LLPS-Hos-3171
TOMM70
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Mitochondrial import receptor subunit TOM70; Mitochondrial precursor proteins import receptor; Translocase of outer membrane 70 kDa subunit; Translocase of outer mitochondrial membrane protein 70 |
| Gene Name: | TOMM70, KIAA0719, TOM70, TOMM70A |
| Ensembl Gene: | ENSG00000154174.7 |
| Ensembl Protein: | ENSP00000284320.5 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Human cortex | 23071613 |
| Nuclear speckle, Nucleolus | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| Receptor that accelerates the import of all mitochondrial precursor proteins. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000284320.5 | ENSP00000284320.5 |
| UniProt | O94826, TOM70_HUMAN, D3DN48 | |
| GeneBank | AB018262, BC052994, BC003633, CH471052 | BAA34439.2, AAH52994.1, EAW79822.1, EAW79823.1, AAH03633.1 |
| RefSeq | NM_014820.4 | NP_055635.3 |
| Entrez | 9868 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAASKPVEAA VVAAAVPSSG SGVGGGGTAG PGTGGLPRWQ LALAVGAPLL LGAGAIYLWS 60 61 RQQRRREARG RGDASGLKRN SERKTPEGRA SPAPGSGHPE GPGAHLDMNS LDRAQAAKNK 120 121 GNKYFKAGKY EQAIQCYTEA ISLCPTEKNV DLSTFYQNRA AAFEQLQKWK EVAQDCTKAV 180 181 ELNPKYVKAL FRRAKAHEKL DNKKECLEDV TAVCILEGFQ NQQSMLLADK VLKLLGKEKA 240 241 KEKYKNREPL MPSPQFIKSY FSSFTDDIIS QPMLKGEKSD EDKDKEGEAL EVKENSGYLK 300 301 AKQYMEEENY DKIISECSKE IDAEGKYMAE ALLLRATFYL LIGNANAAKP DLDKVISLKE 360 361 ANVKLRANAL IKRGSMYMQQ QQPLLSTQDF NMAADIDPQN ADVYHHRGQL KILLDQVEEA 420 421 VADFDECIRL RPESALAQAQ KCFALYRQAY TGNNSSQIQA AMKGFEEVIK KFPRCAEGYA 480 481 LYAQALTDQQ QFGKADEMYD KCIDLEPDNA TTYVHKGLLQ LQWKQDLDRG LELISKAIEI 540 541 DNKCDFAYET MGTIEVQRGN MEKAIDMFNK AINLAKSEME MAHLYSLCDA AHAQTEVAKK 600 601 YGLKPPTL 608 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCGCCT CTAAACCTGT GGAGGCAGCG GTGGTCGCAG CCGCTGTACC GAGCTCCGGG 60 61 AGTGGGGTGG GCGGCGGCGG GACTGCGGGC CCGGGCACGG GGGGGCTGCC GCGATGGCAG 120 121 CTGGCTCTGG CGGTCGGGGC ACCCCTGCTG CTGGGCGCGG GTGCCATATA CCTGTGGAGT 180 181 CGGCAGCAAC GGCGCCGGGA GGCCAGAGGC CGGGGCGACG CCAGCGGCCT GAAGCGCAAC 240 241 AGCGAACGGA AGACCCCGGA GGGCAGGGCC AGTCCGGCCC CGGGCAGCGG ACACCCTGAA 300 301 GGTCCCGGTG CTCACTTGGA CATGAACTCT CTTGATAGAG CCCAAGCAGC CAAGAATAAA 360 361 GGCAATAAAT ATTTTAAAGC AGGAAAATAT GAACAAGCTA TTCAGTGCTA TACTGAGGCT 420 421 ATTAGCTTGT GCCCTACAGA GAAGAATGTT GACCTTTCTA CATTTTATCA AAACAGAGCT 480 481 GCTGCCTTTG AACAGTTGCA AAAATGGAAA GAAGTGGCAC AAGACTGTAC AAAAGCTGTT 540 541 GAACTTAATC CCAAATATGT GAAAGCTCTC TTTAGACGTG CAAAAGCCCA TGAGAAGCTA 600 601 GACAATAAGA AGGAATGTTT AGAAGATGTC ACTGCTGTGT GTATATTAGA AGGGTTCCAA 660 661 AATCAACAAA GCATGCTGTT AGCCGATAAA GTTCTTAAAC TCCTTGGAAA AGAGAAAGCC 720 721 AAAGAAAAAT ATAAGAATCG TGAACCTCTG