LLPS-Hos-2539
FRMD8
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | FERM domain-containing protein 8 |
| Gene Name: | FRMD8, FKSG44 |
| Ensembl Gene: | ENSG00000126391.13 |
| Ensembl Protein: | ENSP00000319726.4 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Nuclear speckle | "...In total, we identified 325 proteins localized to distinct nuclear bodies, including nucleoli, promyelocytic leukemia nuclear bodies, nuclear speckles, paraspeckles, Cajal bodies, Sam68 nuclear bodies, Polycomb bodies, and uncharacterized nuclear bodies." | HeLa cells | 24127217 |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000317568.9 | ENSP00000319726.4 |
| Ensembl | ENST00000416776.6 | ENSP00000392111.2 |
| Ensembl | ENST00000531296.1 | ENSP00000433479.1 |
| Ensembl | ENST00000355991.9 | ENSP00000348270.5 |
| Ensembl | ENST00000533782.5 | ENSP00000435913.1 |
| Ensembl | ENST00000526201.1 | ENSP00000435991.1 |
| Ensembl | ENST00000525156.1 | ENSP00000434274.1 |
| UniProt | Q9BZ67, FRMD8_HUMAN, B4E2P1, Q86V56, Q8NCB5 | |
| GeneBank | BC044658, AK074850, AF334946, AP000944, BC051695, AK304363 | AAH44658.1, AAG50295.1, BAG65203.1, BAC11244.1, AAH51695.1 |
| RefSeq | NM_001300832.2, NM_001300833.2, NM_031904.4 | NP_001287761.1, NP_001287762.1, NP_114110.1 |
| Entrez | 83786 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MDGTEGSAGQ PGPAERSHRS SVSSVGARAA DVLVYLADDT VVPLAVENLP SLSAHELHRA 60 61 VREVLQLPDI ALDVFALWLV SPLLEVQLKP KHQPYKLGRQ WPELLLRFTS APDDDVAMDE 120 121 PFLQFRRNVF FPKRRELQIH DEEVLRLLYE EAKGNVLAAR YPCDVEDCEA LGALVCRVQL 180 181 GPYQPGRPAA CDLREKLDSF LPAHLCKRGQ SLFAALRGRG ARAGPGEQGL LNAYRQVQEV 240 241 SSDGGCEAAL GTHYRAYLLK CHELPFYGCA FFHGEVDKPA QGFLHRGGRK PVSVAISLEG 300 301 VHVIDSREKH VLLGLRFQEL SWDHTSPEEE EPILWLEFDG DSEGTPVNKL LKIYSKQAEL 360 361 MSSLIEYCIE LSQAAEPAGP QDSATGSPSD PSSSLAPVQR PKLRRQGSVV SSRIQHLSTI 420 421 DYVEDGKGIR RVKPKRTTSF FSRQLSLGQG SYTVVQPGDS LEQG 464 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGACGGGA CAGAAGGCAG TGCCGGGCAG CCCGGCCCCG CTGAGCGATC CCACCGAAGC 60 61 AGCGTGTCCT CCGTGGGAGC CCGAGCGGCT GACGTGCTGG TATACCTAGC GGATGACACG 120 121 GTGGTGCCCC TGGCTGTGGA GAACCTGCCC TCGCTCAGTG CCCATGAGCT GCACCGCGCT 180 181 GTCCGCGAGG TCCTGCAGCT TCCAGACATC GCCCTGGATG TCTTCGCGCT CTGGCTGGTC 240 241 TCCCCTCTGC TGGAGGTGCA GCTGAAACCC AAGCACCAGC CCTACAAGCT GGGACGCCAG 300 301 TGGCCGGAGC TGCTGCTGCG CTTCACCAGT GCCCCAGACG ATGACGTGGC CATGGATGAG 360 361 CCTTTCCTGC AGTTCCGAAG GAACGTGTTC TTCCCAAAGC GGCGGGAGCT CCAGATCCAT 420 421 GACGAGGAGG TCCTGCGGCT GCTCTATGAG GAGGCCAAGG GCAACGTGCT