LLPS-Hos-3541
ISY1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Pre-mRNA-splicing factor ISY1 homolog
Gene Name: ISY1, KIAA1160
Ensembl Gene: ENSG00000261796.1
Ensembl Protein: ENSP00000411822.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nuclear speckle, NucleolusPredicted from orthologs(View)

▼ FUNCTION

May play a role in pre-mRNA splicing as component of the spliceosome.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MARNAEKAMT  ALARFRQAQL  EEGKVKERRP  FLASECTELP  KAEKWRRQII  GEISKKVAQI  60
61    QNAGLGEFRI  RDLNDEINKL  LREKGHWEVR  IKELGGPDYG  KVGPKMLDHE  GKEVPGNRGY  120
121   KYFGAAKDLP  GVRELFEKEP  LPPPRKTRAE  LMKAIDFEYY  GYLDEDDGVI  VPLEQEYEKK  180
181   LRAELVEKWK  AEREARLARG  EKEEEEEEEE  EINIYAVTEE  ESDEEGSQEK  GGDDSQQKFI  240
241   AHVPVPSQQE  IEEALVRRKK  MELLQKYASE  TLQAQSEEAR  RLLGCRSGTR  PARSGSAPSP  300
301   RATTAVPMGP  SLPTTSPRGA  PSCRCLTGLR  M  331
Nucleotide CDS Sequence (FASTA)
1     ATGGCCCGAA  ATGCAGAAAA  GGCCATGACG  GCCTTAGCAA  GATTTCGCCA  GGCTCAGCTG  60
61    GAAGAGGGAA  AAGTGAAGGA  ACGAAGACCC  TTTCTGGCCT  CAGAATGTAC  TGAACTGCCT  120
121   AAAGCTGAGA  AGTGGAGACG  ACAGATCATT  GGAGAGATCT  CTAAAAAAGT  GGCTCAGATT  180
181   CAGAATGCTG  GTTTAGGTGA  ATTTCGAATT  CGTGACCTGA  ATGATGAAAT  TAACAAGCTG  240
241   CTAAGGGAGA  AAGGACACTG  GGAGGTCCGG  ATAAAGGAGC  TGGGAGGTCC  TGATTATGGA  300
301   AAAGTTGGCC  CTAAAATGCT  GGATCATGAA  GGAAAAGAAG  TCCCAGGAAA  CCGAGGTTAC  360
361   AAGTACTTTG  GAGCAGCAAA  AGATTTGCCT  GGTGTTAGAG  AGCTGTTTGA  AAAAGAACCT  420
421   CTTCCTCCTC  CCAGAAAGAC  ACGTGCTGAG  CTCATGAAGG  CAATCGATTT  TGAGTACTAT  480
481   GGTTACCTAG  ATGAAGATGA  TGGTGTTATT  GTGCCTTTGG  AACAGGAATA  TGAAAAGAAA  540
541   CTCAGAGCCG  AGTTAGTGGA  AAAGTGGAAA  GCAGAGAGAG  AGGCTCGGCT  GGCAAGAGGA  600
601   GAAAAGGAAG  AGGAGGAGGA  AGAGGAGGAA  GAGATCAACA  TCTATGCAGT  CACCGAGGAG  660
661   GAGTCGGACG  AGGAAGGCAG  CCAGGAGAAA  GGAGGGGACG  ACAGCCAGCA  GAAGTTCATT  720
721   GCTCACGTCC  CTGTTCCCTC  GCAGCAAGAG  ATTGAGGAGG  CACTGGTGCG  AAGGAAGAAA  780
781   ATGGAACTCC  TCCAGAAGTA  TGCAAGCGAG  ACCCTGCAGG  CCCAAAGTGA  AGAAGCCAGA  840
841   AGGCTCCTGG  GCTGCAGATC  TGGGACACGG  CCGGCCAGGA  GCGGTTCCGC  ACCATCACCC  900
901   AGAGCTACTA  CCGCAGTGCC  AATGGGGCCA  TCCTTGCCTA  CGACATCACC  AAGAGGAGCT  960
961   CCTTCCTGTC  GGTGCCTCAC  TGGATTGAGG  ATGTGA  996

▼ KEYWORD

ID
Family
3D-structure
Acetylation
Alternative splicing
Complete proteome
mRNA processing
mRNA splicing
Nucleus
Phosphoprotein
Reference proteome
Spliceosome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Catalytic step 2 spliceosome
Cellular Component
Nucleoplasm
Cellular Component
