LLPS-Hos-3437
SETD2

▼ OVERVIEW

Status: Unreviewed
Protein Name: Histone-lysine N-methyltransferase SETD2; HIF-1; Huntingtin yeast partner B; Huntingtin-interacting protein 1; HIP-1; Huntingtin-interacting protein B; Lysine N-methyltransferase 3A; Protein-lysine N-methyltransferase SETD2
Gene Name: SETD2, HIF1, HYPB, KIAA1732, KMT3A, SET2, HSPC069
Ensembl Gene: ENSG00000181555.20
Ensembl Protein: ENSP00000386759.3
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: LLPS regulator
PDB: 5JJY (A, B) More


▼ PROPERTY


▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKQLQPQPPP  KMGDFYDPEH  PTPEEEENEA  KIENVQKTGF  IKGPMFKGVA  SSRFLPKGTK  60
61    TKVNLEEQGR  QKVSFSFSLT  KKTLQNRFLT  ALGNEKQSDT  PNPPAVPLQV  DSTPKMKMEI  120
121   GDTLSTAEES  SPPKSRVELG  KIHFKKHLLH  VTSRPLLATT  TAVASPPTHA  APLPAVIAES  180
181   TTVDSPPSSP  PPPPPPAQAT  TLSSPAPVTE  PVALPHTPIT  VLMAAPVPLP  VDVAVRSLKE  240
241   PPIIIVPESL  EADTKQDTIS  NSLEEHVTQI  LNEQADISSK  KEDSHIGKDE  EIPDSSKISL  300
301   SCKKTGSKKK  SSQSEGIFLG  SESDEDSVRT  SSSQRSHDLK  FSASIEKERD  FKKSSAPLKS  360
361   EDLGKPSRSK  TDRDDKYFSY  SKLERDTRYV  SSRCRSERER  RRSRSHSRSE  RGSRTNLSYS  420
421   RSERSHYYDS  DRRYHRSSPY  RERTRYSRPY  TDNRARESSD  SEEEYKKTYS  RRTSSHSSSY  480
481   RDLRTSSYSK  SDRDCKTETS  YLEMERRGKY  SSKLERESKR  TSENEAIKRC  CSPPNELGFR  540
541   RGSSYSKHDS  SASRYKSTLS  KPIPKSDKFK  NSFCCTELNE  EIKQSHSFSL  QTPCSKGSEL  600
601   RMINKNPERE  KAGSPAPSNR  LNDSPTLKKL  DELPIFKSEF  ITHDSHDSIK  ELDSLSKVKN  660
661   DQLRSFCPIE  LNINGSPGAE  SDLATFCTSK  TDAVLMTSDD  SVTGSELSPL  VKACMLSSNG  720
721   FQNISRCKEK  DLDDTCMLHK  KSESPFRETE  PLVSPHQDKL  MSMPVMTVDY  SKTVVKEPVD  780
781   TRVSCCKTKD  SDIYCTLNDS  NPSLCNSEAE  NIEPSVMKIS  SNSFMNVHLE  SKPVICDSRN  840
841   LTDHSKFACE  EYKQSIGSTS  SASVNHFDDL  YQPIGSSGIA  SSLQSLPPGI  KVDSLTLLKC  900
901   GENTSPVLDA  VLKSKKSSEF  LKHAGKETIV  EVGSDLPDSG  KGFASRENRR  NNGLSGKCLQ  960
961   EAQEEGNSIL  PERRGRPEIS  LDERGEGGHV  HTSDDSEVVF  SSCDLNLTME  DSDGVTYALK  1020
1021  CDSSGHAPEI  VSTVHEDYSG  SSESSNDESD  SEDTDSDDSS  IPRNRLQSVV  VVPKNSTLPM  1080
1081  EETSPCSSRS  SQSYRHYSDH  WEDERLESRR  HLYEEKFESI  ASKACPQTDK  FFLHKGTEKN  1140
1141  PEISFTQSSR  KQIDNRLPEL  SHPQSDGVDS  TSHTDVKSDP  LGHPNSEETV  KAKIPSRQQE  1200
1201  ELPIYSSDFE  DVPNKSWQQT  TFQNRPDSRL  GKTELSFSSS  CEIPHVDGLH  SSEELRNLGW  1260
1261  DFSQEKPSTT  YQQPDSSYGA  CGGHKYQQNA  EQYGGTRDYW  QGNGYWDPRS  GRPPGTGVVY  1320
