LLPS-Hos-2393
CAMP
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Cathelicidin antimicrobial peptide; 18 kDa cationic antimicrobial protein; CAP-18; hCAP-18 |
| Gene Name: | CAMP, CAP18, FALL39, HSD26 |
| Ensembl Gene: | ENSG00000164047.4 |
| Ensembl Protein: | ENSP00000296435.2 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Regulator |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Receptor cluster | "...PDE3A inhibition generates compartmentalized cyclic adenosine 3′,5′-monophosphate, which further clusters PDE3A and CFTR into microdomains at the plasma membrane and potentiates CFTR channel function." | Calu-3 cells | 20089840 |
▼ FUNCTION
| Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000296435.2 | ENSP00000296435.2 |
| UniProt | P49913, CAMP_HUMAN, Q71SN9 | |
| GeneBank | AY162210, Z38026, X89658, AY251531, U48795, AF288284, X96735, CR541961, U19970, CR457083, BC055089 | CAG46759.1, CAG33364.1, AAA74084.1, AAP20054.1, AAC02634.1, AAG40802.1, AAN78318.1, CAA86115.1, AAH55089.1, CAA61805.1 |
| RefSeq | NM_004345.4 | NP_004336.3 |
| Entrez | 820 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGTMKTQRDG HSLGRWSLVL LLLGLVMPLA IIAQVLSYKE AVLRAIDGIN QRSSDANLYR 60 61 LLDLDPRPTM DGDPDTPKPV SFTVKETVCP RTTQQSPEDC DFKKDGLVKR CMGTVTLNQA 120 121 RGSFDISCDK DNKRFALLGD FFRKSKEKIG KEFKRIVQRI KDFLRNLVPR TES 173 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGGACCA TGAAGACCCA AAGGGATGGC CACTCCCTGG GGCGGTGGTC ACTGGTGCTC 60 61 CTGCTGCTGG GCCTGGTGAT GCCTCTGGCC ATCATTGCCC AGGTCCTCAG CTACAAGGAA 120 121 GCTGTGCTTC GTGCTATAGA TGGCATCAAC CAGCGGTCCT CGGATGCTAA CCTCTACCGC 180 181 CTCCTGGACC TGGACCCCAG GCCCACGATG GATGGGGACC CAGACACGCC AAAGCCTGTG 240 241 AGCTTCACAG TGAAGGAGAC AGTGTGCCCC AGGACGACAC AGCAGTCACC AGAGGATTGT 300 301 GACTTCAAGA AGGACGGGCT GGTGAAGCGG TGTATGGGGA CAGTGACCCT CAACCAGGCC 360 361 AGGGGCTCCT TTGACATCAG TTGTGATAAG GATAACAAGA GATTTGCCCT GCTGGGTGAT 420 421 TTCTTCCGGA AATCTAAAGA GAAGATTGGC AAAGAGTTTA AAAGAATTGT CCAGAGAATC 480 481 AAGGATTTTT TGCGGAATCT TGTACCCAGG ACAGAGTCCT AG 522 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Extracellular exosome | |
Cellular Component | Extracellular region | |
Cellular Component | Extracellular space | |
Cellular Component | Intracellular | |
Cellular Component | Specific granule | |
Cellular Component | Specific granule lumen | |
Cellular Component | Tertiary granule lumen | |
Molecular Function | Lipopolysaccharide binding | |
Biological Process | Antibacterial humoral response | |
Biological Process | Antifungal humoral response | |
Biological Process | Antimicrobial humoral immune response mediated by antimicrobial peptide | |
Biological Process | Antimicrobial humoral response | |
Biological Process | Chronic inflammatory response | |
Biological Process | Cytolysis by host of symbiont cells | |
Biological Process | Defense response to bacterium | |
Biological Process | Defense response to Gram-negative bacterium | |
Biological Process | Defense response to Gram-positive bacterium | |
Biological Process | Innate immune response | |
Biological Process | Innate immune response in mucosa | |
Biological Process | Killing by host of symbiont cells | |
