DrLLPS - Data resource of LLPS

Overview
Property
Classification
Function
Cross Reference
Sequence
GO
Annotation
Orthology
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LLPS-Hos-3498
CHMP1A

▼ OVERVIEW


Status:	Reviewed
Protein Name:	Charged multivesicular body protein 1a; Chromatin-modifying protein 1a; CHMP1a; Vacuolar protein sorting-associated protein 46-1; Vps46-1; hVps46-1
Gene Name:	CHMP1A, CHMP1, KIAA0047, PCOLN3, PRSM1
Ensembl Gene:	ENSG00000131165.14
Ensembl Protein:	ENSP00000449243.1
Organism:	Homo sapiens
Taxa ID:	9606
LLPS Type:	Client

PDB: 2JQ9 (A, B) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Postsynaptic density	"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."	Human cortex	23071613
Nucleolus	Predicted from orthologs	N/A	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Mus musculus	LLPS-Mum-0986	Q921W0	Client	Nucleolus, Postsynaptic density	97.45	7e-117	337

▼ FUNCTION

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENST00000550102.5	ENSP00000449243.1
Ensembl	ENST00000549328.1	ENSP00000447899.1
Ensembl	ENST00000397901.7	ENSP00000380998.3
Ensembl	ENST00000535997.6	ENSP00000442120.2
UniProt		Q9HD42, CHM1A_HUMAN, A2RU09, Q14468, Q15779, Q96G31
GeneBank	D38554, AC010538, BC010000, BT006841, AF281063, BC132711, BC132713, BC007527, U58048	AAC50775.1, AAI32712.1, AAP35487.1, AAG01448.1, AAH10000.2, BAA07557.1, AAI32714.1
RefSeq	NM_002768.4	NP_002759.2
Entrez	5119

▼ SEQUENCE

Protein Sequence (FASTA)
1 MDDTLFQLKF TAKQLEKLAK KAEKDSKAEQ AKVKKALLQK NVECARVYAE NAIRKKNEGV 60 61 NWLRMASRVD AVASKVQTAV TMKGVTKNMA QVTKALDKAL STMDLQKVSS VMDRFEQQVQ 120 121 NLDVHTSVME DSMSSATTLT TPQEQVDSLI MQIAEENGLE VLDQLSQLPE GASAVGESSV 180 181 RSQEDQLSRR LAALRN 196
Nucleotide CDS Sequence (FASTA)
1 ATGGACGATA CCCTGTTCCA GTTGAAGTTC ACGGCGAAGC AGCTGGAGAA GCTGGCCAAG 60 61 AAGGCGGAGA AGGACTCCAA GGCGGAGCAG GCCAAAGTGA AGAAGGCCCT TCTGCAGAAA 120 121 AATGTAGAGT GTGCCCGTGT GTATGCCGAG AACGCCATCC GCAAGAAGAA CGAAGGTGTG 180 181 AACTGGCTTC GGATGGCGTC CCGCGTAGAC GCAGTGGCCT CCAAGGTGCA GACAGCTGTG 240 241 ACTATGAAGG GGGTGACCAA GAATATGGCC CAGGTGACCA AAGCCCTGGA CAAGGCCCTG 300 301 AGCACCATGG ACCTGCAGAA GGTCTCCTCA GTGATGGACA GGTTCGAGCA GCAGGTGCAG 360 361 AACCTGGACG TCCATACATC GGTGATGGAG GACTCCATGA GCTCGGCCAC CACCCTGACC 420 421 ACGCCGCAGG AGCAGGTGGA CAGCCTCATC ATGCAGATCG CCGAGGAGAA TGGCCTGGAG 480 481 GTGCTGGACC AGCTCAGCCA GCTGCCCGAG GGCGCCTCTG CCGTGGGCGA GAGCTCTGTG 540 541 CGCAGCCAGG AGGACCAGCT GTCACGGAGG TTGGCCGCCT TGAGGAACTA G 591

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0007	Acetylation
KW-0025	Alternative splicing
KW-0131	Cell cycle
KW-0132	Cell division
KW-0175	Coiled coil
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0967	Endosome
KW-0472	Membrane
KW-0523	Neurodegeneration
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-0653	Protein transport
KW-1185	Reference proteome
KW-0678	Repressor
KW-0804	Transcription
KW-0805	Transcription regulation
KW-0813	Transport

