LLPS-Hos-a1021
CACNB4

▼ OVERVIEW

Status: Reviewed
Protein Name: Voltage-dependent L-type calcium channel subunit beta-4
Gene Name: CACNB4, CACNLB4
Ensembl Gene: ENSG00000182389.19
Ensembl Protein: ENSP00000489732.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client
PDB: 2D46 (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENST00000637779.1ENSP00000489732.1
EnsemblENST00000637550.1ENSP00000489943.1
EnsemblENST00000636664.1ENSP00000490572.1
EnsemblENST00000636901.1ENSP00000490145.1
EnsemblENST00000635930.1ENSP00000489953.1
EnsemblENST00000637547.1ENSP00000490124.1
EnsemblENST00000636390.1ENSP00000490603.1
EnsemblENST00000637309.1ENSP00000490127.1
EnsemblENST00000637007.1ENSP00000489772.1
EnsemblENST00000638091.1ENSP00000489967.1
EnsemblENST00000637762.1ENSP00000489876.1
EnsemblENST00000201943.10ENSP00000201943.5
EnsemblENST00000636947.1ENSP00000490337.1
EnsemblENST00000636108.1ENSP00000490176.1
EnsemblENST00000636129.1ENSP00000489912.1
EnsemblENST00000637217.1ENSP00000490250.1
EnsemblENST00000439467.6ENSP00000390161.2
EnsemblENST00000637330.1ENSP00000490817.1
EnsemblENST00000637436.1ENSP00000489746.1
EnsemblENST00000636380.1ENSP00000490488.1
EnsemblENST00000636762.1ENSP00000490918.1
EnsemblENST00000636507.1ENSP00000490252.1
EnsemblENST00000637312.1ENSP00000490144.1
EnsemblENST00000539935.6ENSP00000438949.1
EnsemblENST00000636785.1ENSP00000489788.1
EnsemblENST00000397327.7ENSP00000380490.3
EnsemblENST00000636598.1ENSP00000490247.1
EnsemblENST00000427385.6ENSP00000410978.2
EnsemblENST00000638005.1ENSP00000489677.1
EnsemblENST00000637828.1ENSP00000490443.1
EnsemblENST00000635738.1ENSP00000489881.1
EnsemblENST00000636773.1ENSP00000489818.1
EnsemblENST00000635904.1ENSP00000490430.1
EnsemblENST00000638150.1ENSP00000490501.1
EnsemblENST00000360283.11ENSP00000353425.8
EnsemblENST00000637132.1ENSP00000490651.1
EnsemblENST00000636617.1ENSP00000490660.1
EnsemblENST00000637535.1ENSP00000490891.1
EnsemblENST00000636721.1ENSP00000490795.1
EnsemblENST00000637232.1ENSP00000490138.1
EnsemblENST00000636130.1ENSP00000490607.1
EnsemblENST00000638056.1ENSP00000490787.1
EnsemblENST00000637284.1ENSP00000489787.1
EnsemblENST00000635890.1ENSP00000489915.1
EnsemblENST00000636442.1ENSP00000489779.1
EnsemblENST00000637514.1ENSP00000490304.1
EnsemblENST00000638040.1ENSP00000489883.1
EnsemblENST00000434468.2ENSP00000399242.2
EnsemblENST00000637956.1ENSP00000490298.1
EnsemblENST00000636350.1ENSP00000489621.1
EnsemblENST00000534999.6ENSP00000443893.1
EnsemblENST00000637491.1ENSP00000490510.1
EnsemblENST00000637216.1ENSP00000490910.1
EnsemblENST00000637418.1ENSP00000489679.1
EnsemblENST00000636496.1ENSP00000490249.1
UniProtO00305, CACB4_HUMAN, A7BJ74, A8K1Y4, B4DG40, O60515, Q6B000, Q96L40
GeneBankAK294398, AK290049, AC068547, CH471058, AF038852, AC079790, AK316045, BC075049, AC097448, AY054985, U95020, AB302276AAH75049.1, AAL14351.1, AAC24206.1, BAF73808.1, EAX11494.1, BAF82738.1, BAH14416.1, AAB53333.1, BAG57651.1
RefSeqNM_000726.4, NM_001005746.3, NM_001005747.3, NM_001145798.2, NM_001320722.2NP_000717.2, NP_001005746.1, NP_001005747.1, NP_001139270.1, NP_001307651.1
Entrez785

