DrLLPS - Data resource of LLPS

LLPS-Hos-4768
ATP6V1F

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	V-type proton ATPase subunit F
Gene Name:	ATP6V1F, ATP6S14, VATF
Ensembl Gene:	ENSG00000128524.4
Ensembl Protein:	ENSP00000417378.1
Organism:	Homo sapiens
Taxa ID:	9606
LLPS Type:	LLPS regulator

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
P-body, Postsynaptic density	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Caenorhabditis elegans	LLPS-Cae-0065	Q23680	Regulator	P-body	56.85	3e-40	137
Mus musculus	LLPS-Mum-3217	Q9D1K2	Client	Postsynaptic density	79.59	9e-75	225

▼ FUNCTION

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENST00000492758.1	ENSP00000417378.1
Ensembl	ENST00000249289.4	ENSP00000249289.4
UniProt		Q16864, VATF_HUMAN, C9J2K4, Q6IBA8
GeneBank	BC104230, BC107854, AC025594, BU956696, CR456896, D49400, BC104231	AAI04231.1, AAI07855.1, CAG33177.1, AAI04232.1, BAA08392.1
RefSeq	NM_001198909.1, NM_004231.3	NP_001185838.1, NP_004222.2
Entrez	9296

▼ SEQUENCE

Protein Sequence (FASTA)
1 MAGRGKLIAV IGDEDTVTGF LLGGIGELNK NRHPNFLVVE KDTTINEIED TFRSLGSLPG 60 61 SVVEANPNQR DPPLWDEIDS RQFLNRDDIG IILINQYIAE MVRHALDAHQ QSIPAVLEIP 120 121 SKEHPYDAAK DSILRRARGM FTAEDLR 147
Nucleotide CDS Sequence (FASTA)
1 ATGGCGGGGA GGGGTAAGCT CATCGCAGTG ATCGGAGACG AGGACACGGT GACTGGTTTC 60 61 CTGCTGGGCG GCATAGGGGA GCTTAACAAG AACCGCCATC CCAATTTCCT GGTGGTGGAG 120 121 AAGGATACAA CCATCAATGA GATCGAAGAC ACTTTCCGGC AATTTCTAAA CCGGGATGAC 180 181 ATTGGCATCA TCCTCATCAA CCAGTACATC GCAGAGATGG TGCGGCATGC CCTGGACGCC 240 241 CACCAGCAGT CCATCCCCGC TGTCCTGGAG ATCCCCTCCA AGGAGCACCC ATATGACGCC 300 301 GCCAAGGACT CCATCCTGCG CAGGGCCAGG GGCATGTTCA CTGCCGAAGA CCTGCGCTAG 360

▼ KEYWORD

ID	Family
KW-0025	Alternative splicing
KW-0181	Complete proteome
KW-0375	Hydrogen ion transport
KW-0406	Ion transport
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0813	Transport

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005829	Cellular Component	Cytosol
GO:0070062	Cellular Component	Extracellular exosome
GO:0016020	Cellular Component	Membrane
GO:0016469	Cellular Component	Proton-transporting two-sector ATPase complex
GO:0033180	Cellular Component	Proton-transporting V-type ATPase, V1 domain
GO:0016471	Cellular Component	Vacuolar proton-transporting V-type ATPase complex
GO:0016887	Molecular Function	ATPase activity
GO:0042625	Molecular Function	ATPase coupled ion transmembrane transporter activity
GO:0015078	Molecular Function	Proton transmembrane transporter activity
GO:0046961	Molecular Function	Proton-transporting ATPase activity, rotational mechanism
GO:0015991	Biological Process	ATP hydrolysis coupled proton transport
GO:0008286	Biological Process	Insulin receptor signaling pathway
GO:0034220	Biological Process	Ion transmembrane transport
GO:0090383	Biological Process	Phagosome acidification
GO:1902600	Biological Process	Proton transmembrane transport
GO:0033572	Biological Process	Transferrin transport

