LLPS-Hos-4709
PRX

▼ OVERVIEW


Status: Unreviewed
Protein Name: Periaxin
Gene Name: PRX, KIAA1620
Ensembl Gene: ENSG00000105227.14
Ensembl Protein: ENSP00000326018.6
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others
PDB: 4CMZ (A) More


▼ PROPERTY



▼ Classification


Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION


Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses. Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions. Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves. Recruits DRP2 to the Schwann cell plasma membrane. Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MEARSRSAEE  LRRAELVEII  VETEAQTGVS  GINVAGGGKE  GIFVRELRED  SPAARSLSLQ  60
61    EGDQLLSARV  FFENFKYEDA  LRLLQCAEPY  KVSFCLKRTV  PTGDLALRPG  TVSGYEIKGP  120
121   RAKVAKLNIQ  SLSPVKKKKM  VPGALGVPAD  LAPVDVEFSF  PKFSRLRRGL  KAEAVKGPVP  180
181   AAPARRRLQL  PRLRVREVAE  EAQAARLAAA  APPPRKAKVE  AEVAAGARFT  APQVELVGPR  240
241   LPGAEVGVPQ  VSAPKAAPSA  EAAGGFALHL  PTLGLGAPAP  PAVEAPAVGI  QVPQVELPAL  300
301   PSLPTLPTLP  CLETREGAVS  VVVPTLDVAA  PTVGVDLALP  GAEVEARGEA  PEVALKMPRL  360
361   SFPRFGARAK  EVAEAKVAKV  SPEARVKGPR  LRMPTFGLSL  LEPRPAAPEV  VESKLKLPTI  420
421   KMPSLGIGVS  GPEVKVPKGP  EVKLPKAPEV  KLPKVPEAAL  PEVRLPEVEL  PKVSEMKLPK  480
481   VPEMAVPEVR  LPEVELPKVS  EMKLPKVPEM  AVPEVRLPEV  QLLKVSEMKL  PKVPEMAVPE  540
541   VRLPEVQLPK  VSEMKLPEVS  EVAVPEVRLP  EVQLPKVPEM  KVPEMKLPKV  PEMKLPEMKL  600
601   PEVQLPKVPE  MAVPDVHLPE  VQLPKVPEMK  LPEMKLPEVK  LPKVPEMAVP  DVHLPEVQLP  660
661   KVPEMKLPKM  PEMAVPEVRL  PEVQLPKVSE  MKLPKVPEMA  VPDVHLPEVQ  LPKVCEMKVP  720
721   DMKLPEIKLP  KVPEMAVPDV  HLPEVQLPKV  SEIRLPEMQV  PKVPDVHLPK  APEVKLPRAP  780
781   EVQLKATKAE  QAEGMEFGFK  MPKMTMPKLG  RAESPSRGKP  GEAGAEVSGK  LVTLPCLQPE  840
841   VDGEAHVGVP  SLTLPSVELD  LPGALGLQGQ  VPAAKMGKGE  RVEGPEVAAG  VREVGFRVPS  900
901   VEIVTPQLPA  VEIEEGRLEM  IETKVKPSSK  FSLPKFGLSG  PKVAKAEAEG  AGRATKLKVS  960
961   KFAISLPKAR  VGAEAEAKGA  GEAGLLPALD  LSIPQLSLDA  HLPSGKVEVA  GADLKFKGPR  1020
1021  FALPKFGVRG  RDTEAAELVP  GVAELEGKGW  GWDGRVKMPK  LKMPSFGLAR  GKEAEVQGDR  1080
1081  ASPGEKAEST  AVQLKIPEVE  LVTLGAQEEG  RAEGAVAVSG  MQLSGLKVST  AGQVVTEGHD  1140
