LLPS-Hos-2803
S100A7A
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Protein S100-A7A; S100 calcium-binding protein A15; S100 calcium-binding protein A7-like 1; S100 calcium-binding protein A7A |
| Gene Name: | S100A7A, S100A15, S100A7L1 |
| Ensembl Gene: | ENSG00000184330.11 |
| Ensembl Protein: | ENSP00000329008.2 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Stress granule | "...By adding known stress granule components not identified by mass spectrometry to this list, we created the first stress granule proteome for a mammalian cell." | U2OS cells | 26777405 |
▼ FUNCTION
| May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000329256.2 | ENSP00000329008.2 |
| Ensembl | ENST00000368729.8 | ENSP00000357718.3 |
| Ensembl | ENST00000368728.2 | ENSP00000357717.1 |
| UniProt | Q86SG5, S1A7A_HUMAN, D3DV38, Q5SY69 | |
| GeneBank | BR000043, AL591704, CH471121, AY189118, AY189117, AY189119 | AAO40033.1, AAO40034.1, AAO40032.1, EAW53329.1, EAW53328.1, FAA00014.1 |
| RefSeq | NM_176823.3 | NP_789793.1 |
| Entrez | 338324 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSNTQAERSI IGMIDMFHKY TGRDGKIEKP SLLTMMKENF PNFLSACDKK GIHYLATVFE 60 61 KKDKNEDKKI DFSEFLSLLG DIAADYHKQS HGAAPCSGGS Q 101 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGCAACA CTCAAGCTGA GAGGTCCATA ATAGGCATGA TCGACATGTT TCACAAATAC 60 61 ACCGGACGTG ATGGCAAGAT TGAGAAGCCA AGCCTGCTGA CGATGATGAA GGAGAACTTC 120 121 CCCAATTTCC TCAGTGCCTG TGACAAAAAG GGCATACATT ACCTCGCCAC TGTCTTTGAG 180 181 AAAAAGGACA AGAATGAGGA TAAGAAGATT GATTTTTCTG AGTTTCTGTC CTTGCTGGGA 240 241 GACATAGCCG CAGACTACCA CAAGCAGAGC CATGGAGCGG CGCCCTGTTC TGGGGGAAGC 300 301 CAGTGA 306 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Molecular Function | Calcium ion binding | |
Molecular Function | Protein self-association | |
Molecular Function | Transition metal ion binding |
▼ ANNOTATION
| Disease | ||||
| OMIM | DisGeNET | ActiveDriverDB | ||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-2463 | Pan troglodytes | 95.05 | 3e-58 | 181 |
| LLPS-Gog-4664 | Gorilla gorilla | 95.05 | 3e-57 | 178 |
| LLPS-Pap-0879 | Pan paniscus | 94.06 | 1e-57 | 179 |
| LLPS-Poa-4558 | Pongo abelii | 88.14 | 5e-32 | 113 |
| LLPS-Orc-0402 | Oryctolagus cuniculus | 40.4 | 3e-17 | 76.3 |
| LLPS-Fud-3072 | Fukomys damarensis | 37.93 | 8e-06 | 44.7 |
| LLPS-Cap-3893 | Cavia porcellus | 37.23 | 2e-11 | 60.8 |
| LLPS-Dio-2892 | Dipodomys ordii | 35.79 | 6e-07 | 47.8 |
| LLPS-Meg-1110 | Meleagris gallopavo | 31.0 | 6e-07 | 48.1 |