▼ KEGG

hsa:9296

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	CDD	Gene3D

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	BioGRID
mUbiSiDa

Variation
dbSNP	VarCards	rSNPBase

Mutation
TCGA	ICGC	CGAP	IntOGen	BioMuta

Interaction
HINT	InWeb_IM	RISE	RAIN	Mentha
PINA	IID	MIST	DifferentialNET	RNAct

Disease
TumorFusions	OMIM	DisGeNET	ActiveDriverDB

Drug
CTD

Physicochemical
Compute pI/Mw	AAindex

Function
PIRSF	CellMarker	RaftProt

Proteomics
THPA	HPM

Localization
COMPARTMENTS

Expression
TCGA	ICGC	COSMIC	GEO	ArrayExpress
TISSUES	BioXpress	THPA

Element
UTRdb	circBase	CircNet	miRTarBase	miRWalk
miRcode	RAID	microRNA.org	m6AVar

Methylation
TCGA	ICGC	MethyCancer

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Gog-1675	Gorilla gorilla	100.0	7e-104	300
LLPS-Nol-3616	Nomascus leucogenys	98.64	1e-101	295
LLPS-Mal-1784	Mandrillus leucophaeus	95.92	4e-99	288
LLPS-Rhb-3309	Rhinopithecus bieti	95.92	3e-99	289
LLPS-Maf-2316	Macaca fascicularis	95.24	3e-98	286
LLPS-Aon-3146	Aotus nancymaae	95.24	8e-98	285
LLPS-Man-3697	Macaca nemestrina	95.24	3e-98	286
LLPS-Mam-2981	Macaca mulatta	94.56	2e-97	284
LLPS-Otg-0268	Otolemur garnettii	89.8	2e-88	261
LLPS-Paa-1246	Papio anubis	89.12	5e-88	259
LLPS-Cea-3351	Cercocebus atys	89.12	7e-88	259
LLPS-Cas-1335	Carlito syrichta	87.84	4e-83	248
LLPS-Fec-1912	Felis catus	83.67	3e-77	232
LLPS-Pap-4631	Pan paniscus	80.95	7e-76	228
LLPS-Pat-4890	Pan troglodytes	80.95	7e-76	228
LLPS-Bot-3718	Bos taurus	80.27	5e-75	226
LLPS-Ova-2617	Ovis aries	80.27	5e-75	226
LLPS-Chs-3679	Chlorocebus sabaeus	80.27	7e-75	226
LLPS-Poa-2689	Pongo abelii	80.27	7e-75	226
LLPS-Dio-1853	Dipodomys ordii	79.59	1e-74	225
LLPS-Ran-3013	Rattus norvegicus	79.59	1e-74	225
LLPS-Myl-2400	Myotis lucifugus	79.59	8e-75	226
LLPS-Mup-1143	Mustela putorius furo	79.59	4e-74	224
LLPS-Aim-2211	Ailuropoda melanoleuca	79.59	4e-74	224
LLPS-Mum-3217	Mus musculus	79.59	1e-74	225
LLPS-Fud-0975	Fukomys damarensis	79.59	1e-74	225
LLPS-Caj-4048	Callithrix jacchus	79.59	1e-73	224
LLPS-Caf-3831	Canis familiaris	79.59	2e-74	224
LLPS-Cap-3854	Cavia porcellus	79.59	1e-74	225
LLPS-Ict-2872	Ictidomys tridecemlineatus	79.59	1e-74	225
LLPS-Urm-3648	Ursus maritimus	79.59	4e-74	224
LLPS-Loa-2483	Loxodonta africana	79.59	1e-74	225
LLPS-Ere-0112	Erinaceus europaeus	78.91	3e-74	224
LLPS-Sus-0656	Sus scrofa	78.91	5e-74	224
LLPS-Ora-1690	Ornithorhynchus anatinus	78.23	3e-73	222
LLPS-Eqc-0896	Equus caballus	78.23	1e-72	220
LLPS-Orc-3216	Oryctolagus cuniculus	78.23	2e-73	222
LLPS-Tar-0470	Takifugu rubripes	70.75	1e-66	204
LLPS-Mod-1270	Monodelphis domestica	70.34	8e-64	197
LLPS-Xim-4068	Xiphophorus maculatus	70.07	5e-66	203
LLPS-Scf-3156	Scleropages formosus	70.07	1e-66	205