Post-mRNA release spliceosomal complex
Cellular Component
Post-spliceosomal complex
Cellular Component
Prp19 complex
Molecular Function
RNA binding
Biological Process
Generation of catalytic spliceosome for second transesterification step
Biological Process
MRNA 3'-splice site recognition
Biological Process
MRNA splicing, via spliceosome
Biological Process
Transcription-coupled nucleotide-excision repair

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Poa-2591Pongo abelii99.658e-164 466
LLPS-Mal-1500Mandrillus leucophaeus99.658e-164 466
LLPS-Maf-1096Macaca fascicularis99.658e-164 466
LLPS-Chs-2628Chlorocebus sabaeus99.658e-164 466
LLPS-Cea-2996Cercocebus atys99.658e-164 466
LLPS-Paa-0960Papio anubis99.38e-164 466
LLPS-Otg-3892Otolemur garnettii99.292e-162 462
LLPS-Cas-2585Carlito syrichta98.945e-163 464
LLPS-Caj-1016Callithrix jacchus98.941e-162 463
LLPS-Eqc-1192Equus caballus98.881e-151 436
LLPS-Pap-0057Pan paniscus98.854e-143 413
LLPS-Mam-1393Macaca mulatta98.790.0 558
LLPS-Cap-3796Cavia porcellus98.592e-163 464
LLPS-Aon-2979Aotus nancymaae98.413e-140 406
LLPS-Caf-2372Canis familiaris98.241e-161 460
LLPS-Orc-1657Oryctolagus cuniculus98.243e-163 464
LLPS-Mum-1088Mus musculus98.242e-163 464
LLPS-Fec-1265Felis catus98.182e-152 441
LLPS-Mea-0167Mesocricetus auratus97.545e-162 461
LLPS-Xet-0766Xenopus tropicalis96.929e-86 261
LLPS-Dio-0064Dipodomys ordii96.741e-154 442
LLPS-Ict-0443Ictidomys tridecemlineatus96.482e-161 460
LLPS-Aim-2294Ailuropoda melanoleuca95.450.0 532
LLPS-Ran-2520Rattus norvegicus93.662e-161 460
LLPS-Sus-1844Sus scrofa93.663e-161 459
LLPS-Myl-2792Myotis lucifugus92.932e-149 429
LLPS-Gog-0057Gorilla gorilla92.481e-157 451
LLPS-Nol-3251Nomascus leucogenys92.162e-157 450
LLPS-Pat-1892Pan troglodytes92.167e-157 449
LLPS-Bot-0395Bos taurus91.236e-161 458
LLPS-Fud-3852Fukomys damarensis90.975e-153 439
LLPS-Tag-0723Taeniopygia guttata90.03e-118 348
LLPS-Tut-1481Tursiops truncatus89.751e-154 442
LLPS-Mup-0473Mustela putorius furo88.383e-136 396
LLPS-Mod-2211Monodelphis domestica88.034e-153 439
LLPS-Sah-2267Sarcophilus harrisii88.034e-153 439
LLPS-Tar-0956Takifugu rubripes87.782e-112 331
LLPS-Ova-0765Ovis aries87.686e-157 449
LLPS-Loa-0536Loxodonta africana87.282e-130 380
LLPS-Pes-1540Pelodiscus sinensis85.961e-147 424
LLPS-Man-0518Macaca nemestrina85.673e-133 389
LLPS-Rhb-1286Rhinopithecus bieti85.562e-124 364
LLPS-Lac-1556Latimeria chalumnae85.264e-148 426
LLPS-Anc-1726Anolis carolinensis84.944e-131 382
LLPS-Fia-0300Ficedula albicollis84.919e-148 425
LLPS-Meg-1084Meleagris gallopavo83.451e-146 422
