LLPS-Hos-3480
PACSIN2
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Human cortex | 23071613 |
| Centrosome/Spindle pole body | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000422336.5 | ENSP00000403435.1 |
| Ensembl | ENST00000634914.1 | ENSP00000489297.1 |
| Ensembl | ENST00000418133.5 | ENSP00000396816.1 |
| Ensembl | ENST00000453079.1 | ENSP00000399953.1 |
| Ensembl | ENST00000402229.5 | ENSP00000385040.1 |
| Ensembl | ENST00000453643.5 | ENSP00000398573.1 |
| Ensembl | ENST00000507586.1 | ENSP00000422788.1 |
| Ensembl | ENST00000263246.7 | ENSP00000263246.3 |
| Ensembl | ENST00000407585.5 | ENSP00000385952.1 |
| Ensembl | ENST00000337959.8 | ENSP00000338379.4 |
| Ensembl | ENST00000403744.7 | ENSP00000385372.3 |
| UniProt | Q9UNF0, PACN2_HUMAN, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2 | |
| GeneBank | CR456536, AL136845, AL049758, BC008037, AL022476, AL389984, AF128536 | CAG30422.1, CAB97538.1, AAH08037.1, CAB66779.1, AAD41781.1 |
| RefSeq | NM_001184970.1, NM_001184971.1, NM_007229.3, XM_005261319.3, XM_017028564.1 | NP_001171899.1, NP_001171900.1, NP_009160.2, XP_005261376.1, XP_016884053.1 |
| Entrez | 11252 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSVTYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCSD LMNCLHERAR IEKAYAQQLT 60 61 EWARRWRQLV EKGPQYGTVE KAWMAFMSEA ERVSELHLEV KASLMNDDFE KIKNWQKEAF 120 121 HKQMMGGFKE TKEAEDGFRK AQKPWAKKLK EVEAAKKAHH AACKEEKLAI SREANSKADP 180 181 SLNPEQLKKL QDKIEKCKQD VLKTKEKYEK SLKELDQGTP QYMENMEQVF EQCQQFEEKR 240 241 LRFFREVLLE VQKHLDLSNV AGYKAIYHDL EQSIRAADAV EDLRWFRANH GPGMAMNWPQ 300 301 FEEWSADLNR TLSRREKKKA TDGVTLTGIN QTGDQSLPSK PSSTLNVPSN PAQSAQSQSS 360 361 YNPFEDEDDT GSTVSEKDDT KAKNVSSYEK TQSYPTDWSD DESNNPFSST DANGDSNPFD 420 421 DDATSGTEVR VRALYDYEGQ EHDELSFKAG DELTKMEDED EQGWCKGRLD NGQVGLYPAN 480 481 YVEAIQ 486 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCTGTCA CATATGATGA TTCCGTTGGA GTAGAAGTGT CCAGCGACAG CTTCTGGGAG 60 61 GTCGGGAACT ACAAGCGGAC TGTGAAGCGG ATCGACGATG GCCACCGCCT GTGCAGCGAC 120 121 CTCATGAACT GCCTGCATGA GCGGGCGCGC ATCGAGAAGG CGTATGCGCA GCAGCTCACT 180 181 GAGTGGGCCC GGCGCTGGAG GCAGCTCGTG GAGAAAGGGC CCCAGTACGG GACCGTGGAG 240 241 AAGGCCTGGA TGGCCTTCAT GTCCGAGGCA GAGAGGGTGA GCGAGCTGCA CCTCGAGGTG 300 301 AAGGCCTCAC TGATGAACGA TGACTTCGAG AAGATCAAGA ACTGGCAGAA GGAAGCCTTT 360 361 CACAAGCAGA TGATGGGCGG CTTCAAGGAG ACCAAGGAAG CTGAGGACGG CTTTCGGAAG 420 421 GCACAGAAGC CCTGGGCCAA GAAGCTGAAA