DrLLPS - Data resource of LLPS

LLPS-Hos-4392
RPS15A

▼ OVERVIEW


Status:	Reviewed
Protein Name:	40S ribosomal protein S15a; Small ribosomal subunit protein uS8
Gene Name:	RPS15A, OK/SW-cl.82
Ensembl Gene:	ENSG00000134419.15
Ensembl Protein:	ENSP00000318646.4
Organism:	Homo sapiens
Taxa ID:	9606
LLPS Type:	LLPS regulator

PDB: 5A2Q (2, 3, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, f, g, h, r, w) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Postsynaptic density	"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."	Human cortex	23071613
Nucleolus, P-body, Others	Predicted from orthologs	N/A	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Caenorhabditis elegans	LLPS-Cae-0122	O17218	Regulator	P-body, P granule	86.15	5e-80	238
Arabidopsis thaliana	LLPS-Art-0664	P42798	Client	Nucleolus	77.69	2e-71	217
Mus musculus	LLPS-Mum-3481	P62245	Client	Nucleolus, Postsynaptic density	100.00	1e-91	268

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENST00000322989.8	ENSP00000318646.4
Ensembl	ENST00000563579.1	ENSP00000458052.1
Ensembl	ENST00000569083.1	ENSP00000460618.1
Ensembl	ENST00000569365.6	ENSP00000457924.2
Ensembl	ENST00000574723.5	ENSP00000460069.1
Ensembl	ENST00000576008.5	ENSP00000459373.1
Ensembl	ENST00000576436.5	ENSP00000459554.1
Ensembl	ENST00000572008.5	ENSP00000458528.1
Ensembl	ENST00000565420.5	ENSP00000458115.1
Ensembl	ENST00000563390.5	ENSP00000457000.1
Ensembl	ENST00000562935.5	ENSP00000457001.1
UniProt		P62244, RS15A_HUMAN, P39027, P39031, Q3MHD9, Q8C023, Q9BV24
GeneBank	AY208299, BC046113, BC105292, AB007154, BC001697, X62691, BC030569, AB062400, X84407, BC105273	AAO48936.1, BAA28592.1, AAI05274.1, BAB93487.1, AAH46113.1, AAI05293.1, CAA59127.1, CAA44568.1, AAH30569.1, AAH01697.1
RefSeq	NM_001019.4, NM_001030009.1	NP_001010.2, NP_001025180.1
Entrez	6210

▼ SEQUENCE

Protein Sequence (FASTA)
1 MVRMNVLADA LKSINNAEKR GKRQVLIRPC SKVIVRFLTV MMKHGYIGEF EIIDDHRAGK 60 61 IVVNLTGRLN KCGVISPRFD VQLKDLEKWQ NNLLPSRQFG FIVLTTSAGI MDHEEARRKH 120 121 TGGKILGFFF 130
Nucleotide CDS Sequence (FASTA)
1 ATGGTGCGCA TGAATGTCCT GGCAGATGCT CTCAAGAGTA TCAACAATGC CGAAAAGAGA 60 61 GGCAAACGCC AGGTGCTTAT TAGGCCGTGC TCCAAAGTCA TCGTCCGGTT TCTCACTGTG 120 121 ATGATGAAGC ATGGTTACAT TGGCGAATTT GAAATCATTG ATGACCACAG AGCTGGGAAA 180 181 ATTGTTGTGA ACCTCACAGG CAGGCTAAAC AAGTGTGGGG TGATCAGCCC CAGATTTGAC 240 241 GTGCAACTCA AAGACCTGGA AAAATGGCAG AATAATCTGC TTCCATCCCG CCAGTTTGGT 300 301 TTCATTGTAC TGACAACCTC AGCTGGCATC ATGGACCATG AAGAAGCAAG ACGAAAACAC 360 361 ACAGGAGGGA AAATCCTGGG ATTCTTTTTC TAG 393

