LLPS-Hos-2808
ATAD3B
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | ATPase family AAA domain-containing protein 3B; AAA-TOB3 |
| Gene Name: | ATAD3B, KIAA1273, TOB3 |
| Ensembl Gene: | ENSG00000160072.19 |
| Ensembl Protein: | ENSP00000311766.7 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Nucleolus | "...Thus, we analyzed the orthologous groups of the remaining 2316 identified proteins to the human nucleolar proteins. We detected 361 orthologues in NoPDB from the 2316 A. thaliana proteins." | N/A | 26980300 |
▼ FUNCTION
| May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000308647.7 | ENSP00000311766.7 |
| UniProt | Q5T9A4, ATD3B_HUMAN, A8K3H1, Q6ZRB5, Q9BUK4, Q9ULE7 | |
| GeneBank | AK290586, BC009938, AL157945, BC002542, AK128357, BC018701, AB033099, CH471183 | EAW56193.1, AAH02542.1, BAA86587.1, BAF83275.1, AAH18701.1 |
| RefSeq | NM_001317238.1, NM_031921.5 | NP_001304167.1, NP_114127.3 |
| Entrez | 83858 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSWLFGVNKG PKGEGAGPPP PLPPAQPGAE GGGDRGLGDR PAPKDKWSNF DPTGLERAAK 60 61 AARELEHSRY AKEALNLAQM QEQTLQLEQQ SKLKEYEAAV EQLKSEQIRA QAEERRKTLS 120 121 EETRQHQARA QYQDKLARQR YEDQLKQQQL LNEENLRKQE ESVQKQEAMR RATVEREMEL 180 181 RHKNEMLRVE TEARARAKAE RENADIIREQ IRLKASEHRQ TVLESIRTAG TLFGEGFRAF 240 241 VTDRDKVTAT VAGLTLLAVG VYSAKNATAV TGRFIEARLG KPSLVRETSR ITVLEALRHP 300 301 IQVSRRLLSR PQDVLEGVVL SPSLEARVRD IAIATRNTKK NRGLYRHILL YGPPGTGKTL 360 361 FAKKLALHSG MDYAIMTGGD VAPMGREGVT AMHKLFDWAN TSRRGLLLFM DEADAFLRKR 420 421 ATEEISKDLR ATLNAFLYHM GQHSNKFMLV LASNLPEQFD CAINSRIDVM VHFDLPQQEE 480 481 RERLVRLHFD NCVLKPATEG KRRLKLAQFD YGRKCSEVAR LTEGMSGREI AQLAVSWQAT 540 541 AYASKDGVLT EAMMDACVQD AVQQYRQKMR WLKAEGPGRG VEHPLSGVQG ETLTSWSLAT 600 601 DPSYPCLAGP CTFRICSWMG TGLCPGPLSP RMSCGGGRPF CPPGHPLL 648 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCGTGGC TCTTCGGCGT TAACAAGGGC CCCAAGGGTG AAGGCGCGGG GCCGCCGCCG 60 61 CCTTTGCCGC CCGCGCAGCC CGGGGCCGAG GGCGGCGGGG ACCGCGGTTT GGGAGACCGG 120 121 CCGGCGCCCA AGGACAAATG GAGCAACTTC GACCCCACCG GCCTGGAGCG CGCCGCCAAG 180 181 GCGGCGCGCG AGCTGGAGCA CTCGCGTTAC GCCAAGGAGG CCCTGAATCT GGCGCAGATG 240 241 CAGGAGCAGA CGCTGCAGTT GGAGCAACAG TCCAAGCTCA AAGAGTATGA GGCCGCCGTG 300 301 GAGCAGCTCA