LLPS-Hos-4351
ORC3

▼ OVERVIEW

Status: Unreviewed
Protein Name: Origin recognition complex subunit 3; Origin recognition complex subunit Latheo
Gene Name: ORC3, LATHEO, ORC3L
Ensembl Gene: ENSG00000135336.14
Ensembl Protein: ENSP00000444695.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others
PDB: 5UJM (A, B, C, D, E) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MATSSMSKGC  FVFKPNSKKR  KISLPIEDYF  NKGKNEPEDS  KLRFETYQLI  WQQMKSENER  60
61    LQEELNKNLF  DNLIEFLQKS  HSGFQKNSRD  LGGQIKLREI  PTAALVLGVN  VTDHDLTFGS  120
121   LTEALQNNVT  PYVVSLQAKD  CPDMKHFLQK  LISQLMDCCV  DIKSKEEESV  HVTQRKTHYS  180
181   MDSLSSWYMT  VTQKTDPKML  SKKRTTSSQW  QSPPVVVILK  DMESFATKVL  QDFIIISSQH  240
241   LHEFPLILIF  GIATSPIIIH  RLLPHAVSSL  LCIELFQSLS  CKEHLTTVLD  KLLLTTQFPF  300
301   KINEKVLQVL  TNIFLYHDFS  VQNFIKGLQL  SLLEHFYSQP  LSVLCCNLPE  AKRRINFLSN  360
361   NQCENIRRLP  SFRRYVEKQA  SEKQVALLTN  ERYLKEETQL  LLENLHVYHM  NYFLVLRCLH  420
421   KFTSSLPKYP  LGRQIRELYC  TCLEKNIWDS  EEYASVLQLL  RMLAKDELMT  ILEKCFKVFK  480
481   SYCENHLGST  AKRIEEFLAQ  FQSLDAETKE  EEDASGSQPK  GLQKTDLYHL  QKSLLEMKEL  540
541   RRSKKQTKFE  VLRENVVNFI  DCLVREYLLP  PETQPLHEVV  YFSAAHALRE  HLNAAPRIAL  600
601   HTALNNPYYY  LKNEALKSEE  GCIPNIAPDI  CIAYKLHLEC  SRLINLVDWS  EAFATVVTAA  660
661   EKMDANSATS  EEMNEIIHAR  FIRAVSELEL  LGFIKPTKQK  TDHVARLTWG  GC  712
Nucleotide CDS Sequence (FASTA)
1     ATGGCTACGT  CCTCGATGTC  TAAGGGTTGC  TTTGTTTTTA  AGCCAAACTC  CAAAAAGAGA  60
61    AAGATCTCTC  TGCCAATAGA  GGACTATTTT  AACAAAGGGA  AAAATGAGCC  TGAGGACAGT  120
121   AAGCTTCGAT  TCGAAACTTA  TCAGTTGATA  TGGCAGCAGA  TGAAATCTGA  AAATGAGCGA  180
181   CTACAAGAGG  AATTAAATAA  AAACTTGTTT  GACAATCTGA  TTGAATTTCT  GCAAAAATCA  240
241   CATTCTGGAT  TCCAGAAGAA  TTCAAGAGAC  TTGGGCGGTC  AAATAAAACT  CAGAGAAATT  300
301   CCAACTGCTG  CTCTTGTTCT  TGGTGTGAAT  GTCACAGATC  ATGATTTGAC  ATTCGGAAGT  360
361   CTAACAGAGG  CCCTTCAGAA  TAATGTCACA  CCATATGTAG  TCTCATTGCA  AGCTAAAGAT  420
421   TGTCCAGATA  TGAAACATTT  TTTGCAAAAG  TTGATCTCAC  AGTTGATGGA  CTGCTGTGTA  480
481   GATATAAAAT  CCAAAGAGGA  GGAAAGTGTT  CACGTCACCC  AAAGAAAGAC  ACATTATTCA  540
541   ATGGATTCAC  TTTCCAGTTG  GTATATGACT  GTCACACAGA  AGACGGACCC  AAAAATGCTA  600
601   AGCAAAAAAA  GGACTACTTC  TAGCCAATGG  CAGTCTCCTC  CTGTTGTCGT  TATCTTGAAG  660
661   GATATGGAAA  GCTTTGCCAC  AAAAGTACTA  CAAGACTTCA  TAATTATCAG  CAGTCAACAT  720
721   CTCCATGAAT  TTCCACTAAT  ACTCATTTTT  GGAATAGCCA  CATCTCCTAT  TATCATCCAC  780
781   CGATTGCTTC  CTCATGCAGT  ATCATCTCTA  TTGTGCATAG  AACTGTTCCA  ATCTTTGTCT  840
841   TGTAAGGAGC  ACCTGACTAC  GGTACTCGAT  AAGCTACTTC  TTACAACTCA  GTTTCCCTTT  900
901   AAAATAAATG  AAAAAGTATT  ACAGGTTCTG  ACCAACATCT  TTTTGTATCA  TGATTTCTCA  960
961   GTTCAAAACT  TTATAAAAGG  ACTTCAGCTT  TCTCTATTAG  AGCATTTCTA  TTCCCAGCCC  1020
1021  TTAAGTGTCC  TGTGCTGTAA  TCTTCCAGAA  GCCAAAAGAA  GAATAAATTT  TTTATCAAAT  1080
