LLPS-Hos-2938
SLK

▼ OVERVIEW

Status: Reviewed
Protein Name: STE20-like serine/threonine-protein kinase
Gene Name: SLK, KIAA0204, STK2
Ensembl Gene: ENSG00000065613.13
Ensembl Protein: ENSP00000358770.3
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client
PDB: 4USF (A) More


▼ PROPERTY


▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Mediates apoptosis and actin stress fiber dissolution.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSFFNFRKIF  KLGSEKKKKQ  YEHVKRDLNP  EDFWEIIGEL  GDGAFGKVYK  AQNKETSVLA  60
61    AAKVIDTKSE  EELEDYMVEI  DILASCDHPN  IVKLLDAFYY  ENNLWILIEF  CAGGAVDAVM  120
121   LELERPLTES  QIQVVCKQTL  DALNYLHDNK  IIHRDLKAGN  ILFTLDGDIK  LADFGVSAKN  180
181   TRTIQRRDSF  IGTPYWMAPE  VVMCETSKDR  PYDYKADVWS  LGITLIEMAE  IEPPHHELNP  240
241   MRVLLKIAKS  EPPTLAQPSR  WSSNFKDFLK  KCLEKNVDAR  WTTSQLLQHP  FVTVDSNKPI  300
301   RELIAEAKAE  VTEEVEDGKE  EDEEEETENS  LPIPASKRAS  SDLSIASSEE  DKLSQNACIL  360
361   ESVSEKTERS  NSEDKLNSKI  LNEKPTTDEP  EKAVEDINEH  ITDAQLEAMT  ELHDRTAVIK  420
421   ENEREKRPKL  ENLPDTEDQE  TVDINSVSEG  KENNIMITLE  TNIEHNLKSE  EEKDQEKQQM  480
481   FENKLIKSEE  IKDTILQTVD  LVSQETGEKE  ANIQAVDSEV  GLTKEDTQEK  LGEDDKTQKD  540
541   VISNTSDVIG  TCEAADVAQK  VDEDSAEDTQ  SNDGKEVVEV  GQKLINKPMV  GPEAGGTKEV  600
601   PIKEIVEMNE  IEEGKNKEQA  INSSENIMDI  NEEPGTTEGE  EITESSSTEE  MEVRSVVADT  660
661   DQKALGSEVQ  DASKVTTQID  KEKKEIPVSI  KKEPEVTVVS  QPTEPQPVLI  PSININSDSG  720
721   ENKEEIGSLS  KTETILPPES  ENPKENDNDS  GTGSTADTSS  IDLNLSISSF  LSKTKDSGSI  780
781   SLQETRRQKK  TLKKTRKFIV  DGVEVSVTTS  KIVTDSDSKT  EELRFLRRQE  LRELRFLQKE  840
841   EQRAQQQLNS  KLQQQREQIF  RRFEQEMMSK  KRQYDQEIEN  LEKQQKQTIE  RLEQEHTNRL  900
901   RDEAKRIKGE  QEKELSKFQN  MLKNRKKEVI  NEVEKAPKEL  RKELMKRRKE  ELAQSQHAQE  960
961   QEFVQKQQQE  LDGSLKKIIQ  QQKAELANIE  RECLNNKQQL  MRAREAAIWE  LEERHLQEKH  1020
1021  QLLKQQLKDQ  YFMQRHQLLK  RHEKETEQMQ  RYNQRLIEEL  KNRQTQERAR  LPKIQRSEAK  1080
1081  TRMAMFKKSL  RINSTATPDQ  DRDKIKQFAA  QEEKRQKNER  MAQHQKHENQ  MRDLQLQCEA  1140
1141  NVRELHQLQN  EKCHLLVEHE  TQKLKELDEE  HSQELKEWRE  KLRPRKKTLE  EEFARKLQEQ  1200
1201  EVFFKMTGES  ECLNPSTQSR  ISKFYPIPSL  HSTGS  1235
Nucleotide CDS Sequence (FASTA)
1     ATGTCCTTCT  TCAATTTCCG  TAAGATCTTC  AAGTTGGGGA  GCGAGAAGAA  GAAGAAGCAG  60
61    TACGAACACG  TGAAGAGGGA  CCTGAACCCC  GAAGACTTTT  GGGAGATTAT  AGGAGAACTG  120
121   GGCGACGGAG  CCTTTGGGAA  AGTGTACAAG  GCCCAGAATA  AAGAGACCAG  TGTTTTAGCT  180
181   GCTGCAAAAG  TGATTGACAC  TAAATCTGAA  GAAGAACTTG  AAGATTACAT  GGTAGAGATT  240
241   GACATATTAG  CATCTTGTGA  TCACCCAAAT  ATAGTCAAGC  TTCTAGATGC  CTTCTATTAT  300
301   GAGAACAATC  TTTGGATCCT  CATTGAATTT  TGTGCAGGTG  GAGCAGTAGA  TGCTGTGATG  360