AGAGCGAGCA GATCCGGGCG CAGGCTGAGG AGAGGAGGAA GACCCTGAGC 360 361 GAGGAGACCC GGCAGCACCA GGCCAGGGCC CAGTATCAAG ACAAGCTGGC CCGGCAGCGC 420 421 TACGAGGACC AACTGAAGCA GCAGCAACTT CTCAATGAGG AGAATTTACG GAAGCAGGAG 480 481 GAGTCCGTGC AGAAGCAGGA AGCCATGCGG CGAGCCACCG TGGAGCGGGA GATGGAGCTG 540 541 CGGCACAAGA ATGAGATGCT GCGAGTGGAG ACCGAGGCCC GGGCGCGCGC CAAGGCCGAG 600 601 CGGGAGAATG CAGACATCAT CCGCGAGCAG ATCCGCCTGA AGGCGTCCGA GCACCGTCAG 660 661 ACCGTCTTGG AGTCCATCAG GACGGCTGGC ACCTTGTTTG GGGAAGGATT CCGTGCCTTT 720 721 GTGACAGACC GGGACAAAGT GACAGCCACG GTGGCTGGGC TGACGCTGCT GGCTGTCGGG 780 781 GTCTACTCAG CCAAGAATGC GACAGCCGTC ACTGGCCGCT TCATCGAGGC TCGGCTGGGG 840 841 AAGCCGTCCC TAGTGAGGGA GACGTCCCGC ATCACGGTGC TGGAGGCGCT GCGGCACCCC 900 901 ATCCAGGTCA GCCGGCGGCT CCTCAGTCGA CCCCAGGACG TGCTGGAGGG TGTTGTGCTT 960 961 AGTCCCAGCC TGGAAGCACG GGTGCGCGAC ATCGCCATAG CAACCAGGAA CACCAAGAAG 1020 1021 AACCGGGGCC TGTACAGGCA CATCCTGCTG TATGGGCCAC CAGGCACCGG GAAGACGCTG 1080 1081 TTTGCCAAGA AACTCGCCCT GCACTCAGGC ATGGACTACG CCATCATGAC AGGCGGGGAC 1140 1141 GTGGCCCCCA TGGGGCGGGA AGGCGTGACC GCCATGCACA AGCTCTTTGA CTGGGCCAAT 1200 1201 ACCAGCCGGC GCGGCCTCCT GCTCTTCATG GATGAAGCAG ACGCCTTCCT TCGGAAGCGA 1260 1261 GCCACTGAGG AGATAAGCAA GGACCTCAGA GCCACACTGA ACGCCTTCCT GTACCACATG 1320 1321 GGCCAACACA GCAACAAATT CATGCTGGTC CTGGCCAGCA ATCTGCCTGA GCAGTTCGAC 1380 1381 TGTGCCATCA ACAGCCGCAT TGACGTGATG GTCCACTTCG ACCTGCCGCA GCAGGAGGAG 1440 1441 CGGGAGCGCC TGGTGAGACT GCATTTTGAC AACTGTGTTC TTAAGCCGGC CACAGAAGGA 1500 1501 AAACGGCGCC TGAAGCTGGC CCAGTTTGAC TACGGGAGGA AGTGCTCGGA GGTCGCTCGG 1560 1561 CTGACGGAGG GCATGTCGGG CCGGGAGATC GCTCAGCTGG CCGTGTCCTG GCAGGCCACG 1620 1621 GCATATGCCT CCAAGGACGG GGTCCTCACT GAGGCCATGA TGGACGCCTG TGTGCAAGAT 1680 1681 GCTGTCCAGC AGTACCGACA GAAGATGCGC TGGCTGAAGG CGGAGGGGCC TGGGCGCGGG 1740 1741 GTCGAGCACC CCCTATCCGG AGTCCAAGGC GAGACCCTCA CCTCATGGAG CCTGGCCACG 1800 1801 GACCCCTCCT ACCCCTGCCT TGCCGGCCCC TGCACATTTA GGATATGCTC CTGGATGGGG 1860 1861 ACTGGGCTGT GCCCAGGGCC TCTGTCCCCC AGGATGTCTT GTGGTGGCGG TCGGCCGTTC 1920 1921 TGCCCCCCAG GGCACCCCCT GTTGTAG 1947 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Ficolin-1-rich granule membrane | |
Cellular Component | Mitochondrial inner membrane | |
Cellular Component | Mitochondrion | |