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0000794	Cellular Component	Condensed nuclear chromosome
GO:0005769	Cellular Component	Early endosome
GO:0012505	Cellular Component	Endomembrane system
GO:0000815	Cellular Component	ESCRT III complex
GO:0070062	Cellular Component	Extracellular exosome
GO:0005815	Cellular Component	Microtubule organizing center
GO:0005771	Cellular Component	Multivesicular body
GO:0016363	Cellular Component	Nuclear matrix
GO:0042802	Molecular Function	Identical protein binding
GO:0008237	Molecular Function	Metallopeptidase activity
GO:0019904	Molecular Function	Protein domain specific binding
GO:0042803	Molecular Function	Protein homodimerization activity
GO:0008270	Molecular Function	Zinc ion binding
GO:0051301	Biological Process	Cell division
GO:0032509	Biological Process	Endosome transport via multivesicular body sorting pathway
GO:1904903	Biological Process	ESCRT III complex disassembly
GO:0016458	Biological Process	Gene silencing
GO:0045324	Biological Process	Late endosome to vacuole transport
GO:0061952	Biological Process	Midbody abscission
GO:0007076	Biological Process	Mitotic chromosome condensation
GO:0007080	Biological Process	Mitotic metaphase plate congression
GO:0036258	Biological Process	Multivesicular body assembly
GO:0045786	Biological Process	Negative regulation of cell cycle
GO:0045892	Biological Process	Negative regulation of transcription, DNA-templated
GO:0006997	Biological Process	Nucleus organization
GO:0015031	Biological Process	Protein transport
GO:0010824	Biological Process	Regulation of centrosome duplication
GO:1901673	Biological Process	Regulation of mitotic spindle assembly
GO:0016192	Biological Process	Vesicle-mediated transport
GO:0039702	Biological Process	Viral budding via host ESCRT complex

▼ KEGG

hsa:5119

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD
Gene3D

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	HPRD
BioGRID	mUbiSiDa

Variation
dbSNP	VarCards	rSNPBase

Mutation
TCGA	ICGC	CGAP	IntOGen	BioMuta

Interaction
HINT	InWeb_IM	RISE	RAIN	Mentha
PINA	IID	iRefIndex	MIST	DifferentialNET
RNAct

