LLPS-Hos-2449
TMEM201
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Transmembrane protein 201; Spindle-associated membrane protein 1 |
| Gene Name: | TMEM201, NET5, SAMP1 |
| Ensembl Gene: | ENSG00000188807.12 |
| Ensembl Protein: | ENSP00000393626.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Spindle apparatus | "...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle." | N/A | 19494128 |
▼ FUNCTION
| Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000416541.5 | ENSP00000393626.1 |
| Ensembl | ENST00000340381.10 | ENSP00000344503.6 |
| Ensembl | ENST00000508400.1 | ENSP00000423430.1 |
| Ensembl | ENST00000340305.9 | ENSP00000344772.5 |
| UniProt | Q5SNT2, TM201_HUMAN, B9EH90, Q5SNT3 | |
| GeneBank | BC137291, BC121187, AL954705 | , AAI37292.1, AAI21188.1 |
| RefSeq | NM_001010866.3, NM_001130924.2, XM_011540910.2 | NP_001010866.1, NP_001124396.2, XP_011539212.1 |
| Entrez | 199953 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEGVSALLAR CPTAGLAGGL GVTACAAAGV LLYRIARRMK PTHTMVNCWF CNQDTLVPYG 60 61 NRNCWDCPHC EQYNGFQENG DYNKPIPAQY LEHLNHVVSS APSLRDPSQP QQWVSSQVLL 120 121 CKRCNHHQTT KIKQLAAFAP REEGRYDEEV EVYRHHLEQM YKLCRPCQAA VEYYIKHQNR 180 181 QLRALLLSHQ FKRREADQTH AQNFSSAVKS PVQVILLRAL AFLACAFLLT TALYGASGHF 240 241 APGTTVPLAL PPGGNGSATP DNGTTPGAEG WRQLLGLLPE HMAEKLCEAW AFGQSHQTGV 300 301 VALGLLTCLL AMLLAGRIRL RRIDAFCTCL WALLLGLHLA EQHLQAASPS WLDTLKFSTT 360 361 SLCCLVGFTA AVATRKATGP RRFRPRRFFP GDSAGLFPTS PSLAIPHPSV GGSPASLFIP 420 421 SPPSFLPLAN QQLFRSPRRT SPSSLPGRLS RALSLGTIPS LTRADSGYLF SGSRPPSQVS 480 481 RSGEFPVSDY FSLLSGSCPS SPLPSPAPSV AGSVASSSGS LRHRRPLISP ARLNLKGQKL 540 541 LLFPSPPGEA PTTPSSSDEH SPHNGSLFTM EPPHVPRKPP LQDVKHALDL RSKLERGSAC 600 601 SNRSIKKEDD SSQSSTCVVD TTTRGCSEEA ATWRGRFGPS LVRGLLAVSL AANALFTSVF 660 661 LYQSLR 666 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAGGGAG TGAGCGCGCT GCTGGCCCGC TGCCCCACGG CCGGCCTGGC CGGCGGCCTG 60 61 GGGGTCACGG CGTGCGCCGC GGCCGGCGTG TTGCTCTACC GGATCGCGCG GAGGATGAAG 120 121 CCAACGCACA CGATGGTCAA CTGCTGGTTC TGCAACCAGG ATACGCTGGT GCCCTATGGG 180 181 AACCGCAACT GCTGGGACTG TCCCCACTGC GAGCAGTACA ACGGCTTCCA GGAGAACGGC 240 241 GACTACAACA AGCCGATCCC CGCCCAGTAC TTGGAGCACC TGAACCACGT GGTGAGCAGC 300 301 GCGCCCAGCC TGCGCGACCC TTCGCAGCCG CAGCAGTGGG TGAGCAGCCA AGTCCTGCTG 360 361 TGCAAGAGGT GCAACCACCA CCAGACCACC AAGATCAAGC AGCTGGCCGC CTTCGCTCCC 420 421 CGCGAGGAGG GCAGGTATGA CGAGGAGGTC GAGGTGTACC GGCATCACCT GGAGCAGATG 480 481 TACAAGCTGT GCCGGCCGTG CCAAGCGGCT GTGGAGTACT ACATCAAGCA CCAGAACCGC 540 541 CAGCTGCGCG CCCTGTTGCT CAGCCACCAG TTCAAGCGCC GGGAGGCCGA CCAGACCCAC 600 601 GCACAGAACT TCTCCTCCGC CGTGAAGTCC CCGGTCCAGG TCATCCTGCT CCGTGCCCTC 660 661 GCCTTCCTGG CCTGCGCCTT CCTACTGACC ACCGCGCTGT ATGGGGCCAG CGGACACTTC 720 721 GCCCCAGGCA CCACTGTGCC CCTGGCCCTG CCACCTGGTG GCAATGGCTC AGCCACACCT 780 781 GACAATGGCA CCACCCCTGG GGCCGAGGGC TGGCGGCAGT