1321  DRTQGQVPDS  LTDDREEEEN  WDQQDGSHFS  DQSDKFLLSL  QKDKGSVQAP  EISSNSIKDT  1380
1381  LAVNEKKDFS  KNLEKNDIKD  RGPLKKRRQE  IESDSESDGE  LQDRKKVRVE  VEQGETSVPP  1440
1441  GSALVGPSCV  MDDFRDPQRW  KECAKQGKMP  CYFDLIEENV  YLTERKKNKS  HRDIKRMQCE  1500
1501  CTPLSKDERA  QGEIACGEDC  LNRLLMIECS  SRCPNGDYCS  NRRFQRKQHA  DVEVILTEKK  1560
1561  GWGLRAAKDL  PSNTFVLEYC  GEVLDHKEFK  ARVKEYARNK  NIHYYFMALK  NDEIIDATQK  1620
1621  GNCSRFMNHS  CEPNCETQKW  TVNGQLRVGF  FTTKLVPSGS  ELTFDYQFQR  YGKEAQKCFC  1680
1681  GSANCRGYLG  GENRVSIRAA  GGKMKKERSR  KKDSVDGELE  ALMENGEGLS  DKNQVLSLSR  1740
1741  LMVRIETLEQ  KLTCLELIQN  THSQSCLKSF  LERHGLSLLW  IWMAELGDGR  ESNQKLQEEI  1800
1801  IKTLEHLPIP  TKNMLEESKV  LPIIQRWSQT  KTAVPPLSEG  DGYSSENTSR  AHTPLNTPDP  1860
1861  STKLSTEADT  DTPKKLMFRR  LKIISENSMD  SAISDATSEL  EGKDGKEDLD  QLENVPVEEE  1920
1921  EELQSQQLLP  QQLPECKVDS  ETNIEASKLP  TSEPEADAEI  EPKESNGTKL  EEPINEETPS  1980
1981  QDEEEGVSDV  ESERSQEQPD  KTVDISDLAT  KLLDSWKDLK  EVYRIPKKSQ  TEKENTTTER  2040
2041  GRDAVGFRDQ  TPAPKTPNRS  RERDPDKQTQ  NKEKRKRRSS  LSPPSSAYER  GTKRPDDRYD  2100
2101  TPTSKKKVRI  KDRNKLSTEE  RRKLFEQEVA  QREAQKQQQQ  MQNLGMTSPL  PYDSLGYNAP  2160
2161  HHPFAGYPPG  YPMQAYVDPS  NPNAGKVLLP  TPSMDPVCSP  APYDHAQPLV  GHSTEPLSAP  2220
2221  PPVPVVPHVA  APVEVSSSQY  VAQSDGVVHQ  DSSVAVLPVP  APGPVQGQNY  SVWDSNQQSV  2280
2281  SVQQQYSPAQ  SQATIYYQGQ  TCPTVYGVTS  PYSQTTPPIV  QSYAQPSLQY  IQGQQIFTAH  2340
2341  PQGVVVQPAA  AVTTIVAPGQ  PQPLQPSEMV  VTNNLLDLPP  PSPPKPKTIV  LPPNWKTARD  2400
2401  PEGKIYYYHV  ITRQTQWDPP  TWESPGDDAS  LEHEAEMDLG  TPTYDENPMK  ASKKPKTAEA  2460
2461  DTSSELAKKS  KEVFRKEMSQ  FIVQCLNPYR  KPDCKVGRIT  TTEDFKHLAR  KLTHGVMNKE  2520
2521  LKYCKNPEDL  ECNENVKHKT  KEYIKKYMQK  FGAVYKPKED  TELE  2564
Nucleotide CDS Sequence (FASTA)
1     NAATCTTCCC  CACCAAAGTC  AAGGGTGGAA  TTGGGCAAAA  TTCATTTTAA  GAAACATCTG  60
61    CTTCATGTAA  CATCCAGGCC  ACTGCTGGCT  ACTACCACAG  CAGTAGCATC  TCCACCTACT  120
121   CATGCAGCAC  CATTACCAGC  AGTGATAGCA  GAATCAACAA  CTGTAGACTC  ACCGCCCTCA  180
181   TCTCCGCCTC  CACCGCCTCC  ACCTGCCCAA  GCCACAACAC  TCTCATCACC  AGCACCAGTA  240
241   ACAGAGCCAG  TGGCCTTGCC  ACATACACCA  ATAACAGTTC  TAATGGCAGC  ACCAGTACCC  300
301   TTACCAGTAG  ATGTAGCAGT  TAGATCTCTG  AAAGAACCAC  CAATTATAAT  TGTACCAGAA  360
361   TCTTTAGAAG  CAGATACTAA  GCAGGACACT  ATATCTAATA  GTTTAGAAGA  ACACGTAACT  420
421   CAAATATTGA  ATGAGCAAGC  AGATATTTCC  TCAAAAAAAG  AAGATTCCCA  TATTGGGAAG  480
