LLPS-Hos-4897
ELP4
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Elongator complex protein 4 |
| Gene Name: | ELP4, C11orf19, PAXNEB |
| Ensembl Gene: | ENSG00000109911.18 |
| Ensembl Protein: | ENSP00000432642.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. |
▼ CROSS REFERENCE
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAAVATCGSV AASTGSAVAT ASKSNVTSFQ RRGPRASVTN DSGPRLVSIA GTRPSVRNGQ 60 61 LLVSTGLPAL DQLLGGGLAV GTVLLIEEDK YNIYSPLLFK YFLAEGIVNG HTLLVASAKE 120 121 DPANILQELP APLLDDKCKK EFDEDVYNHK TPESNIKMKI AWRYQLLPKM EIGPVSSSRF 180 181 GHYYDASKRM PQELIEASNW HGFFLPEKIS STLKVEPCSL TPGYTKLLQF IQNIIYEEGF 240 241 DGSNPQKKQR NILRIGIQNL GSPLWGDDIC CAENGGNSHS LTKFLYVLRG LLRTSLSACI 300 301 ITMPTHLIQN KAIIARVTTL SDVVVGLESF IGSERETNPL YKDYHGLIHI RQIPRLNNLI 360 361 CDESDVKDLA FKLKRKLFTI EAGVQWHDLG SRQPRLLGSS NSPASASLVA GITGAHHHTQ 420 421 LIFVFLVEMG FHHVGQAGLE LLTSGDSSAS ASQSAGITGM SYRARPRALY FKENKSKVGA 480 481 RQLLETREEH LSSRLLILTQ AERLCMGRRF FTAFHIFNEL PCKGDCICLQ TCQTQ 535 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGCAG TGGCAACCTG CGGTAGTGTT GCCGCGAGTA CTGGGTCTGC AGTGGCGACA 60 61 GCCAGCAAGA GCAACGTCAC CAGTTTCCAG AGGAGGGGTC CTAGAGCCAG CGTGACCAAC 120 121 GACAGCGGCC CTCGACTGGT GTCCATTGCG GGCACGCGAC CGTCGGTGCG GAATGGACAG 180 181 CTGCTGGTAT CAACCGGGCT CCCAGCCCTA GACCAGCTCT TAGGTGGAGG TTTAGCCGTT 240 241 GGAACAGTTC TTCTAATTGA GGAGGATAAA TATAATATTT ACTCACCTTT GCTCTTCAAG 300 301 TATTTCCTGG CAGAAGGAAT TGTCAATGGG CATACTTTGT TGGTTGCATC TGCTAAAGAG 360 361 GATCCTGCCA ACATTTTACA GGAACTTCCA GCACCATTAC TTGATGATAA ATGTAAAAAG 420 421 GAATTTGATG AAGATGTATA CAATCATAAA ACACCAGAAT CTAATATTAA GATGAAAATA 480 481 GCTTGGCGTT ACCAGTTATT ACCCAAGATG GAGCAGATTG GACCAGTATC ATCTTCAAGA 540 541 TTTGGTCACT ATTATGATGC ATCAAAAAGA ATGCCACAAG AACTAATTGA GGCTTCAAAT 600 601 TGGCATGGAT TTTTTCTTCC AGAGAAAATA TCTTCAACTC TCAAAGTAGA ACCCTGTTCT 660 661 TTGACCCCTG GCTACACAAA GCTGCTTCAG TTTATCCAGA ACATCATTTA TGAGGAAGGA 720 721 TTTGATGGAT CCAATCCTCA GAAAAAACAG AGAAACATTT TAAGAATAGG AATTCAGAAT 780 781 CTTGGCTCAC CTTTATGGGG AGACGATATT TGCTGTGCAG AAAATGGTGG CAACAGTCAC 840 841 AGCCTTACCA AGTTCCTCTA TGTTCTCCGT GGTCTTCTGA GAACCTCTCT TTCAGCCTGC 900 901 ATCATCACAA TGCCAACACA TCTGATCCAG AATAAAGCCA TTATTGCCCG TGTCACAACC 960 961 TTGTCAGATG TAGTAGTTGG TCTGGAATCA TTTATTGGTT CTGAGAGAGA AACTAACCCA 1020 1021 TTGTATAAGG ATTATCATGG ATTGATTCAT ATACGGCAGA TTCCTCGGCT TAATAACTTG 1080 1081 ATCTGTGATG AATCAGATGT CAAAGACTTA GCTTTTAAAT TAAAAAGGAA GCTATTCACC 1140 1141 ATTGAGCGAC TGCATTTGCC TCCAGACTTG TCAGACACAG TGAGCCGCTC AAGCAAAATG 1200 1201 GATCTGGCAG AATCCGCCAA GCGGCTGGGC CCAGGCTGTG GCATGATGGC CGGAGGCAAG 1260 1261 AAGCACCTGG ACTTCTAG 1278 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Elongator holoenzyme complex | |
Cellular Component | Nucleoplasm | |
Cellular Component | Transcription elongation factor complex | |
Molecular Function | Phosphorylase kinase regulator activity | |
Molecular Function | RNA polymerase II complex binding | |
