LLPS-Hos-a1004
PTPN11

▼ OVERVIEW

Status: Reviewed
Protein Name: Tyrosine-protein phosphatase non-receptor type 11; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3
Gene Name: PTPN11, PTP2C, SHPTP2
Ensembl Gene: ENSG00000179295.17
Ensembl Protein: ENSP00000491593.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others
PDB: 4JEG (A, B) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MTSRRWFHPN  ITGVEAENLL  LTRGVDGSFL  ARPSKSNPGD  FTLSVRRNGA  VTHIKIQNTG  60
61    DYYDLYGGEK  FATLAELVQY  YMEHHGQLKE  KNGDVIELKY  PLNCADPTSE  RWFHGHLSGK  120
121   EAEKLLTEKG  KHGSFLVRES  QSHPGDFVLS  VRTGDDKGES  NDGKSKVTHV  MIRCQELKYD  180
181   VGGGERFDSL  TDLVEHYKKN  PMVETLGTVL  QLKQPLNTTR  INAAEIESRV  RELSKLAETT  240
241   DKVKQGFWEE  FETLQQQECK  LLYSRKEGQR  QENKNKNRYK  NILPFDHTRV  VLHDGDPNEP  300
301   VSDYINANII  MPEFETKCNN  SKPKKSYIAT  QGCLQNTVND  FWRMVFQENS  RVIVMTTKEV  360
361   ERGKSKCVKY  WPDEYALKEY  GVMRVRNVKE  SAAHDYTLRE  LKLSKVGQAL  LQGNTERTVW  420
421   QYHFRTWPDH  GVPSDPGGVL  DFLEEVHHKQ  ESIMDAGPVV  VHCSAGIGRT  GTFIVIDILI  480
481   DIIREKGVDC  DIDVPKTIQM  VRSQRSGMVQ  TEAQYRFIYM  AVQHYIETLQ  RRIEEEQKSK  540
541   RKGHEYTNIK  YSLADQTSGD  QSPLPPCTPT  PPCAEMREDS  ARVYENVGLM  QQQKSFR  597
Nucleotide CDS Sequence (FASTA)
1     ATGACATCGC  GGAGATGGTT  TCACCCAAAT  ATCACTGGTG  TGGAGGCAGA  AAACCTACTG  60
61    TTGACAAGAG  GAGTTGATGG  CAGTTTTTTG  GCAAGGCCTA  GTAAAAGTAA  CCCTGGAGAC  120
121   TTCACACTTT  CCGTTAGAAG  AAATGGAGCT  GTCACCCACA  TCAAGATTCA  GAACACTGGT  180
181   GATTACTATG  ACCTGTATGG  AGGGGAGAAA  TTTGCCACTT  TGGCTGAGTT  GGTCCAGTAT  240
241   TACATGGAAC  ATCACGGGCA  ATTAAAAGAG  AAGAATGGAG  ATGTCATTGA  GCTTAAATAT  300
301   CCTCTGAACT  GTGCAGATCC  TACCTCTGAA  AGGTGGTTTC  ATGGACATCT  CTCTGGGAAA  360
361   GAAGCAGAGA  AATTATTAAC  TGAAAAAGGA  AAACATGGTA  GTTTTCTTGT  ACGAGAGAGC  420
421   CAGAGCCACC  CTGGAGATTT  TGTTCTTTCT  GTGCGCACTG  GTGATGACAA  AGGGGAGAGC  480
481   AATGACGGCA  AGTCTAAAGT  GACCCATGTT  ATGATTCGCT  GTCAGGAACT  GAAATACGAC  540
541   GTTGGTGGAG  GAGAACGGTT  TGATTCTTTG  ACAGATCTTG  TGGAACATTA  TAAGAAGAAT  600
601   CCTATGGTGG  AAACATTGGG  TACAGTACTA  CAACTCAAGC  AGCCCCTTAA  CACGACTCGT  660
661   ATAAATGCTG  CTGAAATAGA  AAGCAGAGTT  CGAGAACTAA  GCAAATTAGC  TGAGACCACA  720
721   GATAAAGTCA  AACAAGGCTT  TTGGGAAGAA  TTTGAGACAC  TACAACAACA  GGAGTGCAAA  780
781   CTTCTCTACA  GCCGAAAAGA  GGGTCAAAGG  CAAGAAAACA  AAAACAAAAA  TAGATATAAA  840
841   AACATCCTGC  CCTTTGATCA  TACCAGGGTT  GTCCTACACG  ATGGTGATCC  CAATGAGCCT  900
901   GTTTCAGATT  ACATCAATGC  AAATATCATC  ATGCCTGAAT  TTGAAACCAA  GTGCAACAAT  960
961   TCAAAGCCCA  AAAAGAGTTA  CATTGCCACA  CAAGGCTGCC  TGCAAAACAC  GGTGAATGAC  1020
1021  TTTTGGCGGA  TGGTGTTCCA  AGAAAACTCC  CGAGTGATTG  TCATGACAAC  GAAAGAAGTG  1080
1081  GAGAGAGGAA  AGAGTAAATG  TGTCAAATAC  TGGCCTGATG  AGTATGCTCT  AAAAGAATAT  1140
1141  GGCGTCATGC  GTGTTAGGAA  CGTCAAAGAA  AGCGCCGCTC  ATGACTATAC  GCTAAGAGAA  1200
1201  CTTAAACTTT  CAAAGGTTGG  ACAAGGGAAT  ACGGAGAGAA  CGGTCTGGCA  ATACCACTTT  1260
1261  CGGACCTGGC  CGGACCACGG  CGTGCCCAGC  GACCCTGGGG  GCGTGCTGGA  CTTCCTGGAG  1320
1321  GAGGTGCACC  ATAAGCAGGA  GAGCATCATG  GATGCAGGGC  CGGTCGTGGT  GCACTGCAGT  1380
1381  GCTGGAATTG  GCCGGACAGG  GACGTTCATT  GTGATTGATA  TTCTTATTGA  CATCATCAGA  1440
1441  GAGAAAGGTG  TTGACTGCGA  TATTGACGTT  CCCAAAACCA  TCCAGATGGT  GCGGTCTCAG  1500
1501  AGGTCAGGGA  TGGTCCAGAC  AGAAGCACAG  TACCGATTTA  TCTATATGGC  GGTCCAGCAT  1560
1561  TATATTGAAA  CACTACAGCG  CAGGATTGAA  GAAGAGCAGA  AAAGCAAGAG  GAAAGGGCAC  1620
1621  GAATATACAA  ATATTAAGTA  TTCTCTAGCG  GACCAGACGA  GTGGAGATCA  GAGCCCTCTC  1680
1681  CCGCCTTGTA  CTCCAACGCC  ACCCTGTGCA  GAAATGAGAG  AAGACAGTGC  TAGAGTCTAT  1740
1741  GAAAACGTGG  GCCTGATGCA  ACAGCAGAAA  AGTTTCAGAT  GA  1782

