LLPS-Hos-2528
ENOX1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Ecto-NOX disulfide-thiol exchanger 1; Candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase; cCNOX; Cell proliferation-inducing gene 38 protein; Constitutive Ecto-NOX; cNOX |
| Gene Name: | ENOX1, PIG38 |
| Ensembl Gene: | ENSG00000120658.13 |
| Ensembl Protein: | ENSP00000261488.6 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Paraspeckle | "...In total, we identified 325 proteins localized to distinct nuclear bodies, including nucleoli, promyelocytic leukemia nuclear bodies, nuclear speckles, paraspeckles, Cajal bodies, Sam68 nuclear bodies, Polycomb bodies, and uncharacterized nuclear bodies." | HeLa cells | 24127217 |
▼ FUNCTION
| Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000261488.10 | ENSP00000261488.6 |
| UniProt | Q8TC92, ENOX1_HUMAN, A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q9NWE0 | |
| GeneBank | AY513282, AK299053, AL161714, AL627430, AL607148, CH471075, EF432052, AK000956, AL136959, AL138823, AL445703, BC024178, AL162713 | AAH24178.1, EAX08693.1, ABO28524.1, AAT08035.1, BAH12937.1, BAA91442.1 |
| RefSeq | NM_001127615.2, NM_001242863.2, NM_001347964.1, NM_001347965.1, NM_001347966.1, NM_001347967.1, NM_001347968.1, NM_001347969.1, NM_017993.4, XM_011535126.2, XM_011535127.2, XM_017020637.1, XM_017020638.1 | NP_001121087.1, NP_001229792.1, NP_001334893.1, NP_001334894.1, NP_001334895.1, NP_001334896.1, NP_001334897.1, NP_001334898.1, NP_060463.2, XP_011533428.1, XP_011533429.1, XP_016876126.1, XP_016876127.1 |
| Entrez | 55068 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MVDAGGVENI TQLPQELPQM MAAAADGLGS IAIDTTQLNM SVTDPTAWAT AMNNLGMVPV 60 61 GLPGQQLVSD SICVPGFDPS LNMMTGITPI NPMIPGLGLV PPPPPTEVAV VKEIIHCKSC 120 121 TLFPQNPNLP PPSTRERPPG CKTVFVGGLP ENATEEIIQE VFEQCGDITA IRKSKKNFCH 180 181 IRFAEEFMVD KAIYLSGYRM RLGSSTDKKD SGRLHVDFAQ ARDDFYEWEC KQRMRAREER 240 241 HRRKLEEDRL RPPSPPAIMH YSEHEAALLA EKLKDDSKFS EAITVLLSWI ERGEVNRRSA 300 301 NQFYSMVQSA NSHVRRLMNE KATHEQEMEE AKENFKNALT GILTQFEQIV AVFNASTRQK 360 361 AWDHFSKAQR KNIDIWRKHS EELRNAQSEQ LMGIRREEEM EMSDDENCDS PTKKMRVDES 420 421 ALAAQAYALK EENDSLRWQL DAYRNEVELL KQEKEQLFRT EENLTKDQQL QFLQQTMQGM 480 481 QQQLLTIQEE LNNKKSELEQ AKEEQSHTQA LLKVLQEQLK GTKELVETNG HSHEDSNEIN 540 541 VLTVALVNQD RENNIEKRSQ GLKSEKEALL IGIISTFLHV HPFGANIEYL WSYMQQLDSK 600 601 ISANEIEMLL MRLPRMFKQE FTGVGATLEK RWKLCAFEGI KTT 643 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGTAGATG CAGGTGGAGT TGAGAACATC ACCCAGCTTC CCCAGGAGCT TCCTCAGATG 60 61 ATGGCTGCAG CAGCCGATGG TTTGGGGAGT ATAGCGATAG ACACGACCCA GCTCAACATG 120 121 TCCGTGACAG ATCCCACAGC CTGGGCTACA GCCATGAATA ACCTGGGCAT GGTTCCCGTA 180 181 GGGTTGCCTG GACAGCAGCT CGTGTCTGAC TCAATCTGTG TCCCAGGCTT TGATCCAAGC 240 241 CTCAACATGA TGACTGGAAT CACCCCCATT AACCCAATGA TACCAGGCCT TGGACTGGTA 300 301 CCTCCCCCAC CACCAACAGA AGTGGCTGTT GTCAAAGAAA TAATCCACTG CAAAAGCTGT 360 361 ACTCTTTTTC CTCAAAATCC AAATCTTCCA CCTCCTTCCA CAAGAGAACG ACCTCCTGGG 420 421 TGTAAGACCG