Biological Process | Regulation of transcription by RNA polymerase II | |
Biological Process | Transcription elongation from RNA polymerase II promoter | |
Biological Process | TRNA wobble uridine modification |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Poa-1281 | Pongo abelii | 98.16 | 0.0 | 717 |
| LLPS-Pat-3537 | Pan troglodytes | 98.13 | 0.0 | 1006 |
| LLPS-Nol-3449 | Nomascus leucogenys | 97.64 | 0.0 | 709 |
| LLPS-Chs-1632 | Chlorocebus sabaeus | 95.01 | 0.0 | 690 |
| LLPS-Maf-3444 | Macaca fascicularis | 94.58 | 0.0 | 969 |
| LLPS-Man-3460 | Macaca nemestrina | 94.21 | 0.0 | 956 |
| LLPS-Aon-3261 | Aotus nancymaae | 93.46 | 0.0 | 674 |
| LLPS-Sus-2218 | Sus scrofa | 90.03 | 0.0 | 658 |
| LLPS-Urm-2743 | Ursus maritimus | 88.45 | 0.0 | 643 |
| LLPS-Mup-4551 | Mustela putorius furo | 87.93 | 0.0 | 637 |
| LLPS-Otg-3155 | Otolemur garnettii | 87.93 | 0.0 | 646 |
| LLPS-Aim-2098 | Ailuropoda melanoleuca | 87.73 | 0.0 | 639 |
| LLPS-Ict-4307 | Ictidomys tridecemlineatus | 87.14 | 0.0 | 644 |
| LLPS-Pap-2992 | Pan paniscus | 86.96 | 1e-17 | 86.3 |
| LLPS-Caf-3040 | Canis familiaris | 86.27 | 0.0 | 629 |
| LLPS-Eqc-3373 | Equus caballus | 84.82 | 0.0 | 617 |
| LLPS-Myl-2044 | Myotis lucifugus | 83.77 | 0.0 | 600 |
| LLPS-Dio-2502 | Dipodomys ordii | 82.94 | 0.0 | 606 |
| LLPS-Mal-0803 | Mandrillus leucophaeus | 78.95 | 1e-09 | 65.9 |
| LLPS-Mod-1364 | Monodelphis domestica | 75.96 | 8e-173 | 504 |
| LLPS-Paa-2504 | Papio anubis | 74.42 | 7e-09 | 62.8 |
| LLPS-Cap-2170 | Cavia porcellus | 73.91 | 0.0 | 586 |
| LLPS-Gog-1511 | Gorilla gorilla | 69.39 | 3e-10 | 64.3 |
| LLPS-Rhb-1086 | Rhinopithecus bieti | 67.35 | 2e-09 | 62.0 |
| LLPS-Mam-1979 | Macaca mulatta | 67.35 | 2e-09 | 62.0 |
| LLPS-Leo-3864 | Lepisosteus oculatus | 57.42 | 1e-124 | 377 |
| LLPS-Phn-1313 | Phaeosphaeria nodorum | 33.07 | 3e-07 | 55.8 |
| LLPS-Beb-0928 | Beauveria bassiana | 32.76 | 1e-14 | 79.7 |
| LLPS-Mao-1634 | Magnaporthe oryzae | 32.04 | 4e-09 | 62.8 |
| LLPS-Nec-0964 | Neurospora crassa | 30.21 | 6e-11 | 68.6 |
| LLPS-Tum-0319 | Tuber melanosporum | 28.69 | 9e-13 | 74.3 |
| LLPS-Cog-1473 | Colletotrichum gloeosporioides | 28.57 | 1e-08 | 60.8 |
| LLPS-Ast-1360 | Aspergillus terreus | 28.42 | 7e-13 | 74.3 |
| LLPS-Trr-0737 | Trichoderma reesei | 28.08 | 1e-08 | 61.2 |
| LLPS-Scs-0855 | Sclerotinia sclerotiorum | 27.95 | 8e-10 | 65.1 |
| LLPS-Lem-1500 | Leptosphaeria maculans | 27.91 | 1e-09 | 64.7 |
| LLPS-Asni-1313 | Aspergillus niger | 27.22 | 1e-10 | 67.8 |
| LLPS-Blg-1333 | Blumeria graminis | 27.14 | 2e-09 | 63.9 |
| LLPS-Map-1218 | Magnaporthe poae | 26.92 | 3e-08 | 60.5 |
| LLPS-Trv-0844 | Trichoderma virens | 26.58 | 3e-10 | 65.9 |
| LLPS-Asc-1612 | Aspergillus clavatus | 25.89 | 2e-11 | 70.1 |
| LLPS-Asn-1500 | Aspergillus nidulans | 25.82 | 1e-07 | 58.2 |
| LLPS-Asfu-0415 | Aspergillus fumigatus | 25.46 | 4e-10 | 65.9 |
| LLPS-Nef-1611 | Neosartorya fischeri | 25.2 | 2e-10 | 67.0 |
| LLPS-Zyt-0855 | Zymoseptoria tritici | 24.01 | 2e-06 | 54.7 |