1141  AGLRMPPLGI  SLPQVELTGF  GEAGTPGQQA  QSTVPSAEGT  AGYRVQVPQV  TLSLPGAQVA  1200
1201  GGELLVGEGV  FKMPTVTVPQ  LELDVGLSRE  AQAGEAATGE  GGLRLKLPTL  GARARVGGEG  1260
1261  AEEQPPGAER  TFCLSLPDVE  LSPSGGNHAE  YQVAEGEGEA  GHKLKVRLPR  FGLVRAKEGA  1320
1321  EEGEKAKSPK  LRLPRVGFSQ  SEMVTGEGSP  SPEEEEEEEE  EGSGEGASGR  RGRVRVRLPR  1380
1381  VGLAAPSKAS  RGQEGDAAPK  SPVREKSPKF  RFPRVSLSPK  ARSGSGDQEE  GGLRVRLPSV  1440
1441  GFSETGAPGP  ARMEGAQAAA  V  1461
Nucleotide CDS Sequence (FASTA)
1     ATGGAGGCCA  GGAGCCGGAG  TGCCGAGGAG  CTGAGGCGGG  CGGAGTTGGT  GGAAATTATC  60
61    GTGGAGACGG  AGGCGCAGAC  CGGGGTCAGC  GGCATCAACG  TAGCGGGCGG  CGGCAAAGAG  120
121   GGAATCTTCG  TTCGGGAGCT  GCGCGAGGAC  TCACCCGCCG  CCAGGAGCCT  CAGCCTGCAG  180
181   GAAGGGGACC  AGCTGCTGAG  TGCCCGAGTG  TTCTTCGAGA  ACTTCAAGTA  CGAGGACGCA  240
241   CTACGCCTGC  TGCAATGCGC  CGAGCCTTAC  AAAGTCTCCT  TCTGCCTGAA  GCGCACTGTG  300
301   CCCACCGGGG  ACCTGGCTCT  GCGGCCCGGG  ACCGTGTCTG  GCTACGAGAT  CAAGGGCCCG  360
361   CGGGCCAAGG  TGGCCAAGCT  GAACATCCAG  AGTCTGTCCC  CTGTGAAGAA  GAAGAAGATG  420
421   GTGCCTGGGG  CTCTGGGGGT  CCCCGCTGAC  CTGGCCCCTG  TTGACGTCGA  GTTCTCCTTT  480
481   CCCAAGTTCT  CCCGCCTGCG  TCGGGGCCTC  AAAGCCGAGG  CTGTCAAGGG  TCCTGTCCCG  540
541   GCTGCCCCTG  CCCGCCGGCG  CCTCCAGCTG  CCTCGGCTGC  GTGTACGAGA  AGTGGCCGAA  600
601   GAGGCTCAGG  CAGCCCGGCT  GGCCGCCGCC  GCTCCTCCCC  CCAGGAAAGC  CAAGGTGGAG  660
661   GCTGAGGTGG  CTGCAGGAGC  TCGTTTCACA  GCCCCTCAGG  TGGAGCTGGT  TGGGCCGCGG  720
721   CTGCCAGGGG  CGGAGGTGGG  TGTCCCCCAG  GTCTCAGCCC  CCAAGGCTGC  CCCCTCAGCA  780
781   GAGGCAGCTG  GTGGCTTTGC  CCTCCACCTG  CCAACCCTTG  GGCTCGGAGC  CCCGGCTCCG  840
841   CCTGCTGTGG  AGGCCCCAGC  CGTGGGAATC  CAGGTCCCCC  AGGTGGAGCT  GCCTGCCTTG  900
901   CCCTCACTGC  CCACTCTGCC  CACACTTCCC  TGCCTAGAGA  CCCGGGAAGG  GGCTGTGTCG  960
961   GTAGTGGTGC  CCACCCTGGA  TGTGGCAGCA  CCGACTGTGG  GGGTGGACCT  GGCCTTGCCG  1020
1021  GGTGCAGAGG  TGGAGGCCCG  GGGAGAGGCA  CCTGAGGTGG  CCCTGAAGAT  GCCCCGCCTT  1080
1081  AGTTTTCCCC  GATTTGGGGC  TCGAGCAAAG  GAAGTTGCTG  AGGCCAAGGT  AGCCAAGGTC  1140
1141  AGCCCTGAGG  CCAGGGTGAA  AGGTCCCAGA  CTTCGAATGC  CCACCTTTGG  GCTTTCCCTC  1200
1201  TTGGAGCCCC  GGCCCGCTGC  TCCTGAAGTT  GTAGAGAGCA  AGCTGAAGCT  GCCCACCATC  1260
