LLPS-Hos-2572
RNH1

▼ OVERVIEW

Status: Reviewed
Protein Name: Ribonuclease inhibitor; Placental ribonuclease inhibitor; Placental RNase inhibitor; Ribonuclease/angiogenin inhibitor 1; RAI
Gene Name: RNH1, PRI, RNH
Ensembl Gene: ENSG00000023191.16
Ensembl Protein: ENSP00000435798.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others
PDB: 1A4Y (A, B) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Stress granule
"...283 proteins identified as APEX hits in HEK293T cells or previously shown to associate with SGs."
N/A29373831
Stress granule
"...By adding known stress granule components not identified by mass spectrometry to this list, we created the first stress granule proteome for a mammalian cell."
U2OS cells26777405

▼ FUNCTION

Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENST00000531149.1ENSP00000435798.1
EnsemblENST00000533410.5ENSP00000435594.1
EnsemblENST00000524464.5ENSP00000431201.1
EnsemblENST00000527485.5ENSP00000435748.1
EnsemblENST00000529768.5ENSP00000432170.1
EnsemblENST00000532055.5ENSP00000434971.1
EnsemblENST00000356187.9ENSP00000348515.5
EnsemblENST00000529368.5ENSP00000435057.1
EnsemblENST00000534797.5ENSP00000433999.1
EnsemblENST00000529306.5ENSP00000434947.1
EnsemblENST00000397615.6ENSP00000380739.2
EnsemblENST00000529115.5ENSP00000433033.1
EnsemblENST00000354420.6ENSP00000346402.2
EnsemblENST00000531540.5ENSP00000432781.1
EnsemblENST00000525701.5ENSP00000436022.1
EnsemblENST00000397614.5ENSP00000380738.1
EnsemblENST00000397604.7ENSP00000380729.3
EnsemblENST00000438658.6ENSP00000416589.2
UniProtP13489, RINI_HUMAN, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
GeneBankAY071904, BC011186, BC003506, BC047730, M22414, BC000677, BC024037, AL161967, BC011500, M36717, BC014629, X13973AAL60586.1, AAH03506.1, CAA32151.1, AAH14629.1, CAB82310.1, AAH47730.1, AAA59130.1, AAA60249.1, AAH00677.1, AAH11186.1, AAH11500.1, AAH24037.1
RefSeqNM_002939.3, NM_203383.1, NM_203384.1, NM_203385.1, NM_203386.2, NM_203387.2, NM_203388.2, NM_203389.2, XM_011520255.1, XM_011520257.2, XM_011520258.2, XM_011520259.2, XM_011520260.2, XM_011520261.2, XM_011520262.2, XM_011520263.1, XM_017018106.1NP_002930.2, NP_976317.1, NP_976318.1, NP_976319.1, NP_976320.1, NP_976321.1, NP_976322.1, NP_976323.1, XP_011518557.1, XP_011518559.1, XP_011518560.1, XP_011518561.1, XP_011518562.1, XP_011518563.1, XP_011518564.1, XP_011518565.1, XP_016873595.1
Entrez6050