481   GATGAAGAAA  TTCCAGATAG  TTCTAAGATT  AGTCTGAGCT  GTAAAAAAAC  AGGTTCTAAG  540
541   AAGAAATCCT  CACAATCTGA  AGGCATCTTT  CTTGGTTCAG  AATCTGATGA  AGATTCTGTA  600
601   CGGACTTCTT  CAAGTCAAAG  ATCACATGAT  TTAAAATTTT  CAGCAAGCAT  TGAAAAGGAA  660
661   AGAGATTTTA  AAAAGAGCTC  AGCACCTTTA  AAAAGTGAGG  ATCTAGGGAA  ACCTTCACGA  720
721   TCTAAAACAG  ACAGAGATGA  TAAATATTTT  AGCTATTCAA  AACTTGAAAG  AGATACTCGG  780
781   TATGTATCTT  CCCGATGTAG  ATCAGAAAGA  GAGCGACGGC  GGAGCAGATC  TCACTCTAGG  840
841   TCTGAGAGAG  GCTCTAGAAC  TAATTTATCC  TATTCCAGGT  CAGAACGATC  TCATTATTAT  900
901   GACTCTGATC  GTCGCTACCA  TAGGAGCTCC  CCTTATCGAG  AGAGGACGCG  CTATTCTCGG  960
961   CCATACACAG  ATAACAGAGC  ACGAGAGAGT  TCTGACTCAG  AAGAAGAGTA  TAAGAAGACA  1020
1021  TACTCAAGGC  GTACCTCATC  TCATTCCTCT  TCTTACAGAG  ACCTAAGGAC  ATCATCCTAT  1080
1081  TCTAAATCTG  ATCGGGACTG  TAAAACTGAG  ACCTCTTACT  TAGAGATGGA  AAGAAGAGGC  1140
1141  AAGTATTCTT  CAAAACTAGA  AAGAGAATCT  AAAAGGACTT  CAGAAAATGA  AGCAATTAAA  1200
1201  AGATGTTGTT  CTCCCCCTAA  TGAACTGGGA  TTCCGACGAG  GGTCATCATA  TTCTAAGCAT  1260
1261  GACAGTAGTG  CTTCCCGTTA  TAAATCTACC  CTTTCAAAAC  CTATACCCAA  GTCTGATAAA  1320
1321  TTTAAAAATT  CTTTCTGTTG  TACAGAATTA  AATGAAGAAA  TCAAACAGTC  TCATTCTTTT  1380
1381  AGTTTACAGA  CACCTTGTTC  AAAAGGTAGT  GAATTAAGAA  TGATTAATAA  AAATCCTGAA  1440
1441  AGAGAAAAGG  CTGGGTCTCC  AGCTCCATCA  AATCGATTAA  ATGATTCACC  TACTTTAAAA  1500
1501  AAGCTAGATG  AATTGCCTAT  TTTTAAGTCC  GAATTTATAA  CACATGATAG  CCATGATAGT  1560
1561  ATTAAGGAAT  TAGACTCTTT  ATCTAAAGTG  AAGAATGATC  AATTAAGAAG  TTTTTGTCCC  1620
1621  ATAGAATTAA  ATATAAATGG  ATCTCCTGGG  GCAGAATCTG  ATTTGGCAAC  ATTTTGCACT  1680
1681  TCTAAAACTG  ATGCTGTTTT  AATGACTTCT  GATGATAGTG  TGACTGGATC  GGAATTATCC  1740
1741  CCTTTGGTCA  AAGCATGCAT  GCTTTCATCA  AATGGATTTC  AGAATATTAG  TAGGTGCAAA  1800
1801  GAAAAAGACT  TGGATGATAC  CTGCATGCTG  CATAAGAAGT  CAGAAAGCCC  ATTTAGAGAA  1860
1861  ACAGAACCTC  TGGTGTCACC  ACACCAAGAT  AAACTCATGT  CTATGCCAGT  TATGACTGTG  1920
1921  GATTATTCCA  AAACAGTAGT  TAAAGAACCA  GTTGATACGA  GGGTTTCTTG  CTGCAAAACC  1980
1981  AAAGATTCAG  ACATATACTG  TACTTTGAAC  GATAGCAACC  CTTCTTTGTG  TAACTCTGAA  2040
2041  GCTGAAAATA  TTGAGCCTTC  AGTTATGAAG  ATTTCTTCAA  ATAGCTTTAT  GAATGTGCAT  2100
2101  TTGGAATCAA  AACCAGTTAT  ATGTGATAGT  AGAAATTTGA  CAGATCACTC  AAAATTTGCA  2160
2161  TGTGAAGAAT  ATAAGCAGAG  CATCGGTAGC  ACTAGTTCAG  CTTCTGTTAA  TCATTTTGAT  2220
2221  GATTTATATC  AACCTATTGG  GAGTTCAGGT  ATTGCTTCAT  CTCTTCAGAG  TCTTCCACCA  2280