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSSSSYAKNG  TADGPHSPTS  QVARGTTTRR  SRLKRSDGST  TSTSFILRQG  SADSYTSRPS  60
61    DSDVSLEEDR  EAIRQEREQQ  AAIQLERAKS  KPVAFAVKTN  VSYCGALDED  VPVPSTAISF  120
121   DAKDFLHIKE  KYNNDWWIGR  LVKEGCEIGF  IPSPLRLENI  RIQQEQKRGR  FHGGKSSGNS  180
181   SSSLGEMVSG  TFRATPTSTA  KQKQKVTEHI  PPYDVVPSMR  PVVLVGPSLK  GYEVTDMMQK  240
241   ALFDFLKHRF  DGRISITRVT  ADISLAKRSV  LNNPSKRAII  ERSNTRSSLA  EVQSEIERIF  300
301   ELARSLQLVV  LDADTINHPA  QLIKTSLAPI  IVHVKVSSPK  VLQRLIKSRG  KSQSKHLNVQ  360
361   LVAADKLAQC  PPEMFDVILD  ENQLEDACEH  LGEYLEAYWR  ATHTTSSTPM  TPLLGRNLGS  420
421   TALSPYPTAI  SGLQSQRMRH  SNHSTENSPI  ERRSLMTSDE  NYHNERARKS  RNRLSSSSQH  480
481   SRDHYPLVEE  DYPDSYQDTY  KPHRNRGSPG  GYSHDSRHRL  520
Nucleotide CDS Sequence (FASTA)
1     ATGTCCTCCT  CCTCCTACGC  CAAGAACGGG  ACCGCGGACG  GGCCGCACTC  CCCCACCTCG  60
61    CAGGTGGCCC  GAGGCACCAC  AACCCGGAGG  AGCAGGTTGA  AAAGATCCGA  TGGCAGCACC  120
121   ACTTCGACCA  GCTTCATCCT  CAGACAGGGT  TCAGCGGATT  CCTACACAAG  CAGGCCGTCT  180
181   GACTCCGATG  TCTCTTTGGA  AGAGGACCGG  GAAGCAATTC  GACAGGAGAG  AGAACAGCAA  240
241   GCAGCTATCC  AGCTTGAGAG  AGCAAAGTCC  AAACCTGTAG  CATTTGCCGT  GAAGACAAAT  300
301   GTGAGCTACT  GCGGCGCCCT  GGACGAGGAT  GTGCCTGTTC  CAAGCACAGC  TATCTCCTTT  360
361   GATGCTAAAG  ACTTTCTACA  TATTAAAGAG  AAATATAACA  ATGATTGGTG  GATAGGAAGG  420
421   CTGGTGAAAG  AGGGCTGTGA  AATTGGCTTC  ATTCCAAGTC  CACTCAGATT  GGAGAACATA  480
481   CGGATCCAGC  AAGAACAAAA  AAGAGGACGT  TTTCACGGAG  GGAAATCAAG  TGGAAATTCT  540
541   TCTTCAAGTC  TTGGAGAAAT  GGTATCTGGG  ACATTCCGAG  CAACTCCCAC  ATCAACAGCA  600
601   AAACAGAAGC  AAAAAGTGAC  GGAGCACATT  CCTCCTTACG  ATGTTGTACC  GTCAATGCGT  660
661   CCGGTGGTGT  TAGTGGGGCC  GTCACTGAAA  GGTTACGAGG  TAACAGACAT  GATGCAGAAA  720
721   GCCCTCTTTG  ATTTCCTGAA  GCACAGGTTT  GATGGGAGGA  TTTCAATAAC  GAGAGTGACA  780
781   GCTGACATTT  CTCTTGCTAA  GAGGTCTGTC  CTAAATAATC  CCAGCAAGAG  AGCAATAATT  840
841   GAACGTTCGA  ACACCCGGTC  CAGCTTAGCG  GAAGTACAAA  GTGAAATTGA  AAGAATCTTT  900
901   GAGTTGGCAA  GATCTTTGCA  ACTGGTTGTT  CTTGATGCAG  ACACCATCAA  TCACCCAGCA  960
961   CAACTTATAA  AGACTTCCTT  AGCACCAATT  ATTGTTCATG  TAAAAGTCTC  ATCTCCAAAG  1020
1021  GTTTTACAGC  GGTTGATTAA  ATCTAGAGGA  AAGTCACAAA  GTAAACACTT  GAATGTTCAA  1080
1081  CTGGTGGCAG  CTGATAAACT  TGCACAATGC  CCCCCAAGTC  AGCGAATGAG  GCACAGCAAC  1140
1141  CACTCCACAG  AGAACTCTCC  AATTGAAAGA  CGAAGTCTAA  TGACCTCTGA  TGAAAATTAT  1200
1201  CACAATGAAA  GGGCTCGGAA  GAGTAGGAAC  CGCTTGTCTT  CCAGTTCTCA  GCATAGCCGA  1260
1261  GATCATTACC  CTCTTGTGGA  AGAAGATTAC  CCTGACTCAT  ACCAGGACAC  TTACAAACCC  1320
1321  CATAGGAACC  GAGGATCACC  TGGGGGATAT  AGCCATGACT  CCCGACATAG  GCTTTGA  1377

