LLPS-Hos-3985
SLC15A1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Solute carrier family 15 member 1; Intestinal H(+)/peptide cotransporter; Oligopeptide transporter, small intestine isoform; Peptide transporter 1
Gene Name: SLC15A1, PEPT1
Ensembl Gene: ENSG00000088386.16
Ensembl Protein: ENSP00000365686.4
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-bodyPredicted from orthologs(View)

▼ FUNCTION

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGMSKSHSFF  GYPLSIFFIV  VNEFCERFSY  YGMRAILILY  FTNFISWDDN  LSTAIYHTFV  60
61    ALCYLTPILG  ALIADSWLGK  FKTIVSLSIV  YTIGQAVTSV  SSINDLTDHN  HDGTPDSLPV  120
121   HVVLSLIGLA  LIALGTGGIK  PCVSAFGGDQ  FEEGQEKQRN  RFFSIFYLAI  NAGSLLSTII  180
181   TPMLRVQQCG  IHSKQACYPL  AFGVPAALMA  VALIVFVLGS  GMYKKFKPQG  NIMGKVAKCI  240
241   GFAIKNRFRH  RSKAFPKREH  WLDWAKEKYD  ERLISQIKMV  TRVMFLYIPL  PMFWALFDQQ  300
301   GSRWTLQATT  MSGKIGALEI  QPDQMQTVNA  ILIVIMVPIF  DAVLYPLIAK  CGFNFTSLKK  360
361   MAVGMVLASM  AFVVAAIVQV  EIDKTLPVFP  KGNEVQIKVL  NIGNNTMNIS  LPGEMVTLGP  420
421   MSQTNAFMTF  DVNKLTRINI  SSPGSPVTAV  TDDFKQGQRH  TLLVWAPNHY  QVVKDGLNQK  480
481   PEKGENGIRF  VNTFNELITI  TMSGKVYANI  SSYNASTYQF  FPSGIKGFTI  SSTEIPPQCQ  540
541   PNFNTFYLEF  GSAYTYIVQR  KNDSCPEVKV  FEDISANTVN  MALQIPQYFL  LTCGEVVFSV  600
601   TGLEFSYSQA  PSNMKSVLQA  GWLLTVAVGN  IIVLIVAGAG  QFSKQWAEYI  LFAALLLVVC  660
661   VIFAIMARFY  TYINPAEIEA  QFDEDEKKNR  LEKSNPYFMS  GANSQKQM  708
Nucleotide CDS Sequence (FASTA)
1     ATGGGAATGT  CCAAATCACA  CAGTTTCTTT  GGTTATCCCC  TGAGCATCTT  CTTCATCGTG  60
61    GTCAATGAGT  TTTGCGAAAG  ATTTTCCTAC  TATGGAATGC  GAGCAATCCT  GATTCTGTAC  120
121   TTCACAAATT  TCATCAGCTG  GGATGATAAC  CTGTCCACCG  CCATCTACCA  TACGTTTGTG  180
181   GCTCTGTGCT  ACCTGACGCC  AATTCTCGGA  GCTCTTATCG  CCGACTCGTG  GCTGGGAAAG  240
241   TTCAAGACCA  TTGTGTCGCT  CTCCATTGTC  TACACAATTG  GACAAGCAGT  CACCTCAGTA  300
301   AGCTCCATTA  ATGACCTCAC  AGACCACAAC  CATGATGGCA  CCCCCGACAG  CCTTCCTGTG  360
361   CACGTGGTGC  TGTCCTTGAT  CGGCCTGGCC  CTGATAGCTC  TCGGGACTGG  AGGAATCAAA  420
421   CCCTGTGTGT  CTGCGTTTGG  TGGAGATCAG  TTTGAAGAGG  GCCAGGAGAA  ACAAAGAAAC  480
481   AGATTTTTTT  CCATCTTTTA  CTTGGCTATT  AATGCTGGAA  GTTTGCTTTC  CACAATCATC  540
