DrLLPS - Data resource of LLPS

Overview
Property
Classification
Function
Cross Reference
Sequence
GO
Annotation
Orthology
TOP

LLPS-Hos-2675
JUN

▼ OVERVIEW


Status:	Reviewed
Protein Name:	Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39
Gene Name:	JUN
Ensembl Gene:	ENSG00000177606.6
Ensembl Protein:	ENSP00000360266.2
Organism:	Homo sapiens
Taxa ID:	9606
LLPS Type:	Client

PDB: 1A02 (A, B, N, F, J) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Others	"...PMLOs are different in size, shape, and composition, and almost invariantly contain intrinsically disordered proteins, which indicates that the formation of these phaseseparated droplets is crucially dependent on intrinsic disorder."	N/A	27838525

▼ FUNCTION

Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENST00000371222.3	ENSP00000360266.2
UniProt		P05412, JUN_HUMAN, Q6FHM7, Q96G93
GeneBank	AY217548, BC009874, J04111, BT019759, BC002646, AL136985, BC006175, CR541724, BC068522	AAH68522.1, AAA59197.1, AAH09874.2, CAG46525.1, AAO22993.1, AAH06175.1, AAV38564.1
RefSeq	NM_002228.3	NP_002219.1
Entrez	3725

▼ SEQUENCE

Protein Sequence (FASTA)
1 MTAKMETTFY DDALNASFLP SESGPYGYSN PKILKQSMTL NLADPVGSLK PHLRAKNSDL 60 61 LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE 120 121 LHSQNTLPSV TSAAQPVNGA GMVAPAVASV AGGSGSGGFS ASLHSEPPVY ANLSNFNPGA 180 181 LSSGGGAPSY GAAGLAFPAQ PQQQQQPPHH LPQQMPVQHP RLQALKEEPQ TVPEMPGETP 240 241 PLSPIDMESQ ERIKAERKRM RNRIAASKCR KRKLERIARL EEKVKTLKAQ NSELASTANM 300 301 LREQVAQLKQ KVMNHVNSGC QLMLTQQLQT F 331
Nucleotide CDS Sequence (FASTA)
1 ATGACTGCAA AGATGGAAAC GACCTTCTAT GACGATGCCC TCAACGCCTC GTTCCTCCCG 60 61 TCCGAGAGCG GACCTTATGG CTACAGTAAC CCCAAGATCC TGAAACAGAG CATGACCCTG 120 121 AACCTGGCCG ACCCAGTGGG GAGCCTGAAG CCGCACCTCC GCGCCAAGAA CTCGGACCTC 180 181 CTCACCTCGC CCGACGTGGG GCTGCTCAAG CTGGCGTCGC CCGAGCTGGA GCGCCTGATA 240 241 ATCCAGTCCA GCAACGGGCA CATCACCACC ACGCCGACCC CCACCCAGTT CCTGTGCCCC 300 301 AAGAACGTGA CAGATGAGCA GGAGGGCTTC GCCGAGGGCT TCGTGCGCGC CCTGGCCGAA 360 361 CTGCACAGCC AGAACACGCT GCCCAGCGTC ACGTCGGCGG CGCAGCCGGT CAACGGGGCA 420 421 GGCATGGTGG CTCCCGCGGT AGCCTCGGTG GCAGGGGGCA GCGGCAGCGG CGGCTTCAGC 480 481 GCCAGCCTGC ACAGCGAGCC GCCGGTCTAC GCAAACCTCA GCAACTTCAA CCCAGGCGCG 540 541 CTGAGCAGCG GCGGCGGGGC GCCCTCCTAC GGCGCGGCCG GCCTGGCCTT TCCCGCGCAA 600 601 CCCCAGCAGC AGCAGCAGCC GCCGCACCAC CTGCCCCAGC AGATGCCCGT GCAGCACCCG 660 661 CGGCTGCAGG CCCTGAAGGA GGAGCCTCAG ACAGTGCCCG AGATGCCCGG CGAGACACCG 720 721 CCCCTGTCCC CCATCGACAT GGAGTCCCAG GAGCGGATCA AGGCGGAGAG GAAGCGCATG 780 781 AGGAACCGCA TCGCTGCCTC CAAGTGCCGA AAAAGGAAGC TGGAGAGAAT CGCCCGGCTG 840 841 GAGGAAAAAG TGAAAACCTT GAAAGCTCAG AACTCGGAGC TGGCGTCCAC GGCCAACATG 900 901 CTCAGGGAAC AGGTGGCACA GCTTAAACAG AAAGTCATGA ACCACGTTAA CAGTGGGTGC 960 961 CAACTCATGC TAACGCAGCA GTTGCAAACA TTTTGA 996

