LLPS-Hos-a037
PHLDB1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Pleckstrin homology-like domain family B member 1; Protein LL5-alpha |
| Gene Name: | PHLDB1, KIAA0638, LL5A, DLNB07 |
| Ensembl Gene: | ENSG00000019144.18 |
| Ensembl Protein: | ENSP00000431508.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Human cortex | 23071613 |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000530994.5 | ENSP00000431508.1 |
| Ensembl | ENST00000534140.2 | ENSP00000482728.1 |
| Ensembl | ENST00000356063.9 | ENSP00000348359.5 |
| Ensembl | ENST00000528594.5 | ENSP00000435520.1 |
| Ensembl | ENST00000600882.5 | ENSP00000469820.1 |
| Ensembl | ENST00000361417.6 | ENSP00000354498.2 |
| Ensembl | ENST00000530708.4 | ENSP00000481393.1 |
| Ensembl | ENST00000532639.3 | ENSP00000478254.1 |
| UniProt | Q86UU1, PHLB1_HUMAN, B0YJ63, B0YJ64, O75133, Q4KMF8, Q8TEQ2 | |
| GeneBank | AP000941, AB014538, AB094090, EF445008, AP002954, BC098586, CH471065, AK074070 | ACA06043.1, BAC76044.1, EAW67401.1, AAH98586.1, BAB84896.2, BAA31613.2, ACA06041.1 |
| RefSeq | NM_001144758.2, NM_001144759.2, NM_015157.3 | NP_001138230.1, NP_001138231.1, NP_055972.1 |
| Entrez | 102466719 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MDALNRNQIG PGCQTQTMVQ KGPLDLIETG KGLKVQTDKP HLVSLGSGRL STAITLLPLE 60 61 EGRTVIGSAA RDISLQGPGL APEHCYIENL RGTLTLYPCG NACTIDGLPV RQPTRLTQGC 120 121 MLCLGQSTFL RFNHPAEAKW MKSMIPAGGR APGPPYSPVP AESESLVNGN HTPQTATRGP 180 181 SACASHSSLV SSIEKDLQEI MDSLVLEEPG AAGKKPAATS PLSPMANGGR YLLSPPTSPG 240 241 AMSVGSSYEN TSPAFSPLSS PASSGSCASH SPSGQEPGPS VPPLVPARSS SYHLALQPPQ 300 301 SRPSGARSES PRLSRKGGHE RPPSPGLRGL LTDSPAATVL AEARRATESP RLGGQLPVVA 360 361 ISLSEYPASG ALSQPTSIPG SPKFQPPVPA PRNKIGTLQD RPPSPFREPP GSERVLTTSP 420 421 SRQLVGRTFS DGLATRTLQP PESPRLGRRG LDSMRELPPL SPSLSRRALS PLPTRTTPDP 480 481 KLNREVAESP RPRRWAAHGA SPEDFSLTLG ARGRRTRSPS PTLGESLAPH KGSFSGRLSP 540 541 AYSLGSLTGA SPCQSPCVQR KLSSGDLRVP VTRERKNSIT EISDNEDDLL EYHRRQRQER 600 601 LREQEMERLE RQRLETILNL CAEYSRADGG PEAGELPSIG EATAALALAG RRPSRGLAGA 660 661 SGRSSEEPGV ATQRLWESME RSDEENLKEE CSSTESTQQE HEDAPSTKLQ GEVLALEEER 720 721 AQVLGHVEQL KVRVKELEQQ LQESAREAEM ERALLQGERE AERALLQKEQ KAVDQLQEKL 780 781 VALETGIQKE RDKEAEALET ETKLFEDLEF