1081  AATCAATGTG  AAAACATCCG  ACGTCTACCA  TCTTTTAGGA  GGTACGTGGA  AAAGCAAGCT  1140
1141  TCAGAAAAGC  AAGTTGCGCT  CTTGACCAAT  GAGAGATATT  TGAAGGAGGA  AACACAATTA  1200
1201  TTACTAGAAA  ACCTGCATGT  TTATCATATG  AATTACTTCC  TGGTTTTGAG  ATGTCTTCAT  1260
1261  AAGTTCACCT  CTTCTCTTCC  CAAGTATCCA  CTAGGTCGAC  AGATCAGAGA  GTTGTACTGT  1320
1321  ACATGTTTAG  AAAAGAACAT  ATGGGATTCA  GAGGAGTATG  CATCAGTCTT  GCAGCTGCTG  1380
1381  AGGATGTTGG  CAAAGGATGA  ACTGATGACC  ATACTTGAGA  AATGTTTCAA  GGTTTTTAAG  1440
1441  TCTTATTGTG  AAAACCACCT  TGGCAGCACA  GCTAAGAGAA  TAGAGGAGTT  CCTGGCCCAG  1500
1501  TTTCAGAGCC  TCGATGCAGA  AACCAAAGAG  GAAGAAGATG  CTTCTGGGTC  ACAGCCAAAG  1560
1561  GGGCTTCAGA  AGACAGACCT  CTATCATCTT  CAGAAGTCCT  TATTGGAAAT  GAAGGAGTTA  1620
1621  AGAAGAAGTA  AGAAGCAAAC  CAAATTTGAA  GTACTCAGAG  AAAATGTTGT  GAACTTCATT  1680
1681  GACTGTCTAG  TGAGAGAATA  CCTTCTGCCT  CCTGAGACAC  AGCCTCTCCA  TGAGGTGGTG  1740
1741  TACTTCAGTG  CTGCCCATGC  CCTTCGTGAG  CATTTAAATG  CTGCTCCGCG  AATTGCCCTC  1800
1801  CATACTGCAC  TCAACAATCC  TTACTATTAT  CTCAAGAATG  AAGCACTGAA  AAGCGAAGAA  1860
1861  GGCTGCATTC  CGAATATCGC  CCCAGACATC  TGCATAGCAT  ACAAACTGCA  CCTAGAGTGT  1920
1921  AGCAGGCTCA  TCAACCTCGT  GGACTGGTCA  GAGGCTTTTG  CAACAGTTGT  GACAGCTGCT  1980
1981  GAAAAAATGG  ATGCAAATTC  TGCAACCTCA  GAAGAAATGA  ATGAAATTAT  CCATGCTCGG  2040
2041  TTTATTAGAG  CTGTTTCTGA  ACTAGAACTT  TTAGGATTTA  TAAAACCTAC  CAAACAGAAG  2100
2101  ACTGACCATG  TGGCAAGACT  AACATGGGGA  GGCTGCTAG  2139

▼ KEYWORD

ID
Family
3D-structure
Alternative splicing
Complete proteome
DNA replication
DNA-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
DNA replication preinitiation complex
Cellular Component
Nuclear body
Cellular Component
Nuclear chromosome, telomeric region
Cellular Component
Nuclear origin of replication recognition complex
Cellular Component
Nuclear pre-replicative complex
Cellular Component
Nucleoplasm
Cellular Component
Origin recognition complex
Molecular Function
DNA replication origin binding
Biological Process
DNA replication
Biological Process
DNA replication initiation
Biological Process
G1/S transition of mitotic cell cycle
Biological Process
Neural precursor cell proliferation
Biological Process
Pre-replicative complex assembly involved in nuclear cell cycle DNA replication

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pap-1196Pan paniscus99.580.01425
LLPS-Gog-3532Gorilla gorilla99.540.01313
LLPS-Pat-3528Pan troglodytes99.440.01424
LLPS-Poa-0145Pongo abelii98.310.01418
LLPS-Nol-4663Nomascus leucogenys98.070.01123
LLPS-Maf-4531Macaca fascicularis97.470.01406
LLPS-Chs-1333Chlorocebus sabaeus97.470.01403
LLPS-Mam-4608Macaca mulatta97.330.01404
LLPS-Man-4527Macaca nemestrina97.050.01401
LLPS-Paa-2782Papio anubis96.620.01324
LLPS-Aon-1059Aotus nancymaae96.210.01386
LLPS-Caj-1711Callithrix jacchus95.790.01379
LLPS-Cea-3619Cercocebus atys95.20.01357
LLPS-Rhb-2148Rhinopithecus bieti94.030.0 712