Disease
TumorFusions	OMIM	DisGeNET	ActiveDriverDB

Drug
CTD

Physicochemical
Compute pI/Mw	AAindex

Function
CGDB	PIRSF	CORUM	CellMarker	RaftProt

Proteomics
THPA	HPM

Structure
PDB	MMDB

Localization
COMPARTMENTS

Expression
TCGA	ICGC	COSMIC	GEO	ArrayExpress
TISSUES	BioXpress	THPA

Element
circBase	CircNet	miRWalk	miRcode	RAID
microRNA.org

Methylation
TCGA	ICGC	MethyCancer

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Poa-4148	Pongo abelii	100.0	6e-121	348
LLPS-Pat-0095	Pan troglodytes	100.0	9e-73	222
LLPS-Pap-4335	Pan paniscus	100.0	6e-121	348
LLPS-Gog-4357	Gorilla gorilla	100.0	5e-114	330
LLPS-Rhb-2736	Rhinopithecus bieti	99.49	9e-120	345
LLPS-Man-2019	Macaca nemestrina	99.49	9e-120	345
LLPS-Maf-1248	Macaca fascicularis	99.49	9e-120	345
LLPS-Chs-2709	Chlorocebus sabaeus	99.49	9e-120	345
LLPS-Cea-1074	Cercocebus atys	99.49	9e-120	345
LLPS-Mal-3209	Mandrillus leucophaeus	99.48	2e-117	338
LLPS-Mam-0820	Macaca mulatta	99.39	2e-113	328
LLPS-Cas-1781	Carlito syrichta	98.47	1e-118	342
LLPS-Caj-1684	Callithrix jacchus	98.47	1e-118	342
LLPS-Aon-2045	Aotus nancymaae	98.47	1e-118	342
LLPS-Cap-4641	Cavia porcellus	97.96	9e-119	342
LLPS-Fec-3857	Felis catus	97.96	5e-118	340
LLPS-Urm-1849	Ursus maritimus	97.94	3e-116	336
LLPS-Fud-3537	Fukomys damarensis	97.56	1e-111	323
LLPS-Ict-0144	Ictidomys tridecemlineatus	97.45	9e-117	337
LLPS-Caf-1272	Canis familiaris	97.45	9e-118	340
LLPS-Ran-3982	Rattus norvegicus	97.45	5e-117	338
LLPS-Mea-4425	Mesocricetus auratus	97.45	5e-117	338
LLPS-Mum-0986	Mus musculus	97.45	5e-117	338
LLPS-Loa-0919	Loxodonta africana	97.42	3e-115	333
LLPS-Aim-2932	Ailuropoda melanoleuca	97.42	1e-115	334
LLPS-Mup-0308	Mustela putorius furo	97.42	8e-116	335
LLPS-Paa-4771	Papio anubis	96.91	3e-113	328
LLPS-Bot-2077	Bos taurus	96.91	2e-107	316
LLPS-Sus-4643	Sus scrofa	96.84	7e-111	325
LLPS-Dio-3292	Dipodomys ordii	96.43	1e-115	334
LLPS-Orc-3303	Oryctolagus cuniculus	96.39	1e-113	332
LLPS-Ova-1464	Ovis aries	96.39	6e-114	330
LLPS-Eqc-0863	Equus caballus	96.3	2e-108	316
LLPS-Otg-2976	Otolemur garnettii	95.92	2e-114	332
LLPS-Pes-1088	Pelodiscus sinensis	95.51	2e-86	259
LLPS-Anp-3283	Anas platyrhynchos	95.12	1e-109	319
LLPS-Gaga-3296	Gallus gallus	94.9	3e-115	333
LLPS-Meg-2873	Meleagris gallopavo	94.85	1e-113	329
LLPS-Fia-0819	Ficedula albicollis	94.51	1e-108	317
LLPS-Sah-1682	Sarcophilus harrisii	94.27	1e-109	319
LLPS-Myl-4202	Myotis lucifugus	93.79	3e-104	304
LLPS-Ora-2912	Ornithorhynchus anatinus	93.78	7e-112	325
LLPS-Tag-2306	Taeniopygia guttata	93.29	4e-108	314
LLPS-Anc-1070	Anolis carolinensis	92.86	3e-114	331
LLPS-Mod-2500	Monodelphis domestica	92.67	1e-106	311
LLPS-Scf-2277	Scleropages formosus	91.41	1e-109	319
LLPS-Leo-2892	Lepisosteus oculatus	90.4	6e-108	315
LLPS-Xet-0600	Xenopus tropicalis	89.69	7e-107	312
LLPS-Icp-0600	Ictalurus punctatus	87.88	1e-104	306
LLPS-Asm-0436	Astyanax mexicanus	87.76	7e-104	305
LLPS-Lac-1892	Latimeria chalumnae	87.37	8e-104	305
LLPS-Dar-1336	Danio rerio	86.36	2e-103	303
LLPS-Orn-3424	Oreochromis niloticus	85.35	1e-101	299
LLPS-Xim-2299	Xiphophorus maculatus	84.94	2e-95	283
LLPS-Pof-4035	Poecilia formosa	84.29	3e-95	284
LLPS-Orl-1892	Oryzias latipes	83.33	1e-99	294
LLPS-Nol-3869	Nomascus leucogenys	82.47	1e-82	250
LLPS-Tar-2900	Takifugu rubripes	82.32	6e-99	292
LLPS-Scm-3054	Scophthalmus maximus	81.91	4e-96	285
LLPS-Ten-3621	Tetraodon nigroviridis	81.31	2e-98	290
LLPS-Tum-0223	Tuber melanosporum	54.08	1e-53	176
LLPS-Cii-1127	Ciona intestinalis	53.85	1e-57	187
LLPS-Abg-0859	Absidia glauca	53.03	5e-50	167
LLPS-Crn-0813	Cryptococcus neoformans	52.28	3e-56	183
LLPS-Scs-0911	Sclerotinia sclerotiorum	51.79	2e-48	163