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0007	Acetylation
KW-0010	Activator
KW-0181	Complete proteome
KW-0903	Direct protein sequencing
KW-0238	DNA-binding
KW-1017	Isopeptide bond
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-0621	Polymorphism
KW-0656	Proto-oncogene
KW-1185	Reference proteome
KW-0804	Transcription
KW-0805	Transcription regulation
KW-0832	Ubl conjugation

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005829	Cellular Component	Cytosol
GO:0000790	Cellular Component	Nuclear chromatin
GO:0000228	Cellular Component	Nuclear chromosome
GO:0005719	Cellular Component	Nuclear euchromatin
GO:0005654	Cellular Component	Nucleoplasm
GO:0005634	Cellular Component	Nucleus
GO:0035976	Cellular Component	Transcription factor AP-1 complex
GO:0005667	Cellular Component	Transcription factor complex
GO:0017053	Cellular Component	Transcriptional repressor complex
GO:0035497	Molecular Function	CAMP response element binding
GO:0003682	Molecular Function	Chromatin binding
GO:0003677	Molecular Function	DNA binding
GO:0001228	Molecular Function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003700	Molecular Function	DNA-binding transcription factor activity
GO:0000981	Molecular Function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0019899	Molecular Function	Enzyme binding
GO:0005096	Molecular Function	GTPase activator activity
GO:0071837	Molecular Function	HMG box domain binding
GO:0042802	Molecular Function	Identical protein binding
GO:0046982	Molecular Function	Protein heterodimerization activity
GO:0042803	Molecular Function	Protein homodimerization activity
GO:0070412	Molecular Function	R-SMAD binding
GO:0003723	Molecular Function	RNA binding
GO:0001102	Molecular Function	RNA polymerase II activating transcription factor binding
GO:0000980	Molecular Function	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000978	Molecular Function	RNA polymerase II proximal promoter sequence-specific DNA binding
GO:0003713	Molecular Function	Transcription coactivator activity
GO:0008134	Molecular Function	Transcription factor binding
GO:0044212	Molecular Function	Transcription regulatory region DNA binding
GO:0031625	Molecular Function	Ubiquitin protein ligase binding
GO:0044389	Molecular Function	Ubiquitin-like protein ligase binding
GO:0007568	Biological Process	Aging
GO:0001525	Biological Process	Angiogenesis
GO:0031103	Biological Process	Axon regeneration
GO:0071276	Biological Process	Cellular response to cadmium ion
GO:0071277	Biological Process	Cellular response to calcium ion
GO:0032870	Biological Process	Cellular response to hormone stimulus
GO:0051365	Biological Process	Cellular response to potassium ion starvation
GO:0034614	Biological Process	Cellular response to reactive oxygen species
GO:0007623	Biological Process	Circadian rhythm
GO:0061029	Biological Process	Eyelid development in camera-type eye
GO:0038095	Biological Process	Fc-epsilon receptor signaling pathway
GO:0035026	Biological Process	Leading edge cell differentiation
GO:0007612	Biological Process	Learning
GO:0001889	Biological Process	Liver development
GO:0051899	Biological Process	Membrane depolarization
GO:0001774	Biological Process	Microglial cell activation
GO:0030224	Biological Process	Monocyte differentiation
GO:0043922	Biological Process	Negative regulation by host of viral transcription
GO:0008285	Biological Process	Negative regulation of cell population proliferation
GO:0043392	Biological Process	Negative regulation of DNA binding
GO:0043524	Biological Process	Negative regulation of neuron apoptotic process
GO:0031953	Biological Process	Negative regulation of protein autophosphorylation
GO:0000122	Biological Process	Negative regulation of transcription by RNA polymerase II
GO:1990441	Biological Process	Negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0045892	Biological Process	Negative regulation of transcription, DNA-templated
GO:0003151	Biological Process	Outflow tract morphogenesis
GO:0043923	Biological Process	Positive regulation by host of viral transcription
GO:0043065	Biological Process	Positive regulation of apoptotic process
GO:0045597	Biological Process	Positive regulation of cell differentiation
GO:0045740	Biological Process	Positive regulation of DNA replication
GO:2000144	Biological Process	Positive regulation of DNA-templated transcription, initiation
GO:0001938	Biological Process	Positive regulation of endothelial cell proliferation
GO:0010634	Biological Process	Positive regulation of epithelial cell migration
GO:0070374	Biological Process	Positive regulation of ERK1 and ERK2 cascade
GO:0048146	Biological Process	Positive regulation of fibroblast proliferation
GO:0045657	Biological Process	Positive regulation of monocyte differentiation
GO:0043525	Biological Process	Positive regulation of neuron apoptotic process
GO:1902895	Biological Process	Positive regulation of pri-miRNA transcription by RNA polymerase II
GO:0045944	Biological Process	Positive regulation of transcription by RNA polymerase II
GO:0045893	Biological Process	Positive regulation of transcription, DNA-templated
GO:1904707	Biological Process	Positive regulation of vascular smooth muscle cell proliferation
GO:0007265	Biological Process	Ras protein signal transduction
GO:0051726	Biological Process	Regulation of cell cycle
GO:0051090	Biological Process	Regulation of DNA-binding transcription factor activity
GO:0001836	Biological Process	Release of cytochrome c from mitochondria
GO:0051591	Biological Process	Response to cAMP
GO:0034097	Biological Process	Response to cytokine
GO:0042493	Biological Process	Response to drug
GO:0042542	Biological Process	Response to hydrogen peroxide
GO:0032496	Biological Process	Response to lipopolysaccharide
GO:0009612	Biological Process	Response to mechanical stimulus
GO:0035994	Biological Process	Response to muscle stretch
GO:0010033	Biological Process	Response to organic substance
GO:0009314	Biological Process	Response to radiation
GO:0060395	Biological Process	SMAD protein signal transduction
GO:0006366	Biological Process	Transcription by RNA polymerase II
GO:0007179	Biological Process	Transforming growth factor beta receptor signaling pathway

