LLPS-Hos-2362
MAGEA4
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Melanoma-associated antigen 4; Cancer/testis antigen 1.4; CT1.4; MAGE-4 antigen; MAGE-41 antigen; MAGE-X2 antigen |
| Gene Name: | MAGEA4, MAGE4 |
| Ensembl Gene: | ENSG00000147381.11 |
| Ensembl Protein: | ENSP00000394073.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Stress granule | "...By adding known stress granule components not identified by mass spectrometry to this list, we created the first stress granule proteome for a mammalian cell." | U2OS cells | 26777405 |
▼ FUNCTION
| Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000416020.1 | ENSP00000394073.1 |
| Ensembl | ENST00000370340.7 | ENSP00000359365.3 |
| Ensembl | ENST00000276344.6 | ENSP00000276344.2 |
| Ensembl | ENST00000441865.5 | ENSP00000402624.1 |
| Ensembl | ENST00000448295.5 | ENSP00000391904.1 |
| Ensembl | ENST00000425182.5 | ENSP00000400900.1 |
| Ensembl | ENST00000360243.6 | ENSP00000353379.2 |
| Ensembl | ENST00000393920.5 | ENSP00000377497.1 |
| Ensembl | ENST00000370335.5 | ENSP00000359360.1 |
| Ensembl | ENST00000393921.5 | ENSP00000377498.1 |
| Ensembl | ENST00000431963.5 | ENSP00000387777.1 |
| Ensembl | ENST00000457310.5 | ENSP00000402186.1 |
| Ensembl | ENST00000431971.1 | ENSP00000390096.1 |
| Ensembl | ENST00000430273.5 | ENSP00000394149.1 |
| UniProt | P43358, MAGA4_HUMAN, Q14798 | |
| GeneBank | AF274855, U10340, U10688, D32077, U10687, BC017723, D32075 | BAA06841.1, AAA19007.1, AAA68872.1, AAH17723.1, AAA68871.1, BAA06843.1 |
| RefSeq | NM_001011548.1, NM_001011549.1, NM_001011550.1, NM_002362.4, XM_005274678.3, XM_005274679.3 | NP_001011548.1, NP_001011549.1, NP_001011550.1, NP_002353.3, XP_005274735.1, XP_005274736.1 |
| Entrez | 4103 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSSEQKSQHC KPEEGVEAQE EALGLVGAQA PTTEEQEAAV SSSSPLVPGT LEEVPAAESA 60 61 GPPQSPQGAS ALPTTISFTC WRQPNEGSSS QEEEGPSTSP DAESLFREAL SNKVDELAHF 120 121 LLRKYRAKEL VTKAEMLERV IKNYKRCFPV IFGKASESLK MIFGIDVKEV DPASNTYTLV 180 181 TCLGLSYDGL LGNNQIFPKT GLLIIVLGTI AMEGDSASEE EIWEELGVMG VYDGREHTVY 240 241 GEPRKLLTQD WVQENYLEYR QVPGSNPARY EFLWGPRALA ETSYVKVLEH VVRVNARVRI 300 301 AYPSLREAAL LEEEEGV 317 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCTTCTG AGCAGAAGAG TCAGCACTGC AAGCCTGAGG AAGGCGTTGA GGCCCAAGAA 60 61 GAGGCCCTGG GCCTGGTGGG TGCACAGGCT CCTACTACTG AGGAGCAGGA GGCTGCTGTC 120 121 TCCTCCTCCT CTCCTCTGGT CCCTGGCACC CTGGAGGAAG TGCCTGCTGC TGAGTCAGCA 180 181 GGTCCTCCCC AGAGTCCTCA GGGAGCCTCT GCCTTACCCA CTACCATCAG CTTCACTTGC 240 241 TGGAGGCAAC CCAATGAGGG TTCCAGCAGC CAAGAAGAGG