LLPS-Orn-1218Oreochromis niloticus83.425e-108 322
LLPS-Gaga-2359Gallus gallus83.167e-150 430
LLPS-Asm-0558Astyanax mexicanus82.461e-147 425
LLPS-Scf-0270Scleropages formosus82.178e-147 422
LLPS-Icp-0593Ictalurus punctatus81.49e-144 415
LLPS-Dar-0217Danio rerio80.75e-145 418
LLPS-Scm-1298Scophthalmus maximus76.493e-137 398
LLPS-Gaa-0973Gasterosteus aculeatus75.445e-135 392
LLPS-Xim-2330Xiphophorus maculatus74.92e-115 344
LLPS-Orl-3066Oryzias latipes74.656e-134 390
LLPS-Leo-0743Lepisosteus oculatus73.96e-137 399
LLPS-Anp-0319Anas platyrhynchos72.826e-119 351
LLPS-Ora-0210Ornithorhynchus anatinus71.291e-118 351
LLPS-Ten-0408Tetraodon nigroviridis69.552e-126 370
LLPS-Pof-0702Poecilia formosa65.562e-61 200
LLPS-Cii-1292Ciona intestinalis63.381e-109 327
LLPS-Vir-1166Vigna radiata62.187e-47 162
LLPS-Bro-1709Brassica oleracea60.998e-63 208
LLPS-Brr-1012Brassica rapa60.991e-62 207
LLPS-Brn-0694Brassica napus60.998e-63 207
LLPS-Cis-0624Ciona savignyi60.43e-110 330
LLPS-Drm-2252Drosophila melanogaster60.154e-101 305
LLPS-Mae-2010Manihot esculenta59.691e-63 210
LLPS-Mel-0315Melampsora laricipopulina58.571e-47 169
LLPS-Zem-0681Zea mays56.574e-61 204
LLPS-Sob-0557Sorghum bicolor56.572e-61 204
LLPS-Sei-1312Setaria italica56.572e-61 205
LLPS-Brd-2313Brachypodium distachyon56.571e-61 205
LLPS-Orbr-1697Oryza brachyantha56.065e-61 204
LLPS-Lep-0380Leersia perrieri56.066e-61 204
LLPS-Orr-0976Oryza rufipogon55.563e-60 202
LLPS-Org-1083Oryza glaberrima55.563e-60 202
LLPS-Ors-0356Oryza sativa55.563e-60 202
LLPS-Orp-0926Oryza punctata55.563e-60 202
LLPS-Orgl-1844Oryza glumaepatula55.563e-60 202
LLPS-Tra-0935Triticum aestivum55.561e-59 200
LLPS-Orb-0736Oryza barthii55.563e-60 202
LLPS-Ori-0674Oryza indica55.563e-60 202
LLPS-Orni-1462Oryza nivara55.563e-60 202
LLPS-Abg-1077Absidia glauca55.51e-64 210
LLPS-Hov-0966Hordeum vulgare54.553e-57 194
LLPS-Tru-0183Triticum urartu54.143e-42 153
LLPS-Map-1022Magnaporthe poae52.464e-0959.3
LLPS-Put-0930Puccinia triticina51.913e-34 134
LLPS-Gas-1231Galdieria sulphuraria51.552e-56 191
LLPS-Usm-0555Ustilago maydis51.389e-45 162
LLPS-Pytr-0757Pyrenophora triticirepentis51.056e-53 181
LLPS-Cog-0369Colletotrichum gloeosporioides50.852e-49 171
LLPS-Gor-0906Gossypium raimondii50.843e-71 230
LLPS-Pyt-0695Pyrenophora teres50.531e-52 180
LLPS-Coc-0733Corchorus capsularis50.172e-69 225
LLPS-Nia-2076Nicotiana attenuata50.172e-70 228
LLPS-Phn-0961Phaeosphaeria nodorum50.08e-51 177
LLPS-Thc-2348Theobroma cacao49.836e-68 221
LLPS-Cogr-0541Colletotrichum graminicola49.465e-50 173
LLPS-Lem-0720Leptosphaeria maculans49.245e-53 181
LLPS-Scs-0739Sclerotinia sclerotiorum49.244e-54 184