QQLERESRVE EERELAGQGL LRSKAELLRS 840 841 IAKRKERLAI LDSQAGQIRA QAVQESERLA RDKNASLQLL QKEKEKLTVL ERRYHSLTGG 900 901 RPFPKTTSTL KEMEKLLLPA VDLEQWYQEL MAGLGTGPAA ASPHSSPPPL PAKASRQLQV 960 961 YRSKMDGEAT SPLPRTRSGP LPSSSGSSSS SSQLSVATLG RSPSPKSALL TQNGTGSLPR 1020 1021 NLAATLQDIE TKRQLALQQK GQQVIEEQRR RLAELKQKAA AEAQCQWDAL HGAAPFPAGP 1080 1081 SGFPPLMHHS ILHHLPAGRE RGEEGEHAYD TLSLESSDSM ETSISTGGNS ACSPDNMSSA 1140 1141 SGLDMGKIEE MEKMLKEAHA EKNRLMESRE REMELRRQAL EEERRRREQV ERRLQSESAR 1200 1201 RQQLVEKEVK MREKQFSQAR PLTRYLPIRK EDFDLKTHIE SSGHGVDTCL HVVLSSKVCR 1260 1261 GYLVKMGGKI KSWKKRWFVF DRLKRTLSYY VDKHETKLKG VIYFQAIEEV YYDHLRSAAK 1320 1321 KRFFRFTMVT ESPNPALTFC VKTHDRLYYM VAPSAEAMRI WMDVIVTGAE GYTQFMN 1377 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGACGCTC TCAATAGGAA CCAAATAGGC CCTGGATGCC AGACCCAGAC CATGGTGCAG 60 61 AAAGGACCCT TGGACCTGAT CGAGACAGGC AAAGGGCTGA AAGTGCAAAC GGACAAACCC 120 121 CACCTGGTGA GCCTGGGCAG TGGGCGACTC AGCACAGCCA TCACCCTCCT GCCGCTGGAG 180 181 GAAGGGAGGA CGGTGATTGG CTCTGCAGCC AGAGACATCT CACTACAGGG CCCAGGCCTG 240 241 GCTCCAGAGC ACTGCTACAT CGAGAACCTG CGGGGCACCC TCACCCTCTA CCCCTGTGGC 300 301 AATGCCTGCA CTATTGATGG GCTCCCTGTC CGGCAGCCTA CCCGGCTCAC TCAGGGCTGC 360 361 ATGTTGTGCC TGGGTCAGTC CACCTTCCTT CGCTTTAACC ACCCGGCTGA AGCCAAGTGG 420 421 ATGAAAAGCA TGATTCCAGC AGGGGGCCGA GCCCCTGGGC CCCCCTACAG CCCTGTTCCT 480 481 GCAGAATCAG AAAGTCTGGT AAATGGGAAC CACACCCCAC AGACTGCAAC ACGGGGACCC 540 541 TCTGCCTGTG CCAGCCACAG TTCCCTGGTG AGCTCTATTG AGAAGGACCT GCAAGAGATC 600 601 ATGGACTCAC TGGTGCTAGA GGAGCCTGGA GCTGCTGGCA AGAAGCCTGC CGCAACCTCT 660 661 CCACTGTCAC CGATGGCTAA TGGTGGGCGC TACCTGCTGT CTCCCCCAAC CAGCCCCGGC 720 721 GCCATGTCTG TGGGCTCCAG CTATGAGAAC ACCTCTCCAG CCTTCTCTCC ACTCTCTTCA 780 781 CCAGCCAGCA GTGGAAGCTG TGCCAGTCAC TCACCCAGTG GGCAAGAGCC AGGACCTTCT 840 841 GTGCCCCCGC TGGTACCTGC CCGTTCCTCC AGCTACCATC TGGCCCTACA GCCCCCACAG 900 901 TCCCGCCCAA GTGGTGCTCG CTCCGAGAGT CCTCGGCTGA GCAGGAAAGG GGGCCATGAG 960 961 AGGCCTCCCA GCCCTGGCCT CCGGGGTCTG CTGACAGACA GCCCTGCAGC TACTGTCTTG 1020 1021 GCGGAGGCCC GGAGAGCCAC TGAGAGCCCC CGGCTGGGTG GGCAGCTGCC TGTGGTGGCC 1080 1081 ATCAGCCTGA GTGAATACCC AGCTTCTGGT GCTCTCAGTC AACCCACCAG CATTCCTGGC 1140 1141 AGCCCCAAGT TTCAGCCTCC AGTCCCTGCT CCCCGAAACA AGATTGGCAC