▼ KEYWORD

ID
Family
3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Deafness
Disease mutation
Hydrolase
Nucleus
Phosphoprotein
Protein phosphatase
Reference proteome
Repeat
SH2 domain

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Mitochondrion
Cellular Component
Nucleoplasm
Cellular Component
Nucleus
Cellular Component
Protein-containing complex
Molecular Function
Cell adhesion molecule binding
Molecular Function
D1 dopamine receptor binding
Molecular Function
Insulin receptor binding
Molecular Function
Insulin receptor substrate binding
Molecular Function
Non-membrane spanning protein tyrosine phosphatase activity
Molecular Function
Peptide hormone receptor binding
Molecular Function
Phospholipase binding
Molecular Function
Phosphoprotein phosphatase activity
Molecular Function
Phosphotyrosine residue binding
Molecular Function
Protein domain specific binding
Molecular Function
Protein kinase binding
Molecular Function
Protein tyrosine phosphatase activity
Molecular Function
Receptor tyrosine kinase binding
Molecular Function
SH3/SH2 adaptor activity
Biological Process
Abortive mitotic cell cycle
Biological Process
Activation of MAPK activity
Biological Process
Atrioventricular canal development
Biological Process
Axon guidance
Biological Process
Bergmann glial cell differentiation
Biological Process
Brain development
Biological Process
Cellular response to cytokine stimulus
Biological Process
Cellular response to epidermal growth factor stimulus
Biological Process
Cellular response to mechanical stimulus
Biological Process
Cerebellar cortex formation
Biological Process
Cytokine-mediated signaling pathway
Biological Process
DNA damage checkpoint
Biological Process
Ephrin receptor signaling pathway
Biological Process
Epidermal growth factor receptor signaling pathway
Biological Process
ERBB signaling pathway
Biological Process
Face morphogenesis
Biological Process
Fibroblast growth factor receptor signaling pathway
Biological Process
Genitalia development
Biological Process
Glucose homeostasis
Biological Process
Heart development
Biological Process
Homeostasis of number of cells within a tissue
Biological Process
Hormone metabolic process
Biological Process
Hormone-mediated signaling pathway
Biological Process
Inner ear development
Biological Process
Integrin-mediated signaling pathway
Biological Process
Interleukin-6-mediated signaling pathway
Biological Process
Intestinal epithelial cell migration
Biological Process
Leukocyte migration
Biological Process
Megakaryocyte development
Biological Process
Microvillus organization
Biological Process
Multicellular organism growth
Biological Process
Multicellular organismal reproductive process
Biological Process
Negative regulation of cell adhesion mediated by integrin
Biological Process
Negative regulation of cortisol secretion
Biological Process
Negative regulation of growth hormone secretion
Biological Process
Negative regulation of insulin secretion
Biological Process
Neurotrophin TRK receptor signaling pathway
Biological Process
Organ growth
Biological Process
Peptidyl-tyrosine dephosphorylation
Biological Process
Platelet activation
Biological Process
Platelet formation
Biological Process
Platelet-derived growth factor receptor signaling pathway
Biological Process
Positive regulation of ERK1 and ERK2 cascade
Biological Process
Positive regulation of glucose import
Biological Process
Positive regulation of hormone secretion
Biological Process
Positive regulation of insulin receptor signaling pathway