▼ ANNOTATION

Disorder
IUPred2A

Domain
SMART	CDD	Gene3D

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	BioGRID
mUbiSiDa	PTMcode

Variation
dbSNP	VarCards	rSNPBase

Mutation
TCGA	ICGC	CGAP	IntOGen	BioMuta

Interaction
HINT	InWeb_IM	RISE	RAIN	Mentha
PINA	IID	MIST	DifferentialNET	RNAct

Disease
OMIM	DisGeNET

Drug
CTD

Physicochemical
Compute pI/Mw	AAindex

Function
PIRSF	CORUM	CellMarker	RaftProt

Proteomics
THPA	HPM

Structure
PDB

Localization
COMPARTMENTS

Expression
TCGA	ICGC	COSMIC	GEO	ArrayExpress
TISSUES	BioXpress	THPA

Element
UTRdb	circBase	CircNet	miRTarBase	miRWalk
miRcode	RAID	microRNA.org

Methylation
TCGA	ICGC	MethyCancer

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Ict-4525	Ictidomys tridecemlineatus	100.0	1e-91	268
LLPS-Cas-2650	Carlito syrichta	100.0	1e-91	268
LLPS-Cap-0738	Cavia porcellus	100.0	1e-91	268
LLPS-Eqc-3584	Equus caballus	100.0	1e-91	268
LLPS-Poa-1248	Pongo abelii	100.0	1e-91	268
LLPS-Rhb-2351	Rhinopithecus bieti	100.0	1e-91	268
LLPS-Orc-2608	Oryctolagus cuniculus	100.0	1e-91	268
LLPS-Otg-0270	Otolemur garnettii	100.0	1e-91	268
LLPS-Man-1884	Macaca nemestrina	100.0	1e-91	268
LLPS-Fec-2148	Felis catus	100.0	1e-91	268
LLPS-Mod-3499	Monodelphis domestica	100.0	1e-91	268
LLPS-Pat-3201	Pan troglodytes	100.0	1e-91	268
LLPS-Pap-0184	Pan paniscus	100.0	1e-91	268
LLPS-Urm-0316	Ursus maritimus	100.0	1e-91	268
LLPS-Mup-1496	Mustela putorius furo	100.0	1e-91	268
LLPS-Myl-2605	Myotis lucifugus	100.0	1e-91	268
LLPS-Ova-1429	Ovis aries	100.0	1e-91	268
LLPS-Mal-0630	Mandrillus leucophaeus	100.0	1e-91	268
LLPS-Paa-3528	Papio anubis	100.0	1e-91	268
LLPS-Ran-1762	Rattus norvegicus	100.0	1e-91	268
LLPS-Bot-2006	Bos taurus	100.0	1e-91	268
LLPS-Caj-0307	Callithrix jacchus	100.0	1e-91	268
LLPS-Fud-1530	Fukomys damarensis	100.0	1e-91	268
LLPS-Gog-1689	Gorilla gorilla	100.0	1e-91	268
LLPS-Sus-2484	Sus scrofa	100.0	1e-91	268
LLPS-Aon-0885	Aotus nancymaae	100.0	1e-91	268
LLPS-Sah-1741	Sarcophilus harrisii	100.0	1e-91	268
LLPS-Cea-3323	Cercocebus atys	100.0	1e-91	268
LLPS-Ora-0050	Ornithorhynchus anatinus	100.0	1e-90	270
LLPS-Chs-2266	Chlorocebus sabaeus	100.0	4e-89	269
LLPS-Maf-0195	Macaca fascicularis	100.0	1e-91	268
LLPS-Mum-3481	Mus musculus	100.0	1e-91	268
LLPS-Mea-0469	Mesocricetus auratus	100.0	1e-91	268
LLPS-Tag-1703	Taeniopygia guttata	99.23	2e-91	268
LLPS-Gaga-0433	Gallus gallus	99.23	2e-91	267
LLPS-Mam-3523	Macaca mulatta	99.23	1e-90	265
LLPS-Fia-0618	Ficedula albicollis	99.23	2e-91	267
LLPS-Pes-0519	Pelodiscus sinensis	99.23	3e-91	267
LLPS-Anp-0689	Anas platyrhynchos	99.23	5e-91	266
LLPS-Meg-1671	Meleagris gallopavo	99.23	2e-91	267
LLPS-Dar-1831	Danio rerio	99.23	3e-91	267
LLPS-Aim-3623	Ailuropoda melanoleuca	99.23	1e-90	265
LLPS-Scf-2330	Scleropages formosus	99.23	2e-91	267
LLPS-Icp-0430	Ictalurus punctatus	99.23	8e-91	266
LLPS-Leo-1457	Lepisosteus oculatus	99.23	2e-91	268
LLPS-Ten-0489	Tetraodon nigroviridis	98.46	7e-91	266