LLPS-Sot-0934Solanum tuberosum48.991e-69 226
LLPS-Miv-1056Microbotryum violaceum48.942e-46 166
LLPS-Coo-1037Colletotrichum orbiculare48.861e-46 164
LLPS-Nec-1213Neurospora crassa48.693e-49 171
LLPS-Arl-0983Arabidopsis lyrata48.663e-72 233
LLPS-Spr-0328Sporisorium reilianum48.593e-42 155
LLPS-Sol-1509Solanum lycopersicum48.51e-69 226
LLPS-Phv-1245Phaseolus vulgaris48.493e-66 217
LLPS-Amt-1258Amborella trichopoda48.476e-70 226
LLPS-Beb-1356Beauveria bassiana48.442e-40 147
LLPS-Chr-0884Chlamydomonas reinhardtii48.442e-76 243
LLPS-Zyt-0567Zymoseptoria tritici48.41e-50 174
LLPS-Cus-0682Cucumis sativus48.347e-69 224
LLPS-Glm-0990Glycine max48.161e-71 231
LLPS-Mua-1128Musa acuminata48.142e-61 211
LLPS-Art-0745Arabidopsis thaliana47.991e-70 228
LLPS-Php-1154Physcomitrella patens47.775e-77 244
LLPS-Blg-0691Blumeria graminis47.474e-51 176
LLPS-Dos-0539Dothistroma septosporum47.347e-48 167
LLPS-Prp-1081Prunus persica47.331e-63 211
LLPS-Tum-1219Tuber melanosporum47.228e-49 169
LLPS-Viv-0604Vitis vinifera47.142e-66 217
LLPS-Hea-2365Helianthus annuus47.143e-65 214
LLPS-Cae-0996Caenorhabditis elegans47.046e-63 207
LLPS-Dac-1371Daucus carota46.941e-67 220
LLPS-Pot-0490Populus trichocarpa46.842e-64 213
LLPS-Mao-0735Magnaporthe oryzae46.772e-46 164
LLPS-Trv-0787Trichoderma virens45.861e-40 148
LLPS-Met-1080Medicago truncatula45.851e-64 213
LLPS-Fuo-0139Fusarium oxysporum45.648e-48 167
LLPS-Fuv-0381Fusarium verticillioides45.642e-47 166
LLPS-Crn-0296Cryptococcus neoformans45.361e-43 159
LLPS-Ved-1043Verticillium dahliae45.03e-45 160
LLPS-Fus-0433Fusarium solani44.167e-41 149
LLPS-Ast-1437Aspergillus terreus43.885e-44 157
LLPS-Trr-0823Trichoderma reesei43.371e-40 148
LLPS-Nef-1599Neosartorya fischeri43.153e-42 153
LLPS-Scj-0947Schizosaccharomyces japonicus42.862e-34 131
LLPS-Gag-0122Gaeumannomyces graminis42.862e-36 137
LLPS-Asn-0535Aspergillus nidulans42.512e-40 148
LLPS-Asni-0885Aspergillus niger42.423e-42 153
LLPS-Aso-0971Aspergillus oryzae41.953e-42 153
LLPS-Asf-1055Aspergillus flavus41.953e-42 153
LLPS-Asc-0496Aspergillus clavatus41.945e-37 139
LLPS-Sem-1744Selaginella moellendorffii41.814e-62 206
LLPS-Asfu-0377Aspergillus fumigatus41.719e-37 138
LLPS-Scp-1339Schizosaccharomyces pombe41.262e-29 117
LLPS-Osl-0782Ostreococcus lucimarinus40.551e-59 199
LLPS-Kop-1095Komagataella pastoris40.153e-25 107
LLPS-Via-0766Vigna angularis39.635e-41 150
LLPS-Yal-0685Yarrowia lipolytica37.762e-35 134
LLPS-Scc-1023Schizosaccharomyces cryophilus36.694e-28 114
LLPS-Asg-0208Ashbya gossypii34.566e-1885.5
LLPS-Sac-1156Saccharomyces cerevisiae33.331e-1372.8