Cellular Component | Plasma membrane | |
Cellular Component | Secretory granule membrane | |
Molecular Function | ATP binding | |
Molecular Function | Zinc ion binding | |
Biological Process | Mitochondrion organization | |
Biological Process | Neutrophil degranulation |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | RaftProt | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Poa-1992 | Pongo abelii | 98.88 | 4e-31 | 131 |
| LLPS-Pat-4799 | Pan troglodytes | 97.51 | 0.0 | 932 |
| LLPS-Gog-4437 | Gorilla gorilla | 96.15 | 6e-27 | 117 |
| LLPS-Chs-2048 | Chlorocebus sabaeus | 92.35 | 0.0 | 534 |
| LLPS-Man-4491 | Macaca nemestrina | 91.24 | 0.0 | 849 |
| LLPS-Rhb-0467 | Rhinopithecus bieti | 90.55 | 0.0 | 842 |
| LLPS-Maf-3369 | Macaca fascicularis | 90.52 | 0.0 | 813 |
| LLPS-Ora-2707 | Ornithorhynchus anatinus | 90.4 | 7e-46 | 164 |
| LLPS-Eqc-4541 | Equus caballus | 89.93 | 0.0 | 839 |
| LLPS-Caj-4183 | Callithrix jacchus | 89.93 | 0.0 | 856 |
| LLPS-Caf-3071 | Canis familiaris | 89.7 | 0.0 | 832 |
| LLPS-Bot-1801 | Bos taurus | 89.51 | 0.0 | 840 |
| LLPS-Mup-1922 | Mustela putorius furo | 89.15 | 0.0 | 801 |
| LLPS-Fec-1025 | Felis catus | 89.14 | 0.0 | 801 |
| LLPS-Cap-1609 | Cavia porcellus | 89.08 | 0.0 | 822 |
| LLPS-Paa-3684 | Papio anubis | 88.87 | 0.0 | 789 |
| LLPS-Ran-4610 | Rattus norvegicus | 88.75 | 0.0 | 835 |
| LLPS-Otg-2705 | Otolemur garnettii | 88.56 | 0.0 | 826 |
| LLPS-Mum-2053 | Mus musculus | 88.38 | 0.0 | 832 |
| LLPS-Dio-2737 | Dipodomys ordii | 88.36 | 0.0 | 791 |
| LLPS-Ict-0381 | Ictidomys tridecemlineatus | 88.21 | 0.0 | 831 |
| LLPS-Myl-1550 | Myotis lucifugus | 87.87 | 0.0 | 787 |
| LLPS-Sus-1301 | Sus scrofa | 87.68 | 0.0 | 781 |
| LLPS-Fud-0620 | Fukomys damarensis | 87.67 | 0.0 | 799 |
| LLPS-Cas-2468 | Carlito syrichta | 87.5 | 0.0 | 711 |
| LLPS-Loa-3385 | Loxodonta africana | 87.48 | 0.0 | 794 |
| LLPS-Meg-2098 | Meleagris gallopavo | 87.47 | 0.0 | 772 |
| LLPS-Mam-4344 | Macaca mulatta | 87.45 | 0.0 | 782 |
| LLPS-Tag-2775 | Taeniopygia guttata | 87.43 | 0.0 | 797 |
| LLPS-Mal-2289 | Mandrillus leucophaeus | 86.87 | 0.0 | 887 |
| LLPS-Aon-1919 | Aotus nancymaae | 86.48 | 0.0 | 632 |
| LLPS-Anp-2658 | Anas platyrhynchos | 86.32 | 0.0 | 774 |