2281  GGAATAAAGG  TGGACAGTCT  AACTCTCTTG  AAATGCGGAG  AGAACACATC  TCCAGTTCTG  2340
2341  GATGCAGTGC  TAAAGAGTAA  AAAAAGTTCA  GAGTTTTTAA  AGCATGCAGG  GAAAGAAACA  2400
2401  ATAGTAGAAG  TAGGTAGTGA  CCTTCCTGAT  TCAGGAAAGG  GATTTGCTTC  CAGGGAGAAC  2460
2461  AGGCGTAATA  ATGGGTTATC  TGGGAAATGT  TTGCAAGAGG  CTCAAGAAGA  AGGGAATTCC  2520
2521  ATATTGCCTG  AAAGAAGAGG  AAGACCAGAA  ATCTCTTTAG  ATGAAAGAGG  AGAAGGAGGA  2580
2581  CATGTGCATA  CTTCTGATGA  CTCAGAAGTT  GTATTTTCTT  CTTGTGATTT  GAATTTAACC  2640
2641  ATGGAAGACA  GTGATGGTGT  AACTTATGCA  TTAAAGTGTG  ACAGTAGTGG  TCATGCCCCA  2700
2701  GAAATTGTGT  CTACAGTTCA  TGAAGATTAT  TCTGGCTCTT  CTGAAAGTTC  AAATGATGAA  2760
2761  AGTGATTCAG  AAGATACAGA  TTCGGATGAT  AGCAGTATTC  CAAGAAACCG  TCTCCAGTCT  2820
2821  GTTGTGGTTG  TGCCAAAGAA  TTCTACTTTG  CCCATGGAAG  AAACAAGTCC  TTGTTCTTCT  2880
2881  CGGAGCAGTC  AAAGTTATAG  ACACTATTCT  GACCATTGGG  AAGATGAGAG  ATTGGAGTCA  2940
2941  AGGAGACATT  TGTATGAGGA  AAAATTTGAA  AGTATAGCAA  GTAAAGCCTG  TCCTCAAACT  3000
3001  GATAAGTTTT  TCCTTCATAA  AGGAACAGAG  AAGAATCCGG  AAATTTCTTT  TACACAGTCC  3060
3061  AGTAGAAAAC  AAATAGATAA  TCGCCTGCCT  GAACTTTCTC  ATCCTCAGAG  TGATGGGGTT  3120
3121  GATAGTACAA  GTCATACAGA  TGTGAAATCT  GACCCTCTGG  GTCACCCAAA  TTCAGAGGAA  3180
3181  ACCGTGAAAG  CCAAAATACC  TTCTAGGCAG  CAAGAAGAGC  TGCCAATTTA  TTCTTCTGAT  3240
3241  TTTGAAGATG  TCCCAAATAA  GTCTTGGCAA  CAGACCACTT  TCCAAAACAG  GCCAGATAGT  3300
3301  AGACTGGGAA  AAACAGAATT  GAGTTTTTCT  TCCTCTTGTG  AGATACCACA  TGTGGATGGC  3360
3361  TTGCACTCAT  CAGAAGAGCT  CAGAAACTTA  GGTTGGGACT  TCTCTCAAGA  AAAGCCTTCT  3420
3421  ACCACGTATC  AGCAACCTGA  CAGTAGCTAT  GGAGCTTGTG  GTGGACACAA  GTATCAGCAA  3480
3481  AATGCAGAAC  AGTATGGTGG  GACACGTGAT  TACTGGCAAG  GCAATGGTTA  CTGGGATCCA  3540
3541  AGATCAGGTA  GACCTCCTGG  AACTGGGGTT  GTGTATGATC  GAACTCAAGG  ACAAGTACCA  3600
3601  GATTCCCTAA  CAGATGATCG  TGAAGAAGAG  GAGAATTGGG  ATCAACAGGA  TGGATCCCAT  3660
3661  TTTTCAGACC  AGTCCGATAA  ATTTCTTCTA  TCCCTTCAGA  AAGACAAGGG  GTCAGTGCAA  3720
3721  GCACCTGAAA  TAAGCAGCAA  TTCCATTAAG  GACACTTTAG  CTGTGAATGA  AAAGAAAGAT  3780
3781  TTTTCAAAAA  ACTTAGAAAA  AAATGATATC  AAAGATAGAG  GGCCTCTTAA  AAAAAGGAGG  3840
3841  CAGGAAATAG  AGAGTGATTC  TGAAAGTGAT  GGTGAGCTTC  AGGACAGAAA  GAAAGTTAGA  3900
3901  GTGGAGGTAG  AGCAGGGAGA  GACATCAGTG  CCCCCAGGTT  CAGCACTGGT  TGGGCCCTCC  3960
3961  TGTGTCATGG  ATGACTTCAG  GGACCCACAG  CGATGGAAGG  AATGTGCCAA  GCAAGGGAAA  4020