361   CTTGAACTTG  AGAGACCATT  AACTGAGTCC  CAAATACAAG  TAGTTTGCAA  GCAGACTTTA  420
421   GATGCATTGA  ACTACTTACA  TGATAATAAG  ATCATCCACA  GAGATCTGAA  GGCTGGCAAC  480
481   ATTCTCTTTA  CCTTAGATGG  AGATATCAAA  TTGGCGGATT  TTGGAGTATC  AGCTAAAAAC  540
541   ACGAGGACAA  TTCAAAGAAG  AGATTCCTTT  ATTGGTACAC  CATATTGGAT  GGCTCCTGAA  600
601   GTAGTCATGT  GTGAAACATC  TAAGGACAGA  CCCTATGACT  ACAAAGCTGA  TGTTTGGTCC  660
661   CTGGGTATCA  CTTTAATAGA  AATGGCTGAG  ATAGAACCAC  CTCATCATGA  ATTAAATCCA  720
721   ATGCGAGTGC  TGCTAAAAAT  AGCAAAATCT  GAGCCACCTA  CATTAGCACA  GCCATCCAGA  780
781   TGGTCTTCAA  ATTTTAAGGA  CTTTCTAAAG  AAATGCTTAG  AAAAGAATGT  GGATGCCAGG  840
841   TGGACTACAT  CTCAGCTGCT  GCAGCATCCC  TTTGTTACTG  TTGATTCCAA  CAAACCCATC  900
901   CGAGAATTGA  TTGCAGAGGC  GAAGGCTGAA  GTAACAGAAG  AAGTTGAAGA  TGGCAAAGAG  960
961   GAAGATGAAG  AGGAGGAAAC  AGAAAATTCT  CTGCCAATAC  CTGCAAGTAA  GCGTGCATCT  1020
1021  TCTGACCTTA  GTATCGCCAG  CTCTGAAGAA  GATAAACTTT  CACAAAATGC  TTGTATTTTG  1080
1081  GAGTCTGTCT  CAGAAAAAAC  AGAACGTAGT  AACTCTGAAG  ATAAACTCAA  CAGCAAAATT  1140
1141  CTTAATGAAA  AACCCACCAC  TGATGAACCT  GAAAAGGCTG  TGGAGGATAT  TAATGAACAT  1200
1201  ATTACCGATG  CTCAGTTAGA  AGCAATGACT  GAACTCCATG  ACAGAACAGC  AGTAATCAAG  1260
1261  GAGAATGAAA  GAGAGAAGAG  GCCCAAGCTT  GAAAATCTGC  CTGACACAGA  AGACCAAGAA  1320
1321  ACTGTGGACA  TTAATTCAGT  CAGTGAAGGA  AAAGAGAATA  ATATAATGAT  AACCTTAGAA  1380
1381  ACAAATATTG  AACATAATCT  AAAATCTGAG  GAAGAAAAGG  ATCAGGAAAA  GCAACAGATG  1440
1441  TTTGAAAATA  AGCTTATAAA  ATCTGAAGAA  ATTAAAGATA  CTATTTTGCA  AACAGTAGAT  1500
1501  TTAGTTTCTC  AAGAGACTGG  AGAAAAAGAG  GCAAATATTC  AGGCAGTTGA  TAGTGAAGTT  1560
1561  GGGCTTACAA  AGGAAGACAC  CCAAGAGAAA  TTGGGGGAAG  ACGACAAAAC  TCAAAAAGAT  1620
1621  GTGATCAGCA  ATACAAGTGA  TGTGATAGGA  ACATGTGAGG  CAGCAGATGT  GGCTCAGAAA  1680
1681  GTGGATGAAG  ACAGTGCTGA  GGATACGCAG  AGTAATGATG  GGAAAGAAGT  GGTCGAAGTA  1740
1741  GGCCAGAAAT  TAATTAATAA  GCCCATGGTG  GGTCCTGAGG  CTGGTGGTAC  TAAGGAAGTT  1800
1801  CCTATTAAAG  AAATAGTTGA  AATGAATGAA  ATAGAAGAAG  GTAAAAATAA  GGAACAAGCA  1860
1861  ATAAACAGTT  CAGAGAACAT  AATGGACATC  AATGAGGAAC  CAGGAACAAC  TGAAGGTGAA  1920
1921  GAAATCACTG  AGTCAAGTAG  CACTGAAGAA  ATGGAGGTCA  GAAGTGTGGT  GGCTGATACT  1980
1981  GACCAAAAGG  CTTTAGGAAG  TGAAGTTCAG  GATGCTTCTA  AAGTCACTAC  TCAGATAGAT  2040
2041  AAAGAGAAAA  AAGAAATTCC  AGTGTCAATT  AAAAAAGAGC  CTGAAGTTAC  TGTAGTTTCA  2100
2101  CAGCCCACTG  AACCTCAGCC  TGTTCTAATA  CCCAGTATTA  ATATCAACTC  TGACAGTGGA  2160
2161  GAAAATAAAG  AAGAAATAGG  TTCTTTATCA  AAAACTGAAA  CTATTCTGCC  ACCAGAATCT  2220
2221  GAGAATCCAA  AGGAAAATGA  TAATGATTCA  GGCACTGGTT  CCACTGCTGA  TACTAGCAGT  2280