TGCTGGGCCT ACTCCCCGAG 840 841 CACATGGCGG AGAAGCTGTG TGAGGCCTGG GCCTTTGGGC AGAGCCACCA GACGGGCGTC 900 901 GTGGCACTGG GCCTACTCAC CTGCCTGCTG GCAATGCTGC TGGCTGGCCG CATCAGGCTC 960 961 CGGAGGATCG ATGCCTTCTG CACCTGCCTG TGGGCCCTGC TGCTGGGGCT GCACCTGGCT 1020 1021 GAGCAGCACC TGCAGGCCGC CTCGCCTAGC TGGCTAGACA CGCTCAAGTT CAGCACCACA 1080 1081 TCTTTGTGCT GCCTGGTTGG CTTCACGGCG GCTGTGGCCA CAAGGAAGGC AACGGGCCCA 1140 1141 CGGAGGTTCC GGCCCCGAAG GTTCTTCCCA GGAGACTCTG CCGGCCTTTT CCCCACCAGC 1200 1201 CCCAGCTTGG CCATCCCTCA CCCGAGTGTC GGAGGCTCTC CAGCGTCTCT GTTCATCCCC 1260 1261 AGCCCGCCCA GCTTCCTGCC CCTCGCCAAC CAGCAGCTCT TCCGGTCTCC TCGACGGACC 1320 1321 TCACCCTCCT CATTGCCTGG CCGCCTCAGC CGGGCCCTCT CTCTGGGAAC CATACCCTCT 1380 1381 CTGACTCGAG CAGACTCCGG CTATCTGTTC AGCGGTAGCC GCCCACCATC TCAGGTGTCT 1440 1441 CGATCTGGGG AGTTTCCTGT TTCAGATTAC TTCTCTCTTC TGTCGGGGAG CTGCCCCTCC 1500 1501 TCCCCACTCC CTTCCCCAGC GCCTTCCGTG GCCGGCTCGG TGGCCTCCAG CTCCGGCTCT 1560 1561 CTGCGCCACC GCAGGCCCCT CATCAGCCCT GCCCGGCTCA ACCTGAAGGG ACAGAAGCTG 1620 1621 CTGCTGTTCC CGTCACCCCC TGGAGAGGCC CCCACCACGC CCAGCAGCTC CGATGAGCAC 1680 1681 TCGCCTCACA ACGGCAGCCT CTTCACCATG GAGCCGCCCC ATGTTCCCCG GAAGCCGCCC 1740 1741 CTGCAGGACG TGAAGCACGC CCTGGACCTG AGATCCAAGC TGGAAAGAGG CAGTGCCTGC 1800 1801 AGCAACCGCT CCATCAAGAA AGAGGACGAC TCTTCCCAGT CATCTACCTG TGTGGTGGAC 1860 1861 ACCACCACCA GGGGCTGCTC GGAGGAGGCC GCCACCTGGA GAGGTCGTTT CGGCCCTTCC 1920 1921 CTGGTCCGGG GCCTCCTGGC CGTGAGCTTG GCCGCCAACG CCCTGTTCAC CTCGGTGTTT 1980 1981 CTGTACCAGA GCCTGCGCTG A 2001 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Integral component of nuclear inner membrane | |
Cellular Component | Nuclear envelope | |
Cellular Component | Nuclear membrane | |
Cellular Component | Spindle pole | |
Molecular Function | Actin filament binding | |
Molecular Function | Lamin binding | |
Biological Process | Centrosome localization | |
Biological Process | Fibroblast migration | |
Biological Process | Nuclear envelope organization | |
Biological Process | Nuclear migration along microtubule | |
Biological Process | Protein localization to nuclear envelope |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | RaftProt | |||
| Localization | ||||
| COMPARTMENTS | NLSdb | |||
| Methylation | ||||
| TCGA | ICGC | COSMIC | MethyCancer | |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-1552 | Pan troglodytes | 100.0 | 0.0 | 977 |
| LLPS-Pap-0961 | Pan paniscus | 99.53 | 0.0 | 950 |
| LLPS-Gog-1113 | Gorilla gorilla | 99.25 | 0.0 | 966 |
| LLPS-Poa-3366 | Pongo abelii | 98.57 | 0.0 | 938 |
| LLPS-Nol-0593 | Nomascus leucogenys | 97.34 | 1e-159 | 481 |
| LLPS-Chs-4449 | Chlorocebus sabaeus | 97.3 | 0.0 | 941 |
| LLPS-Paa-3792 | Papio anubis | 97.0 | 0.0 | 940 |
| LLPS-Maf-1888 | Macaca fascicularis | 97.0 | 0.0 | 941 |
| LLPS-Mal-2719 | Mandrillus leucophaeus | 96.98 | 0.0 | 914 |