541   ACACCCATGC  TCAGAGTTCA  ACAATGTGGA  ATTCACAGTA  AACAAGCTTG  TTACCCACTG  600
601   GCCTTTGGGG  TTCCTGCTGC  TCTCATGGCT  GTAGCCCTGA  TTGTGTTTGT  CCTTGGCAGT  660
661   GGGATGTACA  AGAAGTTCAA  GCCACAGGGC  AACATCATGG  GTAAAGTGGC  CAAGTGCATC  720
721   GGTTTTGCCA  TCAAAAATAG  ATTTAGGCAT  CGGAGTAAGG  CATTTCCCAA  GAGGGAGCAC  780
781   TGGCTGGACT  GGGCTAAAGA  GAAATACGAT  GAGCGGCTCA  TCTCCCAAAT  TAAGATGGTT  840
841   ACGAGGGTGA  TGTTCCTGTA  TATTCCACTC  CCAATGTTCT  GGGCCTTGTT  TGACCAGCAG  900
901   GGCTCCAGGT  GGACACTGCA  GGCAACAACT  ATGTCCGGGA  AAATCGGAGC  TCTTGAAATT  960
961   CAGCCCGATC  AGATGCAGAC  CGTGAACGCC  ATCCTGATCG  TGATCATGGT  CCCGATCTTC  1020
1021  GATGCTGTGC  TGTACCCTCT  CATTGCAAAA  TGTGGCTTCA  ATTTCACCTC  CTTGAAGAAG  1080
1081  ATGGCAGTTG  GCATGGTCCT  GGCCTCCATG  GCCTTTGTGG  TGGCTGCCAT  CGTGCAGGTG  1140
1141  GAAATCGATA  AAACTCTTCC  AGTCTTCCCC  AAAGGAAACG  AAGTCCAAAT  TAAAGTTTTG  1200
1201  AATATAGGAA  ACAATACCAT  GAATATATCT  CTTCCTGGAG  AGATGGTGAC  ACTTGGCCCA  1260
1261  ATGTCTCAAA  CAAATGCATT  TATGACTTTT  GATGTAAACA  AACTGACAAG  GATAAACATT  1320
1321  TCTTCTCCTG  GATCACCAGT  CACTGCTGTA  ACTGACGACT  TCAAGCAGGG  CCAACGCCAC  1380
1381  ACGCTTCTAG  TGTGGGCCCC  CAATCACTAC  CAGGTGGTAA  AGGATGGTCT  TAACCAGAAG  1440
1441  CCAGAAAAAG  GGGAAAATGG  AATCAGATTT  GTAAATACTT  TTAACGAGCT  CATCACCATC  1500
1501  ACAATGAGTG  GGAAAGTTTA  TGCAAACATC  AGCAGCTACA  ATGCCAGCAC  ATACCAGTTT  1560
1561  TTTCCTTCTG  GCATAAAAGG  CTTCACAATA  AGCTCAACAG  AGATTCCGCC  ACAATGTCAA  1620
1621  CCTAATTTCA  ATACTTTCTA  CCTTGAATTT  GGTAGTGCTT  ATACCTATAT  AGTCCAAAGG  1680
1681  AAGAATGACA  GCTGCCCTGA  AGTGAAGGTG  TTTGAAGATA  TTTCAGCCAA  CACAGTTAAC  1740
1741  ATGGCTCTGC  AAATCCCGCA  GTATTTTCTT  CTCACCTGTG  GCGAAGTGGT  CTTCTCTGTC  1800
1801  ACGGGATTGG  AATTCTCATA  TTCTCAGGCT  CCTTCCAACA  TGAAGTCGGT  GCTTCAGGCA  1860
1861  GGATGGCTGC  TGACCGTGGC  TGTTGGCAAC  ATCATTGTGC  TCATCGTGGC  AGGGGCAGGC  1920
1921  CAGTTCAGCA  AACAGTGGGC  CGAGTACATT  CTATTTGCCG  CGTTGCTTCT  GGTCGTCTGT  1980
1981  GTAATTTTTG  CCATCATGGC  TCGGTTCTAT  ACTTACATCA  ACCCAGCGGA  GATCGAAGCT  2040
2041  CAATTTGATG  AGGATGAAAA  GAAAAACAGA  CTGGAAAAGA  GTAACCCATA  TTTCATGTCA  2100
2101  GGGGCCAATT  CACAGAAACA  GATGTGA  2127