ATGCCATCTC CACAGTTTAT CAAATCTTAC 780 781 TTCAGTTCTT TCACGGATGA TATCATTTCC CAGCCCATGC TTAAAGGAGA GAAATCTGAT 840 841 GAAGATAAAG ACAAGGAAGG GGAGGCTTTA GAAGTGAAAG AAAATTCTGG ATACTTAAAG 900 901 GCCAAACAGT ATATGGAAGA AGAAAACTAC GATAAAATCA TAAGTGAATG CTCAAAAGAA 960 961 ATAGATGCTG AAGGCAAATA CATGGCAGAA GCATTGCTAC TACGAGCTAC CTTCTACCTG 1020 1021 CTTATTGGCA ATGCCAATGC AGCCAAACCA GATTTAGATA AAGTCATCAG TTTGAAAGAA 1080 1081 GCTAATGTGA AGCTTCGAGC AAATGCTCTC ATCAAAAGAG GCAGCATGTA CATGCAACAG 1140 1141 CAGCAGCCTT TGCTGTCCAC TCAAGATTTT AACATGGCTG CTGACATCGA TCCTCAGAAT 1200 1201 GCAGATGTTT ATCACCACCG AGGACAGCTG AAAATACTCC TTGATCAAGT TGAAGAAGCA 1260 1261 GTGGCAGATT TTGATGAATG TATTAGGTTA AGACCTGAGT CTGCTCTGGC ACAAGCACAG 1320 1321 AAATGTTTTG CATTGTACCG CCAGGCATAT ACGGGAAACA ACTCTTCACA AATCCAAGCA 1380 1381 GCTATGAAAG GTTTTGAAGA GGTCATAAAG AAATTTCCAA GGTGTGCCGA AGGCTATGCA 1440 1441 CTATACGCCC AGGCATTAAC AGATCAACAA CAGTTTGGTA AAGCTGATGA AATGTATGAT 1500 1501 AAATGTATTG ATTTGGAACC AGATAATGCT ACAACATATG TTCATAAAGG TTTACTTCAA 1560 1561 CTTCAGTGGA AGCAAGATCT GGATAGAGGT TTGGAACTTA TCAGCAAGGC TATTGAAATT 1620 1621 GACAATAAAT GTGATTTTGC CTATGAAACC ATGGGAACTA TTGAAGTACA AAGAGGAAAC 1680 1681 ATGGAGAAAG CCATTGACAT GTTCAACAAA GCTATTAACC TGGCCAAATC GGAAATGGAG 1740 1741 ATGGCCCATC TGTATTCACT TTGCGATGCC GCCCATGCCC AGACAGAAGT TGCAAAGAAA 1800 1801 TACGGATTAA AACCACCAAC ATTATAA 1827 |
▼ KEYWORD
ID | Family |
Acetylation | |
Complete proteome | |
Isopeptide bond | |
Membrane | |
Methylation | |
Mitochondrion | |
Mitochondrion outer membrane | |
Phosphoprotein | |
Reference proteome | |
Repeat | |
TPR repeat | |
Transmembrane | |
Transmembrane helix | |
Ubl conjugation
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Extracellular exosome | |
Cellular Component | Integral component of membrane | |
Cellular Component | Membrane | |
Cellular Component | Mitochondrial outer membrane | |
Cellular Component | Mitochondrial outer membrane translocase complex | |
Cellular Component | Mitochondrion | |
Molecular Function | Protein transmembrane transporter activity | |
Biological Process | Macroautophagy | |
Biological Process | Protein targeting to mitochondrion |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Proteomics | ||||
| THPA | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| MethyCancer | ||||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Gog-4729 | Gorilla gorilla | 100.0 | 0.0 | 1051 |
| LLPS-Poa-3684 | Pongo abelii | 99.84 | 0.0 | 1051 |
| LLPS-Pat-0649 | Pan troglodytes | 99.84 | 0.0 | 1050 |
| LLPS-Pap-0981 | Pan paniscus | 99.84 | 0.0 | 1050 |
| LLPS-Man-0213 | Macaca nemestrina | 99.83 | 0.0 | 1044 |
| LLPS-Mal-0654 | Mandrillus leucophaeus | 99.82 | 0.0 | 1038 |