2281  ATTGACTTGA  ATTTATCCAT  CTCTAGCTTT  CTAAGTAAAA  CTAAAGACAG  TGGATCGATA  2340
2341  TCTTTACAAG  AAACAAGAAG  ACAAAAGAAA  ACATTGAAGA  AAACACGCAA  ATTTATTGTT  2400
2401  GATGGTGTAG  AAGTGAGTGT  AACAACATCA  AAGATAGTTA  CAGATAGTGA  TTCCAAAACT  2460
2461  GAAGAATTGC  GGTTTCTTAG  ACGTCAGGAA  CTTCGGGAAT  TAAGATTTCT  TCAGAAAGAA  2520
2521  GAGCAAAGAG  CCCAACAACA  GCTCAATAGC  AAACTACAGC  AACAACGAGA  ACAAATTTTC  2580
2581  CGGCGCTTTG  AGCAGGAAAT  GATGAGTAAA  AAGCGACAAT  ATGACCAGGA  AATTGAGAAT  2640
2641  CTAGAAAAAC  AGCAGAAACA  GACTATCGAA  CGCCTGGAAC  AAGAGCACAC  AAATCGCTTG  2700
2701  CGAGATGAAG  CCAAACGCAT  CAAAGGAGAA  CAAGAGAAAG  AGTTGTCCAA  ATTTCAGAAT  2760
2761  ATGCTGAAGA  ACCGAAAGAA  GGAGGTTATA  AATGAAGTGG  AGAAAGCACC  CAAAGAGCTG  2820
2821  AGAAAAGAGC  TCATGAAACG  CAGGAAAGAG  GAGCTTGCAC  AAAGCCAGCA  TGCTCAGGAA  2880
2881  CAAGAGTTTG  TTCAGAAACA  ACAGCAAGAA  TTAGATGGCT  CTCTGAAAAA  GATCATCCAG  2940
2941  CAGCAGAAGG  CAGAGTTAGC  TAATATTGAG  AGAGAGTGCC  TGAATAACAA  GCAACAGCTC  3000
3001  ATGAGAGCTC  GAGAAGCTGC  AATTTGGGAG  CTCGAAGAAC  GACACTTACA  AGAAAAACAC  3060
3061  CAGCTGCTCA  AACAGCAGCT  TAAAGATCAG  TATTTCATGC  AAAGACATCA  GCTACTTAAG  3120
3121  CGCCACGAGA  AGGAAACAGA  GCAAATGCAG  CGTTACAATC  AAAGACTTAT  TGAGGAATTG  3180
3181  AAAAACAGAC  AGACTCAAGA  AAGAGCAAGA  CTGCCCAAGA  TTCAGCGCAG  TGAAGCCAAG  3240
3241  ACTCGAATGG  CCATGTTTAA  GAAGAGTTTG  AGAATTAACT  CAACAGCCAC  ACCAGATCAG  3300
3301  GACCGTGATA  AAATTAAACA  GTTTGCTGCA  CAAGAAGAAA  AGAGGCAGAA  AAATGAGAGA  3360
3361  ATGGCTCAGC  ATCAGAAACA  TGAGAATCAA  ATGCGAGATC  TTCAGTTGCA  GTGTGAAGCC  3420
3421  AATGTCCGCG  AACTGCATCA  GCTGCAGAAT  GAAAAATGCC  ACTTGTTGGT  TGAGCATGAG  3480
3481  ACTCAGAAAC  TGAAGGAGTT  AGATGAGGAA  CATAGCCAAG  AATTAAAGGA  GTGGAGAGAG  3540
3541  AAATTGAGAC  CTAGGAAAAA  GACACTGGAA  GAAGAGTTTG  CCAGGAAACT  ACAGGAACAG  3600
3601  GAAGTATTCT  TTAAAATGAC  TGGGGAGTCT  GAATGCCTTA  ACCCATCAAC  ACAGAGCCGG  3660
3661  ATTTCCAAAT  TTTATCCTAT  TCCCAGCTTG  CATTCCACCG  GATCATAA  3708

▼ KEYWORD

ID
Family
3D-structure
Alternative splicing
Apoptosis
ATP-binding
Coiled coil
Complete proteome
Cytoplasm
Kinase
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cell leading edge
Cellular Component
Cytoplasm
Cellular Component
Extracellular exosome
Cellular Component
Perinuclear region of cytoplasm
Molecular Function
ATP binding
Molecular Function
Cadherin binding
Molecular Function
Identical protein binding
Molecular Function
Protein homodimerization activity
Molecular Function
Protein serine/threonine kinase activity
Biological Process
Activation of protein kinase activity
Biological Process
Apoptotic process
Biological Process
Cytoplasmic microtubule organization