| LLPS-Man-0338 | Macaca nemestrina | 96.82 | 0.0 | 907 |
| LLPS-Cea-3680 | Cercocebus atys | 96.7 | 0.0 | 934 |
| LLPS-Rhb-0908 | Rhinopithecus bieti | 96.05 | 0.0 | 910 |
| LLPS-Caj-4333 | Callithrix jacchus | 93.85 | 0.0 | 922 |
| LLPS-Aon-1291 | Aotus nancymaae | 93.7 | 0.0 | 917 |
| LLPS-Eqc-0923 | Equus caballus | 88.28 | 0.0 | 779 |
| LLPS-Fec-0824 | Felis catus | 87.69 | 0.0 | 846 |
| LLPS-Sus-4458 | Sus scrofa | 87.41 | 0.0 | 802 |
| LLPS-Otg-3384 | Otolemur garnettii | 86.83 | 0.0 | 862 |
| LLPS-Aim-4041 | Ailuropoda melanoleuca | 86.75 | 0.0 | 807 |
| LLPS-Ict-3688 | Ictidomys tridecemlineatus | 86.46 | 0.0 | 815 |
| LLPS-Orc-2963 | Oryctolagus cuniculus | 86.06 | 0.0 | 821 |
| LLPS-Bot-0867 | Bos taurus | 85.74 | 0.0 | 755 |
| LLPS-Mup-1122 | Mustela putorius furo | 85.51 | 0.0 | 775 |
| LLPS-Myl-3785 | Myotis lucifugus | 84.12 | 0.0 | 811 |
| LLPS-Fud-0221 | Fukomys damarensis | 83.58 | 3e-157 | 464 |
| LLPS-Caf-4013 | Canis familiaris | 83.54 | 0.0 | 745 |
| LLPS-Mum-3633 | Mus musculus | 83.21 | 0.0 | 771 |
| LLPS-Mea-4368 | Mesocricetus auratus | 83.06 | 0.0 | 760 |
| LLPS-Loa-0778 | Loxodonta africana | 82.62 | 0.0 | 765 |
| LLPS-Ran-4426 | Rattus norvegicus | 82.18 | 0.0 | 723 |
| LLPS-Cap-3606 | Cavia porcellus | 81.83 | 0.0 | 740 |
| LLPS-Ova-1342 | Ovis aries | 78.15 | 0.0 | 664 |
| LLPS-Sah-3492 | Sarcophilus harrisii | 73.58 | 0.0 | 634 |
| LLPS-Mod-0713 | Monodelphis domestica | 72.61 | 0.0 | 637 |
| LLPS-Ora-2882 | Ornithorhynchus anatinus | 71.58 | 0.0 | 601 |
| LLPS-Fia-2465 | Ficedula albicollis | 66.93 | 0.0 | 563 |
| LLPS-Tag-0588 | Taeniopygia guttata | 65.47 | 0.0 | 556 |
| LLPS-Meg-2252 | Meleagris gallopavo | 65.28 | 0.0 | 592 |
| LLPS-Gaga-1291 | Gallus gallus | 65.0 | 0.0 | 608 |
| LLPS-Pes-3598 | Pelodiscus sinensis | 62.01 | 4e-90 | 295 |
| LLPS-Anc-2247 | Anolis carolinensis | 61.92 | 6e-92 | 294 |
| LLPS-Asm-0917 | Astyanax mexicanus | 57.79 | 2e-105 | 341 |
| LLPS-Lac-2298 | Latimeria chalumnae | 55.02 | 2e-120 | 379 |
| LLPS-Leo-2306 | Lepisosteus oculatus | 54.47 | 7e-140 | 431 |
| LLPS-Icp-1195 | Ictalurus punctatus | 54.26 | 1e-136 | 422 |
| LLPS-Dar-0633 | Danio rerio | 53.27 | 8e-134 | 415 |
| LLPS-Scf-2689 | Scleropages formosus | 51.93 | 3e-136 | 421 |
| LLPS-Gaa-1776 | Gasterosteus aculeatus | 51.58 | 3e-103 | 335 |
| LLPS-Xim-1717 | Xiphophorus maculatus | 49.61 | 3e-107 | 346 |
| LLPS-Tar-2319 | Takifugu rubripes | 49.38 | 3e-108 | 348 |
| LLPS-Pof-3109 | Poecilia formosa | 48.99 | 3e-109 | 351 |
| LLPS-Orl-2895 | Oryzias latipes | 48.46 | 2e-104 | 338 |
| LLPS-Orn-2632 | Oreochromis niloticus | 48.09 | 3e-108 | 349 |
| LLPS-Ten-1086 | Tetraodon nigroviridis | 47.77 | 7e-114 | 363 |
| LLPS-Scm-2467 | Scophthalmus maximus | 45.71 | 9e-102 | 331 |
| LLPS-Drm-0829 | Drosophila melanogaster | 38.22 | 2e-25 | 116 |
| LLPS-Cae-0638 | Caenorhabditis elegans | 37.65 | 1e-22 | 106 |