GGCTGCACGG 480 481 TACCCGTGCG ACGTGGAGGA CTGCGAGGCT CTGGGCGCCC TGGTGTGCCG CGTGCAGCTT 540 541 GGGCCCTACC AGCCCGGCCG GCCGGCAGCC TGCGACCTGA GGGAGAAGCT GGACTCCTTC 600 601 CTCCCTGCCC ACCTCTGTAA GCGGGGCCAG AGTCTCTTTG CTGCCCTCCG GGGCCGTGGG 660 661 GCCAGGGCCG GGCCGGGCGA GCAGGGCCTG CTGAACGCCT ACCGCCAGGT GCAGGAGGTC 720 721 AGCAGCGACG GCGGGTGCGA GGCCGCCCTG GGCACCCACT ACCGCGCCTA TCTCCTCAAG 780 781 TGCCACGAGC TGCCGTTTTA TGGGTGTGCC TTCTTCCACG GTGAGGTTGA CAAGCCGGCC 840 841 CAAGGCTTTT TGCACCGGGG TGGGCGCAAG CCAGTTTCTG TGGCCATCAG TCTGGAAGGC 900 901 GTGCACGTCA TCGATAGCAG AGAGAAGCAT GTCCTGCTGG GCCTGCGCTT CCAGGAGCTG 960 961 TCGTGGGACC ACACCTCCCC CGAGGAGGAG GAGCCCATCT TGTGGCTGGA GTTCGACGGG 1020 1021 GACAGCGAGG GCACACCTGT CAACAAGCTC CTCAAGATCT ACTCCAAGCA GGCCGAACTG 1080 1081 ATGAGCAGTC TCATTGAGTA CTGCATCGAA CTGAGCCAGG CGGCGGAGCC CGCAGGCCCC 1140 1141 CAGGACAGTG CGACTGGCTC GCCCTCGGAC CCCAGCTCCT CACTGGCTCC TGTTCAGCGC 1200 1201 CCCAAGCTGC GGAGGCAGGG CAGTGTGGTG TCCAGCCGGA TCCAGCATCT CTCCACCATC 1260 1261 GACTACGTGG AGGACGGCAA GGGGATCAGG CGAGTGAAGC CGAAGCGCAC CACATCCTTC 1320 1321 TTCAGCCGGC AGCTGTCCTT GGGCCAGGGG AGCTACACCG TGGTGCAGCC CGGCGACAGC 1380 1381 CTGGAGCAGG GCTGA 1395 |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pap-0380 | Pan paniscus | 99.78 | 0.0 | 847 |
| LLPS-Pat-0912 | Pan troglodytes | 99.57 | 0.0 | 844 |
| LLPS-Gog-3752 | Gorilla gorilla | 98.92 | 0.0 | 836 |
| LLPS-Rhb-2473 | Rhinopithecus bieti | 97.94 | 7e-113 | 347 |
| LLPS-Cea-3203 | Cercocebus atys | 97.41 | 0.0 | 828 |
| LLPS-Paa-3689 | Papio anubis | 97.41 | 0.0 | 828 |
| LLPS-Man-0704 | Macaca nemestrina | 97.41 | 0.0 | 828 |
| LLPS-Maf-3567 | Macaca fascicularis | 97.2 | 0.0 | 827 |
| LLPS-Chs-2142 | Chlorocebus sabaeus | 96.34 | 0.0 | 823 |
| LLPS-Aon-3734 | Aotus nancymaae | 96.12 | 0.0 | 821 |
| LLPS-Caj-2418 | Callithrix jacchus | 95.47 | 0.0 | 817 |
| LLPS-Poa-0676 | Pongo abelii | 94.17 | 0.0 | 792 |
| LLPS-Mal-0504 | Mandrillus leucophaeus | 92.91 | 0.0 | 646 |
| LLPS-Cas-2599 | Carlito syrichta | 91.05 | 0.0 | 667 |
| LLPS-Otg-2206 | Otolemur garnettii | 89.68 | 0.0 | 772 |
| LLPS-Cap-3894 | Cavia porcellus | 89.03 | 0.0 | 762 |
| LLPS-Bot-4638 | Bos taurus | 87.96 | 0.0 | 754 |
| LLPS-Eqc-3299 | Equus caballus | 87.93 | 0.0 | 758 |
| LLPS-Mam-1515 | Macaca mulatta | 87.79 | 0.0 | 729 |
| LLPS-Mum-4877 | Mus musculus | 87.74 | 0.0 | 758 |
| LLPS-Sus-2823 | Sus scrofa | 87.5 | 0.0 | 737 |
| LLPS-Orc-0597 | Oryctolagus cuniculus | 87.33 | 0.0 | 717 |
| LLPS-Fec-1624 | Felis catus | 87.31 | 0.0 | 748 |
