LLPS-Hos-3160
SSR1
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Translocon-associated protein subunit alpha |
| Gene Name: | SSR1, TRAPA, PSEC0262 |
| Ensembl Gene: | ENSG00000124783.13 |
| Ensembl Protein: | ENSP00000420730.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000489567.5 | ENSP00000420730.1 |
| Ensembl | ENST00000479485.5 | ENSP00000419953.1 |
| Ensembl | ENST00000462112.1 | ENSP00000417290.1 |
| Ensembl | ENST00000650389.1 | ENSP00000497016.1 |
| Ensembl | ENST00000479365.5 | ENSP00000417911.1 |
| Ensembl | ENST00000244763.8 | ENSP00000244763.4 |
| Ensembl | ENST00000474597.5 | ENSP00000418617.1 |
| Ensembl | ENST00000397511.6 | ENSP00000380647.2 |
| UniProt | P43307, SSRA_HUMAN, A8K685, Q53GX2, Q53H19, Q5TAM3, Q6IB43, Q8NBH9, Q96IA2, Q9TNQ8, Q9UN49 | |
| GeneBank | AK222809, Z12830, AF156965, BC007710, AK222762, AL139095, BT007387, AK291550, AK075562, CR456961 | CAA78290.1, AAP36051.1, CAG33242.1, AAD48778.1, BAD96482.1, BAC11701.1, BAF84239.1, AAH07710.1, BAD96529.1 |
| RefSeq | NM_001292008.1, NM_003144.4 | NP_001278937.1, NP_003135.2 |
| Entrez | 6745 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MRLLPRLLLL LLLVFPATVL FRGGPRGLLA VAQDLTEDEE TVEDSIIEDE DDEAEVEEDE 60 61 PTDLVEDKEE EDVSGEPEAS PSADTTILFV KGEDFPANNI VKFLVGFTNK GTEDFIVESL 120 121 DASFRYPQDY QFYIQNFTAL PLNTVVPPQR QATFEYSFIP AEPMGGRPFG LVINLNYKDL 180 181 NGNVFQDAVF NQTVTVIERE DGLDGETIFM YMFLAGLGLL VIVGLHQLLE SRKRKRPIQK 240 241 VEMGTSSQND VDMSWIPQET LNQIMQSRRD KASPRRLPRK RAQKRSVGSD ERRRRETH 298 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGACTCC TCCCCCGCTT GCTGCTGCTT CTCTTACTCG TGTTCCCTGC CACTGTCTTG 60 61 TTCCGAGGCG GCCCCAGAGG CTTGTTAGCA GTGGCACAAG ATCTTACAGA GGATGAAGAA 120 121 ACAGTAGAAG ATTCCATAAT TGAGGATGAA GATGATGAAG CCGAGGTAGA AGAAGATGAA 180 181 CCCACAGATT TGGTAGAAGA TAAAGAGGAA GAAGATGTGT CTGGTGAACC TGAAGCTTCA 240 241 CCGAGTGCAG ATACAACTAT ACTGTTTGTA AAAGGAGAAG ATTTTCCAGC AAATAACATT 300 301 GTGAAGTTCC TGGTAGGCTT TACCAACAAG GGTACAGAAG ATTTTATTGT TGAATCCTTA 360 361 GATGCCTCAT TCCGTTATCC TCAGGACTAC CAGTTTTATA TCCAGAATTT CACAGCTCTT 420 421 CCTCTGAACA CTGTAGTGCC ACCCCAGAGA CAGGCAACTT TTGAGTACTC TTTCATTCCT 480 481 GCAGAGCCCA TGGGCGGACG ACCATTTGGT TTGGTCATCA ATCTGAACTA CAAAGATTTG 540 541 AACGGCAATG TATTCCAAGA TGCAGTCTTC AATCAAACAG TTACAGTTAT TGAAAGAGAG 600 601 GATGGGTTAG ATGGAGAAAC AATCTTTATG TATATGTTCC TTGCTGGTCT TGGGCTTCTG 660 661 GTTATTGTTG GCCTTCATCA ACTCCTAGAA TCTAGAAAGC GTAAGAGACC CATACAGAAA 720 721 GTAGAAATGG GTACATCAAG TCAGAATGAT GTTGACATGA GTTGGATTCC TCAGGAAACA 780 781 TTGAATCAAA TCAATAAAGC TTCACCAAGA AGGTTGCCCA GGAAACGGGC ACAGAAGAGA 840 841 TCAGTGGGAT CTGATGAGTA A 861 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Endoplasmic reticulum | |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Integral component of membrane | |
Biological Process | Cotranslational protein targeting to membrane | |