▼ KEGG

hsa:3725

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD
PROSITE	Gene3D

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	HPRD
BioGRID	PhosphoBase	mUbiSiDa	PTMcode

Variation
dbSNP	VarCards	rSNPBase

Mutation
TCGA	ICGC	COSMIC	CGAP	IntOGen
BioMuta

Interaction
HINT	InWeb_IM	RISE	TRRUST	BindingDB
RAIN	Mentha	RegNetwork	PINA	IID
iRefIndex	MIST	DifferentialNET	RNAct

Disease
PTMD	OMIM	DisGeNET	DiseaseEnhancer.v	ActiveDriverDB

Drug
DrugBank	TTD	ADReCS-Target	DGIdb	CTD

Physicochemical
Compute pI/Mw	AAindex

Function
PIRSF	ENPD	CORUM	CellMarker

Proteomics
THPA	HPM

Structure
PDB	MMDB

Localization
COMPARTMENTS

Expression
TCGA	ICGC	COSMIC	GEO	ArrayExpress
TISSUES	BioXpress	THPA

Element
UTRdb	circBase	CircNet	miRTarBase	miRWalk
miRecords	miRcode	RAID	microRNA.org

Methylation
TCGA	ICGC	MethyCancer

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Ova-1953	Ovis aries	100.0	1e-48	171
LLPS-Aim-1364	Ailuropoda melanoleuca	100.0	2e-69	225
LLPS-Fud-1181	Fukomys damarensis	100.0	3e-69	223
LLPS-Mod-3380	Monodelphis domestica	100.0	6e-69	225
LLPS-Myl-0479	Myotis lucifugus	97.3	4e-66	214
LLPS-Otg-1260	Otolemur garnettii	96.71	1e-177	503
LLPS-Caj-0140	Callithrix jacchus	95.51	9e-177	501
LLPS-Fec-4758	Felis catus	95.51	7e-178	503
LLPS-Xim-0936	Xiphophorus maculatus	95.5	2e-66	217
LLPS-Poa-0346	Pongo abelii	95.21	1e-179	508
LLPS-Chs-0166	Chlorocebus sabaeus	94.91	3e-179	507
LLPS-Mum-0295	Mus musculus	94.31	9e-178	503
LLPS-Mup-0560	Mustela putorius furo	94.01	7e-178	503
LLPS-Loa-2413	Loxodonta africana	93.96	4e-179	506
LLPS-Ran-2992	Rattus norvegicus	93.71	4e-177	501
LLPS-Ict-1543	Ictidomys tridecemlineatus	93.71	1e-179	508
LLPS-Gaa-3563	Gasterosteus aculeatus	90.09	6e-63	207
LLPS-Eqc-0939	Equus caballus	89.62	4e-143	415
LLPS-Orc-2689	Oryctolagus cuniculus	88.82	1e-176	499
LLPS-Caf-3713	Canis familiaris	87.68	5e-175	496
LLPS-Bot-2421	Bos taurus	86.27	1e-169	481
LLPS-Mea-2034	Mesocricetus auratus	85.8	5e-175	496
LLPS-Tut-0371	Tursiops truncatus	84.38	3e-173	491
LLPS-Gaga-2882	Gallus gallus	80.43	2e-161	461
LLPS-Anp-0127	Anas platyrhynchos	80.32	3e-147	424
LLPS-Anc-2534	Anolis carolinensis	80.06	3e-163	466