Biological Process | Modification of morphology or physiology of other organism | |
Biological Process | Negative regulation of growth of symbiont on or near host surface | |
Biological Process | Neutrophil degranulation | |
Biological Process | Positive regulation of interleukin-8 secretion | |
Biological Process | Response to yeast |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pap-1121 | Pan paniscus | 99.42 | 5e-110 | 318 |
| LLPS-Pat-4641 | Pan troglodytes | 99.42 | 5e-110 | 318 |
| LLPS-Gog-4056 | Gorilla gorilla | 98.27 | 1e-108 | 314 |
| LLPS-Nol-1643 | Nomascus leucogenys | 93.06 | 4e-102 | 298 |
| LLPS-Poa-3118 | Pongo abelii | 91.91 | 2e-100 | 294 |
| LLPS-Chs-2341 | Chlorocebus sabaeus | 87.86 | 8e-87 | 259 |
| LLPS-Rhb-1090 | Rhinopithecus bieti | 87.28 | 6e-93 | 275 |
| LLPS-Man-0314 | Macaca nemestrina | 87.28 | 6e-93 | 275 |
| LLPS-Mal-3412 | Mandrillus leucophaeus | 87.28 | 2e-93 | 276 |
| LLPS-Paa-4770 | Papio anubis | 87.28 | 7e-85 | 254 |
| LLPS-Cea-1123 | Cercocebus atys | 87.28 | 2e-93 | 276 |
| LLPS-Mam-4382 | Macaca mulatta | 86.71 | 9e-92 | 272 |
| LLPS-Maf-4828 | Macaca fascicularis | 86.71 | 9e-92 | 272 |
| LLPS-Aon-4425 | Aotus nancymaae | 80.92 | 4e-86 | 257 |
| LLPS-Eqc-2175 | Equus caballus | 76.15 | 3e-51 | 169 |
| LLPS-Caj-0708 | Callithrix jacchus | 75.72 | 2e-80 | 243 |
| LLPS-Ova-2399 | Ovis aries | 68.37 | 8e-42 | 144 |
| LLPS-Otg-4614 | Otolemur garnettii | 67.44 | 4e-64 | 201 |
| LLPS-Cas-3277 | Carlito syrichta | 66.47 | 3e-62 | 196 |
| LLPS-Ict-4249 | Ictidomys tridecemlineatus | 65.7 | 2e-59 | 189 |
| LLPS-Sus-2980 | Sus scrofa | 65.05 | 2e-40 | 143 |
| LLPS-Ere-0398 | Erinaceus europaeus | 63.54 | 8e-41 | 140 |
| LLPS-Tut-0783 | Tursiops truncatus | 62.86 | 4e-53 | 173 |
| LLPS-Mup-2034 | Mustela putorius furo | 61.72 | 3e-38 | 135 |
| LLPS-Urm-3942 | Ursus maritimus | 59.56 | 2e-37 | 135 |
| LLPS-Bot-4306 | Bos taurus | 58.82 | 5e-45 | 152 |
| LLPS-Fec-1235 | Felis catus | 57.75 | 3e-51 | 168 |
| LLPS-Loa-2583 | Loxodonta africana | 57.45 | 1e-48 | 162 |
| LLPS-Orc-0185 | Oryctolagus cuniculus | 57.31 | 1e-48 | 161 |
| LLPS-Myl-2643 | Myotis lucifugus | 56.69 | 9e-41 | 141 |
| LLPS-Ran-3087 | Rattus norvegicus | 56.46 | 2e-50 | 166 |
| LLPS-Caf-3997 | Canis familiaris | 56.34 | 7e-49 | 162 |
| LLPS-Mum-4291 | Mus musculus | 54.42 | 6e-47 | 157 |
| LLPS-Dio-2458 | Dipodomys ordii | 52.35 | 9e-39 | 136 |
| LLPS-Aim-3652 | Ailuropoda melanoleuca | 51.41 | 7e-44 | 149 |
| LLPS-Mea-1863 | Mesocricetus auratus | 50.0 | 6e-43 | 147 |
| LLPS-Fud-1011 | Fukomys damarensis | 48.2 | 1e-37 | 134 |
| LLPS-Cap-3337 | Cavia porcellus | 43.97 | 2e-30 | 115 |
| LLPS-Pes-3343 | Pelodiscus sinensis | 43.62 | 2e-17 | 80.1 |
| LLPS-Ora-1007 | Ornithorhynchus anatinus | 41.41 | 2e-16 | 77.4 |
| LLPS-Mod-3231 | Monodelphis domestica | 38.52 | 7e-26 | 102 |
| LLPS-Sah-2847 | Sarcophilus harrisii | 37.96 | 1e-25 | 102 |
| LLPS-Anc-2748 | Anolis carolinensis | 34.78 | 7e-13 | 67.4 |
| LLPS-Fia-0572 | Ficedula albicollis | 34.74 | 1e-15 | 75.9 |
| LLPS-Gaga-2970 | Gallus gallus | 34.21 | 2e-14 | 71.6 |
| LLPS-Leo-1520 | Lepisosteus oculatus | 32.65 | 8e-10 | 58.2 |