| LLPS-Fud-3379 | Fukomys damarensis | 87.1 | 0.0 | 755 |
| LLPS-Mup-3595 | Mustela putorius furo | 87.1 | 0.0 | 734 |
| LLPS-Loa-2649 | Loxodonta africana | 87.0 | 0.0 | 736 |
| LLPS-Tut-1377 | Tursiops truncatus | 86.98 | 0.0 | 743 |
| LLPS-Ran-2510 | Rattus norvegicus | 86.7 | 0.0 | 753 |
| LLPS-Caf-0833 | Canis familiaris | 86.64 | 0.0 | 745 |
| LLPS-Aim-4183 | Ailuropoda melanoleuca | 85.65 | 0.0 | 721 |
| LLPS-Mea-3238 | Mesocricetus auratus | 84.7 | 0.0 | 736 |
| LLPS-Ova-4047 | Ovis aries | 78.22 | 0.0 | 649 |
| LLPS-Dio-1971 | Dipodomys ordii | 78.06 | 0.0 | 647 |
| LLPS-Ict-2096 | Ictidomys tridecemlineatus | 77.99 | 0.0 | 647 |
| LLPS-Myl-4496 | Myotis lucifugus | 75.76 | 1e-39 | 144 |
| LLPS-Nol-3735 | Nomascus leucogenys | 74.77 | 0.0 | 566 |
| LLPS-Sah-4115 | Sarcophilus harrisii | 72.75 | 0.0 | 616 |
| LLPS-Mod-3389 | Monodelphis domestica | 71.3 | 0.0 | 600 |
| LLPS-Pes-1778 | Pelodiscus sinensis | 70.17 | 0.0 | 608 |
| LLPS-Ora-3023 | Ornithorhynchus anatinus | 67.99 | 0.0 | 564 |
| LLPS-Anc-2581 | Anolis carolinensis | 65.68 | 0.0 | 558 |
| LLPS-Xet-0883 | Xenopus tropicalis | 61.4 | 0.0 | 526 |
| LLPS-Lac-3337 | Latimeria chalumnae | 59.41 | 6e-163 | 476 |
| LLPS-Scf-0242 | Scleropages formosus | 56.7 | 2e-153 | 452 |
| LLPS-Asm-3688 | Astyanax mexicanus | 56.01 | 1e-142 | 424 |
| LLPS-Dar-3582 | Danio rerio | 55.61 | 3e-153 | 451 |
| LLPS-Orl-3780 | Oryzias latipes | 54.38 | 3e-144 | 428 |
| LLPS-Pof-1982 | Poecilia formosa | 54.2 | 1e-144 | 429 |
| LLPS-Gaa-1287 | Gasterosteus aculeatus | 53.5 | 9e-147 | 434 |
| LLPS-Icp-2863 | Ictalurus punctatus | 53.26 | 4e-144 | 427 |
| LLPS-Ten-1646 | Tetraodon nigroviridis | 53.06 | 9e-140 | 416 |
| LLPS-Scm-2220 | Scophthalmus maximus | 52.11 | 1e-141 | 423 |
| LLPS-Tar-1695 | Takifugu rubripes | 51.93 | 3e-137 | 410 |
| LLPS-Orn-1983 | Oreochromis niloticus | 51.32 | 4e-142 | 423 |
| LLPS-Xim-2043 | Xiphophorus maculatus | 50.85 | 6e-137 | 410 |
| LLPS-Cis-2070 | Ciona savignyi | 37.18 | 1e-60 | 207 |
| LLPS-Cii-1882 | Ciona intestinalis | 27.94 | 3e-16 | 85.5 |
| LLPS-Urm-3347 | Ursus maritimus | 26.62 | 2e-20 | 98.6 |
| LLPS-Cae-1911 | Caenorhabditis elegans | 26.24 | 2e-14 | 79.7 |
| LLPS-Fia-3381 | Ficedula albicollis | 26.24 | 2e-19 | 95.1 |
| LLPS-Meg-3261 | Meleagris gallopavo | 26.24 | 3e-19 | 94.7 |
| LLPS-Anp-3142 | Anas platyrhynchos | 26.24 | 2e-19 | 95.5 |
| LLPS-Gaga-0137 | Gallus gallus | 26.24 | 3e-19 | 94.7 |
| LLPS-Tag-1835 | Taeniopygia guttata | 26.24 | 2e-19 | 95.1 |
| LLPS-Leo-3644 | Lepisosteus oculatus | 25.41 | 8e-20 | 96.7 |