LLPS-Tag-0945	Taeniopygia guttata	79.46	4e-162	462
LLPS-Fia-0506	Ficedula albicollis	79.46	7e-162	462
LLPS-Pes-2999	Pelodiscus sinensis	79.46	2e-163	466
LLPS-Meg-0386	Meleagris gallopavo	78.69	3e-108	322
LLPS-Lac-0011	Latimeria chalumnae	74.32	4e-157	450
LLPS-Leo-3611	Lepisosteus oculatus	73.27	1e-147	426
LLPS-Xet-1320	Xenopus tropicalis	72.21	2e-150	432
LLPS-Cis-0583	Ciona savignyi	71.3	2e-42	155
LLPS-Cii-1106	Ciona intestinalis	71.3	7e-42	155
LLPS-Dar-3029	Danio rerio	70.69	3e-145	419
LLPS-Orn-0753	Oreochromis niloticus	70.27	1e-141	411
LLPS-Icp-3267	Ictalurus punctatus	69.88	3e-141	410
LLPS-Pof-1224	Poecilia formosa	69.49	2e-142	413
LLPS-Nol-0445	Nomascus leucogenys	69.07	4e-110	330
LLPS-Orl-3908	Oryzias latipes	68.32	2e-120	355
LLPS-Tar-1615	Takifugu rubripes	68.17	3e-139	405
LLPS-Scm-3154	Scophthalmus maximus	60.9	2e-113	339
LLPS-Dio-3971	Dipodomys ordii	43.64	7e-06	51.6
LLPS-Mal-4299	Mandrillus leucophaeus	43.64	7e-06	51.6
LLPS-Paa-3005	Papio anubis	43.64	7e-06	51.6
LLPS-Sah-4110	Sarcophilus harrisii	43.64	6e-06	52.0
LLPS-Cea-1080	Cercocebus atys	43.64	7e-06	51.6
LLPS-Sus-1535	Sus scrofa	43.64	7e-06	51.6
LLPS-Ora-1879	Ornithorhynchus anatinus	43.64	7e-06	51.6
LLPS-Maf-2212	Macaca fascicularis	43.64	7e-06	51.6
LLPS-Gog-4597	Gorilla gorilla	43.64	7e-06	51.6
LLPS-Mam-3775	Macaca mulatta	43.64	6e-06	51.6
LLPS-Cas-2464	Carlito syrichta	43.64	6e-06	52.0
LLPS-Man-1061	Macaca nemestrina	43.64	7e-06	51.6
LLPS-Pap-2845	Pan paniscus	43.64	7e-06	51.6
LLPS-Pat-4269	Pan troglodytes	43.64	7e-06	51.6
LLPS-Rhb-1056	Rhinopithecus bieti	43.64	7e-06	51.6
LLPS-Asm-3529	Astyanax mexicanus	41.27	9e-07	54.3
LLPS-Urm-1701	Ursus maritimus	39.68	7e-06	51.6
LLPS-Asn-0921	Aspergillus nidulans	39.24	4e-07	55.1
LLPS-Scf-3243	Scleropages formosus	38.1	8e-06	51.6
LLPS-Lem-0354	Leptosphaeria maculans	37.68	4e-06	52.8
LLPS-Kop-1232	Komagataella pastoris	36.9	8e-07	54.3
LLPS-Nec-1498	Neurospora crassa	36.47	1e-07	57.4
LLPS-Coo-1406	Colletotrichum orbiculare	35.71	3e-06	52.8
LLPS-Zyt-1591	Zymoseptoria tritici	35.42	1e-07	57.4
LLPS-Dos-1236	Dothistroma septosporum	32.26	4e-07	55.5

LLPS-Hos-2675JUN

Protein Sequence

Nucleotide Sequence

LLPS-Hos-2675
JUN