ACTCCAGGAC 1200 1201 CGCCCTCCCA GCCCTTTCCG TGAGCCTCCA GGCAGTGAGC GGGTGCTAAC AACCAGCCCC 1260 1261 TCACGCCAAC TGGTGGGCCG AACATTTTCA GATGGGTTAG CCACCCGTAC CCTGCAGCCT 1320 1321 CCTGAGAGTC CCCGCCTGGG CCGGCGGGGC CTGGACAGTA TGCGAGAACT ACCCCCCTTA 1380 1381 AGTCCATCTC TGTCCCGGCG AGCTCTCTCC CCGCTGCCCA CCCGGACCAC CCCAGATCCC 1440 1441 AAGCTAAACA GGGAAGTGGC AGAGAGTCCT CGGCCCCGGC GCTGGGCAGC CCATGGGGCT 1500 1501 TCACCAGAGG ACTTCTCCCT GACGCTGGGG GCACGGGGCC GTAGGACACG GAGCCCCTCA 1560 1561 CCCACACTGG GTGAGTCTCT GGCACCCCAC AAGGGCAGCT TCAGTGGCAG GCTGAGCCCA 1620 1621 GCCTACAGTC TGGGCTCTCT TACTGGGGCT TCACCCTGCC AGAGTCCCTG TGTCCAGAGG 1680 1681 AAGCTCTCCA GCGGGGACTT GCGGGTGCCT GTCACAAGGG AGCGGAAAAA TAGCATCACA 1740 1741 GAGATCAGTG ACAATGAGGA CGACCTCCTG GAGTACCACC GGCGACAGCG CCAAGAGCGG 1800 1801 CTCCGGGAGC AGGAGATGGA GAGGCTGGAA CGCCAGCGCC TGGAGACCAT CCTGAACCTG 1860 1861 TGTGCCGAAT ACAGCCGGGC TGATGGGGGA CCTGAGGCTG GGGAGCTTCC CAGCATTGGG 1920 1921 GAGGCCACCG CAGCATTGGC ACTGGCAGGC CGGAGGCCCT CACGAGGCCT TGCAGGGGCC 1980 1981 TCTGGGCGGA GCAGCGAGGA GCCTGGCGTT GCCACCCAAC GCCTATGGGA GAGTATGGAG 2040 2041 CGCTCAGATG AGGAAAATCT CAAGGAGGAG TGCAGCAGCA CTGAGAGCAC CCAGCAGGAG 2100 2101 CACGAAGATG CACCTAGCAC CAAGCTCCAG GGAGAGGTGC TAGCCCTGGA AGAAGAGCGG 2160 2161 GCTCAGGTGC TGGGGCACGT GGAGCAGCTC AAGGTCCGTG TGAAGGAGCT AGAGCAGCAG 2220 2221 CTGCAGGAGT CAGCCCGAGA GGCCGAAATG GAGCGGGCAC TGCTGCAGGG AGAGAGGGAG 2280 2281 GCAGAGCGGG CACTGCTGCA GAAGGAGCAG AAGGCAGTGG ATCAGCTGCA GGAGAAGCTG 2340 2341 GTGGCCTTGG AGACAGGCAT CCAGAAGGAG AGGGACAAGG AGGCAGAGGC CCTGGAGACT 2400 2401 GAGACAAAGC TCTTTGAGGA CTTGGAGTTC CAGCAGTTGG AGCGGGAGAG CCGCGTGGAG 2460 2461 GAGGAGCGCG AGCTGGCCGG CCAGGGGCTG CTCCGGAGCA AGGCTGAGCT GCTCCGCAGC 2520 2521 ATCGCCAAGA GGAAGGAGCG CCTGGCCATC CTGGACAGTC AGGCTGGGCA GATCCGGGCT 2580 2581 CAGGCCGTGC AGGAATCAGA ACGCCTGGCC CGGGACAAGA ATGCCTCCTT ACAGCTGCTG 2640 2641 CAAAAGGAGA AGGAGAAGCT GACTGTGCTG GAAAGGAGAT ACCACTCACT CACAGGGGGC 2700 2701 AGGCCTTTCC CGAAGACCAC ATCGACCCTC AAAGAGGTTT ACCGCTCCAA GATGGATGGC 2760 2761 GAGGCCACCA GCCCCCTTCC CCGGACCCGC AGCGGCCCCC TCCCCTCCTC CTCTGGCTCT 2820 2821 TCCTCCTCCT CCTCCCAGCT CAGCGTGGCT ACCCTGGGGC GTAGCCCCTC CCCAAAGAGC 2880 2881 GCTCTACTCA CCCAGAATGG CACGGGCAGC CTTCCTCGCA ACCTGGCAGC CACACTGCAG 2940 2941 