| LLPS-Gaga-3813 | Gallus gallus | 86.13 | 0.0 | 768 |
| LLPS-Pes-0274 | Pelodiscus sinensis | 85.69 | 0.0 | 762 |
| LLPS-Fia-3282 | Ficedula albicollis | 85.54 | 0.0 | 766 |
| LLPS-Sah-2547 | Sarcophilus harrisii | 85.45 | 0.0 | 790 |
| LLPS-Ova-2704 | Ovis aries | 83.74 | 0.0 | 784 |
| LLPS-Cea-3699 | Cercocebus atys | 83.54 | 0.0 | 712 |
| LLPS-Anc-3865 | Anolis carolinensis | 82.76 | 1e-172 | 502 |
| LLPS-Urm-2981 | Ursus maritimus | 82.73 | 0.0 | 747 |
| LLPS-Nol-1238 | Nomascus leucogenys | 80.56 | 0.0 | 796 |
| LLPS-Xim-3544 | Xiphophorus maculatus | 80.45 | 0.0 | 770 |
| LLPS-Pof-0967 | Poecilia formosa | 80.26 | 0.0 | 768 |
| LLPS-Tar-1931 | Takifugu rubripes | 79.06 | 0.0 | 738 |
| LLPS-Xet-0602 | Xenopus tropicalis | 78.99 | 0.0 | 790 |
| LLPS-Scf-0865 | Scleropages formosus | 77.95 | 0.0 | 774 |
| LLPS-Mod-2596 | Monodelphis domestica | 77.39 | 0.0 | 701 |
| LLPS-Gaa-2990 | Gasterosteus aculeatus | 76.99 | 0.0 | 715 |
| LLPS-Lac-1449 | Latimeria chalumnae | 76.7 | 0.0 | 620 |
| LLPS-Dar-2109 | Danio rerio | 76.65 | 9e-57 | 197 |
| LLPS-Orn-3080 | Oreochromis niloticus | 76.53 | 0.0 | 781 |
| LLPS-Ten-2410 | Tetraodon nigroviridis | 76.49 | 0.0 | 775 |
| LLPS-Orl-3294 | Oryzias latipes | 76.44 | 0.0 | 783 |
| LLPS-Asm-0348 | Astyanax mexicanus | 75.89 | 0.0 | 762 |
| LLPS-Scm-1988 | Scophthalmus maximus | 75.13 | 0.0 | 767 |
| LLPS-Icp-3630 | Ictalurus punctatus | 72.44 | 0.0 | 698 |
| LLPS-Cii-0579 | Ciona intestinalis | 68.93 | 0.0 | 648 |
| LLPS-Pap-0914 | Pan paniscus | 67.33 | 0.0 | 690 |
| LLPS-Cis-1554 | Ciona savignyi | 66.67 | 0.0 | 635 |
| LLPS-Drm-0887 | Drosophila melanogaster | 64.31 | 0.0 | 551 |
| LLPS-Cae-1718 | Caenorhabditis elegans | 56.61 | 1e-180 | 533 |
| LLPS-Chc-0476 | Chondrus crispus | 44.38 | 1e-115 | 365 |
| LLPS-Org-0324 | Oryza glaberrima | 40.24 | 6e-69 | 234 |
| LLPS-Sot-1042 | Solanum tuberosum | 39.6 | 7e-70 | 237 |
| LLPS-Amt-1358 | Amborella trichopoda | 39.53 | 5e-81 | 268 |
| LLPS-Mua-0889 | Musa acuminata | 39.04 | 3e-81 | 270 |
| LLPS-Orbr-1670 | Oryza brachyantha | 38.18 | 2e-79 | 266 |
| LLPS-Tra-1827 | Triticum aestivum | 38.07 | 1e-80 | 273 |
| LLPS-Osl-1258 | Ostreococcus lucimarinus | 37.86 | 9e-89 | 295 |