4021  ATGCCATGTT  ACTTTGATCT  TATTGAAGAA  AATGTTTATT  TAACAGAAAG  AATGAAGTAT  4080
4081  CTTTGGGTAC  TGTATTAG  4098

▼ KEYWORD

ID
Family
3D-structure
Activator
Alternative splicing
Antiviral defense
Autism spectrum disorder
Chromatin regulator
Chromosome
Coiled coil
Complete proteome
Developmental protein
Differentiation
Disease mutation
DNA damage
DNA repair
Immunity
Innate immunity
Isopeptide bond
Mental retardation
Metal-binding
Methyltransferase
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
S-adenosyl-L-methionine
Transcription
Transcription regulation
Transferase
Tumor suppressor
Ubl conjugation
Zinc

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Chromosome
Cellular Component
Nucleoplasm
Cellular Component
Nucleus
Molecular Function
Alpha-tubulin binding
Molecular Function
Histone methyltransferase activity (H3-K36 specific)
Molecular Function
Histone-lysine N-methyltransferase activity
Molecular Function
Metal ion binding
Molecular Function
Protein-lysine N-methyltransferase activity
Biological Process
Angiogenesis
Biological Process
Cell migration involved in vasculogenesis
Biological Process
Coronary vasculature morphogenesis
Biological Process
Defense response to virus
Biological Process
Embryonic cranial skeleton morphogenesis
Biological Process
Embryonic placenta morphogenesis
Biological Process
Endodermal cell differentiation
Biological Process
Forebrain development
Biological Process
Histone H3-K36 dimethylation
Biological Process
Histone H3-K36 trimethylation
Biological Process
Mesoderm morphogenesis
Biological Process
Microtubule cytoskeleton organization involved in mitosis
Biological Process
Mismatch repair
Biological Process
Morphogenesis of a branching structure
Biological Process
Neural tube closure
Biological Process
Nucleosome organization
Biological Process
Peptidyl-lysine monomethylation
Biological Process
Peptidyl-lysine trimethylation
Biological Process
Pericardium development
Biological Process
Positive regulation of interferon-alpha production
Biological Process
Regulation of cytokinesis
Biological Process
Regulation of double-strand break repair via homologous recombination
Biological Process
Regulation of mRNA export from nucleus
Biological Process
Regulation of protein localization to chromatin
Biological Process
Regulation of transcription, DNA-templated
Biological Process
Response to type I interferon