LLPS-Orl-3500	Oryzias latipes	70.07	4e-66	203
LLPS-Leo-0877	Lepisosteus oculatus	70.07	1e-66	205
LLPS-Asm-3344	Astyanax mexicanus	70.07	4e-66	204
LLPS-Pof-1745	Poecilia formosa	70.07	5e-66	203
LLPS-Xet-1296	Xenopus tropicalis	70.0	5e-65	201
LLPS-Gaa-2839	Gasterosteus aculeatus	69.39	3e-65	201
LLPS-Ten-2301	Tetraodon nigroviridis	69.39	2e-65	202
LLPS-Orn-3812	Oreochromis niloticus	69.39	1e-65	202
LLPS-Lac-3263	Latimeria chalumnae	68.97	3e-64	199
LLPS-Scm-2358	Scophthalmus maximus	68.71	9e-65	200
LLPS-Icp-2849	Ictalurus punctatus	68.03	4e-65	201
LLPS-Dar-2750	Danio rerio	68.03	2e-64	199
LLPS-Cis-1207	Ciona savignyi	58.04	3e-49	160
LLPS-Drm-2080	Drosophila melanogaster	57.93	2e-53	171
LLPS-Cae-0065	Caenorhabditis elegans	56.85	2e-50	164
LLPS-Cii-0280	Ciona intestinalis	55.94	3e-47	155
LLPS-Dac-1085	Daucus carota	50.0	1e-10	58.5
LLPS-Tum-1536	Tuber melanosporum	45.65	5e-31	114
LLPS-Sem-1288	Selaginella moellendorffii	45.52	9e-37	129
LLPS-Trv-1361	Trichoderma virens	45.45	2e-13	66.6
LLPS-Abg-0201	Absidia glauca	44.44	2e-31	114
LLPS-Fus-1388	Fusarium solani	44.2	6e-28	106
LLPS-Crn-0564	Cryptococcus neoformans	44.03	1e-30	113
LLPS-Kop-0350	Komagataella pastoris	43.8	3e-29	109
LLPS-Php-2271	Physcomitrella patens	43.75	2e-37	130
LLPS-Nec-0106	Neurospora crassa	43.48	5e-28	106
LLPS-Fuo-1455	Fusarium oxysporum	43.48	6e-28	106
LLPS-Ved-1503	Verticillium dahliae	43.48	6e-30	111
LLPS-Cogr-1176	Colletotrichum graminicola	43.48	5e-30	111
LLPS-Scj-0102	Schizosaccharomyces japonicus	42.96	8e-29	108
LLPS-Gag-0703	Gaeumannomyces graminis	42.75	1e-28	108
LLPS-Coo-0884	Colletotrichum orbiculare	42.75	1e-29	110
LLPS-Map-1174	Magnaporthe poae	42.75	1e-28	107
LLPS-Mao-1601	Magnaporthe oryzae	42.75	6e-29	108
LLPS-Cog-1173	Colletotrichum gloeosporioides	42.75	9e-30	110
LLPS-Sac-1239	Saccharomyces cerevisiae	42.66	1e-27	105
LLPS-Scc-0668	Schizosaccharomyces cryophilus	42.54	1e-25	100
LLPS-Mel-1454	Melampsora laricipopulina	42.22	9e-29	108
LLPS-Sot-1319	Solanum tuberosum	42.14	2e-35	125
LLPS-Blg-0855	Blumeria graminis	42.03	3e-27	104
LLPS-Mua-1322	Musa acuminata	41.83	3e-36	127
LLPS-Gor-0529	Gossypium raimondii	41.67	2e-33	120
LLPS-Trr-0501	Trichoderma reesei	41.67	2e-26	102
LLPS-Gas-0748	Galdieria sulphuraria	41.3	7e-33	119
LLPS-Asn-0566	Aspergillus nidulans	41.3	1e-28	107
LLPS-Asni-1035	Aspergillus niger	41.3	8e-29	108
LLPS-Dos-1231	Dothistroma septosporum	41.3	1e-27	105
LLPS-Asfu-1299	Aspergillus fumigatus	41.3	1e-27	105
LLPS-Beb-1156	Beauveria bassiana	41.3	2e-27	104
LLPS-Nef-1130	Neosartorya fischeri	41.3	1e-27	105
LLPS-Arl-2183	Arabidopsis lyrata	41.18	2e-35	125
LLPS-Brn-0015	Brassica napus	41.18	4e-36	127