▼ KEYWORD

ID
Family
Complete proteome
Glycoprotein
Membrane
Peptide transport
Polymorphism
Protein transport
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Brush border
Cellular Component
Integral component of membrane
Cellular Component
Integral component of plasma membrane
Cellular Component
Plasma membrane
Molecular Function
Dipeptide transmembrane transporter activity
Molecular Function
Oligopeptide transmembrane transporter activity
Molecular Function
Peptide transmembrane transporter activity
Molecular Function
Peptide:proton symporter activity
Molecular Function
Proton-dependent oligopeptide secondary active transmembrane transporter activity
Biological Process
Ion transport
Biological Process
Protein transport

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pap-3168Pan paniscus98.730.01417
LLPS-Pat-4267Pan troglodytes98.730.01416
LLPS-Gog-2493Gorilla gorilla98.020.01409
LLPS-Chs-3336Chlorocebus sabaeus92.560.01330
LLPS-Paa-3701Papio anubis91.960.01326
LLPS-Cea-0948Cercocebus atys90.830.01315
LLPS-Cap-3043Cavia porcellus82.50.01188
LLPS-Tut-2343Tursiops truncatus79.940.01139
LLPS-Mea-2202Mesocricetus auratus78.050.01083
LLPS-Dio-4327Dipodomys ordii75.250.01028
LLPS-Ora-2790Ornithorhynchus anatinus72.970.01007
LLPS-Sah-3828Sarcophilus harrisii70.640.01032
LLPS-Anp-0303Anas platyrhynchos67.260.0 904
LLPS-Pes-1446Pelodiscus sinensis65.410.0 909
LLPS-Gaga-3437Gallus gallus65.360.0 905
LLPS-Xet-3958Xenopus tropicalis64.970.0 860
LLPS-Meg-1414Meleagris gallopavo64.590.0 904
LLPS-Tag-1188Taeniopygia guttata64.370.0 864
LLPS-Dar-3453Danio rerio60.460.0 790
LLPS-Ten-1835Tetraodon nigroviridis59.220.0 817
LLPS-Gaa-2684Gasterosteus aculeatus58.90.0 800
LLPS-Tar-0159Takifugu rubripes57.470.0 749
LLPS-Lac-1285Latimeria chalumnae51.510.0 643
LLPS-Leo-0288Lepisosteus oculatus51.450.0 637
LLPS-Pof-2468Poecilia formosa51.010.0 611
LLPS-Orl-3800Oryzias latipes50.860.0 630
LLPS-Asm-3787Astyanax mexicanus50.650.0 624
LLPS-Scf-3395Scleropages formosus50.580.0 618
LLPS-Aon-2288Aotus nancymaae50.290.0 617
LLPS-Orn-3543Oreochromis niloticus50.00.0 617
LLPS-Caf-4347Canis familiaris50.00.0 612
LLPS-Orc-2263Oryctolagus cuniculus49.860.0 620
LLPS-Xim-1652Xiphophorus maculatus49.860.0 604
LLPS-Caj-0323Callithrix jacchus49.720.0 596
LLPS-Fud-0618Fukomys damarensis49.720.0 619
LLPS-Sus-4441Sus scrofa49.640.0 617
LLPS-Otg-1298Otolemur garnettii49.50.0 620
LLPS-Nol-2714Nomascus leucogenys49.430.0 606
LLPS-Fec-2969Felis catus49.360.0 611
LLPS-Aim-3176Ailuropoda melanoleuca49.290.0 611
LLPS-Ict-3704Ictidomys tridecemlineatus49.210.0 609
LLPS-Cis-0345Ciona savignyi49.161e-99 328
LLPS-Urm-2694Ursus maritimus49.140.0 605
LLPS-Mup-0522Mustela putorius furo49.140.0 609
LLPS-Eqc-3398Equus caballus49.080.0 639
LLPS-Poa-3929Pongo abelii48.930.0 617
LLPS-Ova-0839Ovis aries48.790.0 614
LLPS-Drm-2161Drosophila melanogaster48.556e-93 312
LLPS-Bot-2371Bos taurus48.510.0 609
LLPS-Myl-3041Myotis lucifugus48.410.0 608
LLPS-Mum-4539Mus musculus48.360.0 611
LLPS-Ran-3635Rattus norvegicus48.360.0 606
LLPS-Mod-3835Monodelphis domestica47.650.0 585
LLPS-Cas-2987Carlito syrichta47.023e-171 511
LLPS-Cii-1320Ciona intestinalis36.588e-134 417
LLPS-Cae-0307Caenorhabditis elegans35.236e-114 366
LLPS-Phn-1352Phaeosphaeria nodorum31.913e-0655.1
LLPS-Art-2288Arabidopsis thaliana30.435e-39 156
LLPS-Brn-1741Brassica napus30.431e-37 152
LLPS-Orr-2431Oryza rufipogon30.142e-38 155
LLPS-Sei-2321Setaria italica30.142e-39 157
LLPS-Arl-2537Arabidopsis lyrata29.981e-38 155
LLPS-Coc-1119Corchorus capsularis29.347e-1376.3
LLPS-Prp-1801Prunus persica28.854e-40 159
LLPS-Ors-0173Oryza sativa28.54e-38 154
LLPS-Org-0921Oryza glaberrima28.54e-38 154
LLPS-Ori-1791Oryza indica28.54e-38 154
LLPS-Orb-1753Oryza barthii28.54e-38 154
LLPS-Orni-2105Oryza nivara28.54e-38 154
LLPS-Orgl-2295Oryza glumaepatula28.54e-38 154
LLPS-Hov-0202Hordeum vulgare28.56e-40 159
LLPS-Orm-1345Oryza meridionalis28.411e-38 155
LLPS-Tru-1336Triticum urartu28.378e-40 158
LLPS-Tra-2627Triticum aestivum28.378e-40 158
LLPS-Zem-1950Zea mays28.341e-39 158
LLPS-Sob-1495Sorghum bicolor28.11e-39 158
LLPS-Orp-1644Oryza punctata28.049e-38 152
LLPS-Orbr-2159Oryza brachyantha27.81e-37 152
LLPS-Brd-1502Brachypodium distachyon27.594e-33 139
LLPS-Brr-2696Brassica rapa27.231e-31 134
LLPS-Bro-0294Brassica oleracea27.232e-31 134
LLPS-Amt-0922Amborella trichopoda27.015e-37 150