Biological Process
Protein autophosphorylation
Biological Process
Regulation of apoptotic process
Biological Process
Regulation of cell migration
Biological Process
Regulation of focal adhesion assembly
Biological Process
Signal transduction by protein phosphorylation
Biological Process
Stress-activated protein kinase signaling cascade

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pap-0738Pan paniscus99.680.02098
LLPS-Pat-4244Pan troglodytes99.60.02098
LLPS-Gog-3981Gorilla gorilla99.190.02085
LLPS-Poa-4015Pongo abelii98.870.02085
LLPS-Chs-2476Chlorocebus sabaeus97.730.02057
LLPS-Cea-4621Cercocebus atys97.650.02058
LLPS-Mal-2162Mandrillus leucophaeus97.570.02055
LLPS-Maf-2061Macaca fascicularis97.410.02052
LLPS-Nol-2818Nomascus leucogenys97.410.02033
LLPS-Man-1052Macaca nemestrina97.410.02052
LLPS-Paa-4355Papio anubis97.330.02048
LLPS-Mam-3212Macaca mulatta97.330.02049
LLPS-Aon-4620Aotus nancymaae95.880.02017
LLPS-Caj-4140Callithrix jacchus95.480.02003
LLPS-Fia-2951Ficedula albicollis92.270.0 706
LLPS-Caf-4422Canis familiaris90.180.01877
LLPS-Tut-2339Tursiops truncatus89.860.01873
LLPS-Fec-2404Felis catus89.690.01859
LLPS-Otg-4366Otolemur garnettii89.610.01868
LLPS-Aim-0606Ailuropoda melanoleuca89.450.01869
LLPS-Sus-2191Sus scrofa89.290.01861
LLPS-Mup-2921Mustela putorius furo88.970.01850
LLPS-Loa-0297Loxodonta africana88.610.01855
LLPS-Ict-4502Ictidomys tridecemlineatus88.410.01847
LLPS-Orc-0654Oryctolagus cuniculus88.090.01835
LLPS-Myl-2277Myotis lucifugus88.010.01815
LLPS-Bot-3281Bos taurus87.840.01830
LLPS-Ova-3318Ovis aries87.760.01825
LLPS-Dio-3451Dipodomys ordii87.180.01804
LLPS-Eqc-3045Equus caballus86.890.01858
LLPS-Anc-3239Anolis carolinensis86.653e-175 557
LLPS-Urm-3907Ursus maritimus86.550.01833
LLPS-Xet-2178Xenopus tropicalis86.410.0 655
LLPS-Fud-1772Fukomys damarensis85.120.01754
LLPS-Orn-2376Oreochromis niloticus83.930.0 582
LLPS-Cap-4186Cavia porcellus83.430.01663
LLPS-Mum-4324Mus musculus82.930.01706
LLPS-Asm-1524Astyanax mexicanus82.450.0 595
LLPS-Lac-1695Latimeria chalumnae82.410.0 644
LLPS-Icp-2307Ictalurus punctatus82.240.0 595
LLPS-Scm-2027Scophthalmus maximus79.950.0 600
LLPS-Leo-0119Lepisosteus oculatus79.560.0 637
LLPS-Ran-1133Rattus norvegicus79.080.01645
LLPS-Sah-3971Sarcophilus harrisii78.770.01548
LLPS-Pof-4001Poecilia formosa78.480.0 584
LLPS-Mea-3751Mesocricetus auratus78.10.01535
LLPS-Pes-1150Pelodiscus sinensis78.040.0 655
LLPS-Mod-2748Monodelphis domestica76.180.01528
LLPS-Tag-3010Taeniopygia guttata70.580.01355
LLPS-Cas-2041Carlito syrichta70.324e-134 439
LLPS-Gaga-1558Gallus gallus68.380.01345
LLPS-Cii-1693Ciona intestinalis66.346e-136 452
LLPS-Cis-1883Ciona savignyi64.716e-132 442