GAGGTAGAAG CAGCAAAGAA AGCCCACCAT 480 481 GCAGCGTGCA AAGAGGAGAA GCTGGCTATC TCACGAGAAG CCAACAGCAA GGCAGACCCA 540 541 TCCCTCAACC CTGAACAGCT CAAGAAATTG CAAGACAAAA TAGAAAAGTG CAAGCAAGAT 600 601 GTTCTTAAGA CCAAAGAGAA GTATGAGAAG TCCCTGAAGG AACTCGACCA GGGCACACCC 660 661 CAGTACATGG AGAACATGGA GCAGGTGTTT GAGCAGTGCC AGCAGTTCGA GGAGAAACGC 720 721 CTTCGCTTCT TCCGGGAGGT TCTGCTGGAG GTTCAGAAGC ACCTAGACCT GTCCAATGTG 780 781 GCTGGCTACA AAGCCATTTA CCATGACCTG GAGCAGAGCA TCAGAGCAGC TGATGCAGTG 840 841 GAGGACCTGA GGTGGTTCCG AGCCAATCAC GGGCCGGGCA TGGCCATGAA CTGGCCGCAG 900 901 TTTGAGGAGT GGTCCGCAGA CCTGAATCGA ACCCTCAGCC GGAGAGAGAA GAAGAAGGCC 960 961 ACTGACGGCG TCACCCTGAC GGGCATCAAC CAGACAGGCG ACCAGTCTCT GCCGAGTAAG 1020 1021 CCCAGCAGCA CCCTTAATGT CCCGAGCAAC CCCGCCCAGT CTGCGCAGTC ACAGTCCAGC 1080 1081 TACAACCCCT TCGAGGATGA GGACGACACG GGCAGCACCG TCAGTGAGAA GGACGACACT 1140 1141 AAGGCCAAAA ATGTGAGCAG CTACGAGAAG ACCCAGAGCT ATCCCACCGA CTGGTCAGAC 1200 1201 GATGAGTCTA ACAACCCCTT CTCCTCCACG GATGCCAATG GGGACTCGAA TCCATTCGAC 1260 1261 GACGACGCCA CCTCGGGGAC GGAAGTGCGA GTCCGGGCCC TGTATGACTA TGAGGGGCAG 1320 1321 GAGCATGATG AGCTGAGCTT CAAGGCTGGG GATGAGCTGA CCAAGATGGA GGACGAGGAT 1380 1381 GAGCAGGGCT GGTGCAAGGG ACGCTTGGAC AACGGGCAAG TTGGCCTATA CCCGGCAAAT 1440 1441 TATGTGGAGG CGATCCAGTG A 1461 |
▼ KEYWORD
ID | Family |
3D-structure | |
Acetylation | |
Alternative splicing | |
Cell membrane | |
Cell projection | |
Coiled coil | |
Complete proteome | |
Cytoplasm | |
Cytoplasmic vesicle | |
Cytoskeleton | |
Endocytosis | |
Endosome | |
Lipid-binding | |
Membrane | |
Phosphoprotein | |
Polymorphism | |
Reference proteome | |
SH3 domain
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Caveola | |
Cellular Component | Cell-cell junction | |
Cellular Component | Cytoplasm | |
Cellular Component | Cytoplasmic vesicle membrane | |
Cellular Component | Cytoskeleton | |
Cellular Component | Cytosol | |
Cellular Component | Early endosome | |
Cellular Component | Extracellular exosome | |
Cellular Component | Extrinsic component of membrane | |
Cellular Component | Focal adhesion | |
Cellular Component | Glutamatergic synapse | |
Cellular Component | Intracellular membrane-bounded organelle | |
Cellular Component | Nuclear speck | |
Cellular Component | Plasma membrane | |
Cellular Component | Recycling endosome membrane | |
Cellular Component | Ruffle membrane | |
Molecular Function | Cadherin binding | |
Molecular Function | Cytoskeletal protein binding | |
