DrLLPS - Data resource of LLPS

LLPS-Hos-3185
HMGB1

▼ OVERVIEW


Status:	Reviewed
Protein Name:	High mobility group protein B1; High mobility group protein 1; HMG-1
Gene Name:	HMGB1, HMG1
Ensembl Gene:	ENSG00000189403.14
Ensembl Protein:	ENSP00000345347.5
Organism:	Homo sapiens
Taxa ID:	9606
LLPS Type:	Client

PDB: 6CIJ (A, F, I, J, G, N, L, D, M) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Nucleolus	"...Thus, we analyzed the orthologous groups of the remaining 2316 identified proteins to the human nucleolar proteins. We detected 361 (co-)orthologues in NoPDB from the 2316 A. thaliana proteins."	N/A	26980300
Nucleolus	"...Thus, we analyzed the orthologous groups of the remaining 2316 identified proteins to the human nucleolar proteins. We detected 361 orthologues in NoPDB from the 2316 A. thaliana proteins."	N/A	26980300
Chromatin, Nuclear speckle	Predicted from orthologs	N/A	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Mus musculus	LLPS-Mum-0353	P63158	Client	Chromatin, Nuclear speckle	100.00	1e-105	310

▼ FUNCTION

Binds preferentially single-stranded DNA and unwinds double-stranded DNA.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENST00000341423.9	ENSP00000345347.5
Ensembl	ENST00000326004.4	ENSP00000369904.1
Ensembl	ENST00000399494.5	ENSP00000382417.1
Ensembl	ENST00000399489.5	ENSP00000382412.1
Ensembl	ENST00000339872.8	ENSP00000343040.4
Ensembl	ENST00000405805.5	ENSP00000384678.1
UniProt		P09429, HMGB1_HUMAN, A5D8W9, Q14321, Q5T7C3, Q6IBE1
GeneBank	U51677, BC141844, AL353648, CH471075, BC003378, CR456863, AY377859, EF157968, BT020159, AK122825, BC067732, D63874, EU012027, CR749614, BC030981, BC066889, AK291494, X12597, BT006940	BAA09924.1, BAF84183.1, CAG33144.1, AAQ91389.1, CAH18408.1, CAA31110.1, AAB08987.1, AAH67732.1, ABM47301.1, BAG53745.1, AAV38961.1, ABS29271.1, AAH30981.1, AAP35586.1, AAH03378.1, AAH66889.1, AAI41845.1, EAX08457.1
RefSeq	NM_001313892.1, NM_001313893.1, NM_002128.5	NP_001300821.1, NP_001300822.1, NP_002119.1
Entrez	3146

▼ SEQUENCE

Protein Sequence (FASTA)
1 MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF 60 61 EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL 120 121 SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK 180 181 SKKKKEEEED EEDEEDEEEE EDEEDEDEEE DDDDE 215
Nucleotide CDS Sequence (FASTA)
1 ATGGGCAAAG GAGATCCTAA GAAGCCGAGA GGCAAAATGT CATCATATGC ATTTTTTGTG 60 61 CAAACTTGTC GGGAGGAGCA TAAGAAGAAG CACCCAGATG CTTCAGTCAA CTTCTCAGAG 120 121 TTTTCTAAGA AGTGCTCAGA GAGGTGGAAG ACCATGTCTG CTAAAGAGAA AGGAAAATTT 180 181 GAAGATATGG CAAAAGCGGA CAAGGCCCGT TATGAAAGAG AAATGAAAAC CTATATCCCT 240 241 CCCAAAGGGG AGACAAAAAA GAAGTTCAAG GATCCCAATG CACCCAAGAG GCCTCCTTCG 300 301 GCCTTCTTCC TCTTCTGCTC TGAGTATCGC CCAAAAATCA AAGGAGAACA TCCTGGCCTG 360 361 TCCATTGGTG ATGTTGCGAA GAAACTGGGA GAGATGTGGA ATAACACTGC TGCAGATGAC 420 421 AAGCAGCCTT ATGAAAAGAA GGCTGCGAAG CTGAAGGAAA AATATGAAAA GTTCTAG 477