Biological Process
Positive regulation of interferon-beta production
Biological Process
Positive regulation of interleukin-6 production
Biological Process
Positive regulation of mitotic cell cycle
Biological Process
Positive regulation of protein kinase B signaling
Biological Process
Positive regulation of tumor necrosis factor production
Biological Process
Regulation of cell adhesion mediated by integrin
Biological Process
Regulation of protein complex assembly
Biological Process
Regulation of protein export from nucleus
Biological Process
Regulation of type I interferon-mediated signaling pathway
Biological Process
T cell costimulation
Biological Process
Triglyceride metabolic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Maf-a986Macaca fascicularis100.00.01253
LLPS-Gog-a979Gorilla gorilla100.00.01253
LLPS-Man-a990Macaca nemestrina100.00.01253
LLPS-Paa-a990Papio anubis100.00.01253
LLPS-Cas-a850Carlito syrichta99.810.01112
LLPS-Otg-a972Otolemur garnettii99.50.01247
LLPS-Mum-a988Mus musculus99.50.01248
LLPS-Fec-a985Felis catus99.330.01243
LLPS-Mam-a972Macaca mulatta99.330.01232
LLPS-Nol-a962Nomascus leucogenys99.320.01230
LLPS-Cea-a986Cercocebus atys99.280.01144
LLPS-Pat-a991Pan troglodytes99.160.01238
LLPS-Mal-a971Mandrillus leucophaeus99.160.01232
LLPS-Caj-a979Callithrix jacchus99.160.01238
LLPS-Loa-a954Loxodonta africana99.160.01234
LLPS-Aon-a992Aotus nancymaae98.990.01235
LLPS-Ran-a984Rattus norvegicus98.990.01241
LLPS-Pap-a964Pan paniscus98.990.01231
LLPS-Eqc-a983Equus caballus98.990.01228
LLPS-Mea-a942Mesocricetus auratus98.990.01227
LLPS-Mup-a947Mustela putorius furo98.830.01234
LLPS-Poa-a962Pongo abelii98.830.01233
LLPS-Chs-a977Chlorocebus sabaeus98.830.01233
LLPS-Caf-a966Canis familiaris98.660.01231
LLPS-Urm-a884Ursus maritimus98.650.01224
LLPS-Aim-a938Ailuropoda melanoleuca98.650.01223
LLPS-Fud-a945Fukomys damarensis98.490.01225
LLPS-Ova-a947Ovis aries98.340.01237
LLPS-Sus-a988Sus scrofa98.320.01228
LLPS-Orc-a918Oryctolagus cuniculus98.320.01229
LLPS-Bot-a988Bos taurus98.320.01228
LLPS-Dio-a947Dipodomys ordii98.130.01199
LLPS-Ora-a809Ornithorhynchus anatinus98.080.0751
LLPS-Meg-a784Meleagris gallopavo98.040.0839
LLPS-Mod-a944Monodelphis domestica97.650.01219
LLPS-Gaga-a884Gallus gallus97.650.01221
LLPS-Tag-a844Taeniopygia guttata97.480.01212
LLPS-Myl-a914Myotis lucifugus97.390.0783
LLPS-Fia-a861Ficedula albicollis97.320.01214
LLPS-Cap-a984Cavia porcellus97.320.01207
LLPS-Sah-a888Sarcophilus harrisii97.160.01216
LLPS-Anc-a890Anolis carolinensis96.710.01043
LLPS-Anp-a785Anas platyrhynchos95.330.01131
LLPS-Pes-a843Pelodiscus sinensis95.130.01146
LLPS-Ict-a971Ictidomys tridecemlineatus93.930.01149
LLPS-Lac-a857Latimeria chalumnae92.130.01089
LLPS-Asm-a850Astyanax mexicanus91.970.01093
LLPS-Leo-a846Lepisosteus oculatus91.960.01120
LLPS-Scf-a829Scleropages formosus91.30.01082
LLPS-Dar-a860Danio rerio90.910.01068
LLPS-Rhb-a978Rhinopithecus bieti90.740.01043
LLPS-Gaa-a830Gasterosteus aculeatus90.00.01082
LLPS-Tar-a812Takifugu rubripes90.00.01084
LLPS-Pof-a851Poecilia formosa89.830.01106
LLPS-Orl-a841Oryzias latipes89.670.01084
LLPS-Xim-a859Xiphophorus maculatus89.50.01101
LLPS-Orn-a853Oreochromis niloticus88.80.01071
LLPS-Scm-a818Scophthalmus maximus88.610.01071
LLPS-Icp-a861Ictalurus punctatus88.540.01045
LLPS-Xet-a837Xenopus tropicalis83.950.0986
LLPS-Ten-a811Tetraodon nigroviridis67.00.0787
LLPS-Cii-a238Ciona intestinalis63.590.0691
LLPS-Cis-a201Ciona savignyi59.830.0693
LLPS-Drm-a206Drosophila melanogaster56.86e-85293