LLPS-Orn-2466	Oreochromis niloticus	98.46	7e-91	266
LLPS-Pof-3459	Poecilia formosa	98.46	7e-91	266
LLPS-Tar-2513	Takifugu rubripes	98.46	7e-91	266
LLPS-Xim-0090	Xiphophorus maculatus	98.46	5e-91	268
LLPS-Orl-1331	Oryzias latipes	98.46	7e-91	266
LLPS-Scm-1939	Scophthalmus maximus	97.69	6e-90	264
LLPS-Gaa-2541	Gasterosteus aculeatus	96.92	1e-89	263
LLPS-Nol-0210	Nomascus leucogenys	96.58	4e-78	233
LLPS-Anc-0266	Anolis carolinensis	96.15	2e-87	258
LLPS-Loa-1759	Loxodonta africana	96.15	3e-87	257
LLPS-Caf-3373	Canis familiaris	96.12	3e-88	259
LLPS-Lac-0050	Latimeria chalumnae	92.0	1e-62	193
LLPS-Drm-1107	Drosophila melanogaster	88.46	3e-83	247
LLPS-Cis-1420	Ciona savignyi	87.69	3e-80	239
LLPS-Asm-1811	Astyanax mexicanus	86.92	7e-75	225
LLPS-Cae-0122	Caenorhabditis elegans	86.15	5e-80	238
LLPS-Xet-0810	Xenopus tropicalis	82.58	7e-73	220
LLPS-Amt-1354	Amborella trichopoda	80.0	5e-72	218
LLPS-Chc-0616	Chondrus crispus	79.84	3e-74	224
LLPS-Viv-0050	Vitis vinifera	79.23	6e-72	219
LLPS-Gas-0560	Galdieria sulphuraria	79.23	1e-75	227
LLPS-Via-0472	Vigna angularis	79.23	1e-72	219
LLPS-Mua-2304	Musa acuminata	79.23	9e-72	219
LLPS-Zem-0470	Zea mays	78.46	2e-72	219
LLPS-Prp-2101	Prunus persica	78.46	8e-72	218
LLPS-Coc-1319	Corchorus capsularis	78.46	8e-72	218
LLPS-Phv-1824	Phaseolus vulgaris	78.46	6e-72	218
LLPS-Sob-1397	Sorghum bicolor	78.46	2e-72	219
LLPS-Pot-2060	Populus trichocarpa	78.46	5e-72	218
LLPS-Vir-0954	Vigna radiata	78.46	1e-71	217
LLPS-Cus-1658	Cucumis sativus	78.46	5e-71	219
LLPS-Thc-1627	Theobroma cacao	78.46	8e-72	218
LLPS-Glm-1140	Glycine max	78.46	8e-72	218
LLPS-Abg-0505	Absidia glauca	78.29	7e-72	218
LLPS-Tru-1355	Triticum urartu	77.69	2e-71	217
LLPS-Org-1498	Oryza glaberrima	77.69	1e-71	217
LLPS-Bro-1499	Brassica oleracea	77.69	2e-71	217
LLPS-Ved-0571	Verticillium dahliae	77.69	9e-72	218
LLPS-Orr-1074	Oryza rufipogon	77.69	1e-71	217
LLPS-Orm-0882	Oryza meridionalis	77.69	1e-71	217
LLPS-Nia-0073	Nicotiana attenuata	77.69	2e-71	217
LLPS-Mae-1130	Manihot esculenta	77.69	1e-71	217
LLPS-Orp-1271	Oryza punctata	77.69	1e-71	217
LLPS-Ors-0970	Oryza sativa	77.69	1e-71	217
LLPS-Brr-1099	Brassica rapa	77.69	2e-71	217
LLPS-Gor-1906	Gossypium raimondii	77.69	2e-71	217
LLPS-Art-0664	Arabidopsis thaliana	77.69	2e-71	217
LLPS-Arl-1037	Arabidopsis lyrata	77.69	2e-71	217
LLPS-Tra-1027	Triticum aestivum	77.69	2e-71	217
LLPS-Brd-0017	Brachypodium distachyon	77.69	2e-71	217
LLPS-Hov-0965	Hordeum vulgare	77.69	2e-71	217
LLPS-Met-0725	Medicago truncatula	77.69	2e-71	217
LLPS-Sei-1998	Setaria italica	77.69	2e-71	216
LLPS-Sot-1550	Solanum tuberosum	77.69	2e-71	217
LLPS-Lep-2134	Leersia perrieri	77.69	1e-71	217
LLPS-Orni-0863	Oryza nivara	77.69	1e-71	217
LLPS-Hea-0038	Helianthus annuus	77.69	3e-71	218
LLPS-Ori-2258	Oryza indica	77.69	1e-71	217
LLPS-Orb-1244	Oryza barthii	77.69	1e-71	217
LLPS-Brn-2626	Brassica napus	77.69	2e-71	217