LLPS-Cas-2332Carlito syrichta90.880.01313
LLPS-Ict-2439Ictidomys tridecemlineatus90.640.01302
LLPS-Fec-1064Felis catus90.320.01295
LLPS-Orc-1312Oryctolagus cuniculus90.320.01295
LLPS-Mup-3221Mustela putorius furo90.320.01293
LLPS-Caf-2683Canis familiaris90.20.01297
LLPS-Eqc-3210Equus caballus90.040.01288
LLPS-Sus-1740Sus scrofa89.760.01290
LLPS-Fud-0971Fukomys damarensis89.760.01296
LLPS-Urm-2470Ursus maritimus89.620.01287
LLPS-Loa-2088Loxodonta africana88.950.01256
LLPS-Mal-4234Mandrillus leucophaeus88.210.01228
LLPS-Myl-4266Myotis lucifugus88.10.01268
LLPS-Cap-0799Cavia porcellus88.080.01263
LLPS-Bot-1514Bos taurus87.660.01273
LLPS-Ova-2365Ovis aries87.130.01261
LLPS-Otg-1185Otolemur garnettii86.540.01167
LLPS-Aim-1791Ailuropoda melanoleuca86.510.01248
LLPS-Dio-3348Dipodomys ordii83.690.01162
LLPS-Ran-0935Rattus norvegicus82.610.01189
LLPS-Mum-1583Mus musculus79.920.01161
LLPS-Ora-2927Ornithorhynchus anatinus77.830.0 940
LLPS-Sah-3866Sarcophilus harrisii75.880.01068
LLPS-Mod-2819Monodelphis domestica74.830.01063
LLPS-Pes-0918Pelodiscus sinensis70.240.0 993
LLPS-Fia-3231Ficedula albicollis68.920.0 869
LLPS-Tag-1727Taeniopygia guttata66.760.0 927
LLPS-Gaga-2383Gallus gallus66.530.0 965
LLPS-Meg-2826Meleagris gallopavo66.250.0 967
LLPS-Anc-2622Anolis carolinensis66.010.0 937
LLPS-Anp-2853Anas platyrhynchos64.420.0 918
LLPS-Xet-2241Xenopus tropicalis62.430.0 848
LLPS-Lac-1959Latimeria chalumnae59.890.0 874
LLPS-Icp-4140Ictalurus punctatus55.170.0 789
LLPS-Scf-3401Scleropages formosus54.40.0 742
LLPS-Asm-3564Astyanax mexicanus54.110.0 777
LLPS-Pof-2366Poecilia formosa53.980.0 739
LLPS-Ten-0523Tetraodon nigroviridis53.870.0 759
LLPS-Orl-1758Oryzias latipes53.80.0 756
LLPS-Orn-2598Oreochromis niloticus53.60.0 763
LLPS-Xim-3367Xiphophorus maculatus53.590.0 734
LLPS-Scm-3999Scophthalmus maximus53.110.0 764
LLPS-Leo-2990Lepisosteus oculatus53.010.0 720
LLPS-Tar-2200Takifugu rubripes52.550.0 744
LLPS-Dar-1357Danio rerio51.890.0 724
LLPS-Scj-1287Schizosaccharomyces japonicus36.963e-0964.3
LLPS-Cis-1819Ciona savignyi34.92e-128 404
LLPS-Asf-1336Aspergillus flavus33.332e-1581.3
LLPS-Drm-1877Drosophila melanogaster32.146e-101 332
LLPS-Glm-2789Glycine max30.91e-1172.4
LLPS-Hea-1507Helianthus annuus30.531e-1378.6
LLPS-Viv-1647Vitis vinifera28.576e-1375.1
LLPS-Chc-0226Chondrus crispus28.426e-1479.7
LLPS-Mua-1683Musa acuminata28.223e-1274.3
LLPS-Asn-0037Aspergillus nidulans28.075e-1684.3
LLPS-Osl-0983Ostreococcus lucimarinus28.065e-1067.0
LLPS-Sot-1749Solanum tuberosum27.813e-1478.6
LLPS-Php-0603Physcomitrella patens27.782e-1275.1
LLPS-Asc-0466Aspergillus clavatus26.979e-24 107
LLPS-Hov-0677Hordeum vulgare26.524e-1067.4
LLPS-Sem-0645Selaginella moellendorffii25.413e-27 122
LLPS-Abg-0711Absidia glauca25.121e-51 196
LLPS-Fuo-0820Fusarium oxysporum24.841e-28 126
LLPS-Prp-2508Prunus persica24.791e-30 132
LLPS-Scs-0737Sclerotinia sclerotiorum24.711e-28 126
LLPS-Nef-0133Neosartorya fischeri24.475e-44 172