▼ KEYWORD

ID	Family
KW-0007	Acetylation
KW-0158	Chromosome
KW-0181	Complete proteome
KW-0238	DNA-binding
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0677	Repeat

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005737	Cellular Component	Cytoplasm
GO:0000790	Cellular Component	Nuclear chromatin
GO:0008301	Molecular Function	DNA binding, bending
GO:0008134	Molecular Function	Transcription factor binding
GO:0002218	Biological Process	Activation of innate immune response
GO:0060326	Biological Process	Cell chemotaxis
GO:0006338	Biological Process	Chromatin remodeling
GO:0032502	Biological Process	Developmental process
GO:0006310	Biological Process	DNA recombination
GO:0010508	Biological Process	Positive regulation of autophagy
GO:0070374	Biological Process	Positive regulation of ERK1 and ERK2 cascade
GO:0045089	Biological Process	Positive regulation of innate immune response
GO:1902741	Biological Process	Positive regulation of interferon-alpha secretion
GO:0050718	Biological Process	Positive regulation of interleukin-1 beta secretion
GO:0050716	Biological Process	Positive regulation of interleukin-1 secretion
GO:0032755	Biological Process	Positive regulation of interleukin-6 production
GO:1901224	Biological Process	Positive regulation of NIK/NF-kappaB signaling
GO:0045944	Biological Process	Positive regulation of transcription by RNA polymerase II
GO:0032760	Biological Process	Positive regulation of tumor necrosis factor production
GO:0010469	Biological Process	Regulation of signaling receptor activity
GO:0006357	Biological Process	Regulation of transcription by RNA polymerase II

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD
PROSITE	Gene3D

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	HPRD
BioGRID	mUbiSiDa	PTMcode

Variation
dbSNP	VarCards	rSNPBase

Mutation
TCGA	ICGC	CGAP	IntOGen	BioMuta

Interaction
HINT	InWeb_IM	RISE	TRRUST	BindingDB
RAIN	Mentha	PINA	IID	MIST
DifferentialNET	RNAct

