LLPS-Hos-2898
MEX3A

▼ OVERVIEW

Status: Reviewed
Protein Name: RNA-binding protein MEX3A; RING finger and KH domain-containing protein 4
Gene Name: MEX3A, RKHD4
Ensembl Gene: ENSG00000254726.2
Ensembl Protein: ENSP00000432845.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
P-body
"...Comparing protein relative abundances between the sorted and pre-sorted fractions, we identified 125 proteins as significantly enriched in P-bodies."
HEK293 cells28965817
P-body
"...The hMex-3B KH mutant was no longer localized in P bodies and this was not due to the disruption of the P bodies’ integrity, since the punctuate distribution of Dcp1a was not affected by the expression of the hMex-3B KH mutant."
N/A17267406
Stress granule
"...Together, our APEX and IF screening approaches identified 260 SG proteins, including ~150 candidates that had not previously been associated with SGs."
Neural progenitor cells29373831
Stress granule
"...283 proteins identified as APEX hits in HEK293T cells or previously shown to associate with SGs."
N/A29373831
Stress granule
"...By adding known stress granule components not identified by mass spectrometry to this list, we created the first stress granule proteome for a mammalian cell."
U2OS cells26777405

▼ FUNCTION

RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MPSLVVSGIM  ERNGGFGELG  CFGGSAKDRG  LLEDERALQL  ALDQLCLLGL  GEPPAPTAGE  60
61    DGGGGGGGAP  AQPAAPPQPA  PPPPPAAPPA  APTAAPAAQT  PQPPTAPKGA  SDAKLCALYK  120
121   EAELRLKGSS  NTTECVPVPT  SEHVAEIVGR  QGCKIKALRA  KTNTYIKTPV  RGEEPVFMVT  180
181   GRREDVATAR  REIISAAEHF  SMIRASRNKS  GAAFGVAPAL  PGQVTIRVRV  PYRVVGLVVG  240
241   PKGATIKRIQ  QQTNTYIITP  SRDRDPVFEI  TGAPGNVERA  REEIETHIAV  RTGKILEYNN  300
301   ENDFLAGSPD  AAIDSRYSDA  WRVHQPGCKP  LSTFRQNSLG  CIGECGVDSG  FEAPRLGEQG  360
361   GDFGYGGYLF  PGYGVGKQDV  YYGVAETSPP  LWAGQENATP  TSVLFSSASS  SSSSSAKARA  420
421   GPPGAHRSPA  TSAGPELAGL  PRRPPGEPLQ  GFSKLGGGGL  RSPGGGRDCM  VCFESEVTAA  480
481   LVPCGHNLFC  MECAVRICER  TDPECPVCHI  TATQAIRIFS  520
Nucleotide CDS Sequence (FASTA)
1     Sequence u  navailable  20

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Repeat
RNA-binding
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Nucleus
Cellular Component
P-body
Molecular Function
Metal ion binding
Molecular Function
RNA binding

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pap-4409Pan paniscus100.00.0 696
LLPS-Pat-2186Pan troglodytes100.00.0 697
LLPS-Mal-2734Mandrillus leucophaeus99.510.0 691
LLPS-Paa-1511Papio anubis99.510.0 692
LLPS-Chs-2307Chlorocebus sabaeus99.510.0 694
LLPS-Aon-1565Aotus nancymaae99.510.0 693
LLPS-Cea-1680Cercocebus atys99.510.0 693
LLPS-Man-1624Macaca nemestrina99.510.0 692
LLPS-Caj-1328Callithrix jacchus99.270.0 692
LLPS-Nol-3047Nomascus leucogenys99.270.0 688
LLPS-Rhb-2984Rhinopithecus bieti99.190.0 608
LLPS-Bot-3582Bos taurus98.780.0 687
LLPS-Eqc-1366Equus caballus98.540.0 687
LLPS-Sus-1578Sus scrofa98.290.0 686
LLPS-Tut-1332Tursiops truncatus98.230.0 652
LLPS-Fec-1990Felis catus97.570.0 667
LLPS-Dio-0627Dipodomys ordii97.560.0 684
LLPS-Cap-2151Cavia porcellus97.260.0 661
LLPS-Ran-4393Rattus norvegicus96.820.0 671
LLPS-Poa-3531Pongo abelii96.794e-130 385
LLPS-Mum-4352Mus musculus96.110.0 675
LLPS-Caf-2155Canis familiaris95.920.0 531
LLPS-Mod-4271Monodelphis domestica93.990.0 652
LLPS-Sah-3945Sarcophilus harrisii93.350.0 572
LLPS-Aim-4118Ailuropoda melanoleuca85.510.0 600
LLPS-Ova-2390Ovis aries83.022e-22 103
LLPS-Tar-1717Takifugu rubripes83.022e-22 104
LLPS-Gaa-1250Gasterosteus aculeatus83.022e-22 104
LLPS-Scf-1870Scleropages formosus83.022e-22 103
LLPS-Fud-2422Fukomys damarensis83.021e-22 103
LLPS-Mea-4140Mesocricetus auratus83.023e-22 104
LLPS-Gaga-2242Gallus gallus83.021e-21 102
LLPS-Ict-3074Ictidomys tridecemlineatus83.025e-22 103
LLPS-Mam-0802Macaca mulatta83.024e-22 104
LLPS-Otg-4409Otolemur garnettii83.027e-22 103
LLPS-Orc-3413Oryctolagus cuniculus83.021e-21 102
LLPS-Dar-1798Danio rerio83.024e-22 103
LLPS-Anp-2202Anas platyrhynchos81.558e-47 166
LLPS-Leo-2993Lepisosteus oculatus81.131e-21 102
LLPS-Ten-1199Tetraodon nigroviridis81.134e-21 100
LLPS-Fia-1187Ficedula albicollis81.133e-21 101
LLPS-Lac-1616Latimeria chalumnae81.135e-23 107
LLPS-Scm-2644Scophthalmus maximus81.133e-21 101
LLPS-Xim-2952Xiphophorus maculatus79.435e-71 246
LLPS-Icp-0953Ictalurus punctatus79.259e-2199.4
LLPS-Orl-1609Oryzias latipes79.251e-2099.8
LLPS-Xet-2402Xenopus tropicalis79.252e-21 101
LLPS-Pes-0994Pelodiscus sinensis79.252e-2099.0
LLPS-Pof-0843Poecilia formosa79.257e-21 100
LLPS-Meg-0468Meleagris gallopavo79.252e-21 100
LLPS-Asm-2307Astyanax mexicanus78.268e-1684.0
LLPS-Tag-2533Taeniopygia guttata77.076e-176 508
LLPS-Anc-3914Anolis carolinensis74.154e-169 491
LLPS-Cii-0438Ciona intestinalis72.434e-66 228
LLPS-Myl-4280Myotis lucifugus71.76e-1890.5
LLPS-Mup-0275Mustela putorius furo71.094e-81 267
LLPS-Gog-1684Gorilla gorilla71.093e-81 266
LLPS-Maf-0326Macaca fascicularis71.091e-80 267
LLPS-Loa-1710Loxodonta africana71.092e-80 267
LLPS-Cae-0239Caenorhabditis elegans71.043e-61 214
LLPS-Ora-2239Ornithorhynchus anatinus70.951e-64 222
LLPS-Ere-1061Erinaceus europaeus70.795e-64 220
LLPS-Urm-2087Ursus maritimus70.791e-63 220
LLPS-Orn-0746Oreochromis niloticus69.383e-71 243
LLPS-Drm-2189Drosophila melanogaster67.021e-62 222