LLPS-Tum-1161Tuber melanosporum24.471e-49 189
LLPS-Cus-1988Cucumis sativus24.421e-30 133
LLPS-Thc-1890Theobroma cacao24.374e-31 134
LLPS-Bro-3059Brassica oleracea24.243e-25 115
LLPS-Asfu-0487Aspergillus fumigatus24.131e-43 171
LLPS-Asni-1578Aspergillus niger24.057e-28 123
LLPS-Phv-1549Phaseolus vulgaris23.791e-27 123
LLPS-Fus-1431Fusarium solani23.766e-34 142
LLPS-Coc-0293Corchorus capsularis23.689e-1478.6
LLPS-Mae-2386Manihot esculenta23.61e-1998.2
LLPS-Gor-1574Gossypium raimondii23.532e-32 137
LLPS-Via-1695Vigna angularis23.353e-27 122
LLPS-Met-2391Medicago truncatula23.262e-26 119
LLPS-Art-2512Arabidopsis thaliana23.184e-25 115
LLPS-Blg-0824Blumeria graminis23.141e-40 162
LLPS-Zyt-0158Zymoseptoria tritici23.146e-1789.0
LLPS-Phn-1403Phaeosphaeria nodorum23.119e-30 129
LLPS-Pyt-0738Pyrenophora teres23.085e-33 139
LLPS-Sol-0088Solanum lycopersicum23.042e-27 122
LLPS-Lem-0594Leptosphaeria maculans22.994e-35 145
LLPS-Brn-2357Brassica napus22.947e-25 114
LLPS-Scp-1328Schizosaccharomyces pombe22.914e-1480.5
LLPS-Tra-2098Triticum aestivum22.832e-22 106
LLPS-Dac-1946Daucus carota22.791e-30 132
LLPS-Nec-0853Neurospora crassa22.782e-36 150
LLPS-Sei-1356Setaria italica22.732e-27 122
LLPS-Mao-0990Magnaporthe oryzae22.717e-31 133
LLPS-Dos-0799Dothistroma septosporum22.661e-1790.9
LLPS-Trv-1589Trichoderma virens22.643e-34 144
LLPS-Sob-2138Sorghum bicolor22.582e-26 119
LLPS-Orp-1749Oryza punctata22.573e-28 125
LLPS-Trr-0587Trichoderma reesei22.571e-30 132
LLPS-Pytr-0229Pyrenophora triticirepentis22.449e-35 144
LLPS-Pot-1887Populus trichocarpa22.441e-26 120
LLPS-Orbr-1717Oryza brachyantha22.441e-27 123
LLPS-Org-1891Oryza glaberrima22.372e-27 122
LLPS-Vir-1748Vigna radiata22.363e-24 112
LLPS-Tru-2072Triticum urartu22.322e-21 103
LLPS-Brr-2314Brassica rapa22.36e-23 108
LLPS-Ors-0454Oryza sativa22.243e-26 119
LLPS-Aso-0979Aspergillus oryzae22.242e-33 141
LLPS-Ast-0570Aspergillus terreus22.162e-28 125
LLPS-Beb-1613Beauveria bassiana22.163e-25 115
LLPS-Lep-1140Leersia perrieri22.162e-22 107
LLPS-Orb-1743Oryza barthii22.099e-2098.6
LLPS-Yal-1269Yarrowia lipolytica22.053e-34 143
LLPS-Orr-1348Oryza rufipogon21.953e-1996.7
LLPS-Cogr-0066Colletotrichum graminicola21.951e-32 138
LLPS-Orgl-2154Oryza glumaepatula21.951e-1997.8
LLPS-Coo-0402Colletotrichum orbiculare21.935e-32 136
LLPS-Brd-1709Brachypodium distachyon21.866e-25 114
LLPS-Arl-0245Arabidopsis lyrata21.852e-23 110
LLPS-Gag-1364Gaeumannomyces graminis21.796e-23 108
LLPS-Map-0327Magnaporthe poae21.723e-1893.2
LLPS-Scc-0131Schizosaccharomyces cryophilus21.698e-1169.7
LLPS-Orni-2288Oryza nivara21.666e-1995.5
LLPS-Orm-0375Oryza meridionalis21.511e-23 110
LLPS-Cog-1126Colletotrichum gloeosporioides21.481e-32 139
LLPS-Amt-1571Amborella trichopoda21.215e-22 105
LLPS-Pug-0621Puccinia graminis20.93e-0861.2
LLPS-Ved-0879Verticillium dahliae20.476e-26 118
LLPS-Miv-0353Microbotryum violaceum20.141e-1481.6