▼ KEYWORD

ID
Family
3D-structure
Alternative splicing
Calcium
Calcium channel
Calcium transport
Complete proteome
Disease mutation
Epilepsy
Ion channel
Ion transport
Methylation
Phosphoprotein
Reference proteome
SH3 domain
Transport
Voltage-gated channel

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasmic side of plasma membrane
Cellular Component
Cytosol
Cellular Component
Plasma membrane
Cellular Component
Synapse
Cellular Component
Voltage-gated calcium channel complex
Molecular Function
High voltage-gated calcium channel activity
Biological Process
Cardiac conduction
Biological Process
Chemical synaptic transmission
Biological Process
Membrane depolarization
Biological Process
Neuromuscular junction development
Biological Process
Regulation of voltage-gated calcium channel activity

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-a1007Pan troglodytes100.00.01075
LLPS-Caf-a982Canis familiaris100.00.0981
LLPS-Aon-a1007Aotus nancymaae100.00.01075
LLPS-Otg-a988Otolemur garnettii100.00.0981
LLPS-Chs-a994Chlorocebus sabaeus100.00.0978
LLPS-Maf-a1001Macaca fascicularis100.00.01075
LLPS-Caj-a993Callithrix jacchus100.00.01075
LLPS-Pap-a977Pan paniscus100.00.01075
LLPS-Eqc-a1001Equus caballus100.00.0979
LLPS-Gog-a994Gorilla gorilla100.00.01075
LLPS-Man-a1005Macaca nemestrina100.00.01075
LLPS-Paa-a1005Papio anubis100.00.01075
LLPS-Mam-a987Macaca mulatta100.00.01075
LLPS-Cea-a1001Cercocebus atys100.00.01075
LLPS-Rhb-a992Rhinopithecus bieti99.810.01073
LLPS-Mup-a964Mustela putorius furo99.790.0977
LLPS-Fec-a1001Felis catus99.610.01068
LLPS-Cap-a998Cavia porcellus99.420.01064
LLPS-Myl-a928Myotis lucifugus99.360.0973
LLPS-Bot-a1004Bos taurus99.230.01068
LLPS-Sus-a1004Sus scrofa99.160.0946
LLPS-Ran-a999Rattus norvegicus99.150.0971
LLPS-Fud-a960Fukomys damarensis98.950.0974
LLPS-Poa-a980Pongo abelii98.940.0963
LLPS-Mod-a958Monodelphis domestica98.730.0967
LLPS-Mum-a1005Mus musculus98.650.01059
LLPS-Mea-a958Mesocricetus auratus98.650.01061
LLPS-Sah-a901Sarcophilus harrisii98.510.0543
LLPS-Anc-a902Anolis carolinensis98.00.01016
LLPS-Mal-a984Mandrillus leucophaeus96.520.0967
LLPS-Ova-a962Ovis aries96.340.0979
LLPS-Lac-a868Latimeria chalumnae94.960.0920
LLPS-Gaga-a897Gallus gallus92.930.0888
LLPS-Ict-a989Ictidomys tridecemlineatus92.040.0961
LLPS-Leo-a857Lepisosteus oculatus91.730.0944
LLPS-Scf-a840Scleropages formosus91.680.0899
LLPS-Fia-a874Ficedula albicollis91.580.0885
LLPS-Xet-a848Xenopus tropicalis90.530.0835
LLPS-Urm-a894Ursus maritimus90.410.0854
LLPS-Loa-a971Loxodonta africana88.910.0928
LLPS-Orc-a933Oryctolagus cuniculus88.260.0850
LLPS-Dar-a871Danio rerio87.140.0886
LLPS-Asm-a861Astyanax mexicanus86.760.0889
LLPS-Orn-a863Oreochromis niloticus86.210.0910
LLPS-Tar-a824Takifugu rubripes85.60.0906
LLPS-Xim-a870Xiphophorus maculatus85.060.0902
LLPS-Ten-a821Tetraodon nigroviridis84.390.0807
LLPS-Tag-a856Taeniopygia guttata83.940.0602
LLPS-Gaa-a841Gasterosteus aculeatus82.060.0866
LLPS-Orl-a851Oryzias latipes80.930.0797
LLPS-Icp-a871Ictalurus punctatus80.340.0814
LLPS-Scm-a829Scophthalmus maximus80.070.0858
LLPS-Pof-a861Poecilia formosa79.110.0853
LLPS-Ora-a821Ornithorhynchus anatinus69.160.0586
LLPS-Pes-a854Pelodiscus sinensis68.082e-130392
LLPS-Dio-a962Dipodomys ordii66.270.0617
LLPS-Cas-a862Carlito syrichta63.980.0614
LLPS-Aim-a955Ailuropoda melanoleuca61.970.0543
LLPS-Nol-a975Nomascus leucogenys54.138e-161479