Molecular Function | Identical protein binding | |
Molecular Function | Phosphatidic acid binding | |
Molecular Function | Phospholipid binding | |
Molecular Function | Transporter activity | |
Biological Process | Actin cytoskeleton organization | |
Biological Process | Caveola assembly | |
Biological Process | Caveolin-mediated endocytosis | |
Biological Process | Cell projection morphogenesis | |
Biological Process | Cytoskeleton organization | |
Biological Process | Membrane organization | |
Biological Process | Modulation of chemical synaptic transmission | |
Biological Process | Negative regulation of endocytosis | |
Biological Process | Plasma membrane tubulation | |
Biological Process | Protein localization to endosome |
▼ ANNOTATION
| Variation | ||||
| dbSNP | ||||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pap-3515 | Pan paniscus | 99.38 | 0.0 | 856 |
| LLPS-Nol-2308 | Nomascus leucogenys | 99.38 | 0.0 | 857 |
| LLPS-Gog-2735 | Gorilla gorilla | 99.38 | 0.0 | 857 |
| LLPS-Pat-3119 | Pan troglodytes | 99.18 | 0.0 | 854 |
| LLPS-Man-1379 | Macaca nemestrina | 98.97 | 0.0 | 854 |
| LLPS-Mam-4314 | Macaca mulatta | 98.97 | 0.0 | 854 |
| LLPS-Cea-2434 | Cercocebus atys | 98.97 | 0.0 | 854 |
| LLPS-Maf-4003 | Macaca fascicularis | 98.97 | 0.0 | 854 |
| LLPS-Mal-3293 | Mandrillus leucophaeus | 98.77 | 0.0 | 851 |
| LLPS-Paa-4789 | Papio anubis | 98.77 | 0.0 | 852 |
| LLPS-Chs-1680 | Chlorocebus sabaeus | 98.43 | 0.0 | 793 |
| LLPS-Aon-1118 | Aotus nancymaae | 97.12 | 0.0 | 838 |
| LLPS-Caj-3707 | Callithrix jacchus | 97.12 | 0.0 | 838 |
| LLPS-Cas-3618 | Carlito syrichta | 95.88 | 0.0 | 831 |
| LLPS-Dio-1160 | Dipodomys ordii | 95.06 | 0.0 | 822 |
| LLPS-Ict-4314 | Ictidomys tridecemlineatus | 94.86 | 0.0 | 823 |
| LLPS-Fec-2982 | Felis catus | 94.65 | 0.0 | 823 |
| LLPS-Urm-2516 | Ursus maritimus | 94.24 | 0.0 | 817 |
| LLPS-Mup-2457 | Mustela putorius furo | 94.24 | 0.0 | 818 |
| LLPS-Caf-0375 | Canis familiaris | 94.03 | 0.0 | 816 |
| LLPS-Mum-2414 | Mus musculus | 93.83 | 0.0 | 812 |
| LLPS-Aim-1405 | Ailuropoda melanoleuca | 93.83 | 0.0 | 812 |
| LLPS-Sus-2650 | Sus scrofa | 93.81 | 0.0 | 813 |
| LLPS-Myl-1652 | Myotis lucifugus | 93.42 | 0.0 | 815 |
| LLPS-Ran-3000 | Rattus norvegicus | 93.24 | 0.0 | 807 |
| LLPS-Orc-1397 | Oryctolagus cuniculus | 93.21 | 0.0 | 807 |
| LLPS-Tut-1982 | Tursiops truncatus | 92.72 | 0.0 | 766 |
| LLPS-Rhb-3071 | Rhinopithecus bieti | 92.18 | 0.0 | 810 |
