LLPS-Hos-2366
MAP6

▼ OVERVIEW

Status: Reviewed
Protein Name: Microtubule-associated protein 6
Gene Name: MAP6, KIAA1878
Ensembl Gene: ENSG00000171533.11
Ensembl Protein: ENSP00000434278.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Centrosome/Spindle pole body
"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."
N/A2249667, 16837464
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAWPCITRAC  CIARFWNQLD  KADIAVPLVF  TKYSEATEHP  GAPPQPPPPQ  QQAQPALAPP  60
61    SARAVAIETQ  PAQGELDAVA  RATGPAPGPT  GEREPAAGPG  RSGPGPGLGS  GSTSGPADSV  120
121   MRQDYRAWKV  QRPEPSCRPR  SEYQPSDAPF  ERETQYQKDF  RAWPLPRRGD  HPWIPKPVQI  180
181   SAASQASAPI  LGAPKRRPQS  QERWPVQAAA  EAREQEAAPG  GAGGLAAGKA  SGADERDTRR  240
241   KAGPAWIVRR  AEGLGHEQTP  LPAAQAQVQA  TGPEAGRGRA  AADALNRQIR  EEVASAVSSS  300
301   YRNEFRAWTD  IKPVKPIKAK  PQYKPPDDKM  VHETSYSAQF  KGEASKPTTA  DNKVIDRRRI  360
361   RSLYSEPFKE  PPKVEKPSVQ  SSKPKKTSAS  HKPTRKAKDK  QAVSGQAAKK  KSAEGPSTTK  420
421   PDDKEQSKEM  NNKLAEAKES  LAQPVSDSSK  TQGPVATEPD  KDQGSVVPGL  LKGQGPMVQE  480
481   PLKKQGSVVP  GPPKDLGPMI  PLPVKDQDHT  VPEPLKNESP  VISAPVKDQG  PSVPVPPKNQ  540
541   SPMVPAKVKD  QGSVVPESLK  DQGPRIPEPV  KNQAPMVPAP  VKDEGPMVSA  SVKDQGPMVS  600
601   APVKDQGPIV  PAPVKGEGPI  VPAPVKDEGP  MVSAPIKDQD  PMVPEHPKDE  SAMATAPIKN  660
661   QGSMVSEPVK  NQGLVVSGPV  KDQDVVVPEH  AKVHDSAVVA  PVKNQGPVVP  ESVKNQDPIL  720
721   PVLVKDQGPT  VLQPPKNQGR  IVPEPLKNQV  PIVPVPLKDQ  DPLVPVPAKD  QGPAVPEPLK  780
781   TQGPRDPQLP  TVSPLPRVMI  PTAPHTEYIE  SSP  813
Nucleotide CDS Sequence (FASTA)
1     ATGGCGTGGC  CGTGCATCAC  GAGGGCCTGC  TGCATCGCCC  GCTTCTGGAA  CCAGTTGGAC  60
61    AAAGCGGACA  TCGCTGTGCC  GCTGGTTTTC  ACCAAGTACT  CGGAGGCCAC  CGAGCACCCG  120
121   GGCGCCCCGC  CGCAGCCACC  GCCGCCGCAG  CAGCAGGCGC  AGCCGGCGCT  CGCGCCCCCC  180
181   TCGGCGCGCG  CGGTTGCCAT  AGAGACGCAG  CCAGCCCAGG  GCGAGTTGGA  TGCAGTTGCC  240
241   CGGGCAACGG  GGCCAGCGCC  TGGGCCTACC  GGCGAGCGCG  AGCCGGCGGC  GGGCCCCGGC  300
301   CGGAGCGGGC  CGGGCCCGGG  CCTGGGCTCC  GGCTCCACCT  CCGGCCCCGC  GGACTCGGTG  360
361   ATGCGGCAGG  ATTACCGAGC  CTGGAAGGTG  CAGCGGCCCG  AGCCCAGCTG  CCGGCCGCGC  420
421   AGCGAATACC  AGCCCTCCGA  CGCTCCCTTC  GAGCGCGAGA  CCCAGTACCA  GAAGGACTTC  480
481   CGCGCCTGGC  CGCTGCCGCG  CCGCGGGGAC  CACCCGTGGA  TCCCCAAGCC  CGTGCAGATC  540
541   TCTGCGGCCT  CCCAGGCGTC  GGCGCCCATT  CTCGGGGCGC  CCAAGCGCCG  GCCGCAGAGC  600
601   CAGGAGCGCT  GGCCAGTGCA  GGCCGCCGCT  GAGGCCCGGG  AGCAGGAGGC  GGCCCCCGGC  660
