LLPS-Hos-a100
PDE8A

▼ OVERVIEW

Status: Reviewed
Protein Name: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Gene Name: PDE8A
Ensembl Gene: ENSG00000073417.14
Ensembl Protein: ENSP00000378056.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client
PDB: 3ECM (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGCAPSIHIS  ERLVAEDAPS  PAAPPLSSGG  PRLPQGQKTA  ALPRTRGAGL  LESELRDGSG  60
61    KKVAVADVQF  GPMRFHQDQL  QVLLVFTKED  NQCNGFCRAC  EKAGFKCTVT  KEAQAVLACF  120
121   LDKHHDIIII  DHRNPRQLDA  EALCRSIRSS  KLSENTVIVG  VVRRVDREEL  SVMPFISAGF  180
181   TRRYVENPNI  MACYNELLQL  EFGEVRSQLK  LRACNSVFTA  LENSEDAIEI  TSEDRFIQYA  240
241   NPAFETTMGY  QSGELIGKEL  GEVPINEKKA  DLLDTINSCI  RIGKEWQGIY  YAKKKNGDNI  300
301   QQNVKIIPVI  GQGGKIRHYV  SIIRVCNGNN  KAEKISECVQ  SDTHTDNQTG  KHKDRRKGSL  360
361   DVKAVASRAT  EVSSQRRHSS  MARIHSMTIE  APITKVINII  NAAQESSPMP  VTEALDRVLE  420
421   ILRTTELYSP  QFGAKDDDPH  ANDLVGGLMS  DGLRRLSGNE  YVLSTKNTQM  VSSNIITPIS  480
481   LDDVPPRIAR  AMENEEYWDF  DIFELEAATH  NRPLIYLGLK  MFARFGICEF  LHCSESTLRS  540
541   WLQIIEANYH  SSNPYHNSTH  SADVLHATAY  FLSKERIKET  LDPIDEVAAL  IAATIHDVDH  600
601   PGRTNSFLCN  AGSELAILYN  DTAVLESHHA  ALAFQLTTGD  DKCNIFKNME  RNDYRTLRQG  660
661   IIDMVLATEM  TKHFEHVNKF  VNSINKPLAT  LEENGETDKN  QEVINTMLRT  PENRTLIKRM  720
721   LIKCADVSNP  CRPLQYCIEW  AARISEEYFS  QTDEEKQQGL  PVVMPVFDRN  TCSIPKSQIS  780
781   FIDYFITDMF  DAWDAFVDLP  DLMQHLDNNF  KYWKGLDEMK  LRNLRPPPE  829
Nucleotide CDS Sequence (FASTA)
1     ATGGGCTGTG  CCCCGAGCAT  CCACATTTCC  GAGCGCCTGG  TGGCCGAGGA  CGCGCCTAGC  60
61    CCCGCGGCAC  CGCCGCTGTC  GTCCGGCGGG  CCGCGCCTCC  CGCAGGGCCA  GAAGACGGCC  120
121   GCCTTGCCCC  GGACCCGCGG  CGCCGGCCTC  TTGGAGTCGG  AGCTTCGCGA  CGGCAGCGGC  180
181   AAGAAGGTAG  CAGTAGCTGA  TGTGCAGTTT  GGCCCCATGA  GATTTCATCA  AGATCAACTT  240
241   CAGGTACTTT  TAGTGTTTAC  CAAAGAAGAT  AACCAATGTA  ATGGATTCTG  CAGGGCATGT  300
301   GAAAAAGCAG  GGTTTAAGTG  TACAGTTACC  AAGGAGGCTC  AGGCTGTCCT  TGCCTGTTTC  360
361   CTGGACAAAC  ATCATGACAT  TATCATCATA  GACCACAGAA  ATCCTCGACA  GCTGGATGCA  420
421   GAGGCACTGT  GCAGGTCTAT  CAGATCATCA  AAACTCTCAG  AAAACACAGT  TATTGTTGGT  480
481   GTAGTACGCA  GGGTGGATAG  AGAAGAGTTG  TCCGTAATGC  CTTTCATTTC  TGCTGGATTT  540
541   ACAAGGAGGT  ATGTAGAAAA  CCCCAACATC  ATGGCCTGCT  ACAATGAACT  GCTCCAGCTG  600
601   GAGTTTGGAG  AGGTGCGATC  ACAACTGAAA  CTCAGGGCTT  GTAACTCAGT  ATTCACTGCA  660