GACATCGAGA CCAAGCGCCA ACTAGCTCTG CAGCAGAAGG GACAACAAGT GATTGAAGAG 3000 3001 CAGCGGCGGC GACTGGCTGA GCTGAAGCAG AAAGCGGCAG CTGAGGCACA GTGCCAGTGG 3060 3061 GATGCCCTTC ACGGGGCAGC ACCCTTCCCA GCGGGCCCCT CGGGCTTCCC CCCTCTCATG 3120 3121 CACCACTCTA TCCTACACCA CCTGCCTGCG GGGCGGGAGC GTGGGGAGGA GGGTGAGCAC 3180 3181 GCCTATGATA CGCTGAGTCT GGAGAGCTCT GACAGCATGG AGACCAGCAT CTCCACCGGG 3240 3241 GGCAACTCGG CCTGCTCCCC TGACAACATG TCCAGCGCGA GTGGTCTGGA CATGGGGAAG 3300 3301 ATCGAGGAGA TGGAGAAGAT GCTGAAAGAG GCTCATGCAG AGAAGAACCG GCTCATGGAG 3360 3361 TCGAGGGAGC GGGAGATGGA GCTGCGGCGG CAGGCCCTGG AGGAGGAGCG GCGGAGGCGT 3420 3421 GAGCAGGTAG AACGGAGGCT GCAGAGTGAG AGTGCCCGGA GGCAGCAGCT GGTCGAGAAG 3480 3481 GAGGTCAAGA TGCGGGAGAA ACAATTTTCC CAGGCACGAC CCCTGACCCG CTACCTGCCA 3540 3541 ATCCGGAAGG AGGACTTTGA CCTGAAGACA CATATTGAGT CATCGGGCCA TGGTGTTGAT 3600 3601 ACCTGCCTGC ACGTGGTGCT CAGCAGCAAG GTCTGCCGTG GCTACTTGGT CAAGATGGGC 3660 3661 GGCAAGATTA AATCATGGAA GAAGCGCTGG TTTGTCTTCG ACCGGCTCAA GCGCACCCTT 3720 3721 TCCTATTATG TGGACAAGCA TGAGACGAAG CTGAAGGGAG TCATCTATTT CCAGGCCATT 3780 3781 GAGGAAGTGT ACTACGACCA CCTGCGCAGT GCAGCCAAGA GCCCGAACCC AGCCCTCACC 3840 3841 TTCTGCGTAA AGACCCATGA CCGGCTGTAC TACATGGTGG CCCCATCTGC AGAGGCCATG 3900 3901 CGTATCTGGA TGGATGTCAT TGTCACAGGG GCTGAGGGCT ACACTCAGTT CATGAACTAA 3960 |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-a036 | Pan troglodytes | 99.71 | 0.0 | 2764 |
| LLPS-Pap-a036 | Pan paniscus | 99.64 | 0.0 | 2761 |
| LLPS-Poa-a036 | Pongo abelii | 99.27 | 0.0 | 2747 |
| LLPS-Gog-a036 | Gorilla gorilla | 99.2 | 0.0 | 2753 |
| LLPS-Nol-a038 | Nomascus leucogenys | 98.91 | 0.0 | 2744 |
| LLPS-Aon-a039 | Aotus nancymaae | 98.55 | 0.0 | 2732 |
| LLPS-Cea-a038 | Cercocebus atys | 98.13 | 0.0 | 2728 |
| LLPS-Paa-a037 | Papio anubis | 98.13 | 0.0 | 2728 |
| LLPS-Caj-a036 | Callithrix jacchus | 98.11 | 0.0 | 2718 |
| LLPS-Mal-a037 | Mandrillus leucophaeus | 98.05 | 0.0 | 2726 |
| LLPS-Rhb-a036 | Rhinopithecus bieti | 97.98 | 0.0 | 2724 |
| LLPS-Maf-a036 | Macaca fascicularis | 97.69 | 0.0 | 2719 |
| LLPS-Cas-a034 | Carlito syrichta | 97.03 | 0.0 | 2687 |
| LLPS-Otg-a037 | Otolemur garnettii | 96.6 | 0.0 | 2677 |
| LLPS-Man-a037 | Macaca nemestrina | 94.56 | 0.0 | 2706 |