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSLDIQSLDI  QCEELSDARW  AELLPLLQQC  QVVRLDDCGL  TEARCKDISS  ALRVNPALAE  60
61    LNLRSNELGD  VGVHCVLQGL  QTPSCKIQKL  SLQNCCLTGA  GCGVLSSTLR  TLPTLQELHL  120
121   SDNLLGDAGL  QLLCEGLLDP  QCRLEKLQLE  YCSLSAASCE  PLASVLRAKP  DFKELTVSNN  180
181   DINEAGVRVL  CQGLKDSPCQ  LEALKLESCG  VTSDNCRDLC  GIVASKASLR  ELALGSNKLG  240
241   DVGMAELCPG  LLHPSSRLRT  LWIWECGITA  KGCGDLCRVL  RAKESLKELS  LAGNELGDEG  300
301   ARLLCETLLE  PGCQLESLWV  KSCSFTAACC  SHFSSVLAQN  RFLLELQISN  NRLEDAGVRE  360
361   LCQGLGQPGS  VLRVLWLADC  DVSDSSCSSL  AATLLANHSL  RELDLSNNCL  GDAGILQLVE  420
421   SVRQPGCLLE  QLVLYDIYWS  EEMEDRLQAL  EKDKPSLRVI  S  461
Nucleotide CDS Sequence (FASTA)
1     ATGAGCCTGG  ACATCCAGAG  CCTGGACATC  CAGTGTGAGG  AGCTGAGCGA  CGCTAGATGG  60
61    GCCGAGCTCC  TCCCTCTGCT  CCAGCAGTGC  CAAGTGGTCA  GGCTGGACGA  CTGTGGCCTC  120
121   ACGGAAGCAC  GGTGCAAGGA  CATCAGCTCT  GCACTTCGAG  TCAACCCTGC  ACTGGCAGAG  180
181   CTCAACCTGC  GCAGCAACGA  GCTGGGCGAT  GTCGGCGTGC  ATTGCGTGCT  CCAGGGCCTG  240
241   CAGACCCCCT  CCTGCAAGAT  CCAGAAGCTG  AGCCTCCAGA  ACTGCTGCCT  GACGGGGGCC  300
301   GGCTGCGGGG  TCCTGTCCAG  CACACTACGC  ACCCTGCCCA  CCCTGCAGGA  GCTGCACCTC  360
361   AGCGACAACC  TCTTGGGGGA  TGCGGGCCTG  CAGCTGCTCT  GCGAAGGACT  CCTGGACCCC  420
421   CAGTGCCGCC  TGGAAAAGCT  GCAGCTGGAG  TATTGCAGCC  TCTCGGCTGC  CAGCTGCGAG  480
481   CCCCTGGCCT  CCGTGCTCAG  GGCCAAGCCG  GACTTCAAGG  AGCTCACGGT  TAGCAACAAC  540
541   GACATCAATG  AGGCTGGCGT  CCGTGTGCTG  TGCCAGGGCC  TGAAGGACTC  CCCCTGCCAG  600
601   CTGGAGGCGC  TCAAGCTGGA  GAGCTGCGGT  GTGACATCAG  ACAACTGCCG  GGACCTGTGC  660
661   GGCATTGTGG  CCTCCAAGGC  CTCGCTGCGG  GAGCTGGCCC  TGGGCAGCAA  CAAGCTGGGT  720
721   GATGTGGGCA  TGGCGGAGCT  GTGCCCAGGG  CTGCTCCACC  CCAGCTCCAG  GCTCAGGACC  780
781   CTGTGGATCT  GGGAGTGTGG  CATCACTGCC  AAGGGCTGCG  GGGATCTGTG  CCGTGTCCTC  840
841   AGGGCCAAGG  AGAGCCTGAA  GGAGCTCAGC  CTGGCCGGCA  ACGAGCTGGG  GGATGAGGGT  900
901   GCCCGACTGC  TGTGTGAGAC  CCTGCTGGAA  CCTGGCTGCC  AGCTGGAGTC  GCTGTGGGTG  960
961   AAGTCCTGCA  GCTTCACAGC  CGCCTGCTGC  TCCCACTTCA  GCTCAGTGCT  GGCCCAGAAC  1020
1021  AGGTTTCTCC  TGGAGCTACA  GATAAGCAAC  AACAGGCTGG  AGGATGCGGG  CGTGCGGGAG  1080
1081  CTGTGCCAGG  GCCTGGGCCA  GCCTGGCTCT  GTGCTGCGGG  TGCTCTGGTT  GGCCGACTGC  1140
1141  GATGTGAGTG  ACAGCAGCTG  CAGCAGCCTC  GCCGCAACCC  TGTTGGCCAA  CCACAGCCTG  1200
1201  CGTGAGCTGG  ACCTCAGCAA  CAACTGCCTG  GGGGACGCCG  GCATCCTGCA  GCTGGTGGAG  1260
1261  AGCGTCCGGC  AGCCGGGCTG  CCTCCTGGAG  CAGCTGGTCC  TGTACGACAT  TTACTGGTCT  1320
1321  GAGGAGATGG  AGGACCGGCT  GCAGGCCCTG  GAGAAGGACA  AGCCATCCCT  GAGGGTCATC  1380
1381  TCCTGA  1386

▼ KEYWORD

ID
Family
3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Leucine-rich repeat
Phosphoprotein
Polymorphism
Reference proteome
Repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Angiogenin-PRI complex
Cellular Component
Cytosol
Cellular Component
Extracellular exosome
Cellular Component
Nucleoplasm
Molecular Function
Ribonuclease inhibitor activity
Biological Process
MRNA catabolic process
Biological Process
Regulation of angiogenesis