661   TTAGAAAACA  GTGAAGATGC  AATTGAAATT  ACAAGCGAAG  ACCGTTTTAT  ACAGGAGTGG  720
721   CAAGGAATTT  ACTATGCCAA  AAAGAAAAAC  GGAGATAATA  TACAACAAAA  TGTGAAGATA  780
781   ATACCTGTCA  TTGGACAGGG  AGGAAAAATT  AGACACTATG  TGTCCATTAT  CAGAGTGTGC  840
841   AATGGCAACA  ATAAGGCTGA  GAAAATATCC  GAATGTGTTC  AGTCTGACAC  TCATACAGAT  900
901   AATCAGACAG  GCAAACATAA  AGACAGGAGA  AAAGGCTCAC  TAGACGTCAA  AGCTGTTGCC  960
961   TCCCGTGCAA  CTGAAGTTTC  CAGCCAGAGA  CGACACTCTT  CCATGGCCCG  GATACATTCC  1020
1021  ATGACAATTG  AGGCGCCCAT  CACCAAGGTA  ATCAATATTA  TCAATGCTGC  CCAGGAAAGT  1080
1081  AGTCCCATGC  CTGTGACAGA  AGCCCTAGAC  CGTGTGCTGG  AAATTCTAAG  AACCACTGAG  1140
1141  TTATATTCAC  CACAGTTTGG  TGCTAAAGAT  GATGATCCCC  ATGCCAATGA  CCTTGTTGGG  1200
1201  GGCTTAATGT  CTGATGGTTT  GCGAAGACTA  TCAGGGAATG  AATATGTTCT  TTCAACAAAA  1260
1261  AACACTCAAA  TGGTTTCAAG  CAATATAATC  ACTCCCATCT  CCCTTGATGA  TGTCCCACCA  1320
1321  CGGATAGCTC  GGGCCATGGA  AAATGAGGAA  TACTGGGACT  TTGATATTTT  TGAACTGGAG  1380
1381  GCTGCCACCC  ACAATAGGCC  TTTGATTTAT  CTTGGTCTCA  AAATGTTTGC  TCGCTTTGGA  1440
1441  ATCTGTGAAT  TCTTACACTG  CTCCGAGTCA  ACGCTAAGAT  CATGGTTACA  AATTATCGAA  1500
1501  GCCAATTATC  ATTCCTCCAA  TCCCTACCAC  AATTCTACAC  ATTCTGCTGA  TGTGCTTCAT  1560
1561  GCCACTGCCT  ATTTTCTCTC  CAAGGAGAGG  ATAAAGGAAA  CTTTAGATCC  AATTGATGAG  1620
1621  GTCGCTGCAC  TCATCGCAGC  CACCATTCAT  GATGTGGATC  ACCCTGGGAG  AACCAACTCC  1680
1681  TTCCTGTGTA  ATGCTGGAAG  TGAGCTGGCC  ATTTTGTACA  ATGACACTGC  TGTGCTGGAG  1740
1741  AGCCACCATG  CGGCCTTGGC  CTTCCAGCTG  ACCACTGGAG  ATGATAAATG  CAATATATTT  1800
1801  AAAAACATGG  AGAGGAATGA  TTATCGGACA  CTGCGCCAGG  GGATTATCGA  CATGGTCTTA  1860
1861  GCCACAGAAA  TGACAAAGCA  CTTTGAGCAT  GTCAACAAAT  TTGTCAACAG  CATCAACAAA  1920
1921  CCCTTGGCAA  CACTAGAAGA  AAATGGGGAA  ACTGATAAAA  ACCAGGAAGT  GATAAACACT  1980
1981  ATGCTTAGGA  CTCCAGAGAA  CCGGACCCTA  ATCAAACGAA  TGCTGATTAA  ATGTGCTGAT  2040
2041  GTGTCCAATC  CCTGCCGACC  CCTGCAGTAC  TGCATCGAGT  GGGCTGCACG  CATTTCGGAA  2100
2101  GAATATTTTT  CTCAGACTGA  TGAAGAGAAG  CAGCAGGGCT  TACCTGTGGT  GATGCCAGTG  2160
2161  TTTGACAGAA  ATACCTGCAG  CATCCCCAAA  TCCCAAATCT  CTTTCATTGA  TTACTTCATC  2220
2221  ACAGACATGT  TTGATGCTTG  GGATGCCTTT  GTAGACCTGC  CTGATTTAAT  GCAGCATCTT  2280
2281  GACAACAACT  TTAAATACTG  GAAAGGACTG  GACGAAATGA  AGCTGCGGAA  CCTCCGACCA  2340
2341  CCTCCTGAAT  AG  2352