661   GGAGCGGGTG  GCCTGGCGGC  CGGAAAGGCG  TCCGGGGCGG  ACGAGCGCGA  CACGCGCAGG  720
721   AAGGCCGGGC  CTGCCTGGAT  TGTGCGCCGC  GCCGAGGGCC  TGGGGCACGA  GCAGACGCCG  780
781   CTGCCCGCGG  CCCAGGCCCA  GGTCCAGGCC  ACCGGCCCCG  AGGCTGGCAG  GGGGCGCGCC  840
841   GCGGCGGACG  CCCTCAACCG  GCAAATCCGC  GAGGAGGTGG  CGAGTGCAGT  GAGCAGCTCC  900
901   TACAGGAATG  AATTCAGGGC  ATGGACGGAC  ATCAAGCCTG  TGAAACCAAT  AAAGGCCAAG  960
961   CCCCAGTACA  AGCCCCCAGA  TGATAAGATG  GTTCATGAGA  CCAGCTACAG  TGCTCAGTTC  1020
1021  AAAGGAGAGG  CCAGCAAGCC  AACAACAGCT  GACAATAAGG  TCATTGATCG  CAGAAGAATA  1080
1081  CGCAGCCTCT  ACAGCGAACC  CTTCAAGGAA  CCCCCAAAGG  TGGAAAAACC  TAGTGTTCAG  1140
1141  AGTTCCAAAC  CAAAAAAGAC  CTCAGCGAGC  CATAAGCCCA  CGAGGAAGGC  CAAAGACAAG  1200
1201  CAGGCGGTGT  CAGGCCAGGC  TGCCAAGAAA  AAGAGCGCGG  AGGGCCCGAG  TACCACCAAG  1260
1261  CCAGACGACA  AGGAGCAAAG  CAAAGAGATG  AACAATAAAC  TGGCTGAGGC  GAAAGAGAGC  1320
1321  CTGGCTCAAC  CCGTCAGTGA  TTCAAGTAAG  ACTCAAGGTC  CTGTAGCCAC  AGAGCCAGAC  1380
1381  AAGGATCAAG  GTTCTGTGGT  CCCAGGCCTT  CTGAAAGGTC  AAGGTCCTAT  GGTGCAAGAG  1440
1441  CCTCTGAAGA  AGCAAGGTTC  TGTGGTCCCA  GGGCCTCCAA  AGGATCTAGG  TCCCATGATC  1500
1501  CCATTACCAG  TCAAGGATCA  AGATCACACG  GTCCCTGAGC  CTTTAAAGAA  TGAAAGCCCT  1560
1561  GTTATCTCAG  CACCAGTCAA  GGACCAAGGT  CCCTCGGTCC  CAGTTCCTCC  AAAGAATCAA  1620
1621  AGTCCTATGG  TTCCAGCAAA  AGTTAAGGAT  CAAGGCTCTG  TGGTACCAGA  GTCTCTAAAG  1680
1681  GATCAAGGTC  CTAGGATTCC  TGAGCCTGTG  AAGAATCAAG  CTCCTATGGT  CCCAGCACCT  1740
1741  GTCAAGGATG  AAGGTCCCAT  GGTCTCAGCA  TCTGTCAAGG  ATCAAGGTCC  CATGGTCTCA  1800
1801  GCACCTGTCA  AGGATCAAGG  TCCCATAGTC  CCAGCACCTG  TCAAGGGTGA  AGGTCCCATA  1860
1861  GTCCCAGCAC  CTGTCAAGGA  TGAAGGTCCC  ATGGTCTCAG  CACCTATCAA  GGATCAAGAT  1920
1921  CCCATGGTCC  CAGAGCATCC  GAAGGATGAA  AGTGCCATGG  CCACAGCACC  CATAAAGAAT  1980
1981  CAAGGTTCCA  TGGTCTCTGA  GCCTGTAAAG  AATCAAGGTT  TAGTGGTCTC  AGGGCCAGTC  2040
2041  AAGGATCAAG  ATGTTGTAGT  CCCAGAGCAT  GCAAAGGTTC  ACGATTCTGC  AGTTGTGGCA  2100
2101  CCTGTAAAGA  ATCAAGGTCC  TGTGGTCCCC  GAGTCCGTGA  AGAATCAAGA  CCCCATTCTC  2160
2161  CCAGTACTAG  TTAAGGATCA  AGGCCCCACA  GTCCTACAGC  CTCCAAAGAA  TCAAGGTCGT  2220
2221  ATAGTCCCTG  AACCTCTGAA  GAATCAAGTT  CCTATAGTCC  CAGTGCCTCT  GAAGGATCAA  2280
2281  GATCCTCTGG  TGCCAGTACC  AGCAAAGGAC  CAAGGTCCTG  CAGTCCCTGA  ACCTCTGAAG  2340
2341  ACTCAAGGTC  CCAGGGACCC  TCAGCTACCT  ACTGTCTCAC  CTCTACCCCG  AGTCATGATC  2400
2401  CCAACTGCCC  CCCATACGGA  ATACATTGAG  AGCTCCCCTT  GA  2442