TGTTTGTCGG AGGATTACCA GAAAATGCTA CTGAGGAAAT TATTCAAGAA 480 481 GTCTTTGAAC AGTGCGGTGA TATTACAGCA ATTCGGAAAA GCAAGAAGAA TTTTTGTCAC 540 541 ATTCGCTTTG CAGAGGAATT CATGGTTGAT AAAGCCATTT ACCTTTCTGG TTATAGGATG 600 601 CGATTAGGGT CTAGCACCGA CAAAAAGGAT TCAGGCCGCC TTCATGTGGA CTTTGCCCAG 660 661 GCCAGGGATG ACTTCTATGA GTGGGAATGC AAGCAGAGGA TGCGTGCCCG GGAGGAGCGG 720 721 CACCGGCGCA AGCTGGAGGA GGACCGGCTC AGGCCCCCAT CCCCGCCTGC CATAATGCAC 780 781 TACTCGGAGC ACGAAGCCGC TCTGCTGGCT GAAAAGCTGA AAGATGATAG CAAGTTTTCA 840 841 GAGGCTATCA CAGTGCTGCT TTCCTGGATT GAACGAGGGG AAGTGAATCG GCGCTCTGCA 900 901 AACCAGTTCT ATTCCATGGT GCAGTCGGCC AACAGCCACG TCCGCCGGCT AATGAATGAA 960 961 AAAGCCACCC ATGAGCAAGA GATGGAGGAA GCCAAGGAGA ATTTTAAAAA TGCCTTAACT 1020 1021 GGGATTCTCA CTCAATTTGA GCAGATTGTG GCCGTTTTCA ACGCTTCTAC CAGACAAAAA 1080 1081 GCTTGGGACC ATTTCTCGAA AGCCCAGCGC AAGAACATAG ACATTTGGCG AAAGCATTCT 1140 1141 GAGGAGCTCC GGAATGCTCA AAGTGAGCAG CTCATGGGCA TCCGCCGCGA AGAAGAAATG 1200 1201 GAAATGTCTG ATGATGAGAA CTGTGACAGC CCTACAAAGA AAATGAGAGT CGATGAATCA 1260 1261 GCCCTGGCTG CCCAGGCCTA CGCTCTGAAA GAGGAGAATG ACAGTCTCCG CTGGCAGCTG 1320 1321 GATGCCTACA GGAATGAGGT GGAGCTGCTG AAACAAGAAA AAGAACAGCT TTTCCGAACA 1380 1381 GAAGAAAACC TCACCAAGGA CCAGCAACTG CAGTTTCTGC AGCAAACCAT GCAAGGCATG 1440 1441 CAGCAGCAAT TGCTAACCAT CCAGGAGGAG TTAAACAACA AAAAGTCAGA ATTGGAACAA 1500 1501 GCAAAGGAAG AGCAGTCCCA TACACAAGCG TTACTAAAAG TCCTGCAGGA ACAATTAAAA 1560 1561 GGTACCAAGG AATTGGTCGA GACCAATGGC CACAGCCATG AGGATTCAAA TGAAATCAAT 1620 1621 GTGTTGACAG TTGCATTAGT CAACCAAGAC CGAGAGAACA ATATTGAGAA AAGAAGCCAA 1680 1681 GGCTTAAAAT CAGAGAAAGA AGCTCTGCTA ATAGGTATCA TATCAACGTT TCTTCACGTC 1740 1741 CATCCTTTTG GAGCCAACAT AGAATATCTT TGGTCATACA TGCAGCAGCT GGACTCCAAG 1800 1801 ATATCTGCAA ATGAAATAGA AATGCTTTTG ATGAGGCTGC CACGCATGTT CAAACAGGAA 1860 1861 TTCACGGGTG TGGGAGCCAC GCTGGAAAAA AGATGGAAGC TGTGTGCCTT TGAAGGAATT 1920 1921 AAAACTACCT AA 1932 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | External side of plasma membrane | |
Cellular Component | Extracellular space | |
Cellular Component | Plasma membrane | |
Molecular Function | Nucleic acid binding | |
Molecular Function | Oxidoreductase activity | |
Biological Process | Ultradian rhythm |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| ENPD | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | COSMIC | MethyCancer | |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Nol-2460 | Nomascus leucogenys | 100.0 | 0.0 | 1167 |
| LLPS-Otg-4048 | Otolemur garnettii | 100.0 | 0.0 | 746 |
| LLPS-Pap-4408 | Pan paniscus | 100.0 | 0.0 | 995 |
| LLPS-Pat-0702 | Pan troglodytes | 100.0 | 0.0 | 1167 |
| LLPS-Gog-1350 | Gorilla gorilla | 100.0 | 0.0 | 1167 |
| LLPS-Poa-2509 | Pongo abelii | 99.84 | 0.0 | 1167 |
| LLPS-Man-4310 | Macaca nemestrina | 99.84 | 0.0 | 1164 |
| LLPS-Mal-3393 | Mandrillus leucophaeus | 99.84 | 0.0 | 1164 |
| LLPS-Aon-4439 | Aotus nancymaae | 99.84 | 0.0 | 1165 |
| LLPS-Cea-3742 | Cercocebus atys | 99.84 | 0.0 | 1164 |