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pap-0584Pan paniscus98.920.0 849
LLPS-Pat-4361Pan troglodytes98.920.0 849
LLPS-Gog-4064Gorilla gorilla98.70.0 848
LLPS-Rhb-3017Rhinopithecus bieti94.510.0 807
LLPS-Maf-3175Macaca fascicularis93.850.0 800
LLPS-Paa-0352Papio anubis93.850.0 800
LLPS-Mam-2896Macaca mulatta93.850.0 800
LLPS-Mal-3531Mandrillus leucophaeus93.630.0 798
LLPS-Cea-3110Cercocebus atys93.410.0 798
LLPS-Man-3142Macaca nemestrina93.410.0 798
LLPS-Chs-1633Chlorocebus sabaeus92.090.0 783
LLPS-Aon-4350Aotus nancymaae84.820.0 727
LLPS-Nol-2226Nomascus leucogenys83.090.0 605
LLPS-Caj-4643Callithrix jacchus80.270.0 584
LLPS-Eqc-3673Equus caballus79.120.0 669
LLPS-Ict-0262Ictidomys tridecemlineatus78.240.0 680
LLPS-Otg-1584Otolemur garnettii77.80.0 660
LLPS-Sus-4733Sus scrofa77.360.0 659
LLPS-Mea-0316Mesocricetus auratus75.60.0 650
LLPS-Ran-4418Rattus norvegicus75.380.0 650
LLPS-Poa-3182Pongo abelii75.087e-143 420
LLPS-Aim-2641Ailuropoda melanoleuca74.670.0 644
LLPS-Bot-3149Bos taurus74.670.0 646
LLPS-Mum-4387Mus musculus73.850.0 636
LLPS-Fec-1649Felis catus72.310.0 624
LLPS-Fud-2259Fukomys damarensis70.770.0 592
LLPS-Loa-1485Loxodonta africana70.330.0 587
LLPS-Caf-2264Canis familiaris68.790.0 578
LLPS-Mup-1540Mustela putorius furo68.078e-170 492
LLPS-Cap-2070Cavia porcellus67.690.0 548
LLPS-Dio-3760Dipodomys ordii61.812e-69 227
LLPS-Sah-2838Sarcophilus harrisii53.641e-98 305
LLPS-Anp-2787Anas platyrhynchos50.665e-153 450
LLPS-Gaga-3704Gallus gallus50.04e-153 452
LLPS-Pes-1611Pelodiscus sinensis48.726e-133 399
LLPS-Fia-2722Ficedula albicollis48.684e-149 442
LLPS-Tag-2727Taeniopygia guttata47.534e-131 393
LLPS-Meg-2764Meleagris gallopavo47.023e-140 417
LLPS-Anc-2747Anolis carolinensis46.489e-137 409
LLPS-Ten-1105Tetraodon nigroviridis40.81e-55 198
LLPS-Orn-3733Oreochromis niloticus39.951e-63 219
LLPS-Xim-2145Xiphophorus maculatus38.465e-1889.7
LLPS-Sem-1859Selaginella moellendorffii30.853e-1272.8
LLPS-Chc-0843Chondrus crispus28.345e-0858.9
LLPS-Hov-1091Hordeum vulgare28.031e-1273.9
LLPS-Nia-0896Nicotiana attenuata28.02e-0757.0
LLPS-Php-1999Physcomitrella patens27.914e-0962.8
LLPS-Gas-0670Galdieria sulphuraria27.41e-0964.3
LLPS-Tra-1840Triticum aestivum27.346e-1271.6
LLPS-Brd-0425Brachypodium distachyon27.343e-1272.8
LLPS-Sob-2501Sorghum bicolor27.345e-1478.2
LLPS-Thc-1401Theobroma cacao27.249e-1271.2
LLPS-Zem-2293Zea mays27.242e-1273.6
LLPS-Orgl-2019Oryza glumaepatula27.171e-1273.9
LLPS-Dac-0712Daucus carota27.082e-0654.3
LLPS-Sei-2247Setaria italica26.996e-1374.7
LLPS-Ori-0626Oryza indica26.915e-1272.0
LLPS-Orb-0779Oryza barthii26.915e-1272.0
LLPS-Ors-1435Oryza sativa26.914e-1272.0
LLPS-Viv-1096Vitis vinifera26.917e-1065.1
LLPS-Orp-1244Oryza punctata26.912e-1273.2
LLPS-Tru-1575Triticum urartu26.915e-1168.9
LLPS-Org-0446Oryza glaberrima26.914e-1272.4
LLPS-Orm-0879Oryza meridionalis26.913e-1272.4
LLPS-Orni-0506Oryza nivara26.814e-1272.4
LLPS-Orr-0266Oryza rufipogon26.814e-1272.4
LLPS-Cus-2411Cucumis sativus26.753e-0963.2
LLPS-Met-0102Medicago truncatula26.729e-1064.7
LLPS-Hea-2408Helianthus annuus26.627e-0962.0
LLPS-Brr-2993Brassica rapa26.621e-0655.1
LLPS-Lep-1868Leersia perrieri26.553e-1272.8
LLPS-Vir-1566Vigna radiata26.481e-1067.4
LLPS-Via-2398Vigna angularis26.481e-1170.9
LLPS-Phv-1415Phaseolus vulgaris26.444e-0859.7
LLPS-Amt-1731Amborella trichopoda26.433e-0963.2
LLPS-Drm-0896Drosophila melanogaster26.366e-0859.3
LLPS-Orbr-0573Oryza brachyantha26.186e-1168.6
LLPS-Glm-0365Glycine max26.175e-1168.6
LLPS-Pot-2492Populus trichocarpa26.152e-0963.5
LLPS-Gor-1224Gossypium raimondii26.065e-1478.2
LLPS-Prp-1523Prunus persica25.994e-0859.7
LLPS-Mae-2555Manihot esculenta25.97e-1065.1
LLPS-Mua-1827Musa acuminata25.862e-0860.8
LLPS-Brn-1187Brassica napus25.721e-1067.8
LLPS-Bro-1438Brassica oleracea25.721e-1067.8
LLPS-Coc-1001Corchorus capsularis25.471e-1170.5
LLPS-Art-1287Arabidopsis thaliana25.02e-0860.5
LLPS-Sol-2243Solanum lycopersicum24.922e-0860.5
LLPS-Arl-2555Arabidopsis lyrata24.924e-1066.2
LLPS-Sot-2035Solanum tuberosum24.365e-0756.2
LLPS-Icp-3966Ictalurus punctatus24.325e-0653.1