▼ KEYWORD

ID
Family
3D-structure
Alternative splicing
cAMP
Complete proteome
Hydrolase
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Extracellular exosome
Molecular Function
3',5'-cyclic-AMP phosphodiesterase activity
Molecular Function
3',5'-cyclic-GMP phosphodiesterase activity
Molecular Function
Kinase binding
Molecular Function
Metal ion binding
Biological Process
CAMP catabolic process
Biological Process
Cellular response to epidermal growth factor stimulus
Biological Process
G protein-coupled receptor signaling pathway
Biological Process
Negative regulation of cell death
Biological Process
Negative regulation of hydrogen peroxide-induced cell death
Biological Process
Positive regulation of ERK1 and ERK2 cascade
Biological Process
Positive regulation of protein phosphorylation
Biological Process
Regulation of transcription, DNA-templated

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-a099Pan troglodytes99.760.01731
LLPS-Pap-a098Pan paniscus99.640.01713
LLPS-Gog-a100Gorilla gorilla99.520.01726
LLPS-Mal-a098Mandrillus leucophaeus98.360.01633
LLPS-Maf-a101Macaca fascicularis98.310.01704
LLPS-Chs-a101Chlorocebus sabaeus98.310.01702
LLPS-Mam-a098Macaca mulatta98.310.01704
LLPS-Nol-a103Nomascus leucogenys98.310.01709
LLPS-Man-a100Macaca nemestrina98.310.01704
LLPS-Cea-a102Cercocebus atys97.950.01698
LLPS-Rhb-a101Rhinopithecus bieti97.350.01687
LLPS-Paa-a101Papio anubis94.690.01626
LLPS-Aon-a101Aotus nancymaae93.980.01615
LLPS-Poa-a098Pongo abelii92.640.01589
LLPS-Urm-a092Ursus maritimus92.340.01323
LLPS-Mup-a100Mustela putorius furo91.790.01498
LLPS-Ict-a102Ictidomys tridecemlineatus91.380.01478
LLPS-Caf-a098Canis familiaris91.20.01492
LLPS-Orc-a096Oryctolagus cuniculus91.030.01573
LLPS-Fec-a102Felis catus90.350.01552
LLPS-Aim-a098Ailuropoda melanoleuca90.140.01462
LLPS-Sus-a103Sus scrofa90.080.01536
LLPS-Cas-a094Carlito syrichta89.440.01449
LLPS-Otg-a101Otolemur garnettii89.260.01563
LLPS-Eqc-a104Equus caballus89.030.01546
LLPS-Fud-a101Fukomys damarensis88.470.01451
LLPS-Ova-a102Ovis aries88.430.01429
LLPS-Loa-a097Loxodonta africana88.30.01437
LLPS-Cap-a103Cavia porcellus84.840.01476
LLPS-Bot-a104Bos taurus82.890.01456
LLPS-Anp-a092Anas platyrhynchos82.620.01363
LLPS-Meg-a087Meleagris gallopavo82.480.01346
LLPS-Mea-a093Mesocricetus auratus81.680.01409
LLPS-Sah-a096Sarcophilus harrisii81.510.01331
LLPS-Tag-a091Taeniopygia guttata80.260.01306
LLPS-Fia-a094Ficedula albicollis79.560.01308
LLPS-Anc-a096Anolis carolinensis79.540.01162
LLPS-Mum-a103Mus musculus79.160.01385
LLPS-Xet-a088Xenopus tropicalis78.910.01289
LLPS-Mod-a093Monodelphis domestica78.660.01405
LLPS-Lac-a092Latimeria chalumnae78.390.01282
LLPS-Ran-a102Rattus norvegicus78.380.01370
LLPS-Gaa-a088Gasterosteus aculeatus77.180.01235
LLPS-Orn-a090Oreochromis niloticus76.840.01256
LLPS-Pes-a088Pelodiscus sinensis76.140.01365
LLPS-Leo-a085Lepisosteus oculatus73.720.01303
LLPS-Scm-a085Scophthalmus maximus73.560.01288
LLPS-Orl-a094Oryzias latipes73.530.01256
LLPS-Scf-a087Scleropages formosus73.210.01278
LLPS-Xim-a094Xiphophorus maculatus72.970.01275
LLPS-Tar-a088Takifugu rubripes72.850.01276
LLPS-Pof-a092Poecilia formosa72.290.01290
LLPS-Gaga-a092Gallus gallus71.850.01249
LLPS-Icp-a096Ictalurus punctatus70.450.01219
LLPS-Asm-a088Astyanax mexicanus69.270.01159
LLPS-Myl-a098Myotis lucifugus68.670.01185
LLPS-Ten-a092Tetraodon nigroviridis67.850.01087
LLPS-Dio-a098Dipodomys ordii67.650.01120
LLPS-Dar-a088Danio rerio66.580.01065
LLPS-Ora-a090Ornithorhynchus anatinus63.040.01030
LLPS-Caj-a099Callithrix jacchus62.120.01125
LLPS-Cis-a033Ciona savignyi57.931e-46170