| LLPS-Paa-1251 | Papio anubis | 99.67 | 0.0 | 1048 |
| LLPS-Chs-0067 | Chlorocebus sabaeus | 99.67 | 0.0 | 1048 |
| LLPS-Cea-4546 | Cercocebus atys | 99.67 | 0.0 | 1048 |
| LLPS-Rhb-2031 | Rhinopithecus bieti | 99.67 | 0.0 | 1048 |
| LLPS-Maf-2758 | Macaca fascicularis | 99.65 | 0.0 | 1042 |
| LLPS-Mam-2607 | Macaca mulatta | 99.65 | 0.0 | 1042 |
| LLPS-Nol-2880 | Nomascus leucogenys | 99.51 | 0.0 | 1049 |
| LLPS-Caj-4098 | Callithrix jacchus | 98.68 | 0.0 | 1046 |
| LLPS-Tut-2389 | Tursiops truncatus | 98.6 | 0.0 | 1037 |
| LLPS-Aon-3344 | Aotus nancymaae | 98.52 | 0.0 | 1040 |
| LLPS-Myl-2453 | Myotis lucifugus | 98.25 | 0.0 | 1031 |
| LLPS-Ict-1469 | Ictidomys tridecemlineatus | 98.25 | 0.0 | 1031 |
| LLPS-Cap-2071 | Cavia porcellus | 98.25 | 0.0 | 1031 |
| LLPS-Caf-2518 | Canis familiaris | 98.08 | 0.0 | 1030 |
| LLPS-Eqc-2827 | Equus caballus | 98.08 | 0.0 | 1029 |
| LLPS-Otg-2706 | Otolemur garnettii | 97.91 | 0.0 | 1030 |
| LLPS-Mup-4230 | Mustela putorius furo | 97.73 | 0.0 | 1027 |
| LLPS-Fec-4407 | Felis catus | 97.73 | 0.0 | 1026 |
| LLPS-Urm-1196 | Ursus maritimus | 97.41 | 0.0 | 929 |
| LLPS-Ova-1743 | Ovis aries | 97.38 | 0.0 | 1024 |
| LLPS-Orc-0470 | Oryctolagus cuniculus | 97.2 | 0.0 | 1026 |
| LLPS-Dio-3906 | Dipodomys ordii | 97.03 | 0.0 | 1021 |
| LLPS-Loa-0874 | Loxodonta africana | 96.86 | 0.0 | 1018 |
| LLPS-Ere-0806 | Erinaceus europaeus | 96.8 | 0.0 | 926 |
| LLPS-Sah-2012 | Sarcophilus harrisii | 96.39 | 0.0 | 921 |
| LLPS-Bot-1170 | Bos taurus | 95.73 | 0.0 | 1028 |
| LLPS-Fud-0952 | Fukomys damarensis | 95.64 | 0.0 | 1026 |
| LLPS-Mum-1385 | Mus musculus | 94.24 | 0.0 | 992 |
| LLPS-Pes-1380 | Pelodiscus sinensis | 93.98 | 0.0 | 894 |
| LLPS-Ran-4073 | Rattus norvegicus | 93.69 | 0.0 | 884 |
| LLPS-Anc-0399 | Anolis carolinensis | 93.67 | 0.0 | 787 |
| LLPS-Meg-1137 | Meleagris gallopavo | 93.17 | 0.0 | 892 |
| LLPS-Ora-0619 | Ornithorhynchus anatinus | 93.04 | 0.0 | 915 |
| LLPS-Fia-1927 | Ficedula albicollis | 92.97 | 0.0 | 885 |
| LLPS-Anp-1525 | Anas platyrhynchos | 92.97 | 0.0 | 887 |
| LLPS-Mod-1974 | Monodelphis domestica | 92.41 | 0.0 | 981 |
| LLPS-Sus-3125 | Sus scrofa | 90.97 | 0.0 | 933 |
| LLPS-Tag-1281 | Taeniopygia guttata | 87.0 | 0.0 | 906 |
| LLPS-Mea-4316 | Mesocricetus auratus | 86.7 | 0.0 | 870 |
| LLPS-Gaga-3747 | Gallus gallus | 84.92 | 0.0 | 936 |
| LLPS-Xet-0318 | Xenopus tropicalis | 82.96 | 0.0 | 875 |
| LLPS-Icp-0727 | Ictalurus punctatus | 80.63 | 0.0 | 843 |
| LLPS-Tar-0417 | Takifugu rubripes | 79.97 | 0.0 | 856 |
| LLPS-Asm-2088 | Astyanax mexicanus | 79.11 | 0.0 | 875 |
| LLPS-Dar-3765 | Danio rerio | 78.95 | 0.0 | 860 |
| LLPS-Gaa-1791 | Gasterosteus aculeatus | 78.49 | 0.0 | 878 |