1261  AAGATGCCCT  CCCTTGGCAT  CGGAGTGTCA  GGGCCCGAGG  TCAAGGTGCC  CAAGGGACCT  1320
1321  GAAGTGAAGC  TCCCCAAGGC  TCCTGAGGTC  AAGCTTCCAA  AAGTGCCCGA  GGCAGCCCTT  1380
1381  CCAGAGGTTC  GACTCCCAGA  GGTGGAGCTC  CCCAAGGTGT  CAGAGATGAA  ACTCCCAAAG  1440
1441  GTGCCAGAGA  TGGCTGTGCC  GGAGGTGCGG  CTTCCAGAGG  TAGAGCTGCC  CAAAGTGTCA  1500
1501  GAGATGAAAC  TCCCAAAGGT  GCCAGAGATG  GCTGTGCCGG  AGGTGCGGCT  TCCAGAGGTA  1560
1561  CAGCTGCTGA  AAGTGTCGGA  GATGAAACTC  CCAAAGGTGC  CAGAGATGGC  TGTGCCGGAG  1620
1621  GTGCGGCTTC  CAGAGGTACA  GCTGCCGAAA  GTGTCAGAGA  TGAAACTCCC  AGAGGTGTCA  1680
1681  GAGGTGGCTG  TGCCAGAGGT  GCGGCTTCCA  GAGGTGCAGC  TGCCGAAAGT  GCCAGAGATG  1740
1741  AAAGTCCCTG  AGATGAAGCT  TCCAAAGGTG  CCTGAGATGA  AACTTCCTGA  GATGAAACTC  1800
1801  CCTGAAGTGC  AACTCCCGAA  GGTGCCCGAG  ATGGCCGTGC  CCGATGTGCA  CCTCCCAGAA  1860
1861  GTGCAGCTTC  CAAAAGTCCC  AGAGATGAAG  CTCCCTGAGA  TGAAACTCCC  TGAGGTGAAA  1920
1921  CTCCCGAAGG  TGCCCGAGAT  GGCTGTGCCC  GATGTGCACC  TCCCGGAAGT  GCAGCTCCCG  1980
1981  AAAGTCCCAG  AGATGAAACT  CCCTAAAATG  CCTGAGATGG  CTGTGCCAGA  GGTTCGACTC  2040
2041  CCCGAGGTGC  AGCTGCCAAA  AGTCTCAGAG  ATGAAACTCC  CCAAGGTGCC  TGAAATGGCC  2100
2101  GTGCCCGATG  TGCACCTCCC  AGAGGTGCAG  CTGCCCAAAG  TCTGTGAAAT  GAAAGTCCCT  2160
2161  GACATGAAGC  TCCCAGAGAT  AAAACTCCCC  AAGGTGCCTG  AGATGGCTGT  GCCCGATGTG  2220
2221  CACCTCCCCG  AGGTGCAGCT  GCCGAAAGTG  TCAGAGATTC  GGCTGCCGGA  AATGCAAGTG  2280
2281  CCGAAGGTTC  CCGACGTGCA  TCTTCCGAAG  GCACCAGAGG  TGAAGCTGCC  CAGGGCTCCG  2340
2341  GAGGTGCAGC  TAAAGGCCAC  CAAGGCAGAA  CAGGCAGAAG  GGATGGAATT  TGGCTTCAAG  2400
2401  ATGCCCAAGA  TGACCATGCC  CAAGCTAGGG  AGGGCAGAGT  CCCCATCACG  TGGCAAGCCA  2460
2461  GGCGAGGCGG  GTGCTGAGGT  CTCAGGGAAG  CTGGTAACAC  TTCCCTGTCT  GCAGCCAGAG  2520
2521  GTGGATGGTG  AGGCTCATGT  GGGTGTCCCC  TCTCTCACTC  TGCCTTCAGT  GGAGCTAGAC  2580
2581  CTGCCAGGAG  CACTTGGCCT  GCAGGGGCAG  GTCCCAGCCG  CTAAAATGGG  CAAGGGAGAG  2640
2641  CGGGTGGAGG  GCCCTGAGGT  GGCAGCAGGG  GTCAGGGAAG  TGGGCTTCCG  AGTGCCCTCT  2700
2701  GTTGAAATTG  TCACCCCACA  GCTGCCCGCC  GTGGAAATTG  AGGAAGGGCG  GCTGGAGATG  2760
2761  ATAGAGACAA  AAGTCAAGCC  CTCTTCCAAG  TTCTCCTTAC  CTAAGTTTGG  ACTCTCGGGG  2820