| LLPS-Eqc-3740 | Equus caballus | 92.08 | 0.0 | 788 |
| LLPS-Loa-4258 | Loxodonta africana | 91.77 | 0.0 | 794 |
| LLPS-Ova-0471 | Ovis aries | 90.53 | 0.0 | 788 |
| LLPS-Bot-1568 | Bos taurus | 90.12 | 0.0 | 785 |
| LLPS-Sah-2932 | Sarcophilus harrisii | 89.48 | 0.0 | 777 |
| LLPS-Cap-4111 | Cavia porcellus | 89.3 | 0.0 | 775 |
| LLPS-Fud-3804 | Fukomys damarensis | 89.3 | 0.0 | 794 |
| LLPS-Anp-3244 | Anas platyrhynchos | 87.27 | 0.0 | 762 |
| LLPS-Tag-1946 | Taeniopygia guttata | 87.27 | 0.0 | 761 |
| LLPS-Gaga-2308 | Gallus gallus | 87.27 | 0.0 | 763 |
| LLPS-Fia-2308 | Ficedula albicollis | 87.06 | 0.0 | 760 |
| LLPS-Otg-2183 | Otolemur garnettii | 86.15 | 0.0 | 754 |
| LLPS-Pes-2538 | Pelodiscus sinensis | 86.04 | 0.0 | 748 |
| LLPS-Mea-3598 | Mesocricetus auratus | 85.8 | 0.0 | 743 |
| LLPS-Meg-1728 | Meleagris gallopavo | 82.34 | 0.0 | 698 |
| LLPS-Anc-1498 | Anolis carolinensis | 81.24 | 0.0 | 720 |
| LLPS-Ora-1055 | Ornithorhynchus anatinus | 81.04 | 2e-175 | 504 |
| LLPS-Xet-2674 | Xenopus tropicalis | 80.08 | 0.0 | 694 |
| LLPS-Gaa-2904 | Gasterosteus aculeatus | 78.95 | 6e-22 | 102 |
| LLPS-Ten-3709 | Tetraodon nigroviridis | 73.68 | 9e-21 | 98.6 |
| LLPS-Leo-3315 | Lepisosteus oculatus | 69.62 | 0.0 | 610 |
| LLPS-Asm-1910 | Astyanax mexicanus | 66.26 | 0.0 | 580 |
| LLPS-Icp-0295 | Ictalurus punctatus | 65.89 | 0.0 | 555 |
| LLPS-Scf-2058 | Scleropages formosus | 65.24 | 0.0 | 555 |
| LLPS-Orl-1500 | Oryzias latipes | 64.43 | 0.0 | 545 |
| LLPS-Scm-0142 | Scophthalmus maximus | 64.19 | 0.0 | 561 |
| LLPS-Pof-3446 | Poecilia formosa | 63.36 | 0.0 | 548 |
| LLPS-Xim-3090 | Xiphophorus maculatus | 63.23 | 0.0 | 544 |
| LLPS-Tar-0796 | Takifugu rubripes | 63.15 | 0.0 | 549 |
| LLPS-Dar-2823 | Danio rerio | 62.73 | 0.0 | 537 |
| LLPS-Orn-1723 | Oreochromis niloticus | 59.59 | 5e-171 | 496 |
| LLPS-Mod-2716 | Monodelphis domestica | 57.14 | 4e-08 | 60.5 |
| LLPS-Poa-2674 | Pongo abelii | 50.96 | 1e-145 | 431 |
| LLPS-Drm-2242 | Drosophila melanogaster | 50.85 | 5e-08 | 59.7 |
| LLPS-Lac-0486 | Latimeria chalumnae | 49.09 | 2e-07 | 57.0 |
| LLPS-Scj-0856 | Schizosaccharomyces japonicus | 48.28 | 1e-07 | 58.2 |
| LLPS-Crn-1158 | Cryptococcus neoformans | 47.37 | 5e-07 | 56.6 |
| LLPS-Cii-1432 | Ciona intestinalis | 42.68 | 5e-109 | 338 |
| LLPS-Cis-1779 | Ciona savignyi | 40.74 | 9e-50 | 176 |
| LLPS-Cae-1527 | Caenorhabditis elegans | 32.43 | 3e-55 | 198 |