| LLPS-Maf-4734 | Macaca fascicularis | 99.84 | 0.0 | 1164 |
| LLPS-Paa-3879 | Papio anubis | 99.69 | 0.0 | 1163 |
| LLPS-Caj-3660 | Callithrix jacchus | 99.69 | 0.0 | 1163 |
| LLPS-Chs-1705 | Chlorocebus sabaeus | 99.69 | 0.0 | 1162 |
| LLPS-Ict-3353 | Ictidomys tridecemlineatus | 99.38 | 0.0 | 1161 |
| LLPS-Cas-2730 | Carlito syrichta | 99.3 | 0.0 | 1018 |
| LLPS-Mam-0336 | Macaca mulatta | 99.26 | 0.0 | 949 |
| LLPS-Fud-3970 | Fukomys damarensis | 99.22 | 0.0 | 1159 |
| LLPS-Myl-3194 | Myotis lucifugus | 99.13 | 0.0 | 1018 |
| LLPS-Bot-4561 | Bos taurus | 98.88 | 0.0 | 1117 |
| LLPS-Eqc-2434 | Equus caballus | 98.6 | 0.0 | 1156 |
| LLPS-Ova-3037 | Ovis aries | 98.56 | 0.0 | 1113 |
| LLPS-Orc-0863 | Oryctolagus cuniculus | 98.29 | 0.0 | 1144 |
| LLPS-Mup-4099 | Mustela putorius furo | 98.29 | 0.0 | 1149 |
| LLPS-Dio-3593 | Dipodomys ordii | 98.29 | 0.0 | 1145 |
| LLPS-Cap-2454 | Cavia porcellus | 98.13 | 0.0 | 1147 |
| LLPS-Fec-3510 | Felis catus | 98.13 | 0.0 | 1149 |
| LLPS-Caf-4138 | Canis familiaris | 97.98 | 0.0 | 1144 |
| LLPS-Ran-4724 | Rattus norvegicus | 97.98 | 0.0 | 1143 |
| LLPS-Aim-1704 | Ailuropoda melanoleuca | 97.51 | 0.0 | 1132 |
| LLPS-Sus-0355 | Sus scrofa | 97.51 | 0.0 | 1137 |
| LLPS-Rhb-0311 | Rhinopithecus bieti | 97.39 | 0.0 | 1143 |
| LLPS-Mea-2288 | Mesocricetus auratus | 97.05 | 0.0 | 1120 |
| LLPS-Sah-4021 | Sarcophilus harrisii | 95.67 | 0.0 | 1056 |
| LLPS-Loa-3663 | Loxodonta africana | 95.02 | 0.0 | 1117 |
| LLPS-Mod-0743 | Monodelphis domestica | 94.09 | 0.0 | 1073 |
| LLPS-Mum-3989 | Mus musculus | 93.81 | 0.0 | 1110 |
| LLPS-Gaga-0932 | Gallus gallus | 93.26 | 0.0 | 1024 |
| LLPS-Tag-2035 | Taeniopygia guttata | 93.17 | 0.0 | 962 |
| LLPS-Anp-2753 | Anas platyrhynchos | 93.17 | 0.0 | 952 |
| LLPS-Fia-1830 | Ficedula albicollis | 93.12 | 0.0 | 942 |
| LLPS-Urm-1025 | Ursus maritimus | 92.85 | 0.0 | 1097 |
| LLPS-Meg-1894 | Meleagris gallopavo | 92.37 | 0.0 | 926 |
| LLPS-Pes-1250 | Pelodiscus sinensis | 90.81 | 0.0 | 908 |
| LLPS-Anc-2139 | Anolis carolinensis | 90.59 | 0.0 | 889 |
| LLPS-Lac-4087 | Latimeria chalumnae | 80.1 | 0.0 | 860 |
| LLPS-Ora-2634 | Ornithorhynchus anatinus | 77.86 | 0.0 | 823 |
| LLPS-Leo-0222 | Lepisosteus oculatus | 75.12 | 0.0 | 841 |
| LLPS-Xet-2627 | Xenopus tropicalis | 72.93 | 0.0 | 712 |
| LLPS-Dar-4102 | Danio rerio | 72.16 | 0.0 | 813 |
| LLPS-Asm-2004 | Astyanax mexicanus | 71.61 | 0.0 | 805 |
| LLPS-Xim-3277 | Xiphophorus maculatus | 67.82 | 0.0 | 759 |
| LLPS-Orn-1742 | Oreochromis niloticus | 67.3 | 0.0 | 766 |
| LLPS-Pof-1337 | Poecilia formosa | 67.19 | 0.0 | 753 |
| LLPS-Orl-3349 | Oryzias latipes | 65.03 | 0.0 | 729 |
| LLPS-Gaa-2106 | Gasterosteus aculeatus | 64.83 | 0.0 | 679 |
| LLPS-Icp-1482 | Ictalurus punctatus | 64.01 | 0.0 | 649 |
| LLPS-Tar-2190 | Takifugu rubripes | 63.77 | 0.0 | 660 |
| LLPS-Scm-1431 | Scophthalmus maximus | 62.62 | 0.0 | 650 |
| LLPS-Ten-3846 | Tetraodon nigroviridis | 57.49 | 0.0 | 639 |
| LLPS-Drm-0570 | Drosophila melanogaster | 50.73 | 2e-96 | 320 |