Biological Process
Stem cell development
Biological Process
Stem cell differentiation
Biological Process
Transcription elongation from RNA polymerase II promoter

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Nol-0401Nomascus leucogenys99.820.0 845
LLPS-Pat-1311Pan troglodytes99.570.04479
LLPS-Pap-0722Pan paniscus99.520.04424
LLPS-Gog-1003Gorilla gorilla99.260.04472
LLPS-Poa-4156Pongo abelii98.950.04444
LLPS-Rhb-4580Rhinopithecus bieti97.820.04395
LLPS-Mam-0965Macaca mulatta97.750.04398
LLPS-Maf-3152Macaca fascicularis97.750.04398
LLPS-Chs-1830Chlorocebus sabaeus97.660.04411
LLPS-Paa-4841Papio anubis97.510.04387
LLPS-Caj-3181Callithrix jacchus96.180.04316
LLPS-Man-4646Macaca nemestrina96.140.04286
LLPS-Cea-3158Cercocebus atys96.020.04291
LLPS-Dio-2680Dipodomys ordii95.420.0 786
LLPS-Orc-3430Oryctolagus cuniculus94.090.02486
LLPS-Eqc-2047Equus caballus91.550.04072
LLPS-Caf-3386Canis familiaris91.510.04054
LLPS-Urm-2275Ursus maritimus91.250.03986
LLPS-Aim-3520Ailuropoda melanoleuca91.090.04011
LLPS-Fec-2371Felis catus91.050.04047
LLPS-Ict-2217Ictidomys tridecemlineatus90.810.04001
LLPS-Tut-2445Tursiops truncatus90.750.03323
LLPS-Loa-4521Loxodonta africana89.610.03135
LLPS-Sus-2725Sus scrofa89.020.03522
LLPS-Bot-4152Bos taurus88.960.03929
LLPS-Ova-3540Ovis aries88.680.03912
LLPS-Cap-3121Cavia porcellus88.170.03878
LLPS-Fud-3355Fukomys damarensis87.660.03856
LLPS-Myl-3864Myotis lucifugus84.570.03507
LLPS-Ran-3877Rattus norvegicus84.440.03697
LLPS-Mum-4789Mus musculus84.210.03690
LLPS-Mea-4437Mesocricetus auratus83.040.03557
LLPS-Fia-1871Ficedula albicollis79.171e-49 200
LLPS-Scf-0528Scleropages formosus76.31e-99 365
LLPS-Asm-3335Astyanax mexicanus75.569e-102 372
LLPS-Sah-2000Sarcophilus harrisii74.040.03065
LLPS-Mod-0247Monodelphis domestica73.890.03091
LLPS-Xim-3997Xiphophorus maculatus73.612e-98 360
LLPS-Orl-2378Oryzias latipes73.238e-99 362
LLPS-Pof-3027Poecilia formosa72.861e-96 354
LLPS-Tar-2408Takifugu rubripes72.125e-97 356
LLPS-Dar-1348Danio rerio70.963e-103 377
LLPS-Anc-1290Anolis carolinensis68.65e-42 175
LLPS-Pes-3708Pelodiscus sinensis66.230.02693
LLPS-Scm-1114Scophthalmus maximus65.824e-0967.0
LLPS-Lac-3063Latimeria chalumnae64.170.01626
LLPS-Gaga-0926Gallus gallus63.210.02544
LLPS-Cis-0115Ciona savignyi62.892e-78 267
LLPS-Cii-2267Ciona intestinalis61.935e-88 304
LLPS-Anp-1977Anas platyrhynchos61.460.02500
LLPS-Tag-0267Taeniopygia guttata60.460.02350