| LLPS-Leo-3784 | Lepisosteus oculatus | 78.37 | 0.0 | 870 |
| LLPS-Scf-1977 | Scleropages formosus | 78.18 | 0.0 | 874 |
| LLPS-Xim-2807 | Xiphophorus maculatus | 77.83 | 0.0 | 844 |
| LLPS-Orn-2958 | Oreochromis niloticus | 77.83 | 0.0 | 866 |
| LLPS-Orl-1073 | Oryzias latipes | 77.67 | 0.0 | 864 |
| LLPS-Pof-3292 | Poecilia formosa | 77.67 | 0.0 | 843 |
| LLPS-Scm-0681 | Scophthalmus maximus | 77.67 | 0.0 | 863 |
| LLPS-Ten-2712 | Tetraodon nigroviridis | 77.34 | 0.0 | 858 |
| LLPS-Lac-1086 | Latimeria chalumnae | 76.84 | 0.0 | 827 |
| LLPS-Cii-0465 | Ciona intestinalis | 54.46 | 0.0 | 555 |
| LLPS-Cis-1896 | Ciona savignyi | 50.36 | 8e-177 | 522 |
| LLPS-Mua-1370 | Musa acuminata | 46.09 | 4e-21 | 97.4 |
| LLPS-Sei-0227 | Setaria italica | 44.83 | 8e-17 | 85.1 |
| LLPS-Scj-0293 | Schizosaccharomyces japonicus | 44.79 | 9e-15 | 81.3 |
| LLPS-Cogr-0354 | Colletotrichum graminicola | 44.66 | 1e-12 | 74.3 |
| LLPS-Cog-0773 | Colletotrichum gloeosporioides | 44.23 | 2e-13 | 77.0 |
| LLPS-Orni-0883 | Oryza nivara | 44.04 | 3e-16 | 86.3 |
| LLPS-Orr-1200 | Oryza rufipogon | 44.04 | 3e-17 | 86.3 |
| LLPS-Ors-2237 | Oryza sativa | 44.04 | 3e-17 | 86.3 |
| LLPS-Vir-0555 | Vigna radiata | 44.0 | 2e-16 | 84.3 |
| LLPS-Tra-1387 | Triticum aestivum | 43.97 | 8e-18 | 87.8 |
| LLPS-Tru-1300 | Triticum urartu | 43.97 | 8e-18 | 87.8 |
| LLPS-Orbr-0689 | Oryza brachyantha | 43.14 | 5e-15 | 80.1 |
| LLPS-Orgl-1315 | Oryza glumaepatula | 43.12 | 1e-17 | 87.0 |
| LLPS-Sob-2320 | Sorghum bicolor | 43.1 | 4e-16 | 83.2 |
| LLPS-Orb-1537 | Oryza barthii | 42.99 | 2e-17 | 85.5 |
| LLPS-Orp-0531 | Oryza punctata | 42.99 | 1e-16 | 84.3 |
| LLPS-Ori-2389 | Oryza indica | 42.98 | 1e-16 | 85.9 |
| LLPS-Sot-1769 | Solanum tuberosum | 42.74 | 2e-18 | 90.9 |
| LLPS-Phn-0235 | Phaeosphaeria nodorum | 42.71 | 3e-14 | 80.5 |
| LLPS-Brd-0811 | Brachypodium distachyon | 42.2 | 4e-16 | 82.4 |
| LLPS-Lep-0328 | Leersia perrieri | 41.96 | 6e-17 | 85.5 |
| LLPS-Hea-0188 | Helianthus annuus | 41.67 | 5e-16 | 82.8 |
| LLPS-Abg-0636 | Absidia glauca | 41.58 | 6e-14 | 79.0 |
| LLPS-Nia-2431 | Nicotiana attenuata | 41.41 | 2e-18 | 90.5 |
| LLPS-Zem-0667 | Zea mays | 40.98 | 5e-17 | 85.9 |
| LLPS-Spr-0747 | Sporisorium reilianum | 40.95 | 1e-12 | 74.7 |
| LLPS-Cus-1246 | Cucumis sativus | 40.87 | 4e-17 | 86.3 |
| LLPS-Phv-0222 | Phaseolus vulgaris | 40.87 | 9e-18 | 88.6 |
| LLPS-Aim-2295 | Ailuropoda melanoleuca | 40.62 | 8e-15 | 79.3 |
| LLPS-Cas-1050 | Carlito syrichta | 40.62 | 1e-14 | 79.0 |
| LLPS-Glm-1588 | Glycine max | 40.57 | 1e-15 | 81.3 |
| LLPS-Pyt-0169 | Pyrenophora teres | 40.38 | 2e-13 | 77.4 |
| LLPS-Via-2337 | Vigna angularis | 40.0 | 3e-17 | 87.0 |
| LLPS-Usm-0208 | Ustilago maydis | 40.0 | 3e-13 | 77.0 |