LLPS-Bro-1914	Brassica oleracea	41.18	4e-36	127
LLPS-Brr-0830	Brassica rapa	41.18	4e-36	127
LLPS-Art-3105	Arabidopsis thaliana	41.18	2e-35	125
LLPS-Scp-1568	Schizosaccharomyces pombe	41.04	5e-27	103
LLPS-Orm-0892	Oryza meridionalis	40.85	2e-34	124
LLPS-Amt-0462	Amborella trichopoda	40.85	2e-34	122
LLPS-Nia-0423	Nicotiana attenuata	40.85	3e-34	125
LLPS-Phv-2519	Phaseolus vulgaris	40.71	1e-33	121
LLPS-Tru-1915	Triticum urartu	40.69	3e-35	125
LLPS-Asc-1059	Aspergillus clavatus	40.58	6e-27	103
LLPS-Orgl-2232	Oryza glumaepatula	40.52	7e-36	127
LLPS-Hov-1196	Hordeum vulgare	40.52	3e-35	125
LLPS-Sei-1328	Setaria italica	40.52	2e-35	125
LLPS-Tra-2297	Triticum aestivum	40.52	3e-35	125
LLPS-Brd-1862	Brachypodium distachyon	40.52	3e-35	125
LLPS-Orb-2368	Oryza barthii	40.52	7e-36	127
LLPS-Ori-1727	Oryza indica	40.52	7e-36	127
LLPS-Orni-1661	Oryza nivara	40.52	7e-36	127
LLPS-Thc-2416	Theobroma cacao	40.52	4e-36	127
LLPS-Coc-2332	Corchorus capsularis	40.52	5e-35	125
LLPS-Orr-1692	Oryza rufipogon	40.52	7e-36	127
LLPS-Zem-0506	Zea mays	40.52	3e-35	125
LLPS-Org-1286	Oryza glaberrima	40.52	7e-36	127
LLPS-Viv-1245	Vitis vinifera	40.52	4e-36	127
LLPS-Ors-1644	Oryza sativa	40.52	7e-36	127
LLPS-Orp-0859	Oryza punctata	40.52	7e-36	127
LLPS-Sob-1756	Sorghum bicolor	40.52	2e-35	125
LLPS-Orbr-1891	Oryza brachyantha	40.52	7e-36	127
LLPS-Usm-0435	Ustilago maydis	40.43	1e-28	107
LLPS-Aso-0693	Aspergillus oryzae	40.41	3e-28	106
LLPS-Hea-1627	Helianthus annuus	40.15	2e-33	120
LLPS-Glm-2770	Glycine max	40.0	1e-33	120
LLPS-Spr-0689	Sporisorium reilianum	40.0	8e-28	105
LLPS-Put-0223	Puccinia triticina	40.0	8e-28	105
LLPS-Pug-1338	Puccinia graminis	40.0	2e-28	107
LLPS-Lep-2189	Leersia perrieri	39.87	2e-35	125
LLPS-Prp-2287	Prunus persica	39.87	5e-35	124
LLPS-Zyt-1403	Zymoseptoria tritici	39.86	1e-25	100
LLPS-Yal-0242	Yarrowia lipolytica	39.86	7e-25	98.2
LLPS-Pytr-1476	Pyrenophora triticirepentis	39.86	2e-26	102
LLPS-Pyt-1377	Pyrenophora teres	39.13	2e-26	102
LLPS-Lem-1566	Leptosphaeria maculans	39.13	3e-24	96.7
LLPS-Chr-1529	Chlamydomonas reinhardtii	39.13	2e-27	104
LLPS-Mae-0765	Manihot esculenta	38.73	5e-33	119
LLPS-Vir-0423	Vigna radiata	38.62	2e-33	120
LLPS-Cus-1634	Cucumis sativus	38.56	2e-34	123
LLPS-Miv-1206	Microbotryum violaceum	38.52	3e-27	104
LLPS-Osl-0893	Ostreococcus lucimarinus	38.19	3e-27	104
LLPS-Asf-1566	Aspergillus flavus	38.1	4e-24	98.2
LLPS-Via-0734	Vigna angularis	37.88	8e-29	109
LLPS-Asg-0004	Ashbya gossypii	37.76	7e-25	98.2
LLPS-Pot-2053	Populus trichocarpa	36.6	1e-32	118
LLPS-Cym-1109	Cyanidioschyzon merolae	35.71	1e-21	90.1
LLPS-Phn-1535	Phaeosphaeria nodorum	35.71	6e-22	90.9

LLPS-Hos-4768ATP6V1F

Protein Sequence

Nucleotide Sequence

LLPS-Hos-4768
ATP6V1F