LLPS-Yal-0273	Yarrowia lipolytica	77.69	3e-73	221
LLPS-Pytr-0773	Pyrenophora triticirepentis	76.92	1e-70	214
LLPS-Orbr-1501	Oryza brachyantha	76.92	3e-71	216
LLPS-Sac-1418	Saccharomyces cerevisiae	76.92	7e-72	218
LLPS-Zyt-1283	Zymoseptoria tritici	76.92	3e-69	211
LLPS-Dio-0155	Dipodomys ordii	76.92	4e-65	200
LLPS-Orgl-0802	Oryza glumaepatula	76.92	3e-71	216
LLPS-Kop-0695	Komagataella pastoris	76.92	2e-72	219
LLPS-Dac-0178	Daucus carota	76.92	6e-71	215
LLPS-Asg-0345	Ashbya gossypii	76.92	2e-72	219
LLPS-Gag-0815	Gaeumannomyces graminis	76.92	1e-70	215
LLPS-Cogr-0762	Colletotrichum graminicola	76.15	7e-72	218
LLPS-Dos-0380	Dothistroma septosporum	76.15	8e-70	213
LLPS-Asfu-0047	Aspergillus fumigatus	76.15	4e-71	216
LLPS-Trv-0629	Trichoderma virens	76.15	7e-70	213
LLPS-Trr-0097	Trichoderma reesei	76.15	7e-70	213
LLPS-Cog-0358	Colletotrichum gloeosporioides	76.15	4e-71	216
LLPS-Ast-0027	Aspergillus terreus	76.15	1e-71	217
LLPS-Asf-1173	Aspergillus flavus	76.15	9e-72	218
LLPS-Blg-0015	Blumeria graminis	76.15	9e-70	213
LLPS-Aso-1187	Aspergillus oryzae	76.15	9e-72	218
LLPS-Pyt-0383	Pyrenophora teres	76.15	2e-70	214
LLPS-Lem-1537	Leptosphaeria maculans	76.15	2e-69	212
LLPS-Map-0090	Magnaporthe poae	76.15	2e-70	214
LLPS-Mao-0296	Magnaporthe oryzae	76.15	2e-70	214
LLPS-Asn-0560	Aspergillus nidulans	76.15	2e-70	214
LLPS-Coo-0354	Colletotrichum orbiculare	76.15	4e-71	216
LLPS-Scs-0027	Sclerotinia sclerotiorum	76.15	1e-67	207
LLPS-Phn-1427	Phaeosphaeria nodorum	75.38	3e-69	211
LLPS-Nef-0932	Neosartorya fischeri	75.38	1e-70	215
LLPS-Nec-0308	Neurospora crassa	75.38	4e-70	213
LLPS-Asni-0287	Aspergillus niger	75.38	9e-72	218
LLPS-Php-1968	Physcomitrella patens	75.38	7e-70	213
LLPS-Sem-1779	Selaginella moellendorffii	75.38	1e-70	214
LLPS-Asc-0372	Aspergillus clavatus	75.38	1e-70	215
LLPS-Beb-1133	Beauveria bassiana	74.62	3e-69	211
LLPS-Scp-1588	Schizosaccharomyces pombe	74.62	2e-65	202
LLPS-Cii-0816	Ciona intestinalis	74.53	1e-50	163
LLPS-Fuo-0293	Fusarium oxysporum	73.85	1e-68	209
LLPS-Fus-0151	Fusarium solani	73.85	1e-68	210
LLPS-Tum-1454	Tuber melanosporum	73.85	1e-66	204
LLPS-Scc-0803	Schizosaccharomyces cryophilus	73.85	9e-67	205
LLPS-Fuv-0981	Fusarium verticillioides	73.85	1e-68	209
LLPS-Mel-0533	Melampsora laricipopulina	73.64	4e-66	203
LLPS-Osl-0198	Ostreococcus lucimarinus	73.08	3e-66	203
LLPS-Chr-0918	Chlamydomonas reinhardtii	73.08	2e-69	211
LLPS-Spr-1165	Sporisorium reilianum	71.54	2e-68	209
LLPS-Usm-0751	Ustilago maydis	71.54	2e-68	209
LLPS-Put-0974	Puccinia triticina	71.32	5e-64	198
LLPS-Pug-0302	Puccinia graminis	71.32	5e-64	198
LLPS-Scj-0946	Schizosaccharomyces japonicus	70.77	5e-65	200
LLPS-Miv-0212	Microbotryum violaceum	70.54	2e-62	194
LLPS-Crn-0126	Cryptococcus neoformans	70.0	3e-63	196
LLPS-Cym-0598	Cyanidioschyzon merolae	63.85	1e-58	184
LLPS-Sol-0856	Solanum lycopersicum	45.6	9e-39	133

LLPS-Hos-4392RPS15A

Protein Sequence

Nucleotide Sequence

LLPS-Hos-4392
RPS15A