| LLPS-Gor-0373 | Gossypium raimondii | 37.59 | 4e-81 | 275 |
| LLPS-Coc-1714 | Corchorus capsularis | 37.54 | 4e-81 | 275 |
| LLPS-Phv-1183 | Phaseolus vulgaris | 37.24 | 6e-84 | 283 |
| LLPS-Via-0684 | Vigna angularis | 37.15 | 1e-77 | 266 |
| LLPS-Art-1481 | Arabidopsis thaliana | 37.13 | 9e-82 | 277 |
| LLPS-Glm-1181 | Glycine max | 37.13 | 4e-82 | 278 |
| LLPS-Sem-0519 | Selaginella moellendorffii | 37.08 | 5e-79 | 268 |
| LLPS-Sei-2497 | Setaria italica | 37.05 | 3e-82 | 279 |
| LLPS-Brd-0631 | Brachypodium distachyon | 36.98 | 2e-76 | 262 |
| LLPS-Dac-1609 | Daucus carota | 36.86 | 1e-77 | 266 |
| LLPS-Arl-1019 | Arabidopsis lyrata | 36.82 | 3e-81 | 276 |
| LLPS-Lep-1165 | Leersia perrieri | 36.73 | 3e-84 | 284 |
| LLPS-Pot-2468 | Populus trichocarpa | 36.71 | 2e-79 | 271 |
| LLPS-Php-0709 | Physcomitrella patens | 36.71 | 8e-73 | 253 |
| LLPS-Zem-0336 | Zea mays | 36.63 | 2e-82 | 279 |
| LLPS-Thc-0369 | Theobroma cacao | 36.63 | 3e-77 | 265 |
| LLPS-Bro-0590 | Brassica oleracea | 36.56 | 3e-80 | 273 |
| LLPS-Cus-0262 | Cucumis sativus | 36.56 | 5e-84 | 283 |
| LLPS-Brn-0623 | Brassica napus | 36.56 | 3e-80 | 273 |
| LLPS-Chr-0268 | Chlamydomonas reinhardtii | 36.51 | 1e-73 | 255 |
| LLPS-Tru-0380 | Triticum urartu | 36.46 | 2e-77 | 265 |
| LLPS-Vir-0418 | Vigna radiata | 36.43 | 3e-82 | 278 |
| LLPS-Hea-0437 | Helianthus annuus | 36.43 | 2e-80 | 273 |
| LLPS-Nia-0929 | Nicotiana attenuata | 36.36 | 2e-77 | 266 |
| LLPS-Sol-2239 | Solanum lycopersicum | 36.33 | 9e-78 | 266 |
| LLPS-Orni-2419 | Oryza nivara | 36.24 | 1e-78 | 268 |
| LLPS-Prp-1548 | Prunus persica | 36.11 | 2e-77 | 265 |
| LLPS-Mae-2335 | Manihot esculenta | 35.99 | 3e-80 | 273 |
| LLPS-Orr-0321 | Oryza rufipogon | 35.98 | 1e-79 | 271 |
| LLPS-Ors-1818 | Oryza sativa | 35.98 | 2e-79 | 271 |
| LLPS-Orgl-1721 | Oryza glumaepatula | 35.98 | 1e-79 | 272 |
| LLPS-Ori-0494 | Oryza indica | 35.98 | 1e-79 | 271 |
| LLPS-Orb-0815 | Oryza barthii | 35.98 | 3e-80 | 271 |
| LLPS-Viv-1973 | Vitis vinifera | 35.95 | 3e-79 | 270 |
| LLPS-Met-2181 | Medicago truncatula | 35.91 | 8e-76 | 261 |
| LLPS-Sob-0897 | Sorghum bicolor | 35.73 | 1e-82 | 279 |
| LLPS-Orp-0767 | Oryza punctata | 35.71 | 2e-80 | 275 |