Biological Process | IRE1-mediated unfolded protein response | |
Biological Process | Positive regulation of cell population proliferation |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | CellMarker | RaftProt | ||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mam-2583 | Macaca mulatta | 99.65 | 1e-170 | 482 |
| LLPS-Nol-0566 | Nomascus leucogenys | 99.65 | 4e-168 | 476 |
| LLPS-Man-2093 | Macaca nemestrina | 99.65 | 1e-170 | 482 |
| LLPS-Paa-3181 | Papio anubis | 99.65 | 1e-170 | 482 |
| LLPS-Mal-4232 | Mandrillus leucophaeus | 99.65 | 1e-170 | 482 |
| LLPS-Chs-4613 | Chlorocebus sabaeus | 99.65 | 1e-170 | 482 |
| LLPS-Maf-4797 | Macaca fascicularis | 99.65 | 1e-170 | 482 |
| LLPS-Pat-3831 | Pan troglodytes | 99.3 | 1e-169 | 480 |
| LLPS-Gog-1483 | Gorilla gorilla | 99.3 | 3e-170 | 481 |
| LLPS-Pap-4462 | Pan paniscus | 98.95 | 3e-169 | 478 |
| LLPS-Rhb-2678 | Rhinopithecus bieti | 98.95 | 2e-167 | 474 |
| LLPS-Caj-3910 | Callithrix jacchus | 98.95 | 2e-169 | 479 |
| LLPS-Aon-2397 | Aotus nancymaae | 97.86 | 6e-163 | 462 |
| LLPS-Cea-1113 | Cercocebus atys | 97.54 | 2e-163 | 464 |
| LLPS-Otg-1085 | Otolemur garnettii | 97.48 | 1e-162 | 461 |
| LLPS-Poa-3878 | Pongo abelii | 97.19 | 3e-163 | 463 |
| LLPS-Fec-0708 | Felis catus | 97.19 | 9e-167 | 472 |
| LLPS-Eqc-3978 | Equus caballus | 97.13 | 3e-107 | 322 |
| LLPS-Ict-3452 | Ictidomys tridecemlineatus | 95.68 | 3e-155 | 443 |
| LLPS-Ova-4074 | Ovis aries | 95.47 | 3e-144 | 416 |
| LLPS-Cap-0612 | Cavia porcellus | 95.32 | 3e-157 | 448 |
| LLPS-Orc-0374 | Oryctolagus cuniculus | 94.74 | 4e-161 | 458 |
| LLPS-Caf-3424 | Canis familiaris | 94.58 | 2e-152 | 436 |
| LLPS-Mea-1829 | Mesocricetus auratus | 94.53 | 1e-150 | 431 |
| LLPS-Aim-3227 | Ailuropoda melanoleuca | 94.41 | 1e-160 | 457 |
| LLPS-Mup-4361 | Mustela putorius furo | 94.39 | 4e-159 | 452 |
| LLPS-Fud-3104 | Fukomys damarensis | 94.3 | 2e-143 | 413 |
| LLPS-Urm-3241 | Ursus maritimus | 94.24 | 3e-152 | 436 |
| LLPS-Sus-2895 | Sus scrofa | 94.24 | 1e-150 | 431 |
| LLPS-Anc-3421 | Anolis carolinensis | 94.09 | 4e-136 | 394 |
| LLPS-Loa-4358 | Loxodonta africana | 93.86 | 1e-154 | 441 |
| LLPS-Mum-3867 | Mus musculus | 93.73 | 3e-136 | 395 |
| LLPS-Bot-4217 | Bos taurus | 92.83 | 4e-137 | 399 |
| LLPS-Dio-0585 | Dipodomys ordii | 92.81 | 6e-149 | 427 |
| LLPS-Myl-2897 | Myotis lucifugus | 92.81 | 1e-153 | 439 |
| LLPS-Gaga-3457 | Gallus gallus | 92.57 | 1e-147 | 424 |
| LLPS-Ran-4508 | Rattus norvegicus | 92.43 | 8e-124 | 364 |
| LLPS-Ora-1421 | Ornithorhynchus anatinus | 91.67 | 4e-139 | 399 |
| LLPS-Meg-1056 | Meleagris gallopavo | 91.27 | 1e-148 | 426 |
| LLPS-Pes-2500 | Pelodiscus sinensis | 90.99 | 2e-138 | 400 |
| LLPS-Tag-2998 | Taeniopygia guttata | 90.91 | 4e-125 | 365 |
| LLPS-Fia-0022 | Ficedula albicollis | 90.57 | 4e-138 | 400 |
