LLPS-Hos-2501
C8orf59
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Uncharacterized protein C8orf59 |
| Gene Name: | C8orf59 |
| Ensembl Gene: | ENSG00000176731.11 |
| Ensembl Protein: | ENSP00000428722.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Nucleolus | "...The data set from all our nucleolar mass spectrometry analyses defines an updated group of 692 proteins that reproducibly copurify with human nucleoli." | HeLa cells | 15635413 |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000523281.5 | ENSP00000428722.1 |
| Ensembl | ENST00000612809.4 | ENSP00000481745.1 |
| Ensembl | ENST00000615697.4 | ENSP00000482944.1 |
| Ensembl | ENST00000321777.5 | ENSP00000319020.5 |
| Ensembl | ENST00000614462.4 | ENSP00000480167.1 |
| Ensembl | ENST00000619594.4 | ENSP00000484492.1 |
| Ensembl | ENST00000612977.4 | ENSP00000484101.1 |
| Ensembl | ENST00000545322.5 | ENSP00000444092.2 |
| Ensembl | ENST00000611854.4 | ENSP00000484811.1 |
| UniProt | Q8N0T1, CH059_HUMAN, B2RXE7, E5RFW5 | |
| GeneBank | AC011773, BC032347, BC146988, BC062221, CH471068, BC146983, BC157825 | , AAI57826.1, AAI46989.1, AAI46984.1, AAH32347.1, EAW87124.1 |
| RefSeq | NM_001099670.2, NM_001099671.2, NM_001099672.2, NM_001099673.2, XM_011517528.2 | NP_001093140.1, NP_001093141.1, NP_001093142.1, NP_001093143.1, XP_011515830.1 |
| Entrez | 401466 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAKNKLRGPK SRNVFHIASQ KNFKAKNKAK PVTTNLKKIN IMNEEKVNRV NKAFVNVQKE 60 61 LAHFAKSISL EPLQKELIPQ QRHESKPVNV DEATRLMALL 100 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCAAGA ACAAATTAAG AGGGCCGAAG TCCAGGAATG TATTTCACAT AGCCAGCCAA 60 61 AAAAACTTTA AGGCTAAAAA CAAAGCAAAA CCAGTTACCA CTAATCTTAA GAAGGTTCTT 120 121 CATTTTTCCT AG 132 |
▼ ANNOTATION
| Disease | ||||
| ActiveDriverDB | ||||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-3906 | Pan troglodytes | 100.0 | 6e-65 | 197 |
| LLPS-Pap-3587 | Pan paniscus | 100.0 | 6e-65 | 197 |
| LLPS-Gog-4442 | Gorilla gorilla | 100.0 | 6e-65 | 197 |
| LLPS-Nol-2415 | Nomascus leucogenys | 97.0 | 4e-54 | 170 |
| LLPS-Poa-1808 | Pongo abelii | 96.61 | 3e-33 | 116 |
| LLPS-Mam-3340 | Macaca mulatta | 93.0 | 2e-52 | 166 |
| LLPS-Rhb-4276 | Rhinopithecus bieti | 93.0 | 2e-52 | 166 |
| LLPS-Man-1921 | Macaca nemestrina | 93.0 | 2e-52 | 166 |
| LLPS-Cea-1285 | Cercocebus atys | 93.0 | 2e-52 | 166 |
| LLPS-Chs-2189 | Chlorocebus sabaeus | 93.0 | 2e-52 | 166 |
| LLPS-Mal-2995 | Mandrillus leucophaeus | 92.0 | 3e-52 | 166 |
| LLPS-Aon-4162 | Aotus nancymaae | 92.0 | 1e-51 | 164 |
| LLPS-Paa-1402 | Papio anubis | 91.0 | 9e-50 | 159 |
| LLPS-Caj-2199 | Callithrix jacchus | 91.0 | 8e-52 | 164 |
| LLPS-Ere-0899 | Erinaceus europaeus | 89.74 | 2e-08 | 51.2 |
| LLPS-Tut-0731 | Tursiops truncatus | 89.74 | 3e-16 | 72.0 |
| LLPS-Otg-4391 | Otolemur garnettii | 88.0 | 5e-50 | 160 |
| LLPS-Orc-4059 | Oryctolagus cuniculus | 86.0 | 9e-48 | 154 |
| LLPS-Dio-1409 | Dipodomys ordii | 86.0 | 1e-54 | 172 |
| LLPS-Aim-1774 | Ailuropoda melanoleuca | 85.0 | 1e-55 | 174 |
| LLPS-Mup-3660 | Mustela putorius furo | 84.62 | 7e-40 | 134 |
| LLPS-Ict-4583 | Ictidomys tridecemlineatus | 83.0 | 3e-43 | 142 |
| LLPS-Bot-0475 | Bos taurus | 83.0 | 3e-53 | 168 |
| LLPS-Fec-3084 | Felis catus | 82.0 | 6e-53 | 167 |
| LLPS-Ova-1660 | Ovis aries | 81.19 | 9e-51 | 162 |
| LLPS-Loa-4592 | Loxodonta africana | 81.0 | 6e-50 | 160 |
| LLPS-Sus-3500 | Sus scrofa | 81.0 | 7e-51 | 162 |
| LLPS-Cas-3210 | Carlito syrichta | 80.39 | 2e-49 | 158 |
| LLPS-Mum-3394 | Mus musculus | 77.0 | 8e-45 | 148 |
| LLPS-Urm-1431 | Ursus maritimus | 76.0 | 5e-46 | 149 |
| LLPS-Ran-2104 | Rattus norvegicus | 76.0 | 3e-44 | 145 |
| LLPS-Mea-4172 | Mesocricetus auratus | 74.0 | 1e-43 | 144 |
| LLPS-Myl-4482 | Myotis lucifugus | 71.0 | 4e-43 | 142 |
| LLPS-Cap-2994 | Cavia porcellus | 70.0 | 1e-41 | 138 |
| LLPS-Mod-1511 | Monodelphis domestica | 61.0 | 1e-27 | 102 |
| LLPS-Ora-3268 | Ornithorhynchus anatinus | 51.0 | 9e-27 | 102 |
| LLPS-Eqc-4009 | Equus caballus | 50.0 | 2e-18 | 78.2 |
| LLPS-Maf-4597 | Macaca fascicularis | 50.0 | 4e-11 | 58.5 |
| LLPS-Fud-4122 | Fukomys damarensis | 48.0 | 4e-17 | 74.7 |
| LLPS-Scm-2973 | Scophthalmus maximus | 44.44 | 3e-11 | 60.1 |
| LLPS-Orn-3779 | Oreochromis niloticus | 43.18 | 4e-11 | 59.7 |
| LLPS-Orl-3286 | Oryzias latipes | 43.18 | 3e-09 | 55.1 |
| LLPS-Gaga-2749 | Gallus gallus | 42.86 | 8e-12 | 61.6 |
| LLPS-Pof-2087 | Poecilia formosa | 42.53 | 3e-12 | 62.8 |
| LLPS-Gaa-1518 | Gasterosteus aculeatus | 42.53 | 4e-10 | 57.0 |
| LLPS-Tar-0963 | Takifugu rubripes | 42.05 | 5e-10 | 57.0 |
| LLPS-Xim-1743 | Xiphophorus maculatus | 40.91 | 2e-11 | 60.8 |
| LLPS-Icp-1364 | Ictalurus punctatus | 39.08 | 1e-08 | 52.8 |