| LLPS-Brr-2191 | Brassica rapa | 40.0 | 5e-14 | 76.6 |
| LLPS-Art-0167 | Arabidopsis thaliana | 40.0 | 2e-14 | 78.6 |
| LLPS-Coo-1142 | Colletotrichum orbiculare | 39.83 | 1e-12 | 74.3 |
| LLPS-Lem-0042 | Leptosphaeria maculans | 39.58 | 3e-13 | 77.0 |
| LLPS-Pytr-1597 | Pyrenophora triticirepentis | 39.42 | 3e-13 | 77.4 |
| LLPS-Php-0198 | Physcomitrella patens | 39.39 | 6e-13 | 73.9 |
| LLPS-Thc-2202 | Theobroma cacao | 39.17 | 8e-16 | 82.0 |
| LLPS-Viv-2422 | Vitis vinifera | 39.17 | 3e-16 | 83.2 |
| LLPS-Coc-0004 | Corchorus capsularis | 39.13 | 3e-14 | 77.4 |
| LLPS-Bro-1657 | Brassica oleracea | 38.52 | 2e-14 | 79.3 |
| LLPS-Dac-1940 | Daucus carota | 38.18 | 3e-13 | 73.9 |
| LLPS-Brn-2046 | Brassica napus | 37.39 | 1e-12 | 72.4 |
| LLPS-Ast-1314 | Aspergillus terreus | 37.38 | 1e-12 | 75.1 |
| LLPS-Met-2341 | Medicago truncatula | 36.97 | 2e-15 | 80.9 |
| LLPS-Prp-1598 | Prunus persica | 36.97 | 4e-15 | 79.7 |
| LLPS-Gor-1197 | Gossypium raimondii | 36.61 | 7e-13 | 75.1 |
| LLPS-Pot-0397 | Populus trichocarpa | 36.54 | 6e-14 | 76.6 |
| LLPS-Mae-0025 | Manihot esculenta | 34.03 | 3e-15 | 80.5 |
| LLPS-Mao-0196 | Magnaporthe oryzae | 32.41 | 1e-63 | 226 |
| LLPS-Blg-1387 | Blumeria graminis | 32.33 | 3e-57 | 209 |
| LLPS-Ved-0927 | Verticillium dahliae | 31.99 | 2e-55 | 204 |
| LLPS-Miv-1156 | Microbotryum violaceum | 31.98 | 2e-62 | 224 |
| LLPS-Asf-1436 | Aspergillus flavus | 31.91 | 3e-63 | 226 |
| LLPS-Aso-1479 | Aspergillus oryzae | 31.91 | 3e-63 | 226 |
| LLPS-Asni-0595 | Aspergillus niger | 31.91 | 7e-63 | 224 |
| LLPS-Asc-0868 | Aspergillus clavatus | 31.85 | 3e-57 | 209 |
| LLPS-Crn-1326 | Cryptococcus neoformans | 31.84 | 2e-63 | 226 |
| LLPS-Asfu-0544 | Aspergillus fumigatus | 31.71 | 4e-59 | 214 |
| LLPS-Nef-1375 | Neosartorya fischeri | 31.5 | 2e-60 | 218 |
| LLPS-Nec-1280 | Neurospora crassa | 31.49 | 2e-58 | 212 |
| LLPS-Zyt-0367 | Zymoseptoria tritici | 31.15 | 7e-59 | 213 |
| LLPS-Dos-1038 | Dothistroma septosporum | 31.15 | 3e-60 | 217 |
| LLPS-Tum-0969 | Tuber melanosporum | 30.88 | 4e-56 | 205 |
| LLPS-Asn-1329 | Aspergillus nidulans | 30.85 | 6e-56 | 205 |
| LLPS-Scs-1112 | Sclerotinia sclerotiorum | 30.32 | 1e-51 | 192 |
| LLPS-Yal-1017 | Yarrowia lipolytica | 28.29 | 3e-41 | 162 |
| LLPS-Mel-1236 | Melampsora laricipopulina | 28.25 | 4e-43 | 167 |
| LLPS-Scp-1386 | Schizosaccharomyces pombe | 28.23 | 3e-48 | 183 |
| LLPS-Scc-1632 | Schizosaccharomyces cryophilus | 28.19 | 2e-49 | 187 |
| LLPS-Pug-0448 | Puccinia graminis | 27.88 | 6e-39 | 155 |
| LLPS-Kop-0988 | Komagataella pastoris | 27.87 | 7e-32 | 134 |
| LLPS-Asg-1270 | Ashbya gossypii | 25.34 | 2e-25 | 115 |
| LLPS-Sac-1075 | Saccharomyces cerevisiae | 23.99 | 4e-27 | 120 |