2821  CCAAAGGTGG  CTAAGGCAGA  GGCTGAGGGG  GCTGGGCGAG  CTACCAAGCT  GAAGGTATCC  2880
2881  AAATTTGCCA  TCTCACTCCC  CAAGGCTCGG  GTGGGGGCTG  AGGCTGAGGC  CAAAGGGGCT  2940
2941  GGGGAGGCAG  GCCTGCTGCC  TGCCCTCGAT  CTGTCCATCC  CACAGCTCAG  CCTGGATGCC  3000
3001  CACCTGCCCT  CAGGCAAGGT  AGAGGTGGCA  GGGGCCGACC  TCAAGTTCAA  GGGGCCCAGG  3060
3061  TTTGCTCTCC  CCAAGTTTGG  GGTCAGAGGC  CGGGACACTG  AGGCAGCAGA  ACTAGTGCCA  3120
3121  GGGGTGGCTG  AGTTGGAGGG  CAAGGGCTGG  GGCTGGGATG  GGAGGGTGAA  GATGCCCAAG  3180
3181  CTGAAGATGC  CTTCCTTTGG  GCTGGCTCGA  GGGAAGGAAG  CAGAAGTTCA  AGGTGATCGT  3240
3241  GCCAGCCCGG  GGGAAAAGGC  TGAGTCCACC  GCTGTGCAGC  TTAAGATCCC  CGAGGTGGAG  3300
3301  CTGGTCACGC  TGGGCGCCCA  GGAGGAAGGG  AGGGCAGAGG  GGGCTGTGGC  CGTCAGTGGA  3360
3361  ATGCAGCTGT  CAGGCCTGAA  GGTGTCCACA  GCCGGGCAGG  TGGTCACTGA  GGGCCATGAC  3420
3421  GCGGGGCTGA  GGATGCCTCC  GCTGGGCATC  TCCCTGCCAC  AGGTGGAGCT  GACCGGCTTT  3480
3481  GGGGAGGCAG  GTACCCCAGG  GCAGCAGGCT  CAGAGTACAG  TCCCTTCAGC  AGAGGGCACA  3540
3541  GCAGGCTACA  GGGTTCAGGT  GCCCCAGGTG  ACCCTGTCTC  TGCCTGGAGC  CCAGGTTGCA  3600
3601  GGTGGTGAGC  TGCTGGTGGG  TGAGGGTGTC  TTTAAGATGC  CCACCGTGAC  AGTGCCCCAG  3660
3661  CTTGAGCTGG  ACGTGGGGCT  AAGCCGAGAG  GCACAGGCGG  GCGAGGCGGC  CACAGGCGAG  3720
3721  GGTGGGCTGA  GGCTGAAGTT  GCCCACACTG  GGGGCCAGAG  CTAGGGTGGG  GGGCGAGGGT  3780
3781  GCTGAGGAGC  AGCCCCCAGG  GGCCGAGCGT  ACCTTCTGCC  TCTCACTGCC  CGACGTGGAG  3840
3841  CTCTCGCCAT  CCGGGGGCAA  CCATGCCGAG  TACCAGGTGG  CAGAGGGGGA  GGGAGAGGCC  3900
3901  GGACACAAGC  TCAAGGTACG  GCTGCCCCGG  TTTGGCCTGG  TGCGGGCCAA  GGAGGGGGCC  3960
3961  GAGGAGGGTG  AGAAGGCCAA  GAGCCCCAAA  CTCAGGCTGC  CCCGAGTGGG  CTTCAGCCAA  4020
4021  AGTGAGATGG  TCACTGGGGA  AGGGTCCCCC  AGCCCCGAGG  AGGAGGAGGA  GGAGGAGGAA  4080
4081  GAGGGCAGTG  GGGAAGGGGC  CTCGGGTCGC  CGGGGCCGGG  TCCGGGTCCG  CTTGCCACGT  4140
4141  GTAGGCCTGG  CGGCCCCTTC  TAAAGCCTCT  CGGGGGCAGG  AGGGCGATGC  AGCCCCCAAG  4200
4201  TCCCCCGTCA  GAGAGAAGTC  ACCCAAGTTC  CGCTTCCCCA  GGGTGTCCCT  AAGCCCCAAG  4260
4261  GCCCGGAGTG  GGAGTGGGGA  CCAGGAAGAG  GGTGGATTGC  GGGTGCGGCT  GCCCAGCGTG  4320
4321  GGGTTTTCAG  AGACAGGGGC  TCCAGGCCCG  GCCAGGATGG  AGGGGGCTCA  GGCTGCGGCT  4380
4381  GTCTGA  4386

