid biosynthesis | |
Lipid degradation | |
Lipid metabolism | |
Membrane | |
Nitration | |
Phosphoprotein | |
Reference proteome | |
Serine esterase
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Extrinsic component of membrane | |
Cellular Component | Membrane | |
Cellular Component | Nucleoplasm | |
Cellular Component | Plasma membrane | |
Molecular Function | Acylglycerol lipase activity | |
Molecular Function | Lysophospholipase activity | |
Molecular Function | Protein homodimerization activity | |
Biological Process | Acylglycerol acyl-chain remodeling | |
Biological Process | Acylglycerol catabolic process | |
Biological Process | Arachidonic acid metabolic process | |
Biological Process | Fatty acid biosynthetic process | |
Biological Process | Inflammatory response | |
Biological Process | Lipid metabolic process | |
Biological Process | Monoacylglycerol catabolic process | |
Biological Process | Regulation of endocannabinoid signaling pathway | |
Biological Process | Regulation of inflammatory response | |
Biological Process | Regulation of sensory perception of pain | |
Biological Process | Regulation of signal transduction | |
Biological Process | Triglyceride catabolic process |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | CellMarker | RaftProt | ||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | COSMIC | MethyCancer | |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-a102 | Pan troglodytes | 100.0 | 0.0 | 645 |
| LLPS-Pap-a101 | Pan paniscus | 100.0 | 0.0 | 645 |
| LLPS-Gog-a104 | Gorilla gorilla | 99.68 | 0.0 | 641 |
| LLPS-Poa-a101 | Pongo abelii | 98.72 | 0.0 | 640 |
| LLPS-Mal-a101 | Mandrillus leucophaeus | 98.4 | 0.0 | 635 |
| LLPS-Cea-a105 | Cercocebus atys | 98.4 | 0.0 | 635 |
| LLPS-Paa-a104 | Papio anubis | 98.4 | 0.0 | 635 |
| LLPS-Rhb-a104 | Rhinopithecus bieti | 98.4 | 0.0 | 635 |
| LLPS-Aon-a105 | Aotus nancymaae | 95.85 | 0.0 | 624 |
| LLPS-Caj-a102 | Callithrix jacchus | 95.21 | 0.0 | 619 |
| LLPS-Otg-a104 | Otolemur garnettii | 94.17 | 2e-162 | 461 |
| LLPS-Cas-a097 | Carlito syrichta | 93.93 | 0.0 | 615 |
| LLPS-Ict-a105 | Ictidomys tridecemlineatus | 91.19 | 2e-172 | 489 |
| LLPS-Man-a103 | Macaca nemestrina | 91.19 | 0.0 | 604 |
| LLPS-Aim-a101 | Ailuropoda melanoleuca | 90.97 | 0.0 | 588 |
| LLPS-Mam-a101 | Macaca mulatta | 90.86 | 0.0 | 620 |
| LLPS-Chs-a104 | Chlorocebus sabaeus | 90.86 | 0.0 | 620 |
| LLPS-Urm-a095 | Ursus maritimus | 90.73 | 0.0 | 593 |
| LLPS-Myl-a101 | Myotis lucifugus | 90.71 | 2e-148 | 426 |
| LLPS-Loa-a100 | Loxodonta africana | 89.32 | 2e-149 | 428 |
| LLPS-Eqc-a107 | Equus caballus | 89.14 | 0.0 | 581 |
| LLPS-Sus-a106 | Sus scrofa | 88.82 | 0.0 | 585 |
| LLPS-Tut-a055 | Tursiops truncatus | 87.7 | 0.0 | 566 |
| LLPS-Maf-a104 | Macaca fascicularis | 87.69 | 0.0 | 587 |
| LLPS-Orc-a099 | Oryctolagus cuniculus | 87.54 | 0.0 | 560 |
| LLPS-Bot-a107 | Bos taurus | 87.4 | 2e-166 | 479 |
| LLPS-Ova-a105 | Ovis aries | 87.13 | 0.0 | 558 |
| LLPS-Dio-a101 | Dipodomys ordii | 87.01 | 0.0 | 562 |
| LLPS-Ora-a092 | Ornithorhynchus anatinus | 86.8 | 0.0 | 561 |
| LLPS-Sah-a099 | Sarcophilus harrisii | 85.83 | 3e-147 | 424 |
| LLPS-Caf-a101 | Canis familiaris | 84.03 | 4e-173 | 492 |
| LLPS-Mup-a103 | Mustela putorius furo | 83.71 | 0.0 | 534 |
| LLPS-Fec-a105 | Felis catus | 82.43 | 3e-175 | 499 |
| LLPS-Nol-a106 | Nomascus leucogenys | 82.43 | 0.0 | 510 |
| LLPS-Mod-a096 | Monodelphis domestica | 82.2 | 0.0 | 532 |
| LLPS-Fud-a104 | Fukomys damarensis | 79.87 | 2e-171 | 487 |
| LLPS-Mea-a096 | Mesocricetus auratus | 77.96 | 1e-175 | 497 |
| LLPS-Mum-a106 | Mus musculus | 77.04 | 0.0 | 534 |
| LLPS-Cap-a106 | Cavia porcellus | 70.13 | 2e-142 | 414 |
| LLPS-Anp-a095 | Anas platyrhynchos | 69.1 | 3e-159 | 456 |
| LLPS-Ran-a105 | Rattus norvegicus | 68.91 | 4e-165 | 471 |
| LLPS-Meg-a089 | Meleagris gallopavo | 68.49 | 2e-163 | 467 |
| LLPS-Anc-a099 | Anolis carolinensis | 68.29 | 1e-148 | 430 |
| LLPS-Tag-a094 | Taeniopygia guttata | 67.99 | 1e-160 | 460 |
| LLPS-Pes-a090 | Pelodiscus sinensis | 67.85 | 1e-161 | 462 |
| LLPS-Fia-a097 | Ficedula albicollis | 66.88 | 1e-159 | 457 |
| LLPS-Lac-a095 | Latimeria chalumnae | 63.16 | 7e-135 | 394 |
| LLPS-Xet-a091 | Xenopus tropicalis | 62.46 | 5e-145 | 421 |
| LLPS-Gaga-a095 | Gallus gallus | 60.81 | 3e-117 | 350 |
| LLPS-Leo-a088 | Lepisosteus oculatus | 60.14 | 2e-136 | 398 |
| LLPS-Orn-a092 | Oreochromis niloticus | 57.97 | 1e-129 | 381 |
| LLPS-Orl-a097 | Oryzias latipes | 57.86 | 9e-127 | 375 |
| LLPS-Xim-a097 | Xiphophorus maculatus | 57.7 | 2e-127 | 377 |
| LLPS-Scf-a090 | Scleropages formosus | 57.63 | 5e-118 | 352 |
| LLPS-Icp-a099 | Ictalurus punctatus | 56.66 | 5e-125 | 369 |
| LLPS-Dar-a092 | Danio rerio | 56.33 | 7e-123 | 363 |
| LLPS-Pof-a095 | Poecilia formosa | 55.92 | 7e-124 | 366 |
| LLPS-Ten-a094 | Tetraodon nigroviridis | 55.7 | 4e-127 | 375 |