▼ KEYWORD

ID
Family
Alternative splicing
Calmodulin-binding
Cell projection
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton
Golgi apparatus
Lipoprotein
Membrane
Microtubule
Palmitate
Phosphoprotein
Polymorphism
Reference proteome
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Axon
Cellular Component
Cis-Golgi network
Cellular Component
Dendrite
Cellular Component
Golgi-associated vesicle
Cellular Component
Microtubule
Cellular Component
Perinuclear region of cytoplasm
Cellular Component
Transport vesicle membrane
Molecular Function
Calmodulin binding
Molecular Function
Microtubule binding
Biological Process
Cytoskeleton-dependent intracellular transport
Biological Process
Dendrite morphogenesis
Biological Process
Lysosome localization
Biological Process
Microtubule cytoskeleton organization
Biological Process
Positive regulation of axonogenesis
Biological Process
Regulation of microtubule cytoskeleton organization

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-3740Pan troglodytes97.910.01355
LLPS-Gog-3214Gorilla gorilla97.670.01347
LLPS-Nol-2917Nomascus leucogenys97.050.01348
LLPS-Cea-0352Cercocebus atys96.360.0 659
LLPS-Pap-0286Pan paniscus95.240.0 625
LLPS-Chs-4075Chlorocebus sabaeus93.490.01296
LLPS-Maf-4550Macaca fascicularis92.630.01286
LLPS-Mam-4181Macaca mulatta91.120.0 812
LLPS-Man-3291Macaca nemestrina91.030.01254
LLPS-Caj-3155Callithrix jacchus89.940.01251
LLPS-Ict-4395Ictidomys tridecemlineatus87.384e-98 321
LLPS-Aon-3807Aotus nancymaae87.020.0 705
LLPS-Eqc-0510Equus caballus86.433e-100 342
LLPS-Cap-2399Cavia porcellus85.929e-92 305
LLPS-Paa-4809Papio anubis85.50.01142
LLPS-Asm-2136Astyanax mexicanus84.215e-1582.8
LLPS-Ova-1859Ovis aries82.283e-90 311
LLPS-Caf-1738Canis familiaris81.063e-100 338
LLPS-Dio-3268Dipodomys ordii80.124e-64 226
LLPS-Loa-2752Loxodonta africana79.122e-111 369
LLPS-Lac-2813Latimeria chalumnae76.798e-23 104
LLPS-Rhb-0219Rhinopithecus bieti75.280.0 961
LLPS-Bot-2736Bos taurus74.493e-86 303
LLPS-Mum-4169Mus musculus73.832e-98 333
LLPS-Tut-0494Tursiops truncatus73.550.0 949
LLPS-Ran-2459Rattus norvegicus73.491e-97 332
LLPS-Fec-0873Felis catus72.760.0 904
LLPS-Otg-2996Otolemur garnettii71.480.0 910
LLPS-Myl-4349Myotis lucifugus70.553e-40 164
LLPS-Orc-3683Oryctolagus cuniculus69.11e-96 328
LLPS-Ora-0554Ornithorhynchus anatinus68.991e-29 121
LLPS-Mup-2021Mustela putorius furo68.160.0 845
LLPS-Cas-3683Carlito syrichta65.670.0 598
LLPS-Leo-2737Lepisosteus oculatus64.025e-50 187
LLPS-Anc-3305Anolis carolinensis62.225e-51 189
LLPS-Sus-0291Sus scrofa61.710.0 773
LLPS-Fud-1732Fukomys damarensis61.380.0 561
LLPS-Fia-0783Ficedula albicollis59.416e-84 275
LLPS-Mea-2480Mesocricetus auratus59.380.0 788
LLPS-Gaga-1206Gallus gallus59.268e-93 302
LLPS-Anp-2265Anas platyrhynchos54.731e-118 371
LLPS-Pes-3419Pelodiscus sinensis54.448e-119 372
LLPS-Tar-3587Takifugu rubripes53.858e-32 132
LLPS-Dar-0978Danio rerio51.875e-36 146
LLPS-Xet-1741Xenopus tropicalis50.346e-109 346
LLPS-Ten-3804Tetraodon nigroviridis47.735e-38 151
LLPS-Icp-0175Ictalurus punctatus46.897e-36 144
LLPS-Orn-0664Oreochromis niloticus45.337e-81 271
LLPS-Scf-1432Scleropages formosus44.472e-93 305
LLPS-Pof-0655Poecilia formosa42.672e-81 275
LLPS-Orl-0414Oryzias latipes42.241e-80 273
LLPS-Gaa-1208Gasterosteus aculeatus41.834e-21 102
LLPS-Scm-0355Scophthalmus maximus41.594e-74 255
LLPS-Xim-1917Xiphophorus maculatus41.162e-76 261