| LLPS-Hov-0177 | Hordeum vulgare | 35.58 | 5e-80 | 273 |
| LLPS-Brr-1628 | Brassica rapa | 35.43 | 1e-75 | 263 |
| LLPS-Gas-0335 | Galdieria sulphuraria | 34.01 | 1e-15 | 84.3 |
| LLPS-Pug-0580 | Puccinia graminis | 31.79 | 8e-14 | 78.2 |
| LLPS-Mel-0130 | Melampsora laricipopulina | 31.28 | 2e-13 | 77.0 |
| LLPS-Cogr-1560 | Colletotrichum graminicola | 31.12 | 1e-14 | 80.9 |
| LLPS-Pytr-0885 | Pyrenophora triticirepentis | 30.93 | 2e-15 | 82.8 |
| LLPS-Lem-0542 | Leptosphaeria maculans | 30.93 | 6e-15 | 81.6 |
| LLPS-Zyt-0226 | Zymoseptoria tritici | 30.53 | 2e-15 | 83.2 |
| LLPS-Dos-0949 | Dothistroma septosporum | 30.37 | 3e-14 | 79.3 |
| LLPS-Coo-1010 | Colletotrichum orbiculare | 30.1 | 7e-14 | 78.6 |
| LLPS-Yal-1177 | Yarrowia lipolytica | 30.09 | 5e-13 | 76.6 |
| LLPS-Asg-0429 | Ashbya gossypii | 29.95 | 7e-14 | 78.2 |
| LLPS-Asni-0022 | Aspergillus niger | 29.84 | 3e-14 | 79.3 |
| LLPS-Crn-1310 | Cryptococcus neoformans | 29.83 | 5e-13 | 76.6 |
| LLPS-Fuo-0279 | Fusarium oxysporum | 29.65 | 1e-13 | 77.4 |
| LLPS-Usm-0594 | Ustilago maydis | 29.65 | 5e-13 | 75.9 |
| LLPS-Fuv-1141 | Fusarium verticillioides | 29.65 | 1e-13 | 77.4 |
| LLPS-Trv-0993 | Trichoderma virens | 29.59 | 1e-13 | 77.8 |
| LLPS-Cog-0741 | Colletotrichum gloeosporioides | 29.59 | 2e-13 | 77.0 |
| LLPS-Gag-0359 | Gaeumannomyces graminis | 29.44 | 4e-14 | 79.3 |
| LLPS-Ast-0832 | Aspergillus terreus | 29.38 | 3e-14 | 79.7 |
| LLPS-Asc-0067 | Aspergillus clavatus | 29.38 | 5e-14 | 79.0 |
| LLPS-Trr-0807 | Trichoderma reesei | 29.35 | 7e-14 | 78.2 |
| LLPS-Asfu-0833 | Aspergillus fumigatus | 29.32 | 4e-14 | 79.3 |
| LLPS-Nef-0231 | Neosartorya fischeri | 29.32 | 4e-14 | 79.0 |
| LLPS-Asf-0380 | Aspergillus flavus | 29.32 | 3e-14 | 79.3 |
| LLPS-Aso-1228 | Aspergillus oryzae | 29.32 | 3e-14 | 79.3 |
| LLPS-Kop-0338 | Komagataella pastoris | 29.26 | 1e-14 | 80.5 |
| LLPS-Sac-1177 | Saccharomyces cerevisiae | 29.24 | 2e-14 | 80.9 |
| LLPS-Leo-1432 | Lepisosteus oculatus | 29.23 | 3e-13 | 76.3 |
| LLPS-Pyt-0568 | Pyrenophora teres | 29.17 | 5e-14 | 79.0 |
| LLPS-Mao-0131 | Magnaporthe oryzae | 29.08 | 1e-13 | 77.4 |
| LLPS-Ved-0260 | Verticillium dahliae | 29.02 | 2e-13 | 77.0 |
| LLPS-Map-0592 | Magnaporthe poae | 27.92 | 5e-13 | 75.9 |