LLPS-Hos-2504
NTNG1

▼ OVERVIEW

Status: Reviewed
Protein Name: Netrin-G1; Laminet-1
Gene Name: NTNG1, KIAA0976, LMNT1, UNQ571/PRO1133
Ensembl Gene: ENSG00000162631.18
Ensembl Protein: ENSP00000359090.2
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client
PDB: 3ZYJ (A, B) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...Finally, 221 proteins were found as nucleolar with No/Cyto > 1 and No/Nuc > 1."
HCT116 cells20026476

▼ FUNCTION

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MYLSRFLSIH  ALWVTVSSVM  QPYPLVWGHY  DLCKTQIYTE  EGKVWDYMAC  QPESTDMTKY  60
61    LKVKLDPPDI  TCGDPPETFC  AMGNPYMCNN  ECDASTPELA  HPPELMFDFE  GRHPSTFWQS  120
121   ATWKEYPKPL  QVNITLSWSK  TIELTDNIVI  TFESGRPDQM  ILEKSLDYGR  TWQPYQYYAT  180
181   DCLDAFHMDP  KSVKDLSQHT  VLEIICTEEY  STGYTTNSKI  IHFEIKDRFA  FFAGPRLRNM  240
241   ASLYGQLDTT  KKLRDFFTVT  DLRIRLLRPA  VGEIFVDELH  LARYFYAISD  IKVRGRCKCN  300
301   LHATVCVYDN  SKLTCECEHN  TTGPDCGKCK  KNYQGRPWSP  GSYLPIPKGT  ANTCIPSISS  360
361   IGNCECFGHS  NRCSYIDLLN  TVICVSCKHN  TRGQHCELCR  LGYFRNASAQ  LDDENVCIEC  420
421   YCNPLGSIHD  RCNGSGFCEC  KTGTTGPKCD  ECLPGNSWHY  GCQPNVCDNE  LLHCQNGGTC  480
481   HNNVRCLCPA  AYTGILCEKL  RCEEAGSCGS  DSGQGAPPHG  SPALLLLTTL  LGTASPLVF  539
Nucleotide CDS Sequence (FASTA)
1     Sequence u  navailable  20

▼ KEYWORD

ID
Family
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Developmental protein
Differentiation
Direct protein sequencing
Disulfide bond
Glycoprotein
GPI-anchor
Laminin EGF-like domain
Lipoprotein
Membrane
Neurogenesis
Reference proteome
Repeat
Signal

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Anchored component of plasma membrane
Cellular Component
Anchored component of presynaptic active zone membrane
Cellular Component
Extracellular region
Cellular Component
Glutamatergic synapse
Cellular Component
Plasma membrane
Cellular Component
Schaffer collateral - CA1 synapse
Molecular Function
Cell adhesion molecule binding
Molecular Function
Cell-cell adhesion mediator activity
Biological Process
Axonogenesis
Biological Process
Modulation of chemical synaptic transmission
Biological Process
Synaptic membrane adhesion

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Paa-4171Papio anubis100.00.01087
LLPS-Mal-2818Mandrillus leucophaeus100.00.01086
LLPS-Maf-4621Macaca fascicularis100.00.01086
LLPS-Chs-3556Chlorocebus sabaeus100.00.0 914
LLPS-Cea-3375Cercocebus atys100.00.01086
LLPS-Gog-1098Gorilla gorilla100.00.01086
LLPS-Mam-4178Macaca mulatta100.00.01086
LLPS-Nol-1981Nomascus leucogenys100.00.01086
LLPS-Pat-2888Pan troglodytes100.00.01087
LLPS-Pap-4442Pan paniscus100.00.01086
LLPS-Man-3832Macaca nemestrina99.810.01084
LLPS-Rhb-4537Rhinopithecus bieti99.810.01083
LLPS-Aon-2155Aotus nancymaae99.610.01082
LLPS-Caj-2757Callithrix jacchus99.610.01083
LLPS-Ict-4603Ictidomys tridecemlineatus99.230.01081
LLPS-Poa-1311Pongo abelii99.180.0 757
LLPS-Orc-4236Oryctolagus cuniculus99.080.0 897
LLPS-Caf-2421Canis familiaris98.90.0 751
LLPS-Aim-1388Ailuropoda melanoleuca98.870.0 734
LLPS-Cap-4513Cavia porcellus98.840.01077
LLPS-Fec-0828Felis catus98.840.01071
LLPS-Fud-2050Fukomys damarensis98.830.01063
LLPS-Otg-4733Otolemur garnettii98.460.01066
LLPS-Urm-3830Ursus maritimus98.280.0 959
LLPS-Ran-3706Rattus norvegicus97.950.0 902
LLPS-Dio-0557Dipodomys ordii97.880.01062
LLPS-Loa-2872Loxodonta africana97.470.0 890
LLPS-Tut-0678Tursiops truncatus97.290.01048
LLPS-Mum-4779Mus musculus96.720.01052
LLPS-Sah-2785Sarcophilus harrisii96.390.0 563
LLPS-Mod-0227Monodelphis domestica93.720.0 853
LLPS-Pes-3735Pelodiscus sinensis91.460.0 700
LLPS-Bot-3851Bos taurus91.430.01053
LLPS-Sus-2549Sus scrofa91.430.01054
LLPS-Fia-1094Ficedula albicollis91.180.0 697
LLPS-Mup-1113Mustela putorius furo91.070.01048
LLPS-Tag-2373Taeniopygia guttata88.780.0 956
LLPS-Ova-4234Ovis aries88.360.0 837
LLPS-Anp-2692Anas platyrhynchos88.150.0 962
LLPS-Myl-2234Myotis lucifugus88.050.0 690
LLPS-Ora-1846Ornithorhynchus anatinus83.990.0 976
LLPS-Cas-2254Carlito syrichta83.980.0 729
LLPS-Eqc-1175Equus caballus80.120.0 805
LLPS-Lac-2456Latimeria chalumnae79.720.0 738
LLPS-Anc-2899Anolis carolinensis79.525e-112 338
LLPS-Leo-3319Lepisosteus oculatus76.150.0 841
LLPS-Ten-0450Tetraodon nigroviridis76.090.0 813
LLPS-Gaga-3666Gallus gallus74.950.0 773
LLPS-Scm-1513Scophthalmus maximus74.660.0 826
LLPS-Tar-2533Takifugu rubripes74.520.0 813
LLPS-Scf-3283Scleropages formosus74.510.0 740
LLPS-Orn-3215Oreochromis niloticus74.140.0 816
LLPS-Asm-3392Astyanax mexicanus73.230.0 783
LLPS-Xim-1898Xiphophorus maculatus72.330.0 799
LLPS-Dar-1769Danio rerio72.140.0 798
LLPS-Xet-3627Xenopus tropicalis68.450.0 620
LLPS-Mea-3471Mesocricetus auratus65.910.0 631
LLPS-Orl-2556Oryzias latipes62.480.0 644
LLPS-Gaa-0933Gasterosteus aculeatus62.020.0 651
LLPS-Pof-0310Poecilia formosa54.220.0 543
LLPS-Icp-4220Ictalurus punctatus54.120.0 593
LLPS-Meg-2185Meleagris gallopavo35.876e-45 166
LLPS-Cae-1282Caenorhabditis elegans32.651e-52 194
LLPS-Drm-0711Drosophila melanogaster28.783e-41 162