| LLPS-Tut-a020 | Tursiops truncatus | 94.42 | 0.0 | 2402 |
| LLPS-Eqc-a041 | Equus caballus | 94.34 | 0.0 | 2436 |
| LLPS-Aim-a038 | Ailuropoda melanoleuca | 93.99 | 0.0 | 2418 |
| LLPS-Cap-a038 | Cavia porcellus | 93.37 | 0.0 | 1648 |
| LLPS-Chs-a039 | Chlorocebus sabaeus | 93.1 | 0.0 | 2414 |
| LLPS-Sus-a039 | Sus scrofa | 93.07 | 0.0 | 1430 |
| LLPS-Caf-a036 | Canis familiaris | 91.0 | 0.0 | 1672 |
| LLPS-Loa-a038 | Loxodonta africana | 90.12 | 0.0 | 2405 |
| LLPS-Mum-a039 | Mus musculus | 89.51 | 0.0 | 2398 |
| LLPS-Fec-a040 | Felis catus | 88.9 | 0.0 | 2392 |
| LLPS-Orc-a036 | Oryctolagus cuniculus | 88.61 | 0.0 | 1645 |
| LLPS-Ran-a040 | Rattus norvegicus | 88.28 | 0.0 | 2354 |
| LLPS-Myl-a040 | Myotis lucifugus | 88.2 | 0.0 | 1008 |
| LLPS-Bot-a041 | Bos taurus | 88.17 | 0.0 | 2298 |
| LLPS-Mam-a037 | Macaca mulatta | 88.1 | 0.0 | 1721 |
| LLPS-Mea-a035 | Mesocricetus auratus | 86.82 | 0.0 | 2290 |
| LLPS-Fud-a039 | Fukomys damarensis | 86.58 | 0.0 | 2298 |
| LLPS-Mup-a039 | Mustela putorius furo | 86.52 | 0.0 | 1648 |
| LLPS-Urm-a038 | Ursus maritimus | 85.48 | 0.0 | 1696 |
| LLPS-Ict-a039 | Ictidomys tridecemlineatus | 84.28 | 0.0 | 1223 |
| LLPS-Ova-a041 | Ovis aries | 80.08 | 0.0 | 1338 |
| LLPS-Mod-a035 | Monodelphis domestica | 75.79 | 0.0 | 1397 |
| LLPS-Sah-a037 | Sarcophilus harrisii | 70.08 | 0.0 | 1651 |
| LLPS-Tag-a034 | Taeniopygia guttata | 66.4 | 0.0 | 1119 |
| LLPS-Lac-a032 | Latimeria chalumnae | 62.79 | 0.0 | 1557 |
| LLPS-Gaga-a034 | Gallus gallus | 61.1 | 0.0 | 842 |
| LLPS-Ora-a033 | Ornithorhynchus anatinus | 60.9 | 0.0 | 1123 |
| LLPS-Orn-a033 | Oreochromis niloticus | 58.73 | 0.0 | 1352 |
| LLPS-Fia-a036 | Ficedula albicollis | 56.78 | 0.0 | 972 |
| LLPS-Gaa-a031 | Gasterosteus aculeatus | 56.49 | 0.0 | 1238 |
| LLPS-Pof-a036 | Poecilia formosa | 55.44 | 0.0 | 1257 |
| LLPS-Dar-a035 | Danio rerio | 54.46 | 0.0 | 1241 |
| LLPS-Anc-a035 | Anolis carolinensis | 54.17 | 0.0 | 979 |
| LLPS-Orl-a034 | Oryzias latipes | 53.62 | 0.0 | 1172 |
| LLPS-Icp-a035 | Ictalurus punctatus | 53.02 | 0.0 | 1235 |
| LLPS-Ten-a032 | Tetraodon nigroviridis | 52.67 | 0.0 | 754 |
| LLPS-Leo-a028 | Lepisosteus oculatus | 51.01 | 0.0 | 719 |
| LLPS-Asm-a032 | Astyanax mexicanus | 50.24 | 0.0 | 729 |