LLPS-Hos-a1006
AKAP5

▼ OVERVIEW

Status: Unreviewed
Protein Name: A-kinase anchor protein 5
Gene Name: AKAP5, AKAP79
Ensembl Gene: ENSG00000179841.8
Ensembl Protein: ENSP00000315615.5
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others
PDB: 3LL8 (E, A, B) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.

▼ SEQUENCE

Protein Sequence (FASTA)
1     METTISEIHV  ENKDEKRSAE  GSPGAERQKE  KASMLCFKRR  KKAAKALKPK  AGSEAADVAR  60
61    KCPQEAGASD  QPEPTRGAWA  SLKRLVTRRK  RSESSKQQKP  LEGEMQPAIN  AEDADLSKKK  120
121   AKSRLKIPCI  KFPRGPKRSN  HSKIIEDSDC  SIKVQEEAEI  LDIQTQTPLN  DQATKAKSTQ  180
181   DLSEGISRKD  GDEVCESNVS  NSTTSGEKVI  SVELGLDNGH  SAIQTGTLIL  EEIETIKEKQ  240
241   DVQPQQASPL  ETSETDHQQP  VLSDVPPLPA  IPDQQIVEEA  SNSTLESAPN  GKDYESTEIV  300
301   AEETKPKDTE  LSQESDFKEN  GITEEKSKSE  ESKRMEPIAI  IITDTEISEF  DVTKSKNVPK  360
361   QFLISAENEQ  VGVFANDNGF  EDRTSEQYET  LLIETASSLV  KNAIQLSIEQ  LVNEMASDDN  420
421   KINNLLQ  427
Nucleotide CDS Sequence (FASTA)
1     ATGGAAACCA  CAATTTCAGA  AATTCATGTA  GAAAACAAGG  ATGAGAAGAG  ATCAGCAGAA  60
61    GGTAGTCCTG  GGGCTGAAAG  GCAGAAGGAA  AAGGCATCCA  TGCTTTGCTT  CAAGAGAAGA  120
121   AAGAAAGCAG  CCAAAGCACT  GAAGCCCAAA  GCTGGCTCTG  AAGCTGCTGA  TGTGGCAAGG  180
181   AAGTGTCCAC  AAGAAGCAGG  AGCTTCTGAT  CAGCCAGAGC  CCACACGGGG  GGCCTGGGCC  240
241   TCACTCAAAC  GTCTTGTAAC  ACGCAGGAAA  AGGTCAGAGT  CTTCAAAGCA  GCAAAAGCCA  300
301   TTGGAGGGTG  AAATGCAACC  TGCAATAAAT  GCTGAGGATG  CTGATCTTTC  TAAGAAAAAG  360
361   GCAAAATCTA  GACTTAAGAT  TCCCTGCATA  AAATTCCCAA  GAGGGCCAAA  AAGGAGTAAT  420
421   CATTCCAAAA  TTATAGAAGA  CTCAGACTGC  AGCATCAAAG  TCCAGGAAGA  AGCTGAAATT  480
481   TTGGATATAC  AAACACAGAC  CCCATTGAAT  GATCAGGCAA  CAAAGGCTAA  GTCAACCCAG  540
541   GATCTAAGTG  AAGGCATCTC  ACGGAAAGAT  GGTGATGAGG  TCTGTGAATC  AAATGTGAGC  600
601   AATAGCACAA  CTTCTGGAGA  GAAAGTGATT  TCAGTAGAAC  TTGGATTAGA  TAATGGGCAT  660
661   TCTGCTATTC  AAACGGGAAC  TCTAATCCTT  GAAGAAATTG  AAACGATCAA  GGAAAAACAA  720
721   GATGTTCAAC  CCCAGCAAGC  AAGCCCACTT  GAAACTTCAG  AAACAGACCA  TCAGCAGCCA  780
781   GTACTTTCTG  ATGTTCCTCC  TTTACCTGCA  ATTCCAGATC  AACAAATTGT  GGAAGAAGCC  840
841   AGTAACAGTA  CCCTAGAAAG  TGCACCAAAT  GGAAAAGACT  ATGAAAGTAC  AGAGATTGTA  900
901   GCTGAAGAAA  CTAAGCCAAA  AGATACTGAA  TTGAGCCAAG  AATCAGATTT  TAAAGAAAAT  960
961   GGGATCACTG  AAGAGAAATC  CAAATCAGAA  GAAAGCAAAA  GAATGGAGCC  AATTGCTATT  1020
1021  ATTATTACAG  ACACTGAAAT  CAGTGAATTT  GATGTTACAA  AATCTAAAAA  TGTCCCTAAG  1080
1081  CAATTCTTAA  TTTCAGCTGA  AAATGAGCAA  GTAGGGGTTT  TTGCTAATGA  TAATGGTTTT  1140
1141  GAGGATAGAA  CTTCAGAACA  ATATGAAACA  CTCTTAATTG  AAACAGCCTC  TTCTCTAGTC  1200
1201  AAGAATGCTA  TTCAGTTGTC  AATAGAACAG  CTGGTTAATG  AAATGGCCTC  TGATGATAAT  1260
1261  AAAATAAACA  ATCTTCTACA  GTGA  1284