LLPS-Usm-0895	Ustilago maydis	51.72	2e-52	174
LLPS-Spr-1397	Sporisorium reilianum	51.72	7e-53	175
LLPS-Dos-0122	Dothistroma septosporum	51.01	1e-45	155
LLPS-Miv-0919	Microbotryum violaceum	50.26	4e-47	160
LLPS-Blg-0195	Blumeria graminis	50.25	2e-48	163
LLPS-Zyt-0128	Zymoseptoria tritici	49.75	2e-40	142
LLPS-Yal-1390	Yarrowia lipolytica	48.72	7e-46	156
LLPS-Asg-1287	Ashbya gossypii	48.48	6e-43	149
LLPS-Mel-0511	Melampsora laricipopulina	48.04	3e-50	168
LLPS-Php-1524	Physcomitrella patens	47.94	3e-47	160
LLPS-Sac-1551	Saccharomyces cerevisiae	47.47	2e-42	147
LLPS-Gor-1585	Gossypium raimondii	47.4	6e-42	147
LLPS-Scc-1118	Schizosaccharomyces cryophilus	47.15	7e-45	154
LLPS-Hea-0741	Helianthus annuus	46.6	3e-43	150
LLPS-Brn-0218	Brassica napus	46.6	6e-42	146
LLPS-Pug-1125	Puccinia graminis	46.46	8e-47	159
LLPS-Scp-0760	Schizosaccharomyces pombe	46.43	1e-44	153
LLPS-Kop-0237	Komagataella pastoris	46.11	3e-40	142
LLPS-Bro-0620	Brassica oleracea	46.07	2e-41	145
LLPS-Nia-0975	Nicotiana attenuata	46.07	2e-43	150
LLPS-Art-1586	Arabidopsis thaliana	46.07	1e-41	145
LLPS-Arl-0260	Arabidopsis lyrata	46.07	1e-41	145
LLPS-Org-1505	Oryza glaberrima	45.83	1e-39	140
LLPS-Orr-2180	Oryza rufipogon	45.83	1e-39	140
LLPS-Orm-1775	Oryza meridionalis	45.83	1e-39	140
LLPS-Ors-2192	Oryza sativa	45.83	1e-39	140
LLPS-Orp-0750	Oryza punctata	45.83	1e-39	140
LLPS-Orgl-0353	Oryza glumaepatula	45.83	1e-39	140
LLPS-Orni-0784	Oryza nivara	45.83	1e-39	140
LLPS-Orb-1789	Oryza barthii	45.83	1e-39	140
LLPS-Ori-1166	Oryza indica	45.83	1e-39	140
LLPS-Dac-1855	Daucus carota	45.64	3e-42	147
LLPS-Scj-1220	Schizosaccharomyces japonicus	45.63	3e-45	155
LLPS-Sob-1699	Sorghum bicolor	45.55	5e-40	141
LLPS-Viv-1051	Vitis vinifera	45.55	1e-39	140
LLPS-Sei-2280	Setaria italica	45.55	5e-40	141
LLPS-Hov-1119	Hordeum vulgare	45.55	8e-44	151
LLPS-Sot-1813	Solanum tuberosum	45.55	2e-42	147
LLPS-Sol-1761	Solanum lycopersicum	45.55	2e-42	147
LLPS-Pyt-1468	Pyrenophora teres	45.41	2e-41	144
LLPS-Orbr-1229	Oryza brachyantha	45.31	3e-39	139
LLPS-Lep-0021	Leersia perrieri	45.31	9e-39	139
LLPS-Put-1234	Puccinia triticina	45.29	1e-43	150
LLPS-Zem-1423	Zea mays	45.03	2e-39	140
LLPS-Brr-1775	Brassica rapa	45.03	2e-39	140
LLPS-Tra-1719	Triticum aestivum	45.03	1e-40	143
LLPS-Mua-0037	Musa acuminata	45.03	9e-38	135
LLPS-Pytr-1556	Pyrenophora triticirepentis	44.9	4e-41	144
LLPS-Chr-1172	Chlamydomonas reinhardtii	44.85	2e-39	139
LLPS-Prp-2235	Prunus persica	44.5	3e-39	139
LLPS-Phv-2156	Phaseolus vulgaris	44.5	4e-39	139
LLPS-Via-1673	Vigna angularis	44.5	4e-39	139
LLPS-Coc-2325	Corchorus capsularis	44.38	1e-39	140
LLPS-Pot-1815	Populus trichocarpa	44.38	1e-39	140
LLPS-Met-0388	Medicago truncatula	44.27	5e-38	136
LLPS-Cus-2359	Cucumis sativus	43.98	9e-39	138
LLPS-Brd-1053	Brachypodium distachyon	43.98	1e-38	138
LLPS-Glm-0098	Glycine max	43.98	3e-39	139
LLPS-Mae-1635	Manihot esculenta	43.75	1e-39	140
LLPS-Thc-0636	Theobroma cacao	43.75	8e-39	139
LLPS-Lem-0854	Leptosphaeria maculans	43.2	5e-38	136
LLPS-Gas-0586	Galdieria sulphuraria	42.94	5e-39	139
LLPS-Amt-1842	Amborella trichopoda	42.86	7e-36	131
LLPS-Sem-1595	Selaginella moellendorffii	42.6	6e-40	141
LLPS-Osl-0915	Ostreococcus lucimarinus	42.56	2e-40	142
LLPS-Cym-0977	Cyanidioschyzon merolae	31.22	3e-24	101
LLPS-Asc-1171	Aspergillus clavatus	26.32	7e-08	54.3
LLPS-Asfu-1520	Aspergillus fumigatus	25.73	1e-08	56.2
LLPS-Nef-1566	Neosartorya fischeri	25.73	2e-08	55.8
LLPS-Asf-0287	Aspergillus flavus	24.56	1e-07	53.5
LLPS-Aso-0482	Aspergillus oryzae	24.56	1e-07	53.5

LLPS-Hos-3498CHMP1A

Protein Sequence

Nucleotide Sequence

LLPS-Hos-3498
CHMP1A