LLPS-Icp-4243Ictalurus punctatus60.110.0 779
LLPS-Leo-0550Lepisosteus oculatus57.362e-153 537
LLPS-Orn-1145Oreochromis niloticus56.610.0 795
LLPS-Drm-1567Drosophila melanogaster52.276e-72 273
LLPS-Abg-0156Absidia glauca50.885e-64 243
LLPS-Xet-1554Xenopus tropicalis47.969e-50 199
LLPS-Php-2245Physcomitrella patens47.512e-61 238
LLPS-Bro-1679Brassica oleracea47.31e-60 235
LLPS-Brr-2148Brassica rapa47.32e-60 235
LLPS-Brn-0757Brassica napus47.31e-60 235
LLPS-Sem-1052Selaginella moellendorffii47.035e-62 220
LLPS-Kop-1228Komagataella pastoris46.975e-50 197
LLPS-Osl-0784Ostreococcus lucimarinus46.949e-51 200
LLPS-Arl-0673Arabidopsis lyrata46.933e-60 234
LLPS-Amt-1080Amborella trichopoda46.642e-58 229
LLPS-Art-3086Arabidopsis thaliana46.491e-60 236
LLPS-Sei-2431Setaria italica45.094e-55 218
LLPS-Org-2134Oryza glaberrima45.055e-57 217
LLPS-Orr-1483Oryza rufipogon45.052e-55 219
LLPS-Orp-2416Oryza punctata45.059e-56 220
LLPS-Ors-1977Oryza sativa45.056e-57 218
LLPS-Cus-2225Cucumis sativus45.055e-58 228
LLPS-Orgl-1299Oryza glumaepatula45.052e-55 219
LLPS-Orni-1685Oryza nivara45.051e-55 219
LLPS-Sol-1241Solanum lycopersicum45.052e-54 215
LLPS-Pot-2559Populus trichocarpa44.848e-53 210
LLPS-Lep-0809Leersia perrieri44.842e-53 213
LLPS-Dac-2071Daucus carota44.842e-55 219
LLPS-Sob-1538Sorghum bicolor44.781e-55 219
LLPS-Mua-1573Musa acuminata44.753e-54 215
LLPS-Otg-4666Otolemur garnettii44.66e-47 191
LLPS-Mal-0167Mandrillus leucophaeus44.66e-47 191
LLPS-Aon-2997Aotus nancymaae44.66e-47 191
LLPS-Zem-2377Zea mays44.442e-54 216
LLPS-Vir-1196Vigna radiata44.346e-55 217
LLPS-Via-1504Vigna angularis44.345e-55 218
LLPS-Brd-2389Brachypodium distachyon44.293e-54 215
LLPS-Viv-1712Vitis vinifera44.162e-49 188
LLPS-Mup-0600Mustela putorius furo44.131e-46 190
LLPS-Gaa-1963Gasterosteus aculeatus44.022e-46 189
LLPS-Hea-1827Helianthus annuus44.022e-57 225
LLPS-Thc-1419Theobroma cacao43.952e-55 219
LLPS-Phv-2471Phaseolus vulgaris43.892e-54 216
LLPS-Met-1769Medicago truncatula43.894e-55 218
LLPS-Orbr-1498Oryza brachyantha43.844e-53 211
LLPS-Mae-1556Manihot esculenta43.814e-54 215
LLPS-Hov-1667Hordeum vulgare43.721e-54 216
LLPS-Glm-1583Glycine max43.572e-57 226
LLPS-Cas-1923Carlito syrichta43.46e-47 191
LLPS-Tra-3051Triticum aestivum43.293e-54 215
LLPS-Ori-0479Oryza indica43.181e-53 203
LLPS-Gor-2626Gossypium raimondii43.115e-54 214
LLPS-Chr-1335Chlamydomonas reinhardtii43.13e-58 228