LLPS-Drm-0115Drosophila melanogaster60.396e-122 421
LLPS-Ora-3053Ornithorhynchus anatinus59.791e-123 404
LLPS-Php-2106Physcomitrella patens46.429e-72 259
LLPS-Bro-2491Brassica oleracea46.042e-71 260
LLPS-Prp-1949Prunus persica46.042e-71 260
LLPS-Nia-2126Nicotiana attenuata45.673e-63 234
LLPS-Phv-2354Phaseolus vulgaris45.673e-61 228
LLPS-Orbr-1276Oryza brachyantha45.674e-63 234
LLPS-Arl-0717Arabidopsis lyrata45.665e-70 260
LLPS-Mua-2259Musa acuminata45.663e-73 265
LLPS-Hea-2689Helianthus annuus45.663e-71 259
LLPS-Brn-2717Brassica napus45.662e-70 257
LLPS-Mae-0371Manihot esculenta45.662e-70 257
LLPS-Art-3052Arabidopsis thaliana45.661e-71 261
LLPS-Brr-2130Brassica rapa45.662e-70 258
LLPS-Met-2639Medicago truncatula45.282e-61 229
LLPS-Orgl-2270Oryza glumaepatula45.284e-62 231
LLPS-Dac-0621Daucus carota45.282e-71 260
LLPS-Thc-1448Theobroma cacao45.281e-70 258
LLPS-Orni-2244Oryza nivara45.283e-62 231
LLPS-Glm-1318Glycine max45.289e-62 230
LLPS-Org-0880Oryza glaberrima45.284e-62 231
LLPS-Orr-2128Oryza rufipogon45.284e-62 231
LLPS-Orp-1806Oryza punctata45.282e-62 231
LLPS-Ors-0980Oryza sativa45.284e-62 231
LLPS-Yal-1557Yarrowia lipolytica45.082e-67 243
LLPS-Sol-1955Solanum lycopersicum44.912e-69 254
LLPS-Tra-2496Triticum aestivum44.882e-62 231
LLPS-Sei-0870Setaria italica44.882e-63 232
LLPS-Hov-1300Hordeum vulgare44.882e-62 232
LLPS-Sob-0837Sorghum bicolor44.882e-62 231
LLPS-Orm-1625Oryza meridionalis44.852e-70 258
LLPS-Sem-1272Selaginella moellendorffii44.691e-71 260
LLPS-Zem-0628Zea mays44.533e-69 254
LLPS-Brd-2266Brachypodium distachyon44.498e-62 230
LLPS-Lep-2249Leersia perrieri44.443e-63 234
LLPS-Crn-1482Cryptococcus neoformans43.821e-63 236
LLPS-Gor-2495Gossypium raimondii43.771e-67 249
LLPS-Chr-1684Chlamydomonas reinhardtii43.757e-64 237
LLPS-Scj-1599Schizosaccharomyces japonicus43.535e-62 225
LLPS-Spr-0905Sporisorium reilianum43.515e-61 229
LLPS-Amt-0793Amborella trichopoda43.44e-69 253
LLPS-Lem-0825Leptosphaeria maculans43.222e-63 235
LLPS-Mao-1427Magnaporthe oryzae43.134e-61 227
LLPS-Scs-0386Sclerotinia sclerotiorum43.139e-64 234
LLPS-Phn-0364Phaeosphaeria nodorum43.071e-62 233
LLPS-Asc-0319Aspergillus clavatus42.551e-63 233
LLPS-Scp-1254Schizosaccharomyces pombe42.424e-61 227
LLPS-Tum-0988Tuber melanosporum42.377e-64 225
LLPS-Pyt-0455Pyrenophora teres42.184e-62 231
LLPS-Pytr-1587Pyrenophora triticirepentis42.187e-63 231
LLPS-Blg-1120Blumeria graminis41.65e-62 229
LLPS-Asfu-0711Aspergillus fumigatus41.451e-63 231
LLPS-Nef-0034Neosartorya fischeri41.452e-62 229
LLPS-Asf-1384Aspergillus flavus41.092e-61 227
LLPS-Aso-1475Aspergillus oryzae41.092e-61 227
LLPS-Map-0887Magnaporthe poae41.097e-62 222