▼ KEYWORD

ID
Family
3D-structure
Calmodulin-binding
Complete proteome
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasmic side of plasma membrane
Cellular Component
Cytosol
Cellular Component
Dendrite membrane
Cellular Component
Dendritic spine
Cellular Component
Excitatory synapse
Cellular Component
Membrane raft
Cellular Component
Plasma membrane
Cellular Component
Postsynaptic density
Molecular Function
Adenylate cyclase binding
Molecular Function
Beta-2 adrenergic receptor binding
Molecular Function
Calmodulin binding
Molecular Function
GABA receptor binding
Molecular Function
Glutamate receptor binding
Molecular Function
Protein kinase A binding
Molecular Function
Protein kinase A regulatory subunit binding
Molecular Function
Protein phosphatase 2B binding
Molecular Function
Scaffold protein binding
Molecular Function
SH3 domain binding
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process
Chemical synaptic transmission
Biological Process
Negative regulation of adenylate cyclase activity
Biological Process
Positive regulation of adenylate cyclase activity
Biological Process
Positive regulation of protein localization to plasma membrane
Biological Process
Protein targeting
Biological Process
Regulation of protein kinase A signaling
Biological Process
Signal transduction

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-a992Pan troglodytes99.30.0853
LLPS-Pap-a965Pan paniscus99.060.0851
LLPS-Gog-a980Gorilla gorilla98.830.0849
LLPS-Poa-a964Pongo abelii97.420.0836
LLPS-Nol-a964Nomascus leucogenys96.960.0835
LLPS-Chs-a979Chlorocebus sabaeus95.080.0788
LLPS-Mam-a974Macaca mulatta94.380.0781
LLPS-Mea-a944Mesocricetus auratus84.621e-55199
LLPS-Eqc-a985Equus caballus79.250.0650
LLPS-Ict-a973Ictidomys tridecemlineatus78.970.0622
LLPS-Otg-a974Otolemur garnettii78.250.0613
LLPS-Sus-a990Sus scrofa77.860.0640
LLPS-Cas-a851Carlito syrichta76.40.0620
LLPS-Urm-a885Ursus maritimus75.990.0603
LLPS-Aim-a940Ailuropoda melanoleuca75.930.0602
LLPS-Caf-a968Canis familiaris75.760.0619
LLPS-Bot-a990Bos taurus75.520.0566
LLPS-Ova-a949Ovis aries74.830.0602
LLPS-Fec-a987Felis catus73.890.0596
LLPS-Myl-a916Myotis lucifugus73.190.0597
LLPS-Dio-a949Dipodomys ordii69.210.0541
LLPS-Mum-a990Mus musculus54.148e-84280
LLPS-Mod-a946Monodelphis domestica52.324e-130392
LLPS-Ran-a986Rattus norvegicus51.917e-65229
LLPS-Orc-a920Oryctolagus cuniculus51.472e-118360
LLPS-Sah-a890Sarcophilus harrisii51.433e-116356