| LLPS-Anp-0648 | Anas platyrhynchos | 89.93 | 5e-151 | 432 |
| LLPS-Sah-3082 | Sarcophilus harrisii | 89.42 | 6e-140 | 405 |
| LLPS-Asm-3548 | Astyanax mexicanus | 88.68 | 3e-122 | 359 |
| LLPS-Mod-3212 | Monodelphis domestica | 87.9 | 5e-144 | 416 |
| LLPS-Dar-3811 | Danio rerio | 83.94 | 1e-103 | 311 |
| LLPS-Xet-2491 | Xenopus tropicalis | 80.36 | 2e-119 | 352 |
| LLPS-Scf-0667 | Scleropages formosus | 68.57 | 1e-88 | 273 |
| LLPS-Ten-2266 | Tetraodon nigroviridis | 68.08 | 5e-90 | 276 |
| LLPS-Orn-3243 | Oreochromis niloticus | 66.2 | 1e-89 | 276 |
| LLPS-Icp-1077 | Ictalurus punctatus | 65.6 | 1e-90 | 278 |
| LLPS-Orl-2949 | Oryzias latipes | 64.79 | 4e-86 | 266 |
| LLPS-Lac-0134 | Latimeria chalumnae | 64.65 | 1e-88 | 273 |
| LLPS-Tar-3321 | Takifugu rubripes | 64.32 | 5e-85 | 264 |
| LLPS-Pof-4179 | Poecilia formosa | 64.16 | 1e-87 | 271 |
| LLPS-Gaa-3405 | Gasterosteus aculeatus | 63.64 | 2e-89 | 276 |
| LLPS-Xim-2472 | Xiphophorus maculatus | 63.27 | 3e-86 | 270 |
| LLPS-Scm-1216 | Scophthalmus maximus | 63.0 | 7e-88 | 271 |
| LLPS-Leo-3120 | Lepisosteus oculatus | 61.98 | 5e-89 | 275 |
| LLPS-Drm-1746 | Drosophila melanogaster | 42.29 | 2e-51 | 177 |
| LLPS-Cae-1177 | Caenorhabditis elegans | 37.07 | 7e-39 | 143 |
| LLPS-Arl-2759 | Arabidopsis lyrata | 31.33 | 9e-12 | 67.8 |
| LLPS-Art-0437 | Arabidopsis thaliana | 31.13 | 1e-12 | 70.1 |
| LLPS-Gor-2002 | Gossypium raimondii | 30.77 | 2e-09 | 60.8 |
| LLPS-Bro-0938 | Brassica oleracea | 30.6 | 3e-10 | 63.5 |
| LLPS-Brr-2957 | Brassica rapa | 30.6 | 5e-10 | 62.8 |
| LLPS-Brn-3256 | Brassica napus | 30.6 | 3e-10 | 63.5 |
| LLPS-Sol-1467 | Solanum lycopersicum | 28.74 | 4e-11 | 67.4 |
| LLPS-Hov-1058 | Hordeum vulgare | 28.42 | 2e-09 | 60.8 |
| LLPS-Thc-2010 | Theobroma cacao | 28.06 | 2e-08 | 58.5 |
| LLPS-Tru-1419 | Triticum urartu | 28.02 | 1e-09 | 61.6 |
| LLPS-Coc-1475 | Corchorus capsularis | 27.92 | 5e-09 | 61.2 |
| LLPS-Brd-2354 | Brachypodium distachyon | 27.75 | 1e-08 | 58.9 |
| LLPS-Tra-0538 | Triticum aestivum | 27.47 | 2e-09 | 60.8 |
| LLPS-Amt-1790 | Amborella trichopoda | 27.23 | 6e-12 | 68.2 |
| LLPS-Php-0324 | Physcomitrella patens | 26.8 | 4e-10 | 63.5 |
| LLPS-Orr-0698 | Oryza rufipogon | 26.76 | 5e-11 | 65.5 |
| LLPS-Org-2007 | Oryza glaberrima | 26.76 | 6e-11 | 65.5 |
| LLPS-Ors-2363 | Oryza sativa | 26.76 | 6e-11 | 65.5 |
| LLPS-Orbr-0517 | Oryza brachyantha | 26.76 | 2e-12 | 69.3 |
| LLPS-Lep-0127 | Leersia perrieri | 26.76 | 7e-12 | 68.2 |
| LLPS-Ori-0922 | Oryza indica | 26.76 | 6e-11 | 65.5 |
| LLPS-Orb-2417 | Oryza barthii | 26.76 | 6e-11 | 65.5 |
| LLPS-Sei-1311 | Setaria italica | 26.4 | 2e-11 | 66.6 |
| LLPS-Hea-2550 | Helianthus annuus | 26.21 | 5e-09 | 60.1 |
| LLPS-Orp-1981 | Oryza punctata | 26.07 | 6e-10 | 62.4 |
| LLPS-Sob-1450 | Sorghum bicolor | 26.05 | 5e-10 | 62.8 |