▼ KEYWORD


ID
Family
3D-structure
Alternative splicing
Cell junction
Cell membrane
Charcot-Marie-Tooth disease
Complete proteome
Cytoplasm
Dejerine-Sottas syndrome
Disease mutation
Membrane
Neurodegeneration
Neuropathy
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cell junction
Cellular Component
Cytoplasm
Cellular Component
Nucleus
Cellular Component
Plasma membrane
Cellular Component
T-tubule
Biological Process
Axon ensheathment
Biological Process
Regulation of RNA splicing

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pap-3158Pan paniscus98.270.02164
LLPS-Gog-1879Gorilla gorilla98.20.02158
LLPS-Poa-4266Pongo abelii97.230.02141
LLPS-Paa-2232Papio anubis94.60.02076
LLPS-Ict-4483Ictidomys tridecemlineatus93.92e-82 302
LLPS-Maf-0245Macaca fascicularis92.390.01992
LLPS-Cap-3714Cavia porcellus92.376e-64 220
LLPS-Caj-0362Callithrix jacchus92.330.02010
LLPS-Mam-3121Macaca mulatta92.180.01986
LLPS-Cea-2808Cercocebus atys92.180.01988
LLPS-Man-4500Macaca nemestrina91.830.01979
LLPS-Nol-4463Nomascus leucogenys90.741e-1794.0
LLPS-Fec-4695Felis catus88.061e-67 231
LLPS-Aon-2097Aotus nancymaae87.880.01853
LLPS-Rhb-2017Rhinopithecus bieti87.490.01848
LLPS-Ora-2525Ornithorhynchus anatinus86.094e-58 203
LLPS-Mod-0775Monodelphis domestica85.982e-75 281
LLPS-Eqc-1460Equus caballus84.540.01756
LLPS-Mal-3722Mandrillus leucophaeus81.250.01658
LLPS-Pat-0884Pan troglodytes80.00.01630
LLPS-Cas-1558Carlito syrichta79.150.01668
LLPS-Urm-0414Ursus maritimus77.840.01741
LLPS-Aim-1350Ailuropoda melanoleuca77.710.01147
LLPS-Otg-2801Otolemur garnettii77.590.01609
LLPS-Loa-4468Loxodonta africana77.30.01608
LLPS-Sus-2376Sus scrofa76.580.01546
LLPS-Mup-3325Mustela putorius furo75.510.01575
LLPS-Bot-0197Bos taurus73.690.01528
LLPS-Mum-4695Mus musculus71.210.01464
LLPS-Ova-3470Ovis aries70.740.01397
LLPS-Tut-1723Tursiops truncatus70.060.01356
LLPS-Mea-3727Mesocricetus auratus69.660.01405
LLPS-Orc-4316Oryctolagus cuniculus69.440.01375
LLPS-Fud-3460Fukomys damarensis69.150.01064
LLPS-Ran-3460Rattus norvegicus68.630.01402
LLPS-Caf-2250Canis familiaris67.640.01248
LLPS-Anc-4029Anolis carolinensis65.381e-51 204
LLPS-Myl-3915Myotis lucifugus65.380.01005
LLPS-Sah-2355Sarcophilus harrisii63.644e-73 249
LLPS-Gaa-3038Gasterosteus aculeatus62.394e-40 152
LLPS-Ten-2431Tetraodon nigroviridis61.261e-37 147
LLPS-Dio-1068Dipodomys ordii57.740.01058
LLPS-Phv-2464Phaseolus vulgaris48.581e-22 105
LLPS-Lep-0250Leersia perrieri47.372e-0860.1
LLPS-Tra-3072Triticum aestivum45.861e-1067.4
LLPS-Glm-2144Glycine max45.612e-23 108
LLPS-Brn-0478Brassica napus44.619e-31 132
LLPS-Via-0311Vigna angularis43.988e-1995.9
LLPS-Thc-0658Theobroma cacao43.569e-1373.6
LLPS-Gor-1998Gossypium raimondii43.495e-2097.1
LLPS-Brd-0123Brachypodium distachyon42.72e-1376.6
LLPS-Arl-2050Arabidopsis lyrata42.391e-21 103
LLPS-Coc-0071Corchorus capsularis41.732e-30 130
LLPS-Art-2610Arabidopsis thaliana41.696e-25 113
LLPS-Brr-1203Brassica rapa41.611e-23 108
LLPS-Dac-0978Daucus carota41.043e-0756.2
LLPS-Cog-0461Colletotrichum gloeosporioides40.141e-1688.2
LLPS-Met-0070Medicago truncatula39.233e-24 111
LLPS-Nia-2521Nicotiana attenuata35.412e-0758.9
LLPS-Sol-1782Solanum lycopersicum34.266e-1995.1
LLPS-Sot-0116Solanum tuberosum34.251e-21 103
LLPS-Phn-1107Phaeosphaeria nodorum33.22e-43 178
LLPS-Asg-0258Ashbya gossypii30.331e-1071.2
LLPS-Cae-1387Caenorhabditis elegans26.632e-1275.1
LLPS-Zyt-1448Zymoseptoria tritici24.672e-1379.0