LLPS-Coc-2082Corchorus capsularis43.052e-52 200
LLPS-Sot-0635Solanum tuberosum43.013e-46 178
LLPS-Sac-0217Saccharomyces cerevisiae42.927e-51 199
LLPS-Orm-0695Oryza meridionalis42.442e-52 209
LLPS-Meg-0161Meleagris gallopavo42.342e-47 192
LLPS-Ora-3318Ornithorhynchus anatinus42.341e-47 192
LLPS-Nia-0192Nicotiana attenuata39.913e-46 180
LLPS-Dos-0359Dothistroma septosporum37.115e-59 227
LLPS-Tum-0932Tuber melanosporum36.912e-60 231
LLPS-Asn-1559Aspergillus nidulans36.55e-55 214
LLPS-Yal-1475Yarrowia lipolytica36.445e-56 216
LLPS-Pug-0961Puccinia graminis36.22e-57 222
LLPS-Put-0538Puccinia triticina35.941e-58 225
LLPS-Lem-0660Leptosphaeria maculans35.82e-57 222
LLPS-Pyt-0388Pyrenophora teres35.551e-57 223
LLPS-Mel-0256Melampsora laricipopulina35.555e-58 225
LLPS-Zyt-0808Zymoseptoria tritici35.491e-59 228
LLPS-Scc-0422Schizosaccharomyces cryophilus35.493e-57 220
LLPS-Aso-1540Aspergillus oryzae35.481e-55 216
LLPS-Crn-1154Cryptococcus neoformans35.182e-61 234
LLPS-Phn-1040Phaeosphaeria nodorum35.165e-55 214
LLPS-Scp-1176Schizosaccharomyces pombe35.116e-55 213
LLPS-Cogr-1514Colletotrichum graminicola35.096e-57 220
LLPS-Pytr-1339Pyrenophora triticirepentis35.043e-57 221
LLPS-Trr-1492Trichoderma reesei35.03e-58 224
LLPS-Trv-0111Trichoderma virens34.935e-57 221
LLPS-Fus-1467Fusarium solani34.847e-59 226
LLPS-Asg-1488Ashbya gossypii34.556e-54 208
LLPS-Fuo-1042Fusarium oxysporum34.538e-59 226
LLPS-Fuv-0012Fusarium verticillioides34.531e-58 225
LLPS-Usm-0357Ustilago maydis34.451e-57 223
LLPS-Ved-1563Verticillium dahliae34.442e-56 218
LLPS-Spr-0502Sporisorium reilianum34.292e-56 219
LLPS-Beb-0177Beauveria bassiana34.281e-54 212
LLPS-Nec-1171Neurospora crassa34.013e-59 228
LLPS-Coo-1081Colletotrichum orbiculare33.863e-54 212
LLPS-Asf-1301Aspergillus flavus33.859e-57 220
LLPS-Map-0643Magnaporthe poae33.851e-54 213
LLPS-Miv-0853Microbotryum violaceum33.65e-57 221
LLPS-Mao-1559Magnaporthe oryzae33.592e-56 219
LLPS-Asni-0514Aspergillus niger33.591e-57 221
LLPS-Scj-0035Schizosaccharomyces japonicus33.574e-56 216
LLPS-Asfu-1220Aspergillus fumigatus33.515e-56 218
LLPS-Nef-0601Neosartorya fischeri33.513e-56 218
LLPS-Blg-1234Blumeria graminis33.515e-54 211
LLPS-Gag-0182Gaeumannomyces graminis33.251e-53 209
LLPS-Cae-0749Caenorhabditis elegans33.152e-46 189
LLPS-Cog-1288Colletotrichum gloeosporioides32.981e-55 215
LLPS-Asc-0896Aspergillus clavatus32.82e-57 222
LLPS-Scs-1099Sclerotinia sclerotiorum32.631e-53 210