Disease
PTMD	MSDD	OMIM	DisGeNET	ActiveDriverDB

Drug
DrugBank	TTD	DGIdb	CTD

Physicochemical
Compute pI/Mw	AAindex

Function
ENPD	CORUM	CellMarker	RaftProt

Proteomics
THPA	HPM

Structure
PDB	MMDB

Localization
COMPARTMENTS	NLSdb

Expression
TCGA	ICGC	COSMIC	GEO	ArrayExpress
TISSUES	BioXpress	THPA

Element
UTRdb	CircNet	miRTarBase	miRWalk	miRecords
miRcode	RAID	microRNA.org

Methylation
TCGA	ICGC	COSMIC	MethyCancer

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Paa-2955	Papio anubis	100.0	1e-105	310
LLPS-Mal-3772	Mandrillus leucophaeus	100.0	1e-105	310
LLPS-Myl-3223	Myotis lucifugus	100.0	1e-105	310
LLPS-Dio-3445	Dipodomys ordii	100.0	1e-105	310
LLPS-Bot-4046	Bos taurus	100.0	1e-105	310
LLPS-Gog-2844	Gorilla gorilla	100.0	1e-105	310
LLPS-Caj-4104	Callithrix jacchus	100.0	1e-105	310
LLPS-Mum-0353	Mus musculus	100.0	1e-105	310
LLPS-Chs-3987	Chlorocebus sabaeus	100.0	1e-105	310
LLPS-Cea-4424	Cercocebus atys	100.0	1e-105	310
LLPS-Aon-0308	Aotus nancymaae	100.0	1e-105	310
LLPS-Sus-2329	Sus scrofa	100.0	1e-105	310
LLPS-Nol-4514	Nomascus leucogenys	100.0	1e-105	310
LLPS-Caf-2446	Canis familiaris	100.0	1e-105	310
LLPS-Poa-2796	Pongo abelii	100.0	1e-105	310
LLPS-Eqc-0792	Equus caballus	100.0	1e-105	310
LLPS-Cap-0910	Cavia porcellus	100.0	1e-105	310
LLPS-Otg-3410	Otolemur garnettii	100.0	1e-105	310
LLPS-Urm-1362	Ursus maritimus	100.0	1e-105	310
LLPS-Pap-3455	Pan paniscus	100.0	1e-105	310
LLPS-Pat-4075	Pan troglodytes	100.0	1e-105	310
LLPS-Fec-3527	Felis catus	100.0	1e-105	310
LLPS-Man-4281	Macaca nemestrina	100.0	1e-105	310
LLPS-Loa-3655	Loxodonta africana	100.0	1e-105	310
LLPS-Ran-1068	Rattus norvegicus	99.41	1e-104	308
LLPS-Aim-3443	Ailuropoda melanoleuca	99.41	8e-105	308
LLPS-Sah-1205	Sarcophilus harrisii	99.41	6e-105	308
LLPS-Cas-3435	Carlito syrichta	99.41	2e-104	307
LLPS-Ict-4072	Ictidomys tridecemlineatus	99.41	1e-103	304
LLPS-Mam-4618	Macaca mulatta	99.41	3e-105	309
LLPS-Rhb-2298	Rhinopithecus bieti	99.41	2e-104	307
LLPS-Mod-3325	Monodelphis domestica	99.41	1e-105	309
LLPS-Pes-1669	Pelodiscus sinensis	97.63	2e-103	305
LLPS-Orc-0905	Oryctolagus cuniculus	96.45	1e-103	304
LLPS-Gaga-3577	Gallus gallus	95.86	3e-101	299
LLPS-Fia-0559	Ficedula albicollis	95.86	4e-101	299
LLPS-Anc-2637	Anolis carolinensis	92.9	1e-98	292
LLPS-Ova-1518	Ovis aries	92.35	1e-103	305
LLPS-Xet-3572	Xenopus tropicalis	92.31	3e-99	294
LLPS-Leo-0511	Lepisosteus oculatus	89.94	4e-94	281
LLPS-Fud-3430	Fukomys damarensis	87.57	3e-84	255
LLPS-Maf-3700	Macaca fascicularis	87.57	8e-90	268
LLPS-Icp-3145	Ictalurus punctatus	87.43	1e-87	264
LLPS-Asm-1280	Astyanax mexicanus	86.83	6e-87	262
LLPS-Dar-0557	Danio rerio	86.75	1e-88	266
LLPS-Mup-3742	Mustela putorius furo	86.39	6e-83	252
LLPS-Tut-1320	Tursiops truncatus	86.39	6e-83	252
LLPS-Orn-0007	Oreochromis niloticus	86.39	1e-84	256
LLPS-Mea-4457	Mesocricetus auratus	86.01	8e-80	244
LLPS-Orl-1319	Oryzias latipes	85.89	3e-87	263
LLPS-Scf-0387	Scleropages formosus	85.88	2e-83	254
LLPS-Scm-2607	Scophthalmus maximus	84.76	9e-87	262
LLPS-Xim-2395	Xiphophorus maculatus	84.02	1e-88	266
LLPS-Pof-3520	Poecilia formosa	83.64	9e-87	262
LLPS-Ten-0878	Tetraodon nigroviridis	83.23	1e-76	236
LLPS-Tag-2028	Taeniopygia guttata	82.5	5e-49	163
LLPS-Tar-1762	Takifugu rubripes	81.82	1e-78	241
LLPS-Gaa-2175	Gasterosteus aculeatus	79.88	9e-84	254
LLPS-Ora-2206	Ornithorhynchus anatinus	75.16	5e-66	209
LLPS-Meg-1512	Meleagris gallopavo	75.16	4e-66	209
LLPS-Anp-1388	Anas platyrhynchos	75.16	2e-66	209
LLPS-Lac-2023	Latimeria chalumnae	74.4	2e-72	226
LLPS-Met-1412	Medicago truncatula	50.82	2e-11	63.5
LLPS-Hea-0938	Helianthus annuus	46.75	3e-06	50.4
LLPS-Put-1068	Puccinia triticina	46.03	7e-11	61.2

LLPS-Hos-3185HMGB1

Protein Sequence

Nucleotide Sequence

LLPS-Hos-3185
HMGB1