AGGGGCCAAG CACCTCGCCT 300 301 GACGCAGAGT CCTTGTTCCG AGAAGCACTC AGTAACAAGG TGGATGAGTT GGCTCATTTT 360 361 CTGCTCCGCA AGTATCGAGC CAAGGAGCTG GTCACAAAGG CAGAAATGCT GGAGAGAGTC 420 421 ATCAAAAATT ACAAGCGCTG CTTTCCTGTG ATCTTCGGCA AAGCCTCCGA GTCCCTGAAG 480 481 ATGATCTTTG GCATTGACGT GAAGGAAGTG GACCCCGCCA GCAACACCTA CACCCTTGTC 540 541 ACCTGCCTGG GCCTTTCCTA TGATGGCCTG CTGGGTAATA ATCAGATCTT TCCCAAGACA 600 601 GGCCTTCTGA TAATCGTCCT GGGCACAATT GCAATGGAGG GCGACAGCGC CTCTGAGGAG 660 661 GAAATCTGGG AGGAGCTGGG TGTGATGGGG GTGTATGATG GGAGGGAGCA CACTGTCTAT 720 721 GGGGAGCCCA GGAAACTGCT CACCCAAGAT TGGGTGCAGG AAAACTACCT GGAGTACCGG 780 781 CAGGTACCCG GCAGTAATCC TGCGCGCTAT GAGTTCCTGT GGGGTCCAAG GGCTCTGGCT 840 841 GAAACCAGCT ATGTGAAAGT CCTGGAGCAT GTGGTCAGGG TCAATGCAAG AGTTCGCATT 900 901 GCCTACCCAT CCCTGCGTGA AGCAGCTTTG TTAGAGGAGG AAGAGGGAGT CTGA 954 |
▼ KEYWORD
▼ ANNOTATION
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CGDB | PIRSF | CellMarker | ||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | COSMIC | MethyCancer | |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-3233 | Pan troglodytes | 97.16 | 0.0 | 544 |
| LLPS-Poa-1508 | Pongo abelii | 94.64 | 0.0 | 533 |
| LLPS-Chs-0205 | Chlorocebus sabaeus | 92.11 | 2e-180 | 513 |
| LLPS-Mam-2959 | Macaca mulatta | 92.11 | 0.0 | 518 |
| LLPS-Caj-0735 | Callithrix jacchus | 80.0 | 2e-156 | 447 |
| LLPS-Paa-2630 | Papio anubis | 70.98 | 1e-131 | 384 |
| LLPS-Loa-0556 | Loxodonta africana | 52.71 | 4e-69 | 225 |
| LLPS-Gog-4131 | Gorilla gorilla | 51.27 | 4e-62 | 206 |
| LLPS-Nol-0641 | Nomascus leucogenys | 50.51 | 1e-61 | 205 |
| LLPS-Pap-2077 | Pan paniscus | 49.75 | 3e-61 | 204 |
| LLPS-Sus-1045 | Sus scrofa | 48.12 | 4e-73 | 236 |
| LLPS-Aim-4275 | Ailuropoda melanoleuca | 45.19 | 8e-69 | 224 |
| LLPS-Urm-0960 | Ursus maritimus | 44.91 | 1e-69 | 227 |
| LLPS-Mum-0920 | Mus musculus | 44.62 | 7e-56 | 191 |
| LLPS-Fec-4001 | Felis catus | 44.53 | 3e-70 | 228 |
| LLPS-Myl-3295 | Myotis lucifugus | 44.17 | 1e-58 | 198 |
| LLPS-Ran-2287 | Rattus norvegicus | 43.9 | 5e-59 | 199 |
| LLPS-Mea-1023 | Mesocricetus auratus | 43.33 | 3e-59 | 201 |
| LLPS-Ova-1072 | Ovis aries | 42.37 | 3e-66 | 218 |
| LLPS-Otg-2275 | Otolemur garnettii | 41.88 | 3e-69 | 225 |
| LLPS-Ict-0336 | Ictidomys tridecemlineatus | 41.25 | 8e-61 | 203 |
| LLPS-Cea-4426 | Cercocebus atys | 41.24 | 2e-29 | 123 |
| LLPS-Mup-2375 | Mustela putorius furo | 40.96 | 2e-31 | 129 |
| LLPS-Mal-2652 | Mandrillus leucophaeus | 40.96 | 1e-31 | 130 |
| LLPS-Tut-1357 | Tursiops truncatus | 40.96 | 8e-32 | 130 |
| LLPS-Bot-3115 | Bos taurus | 40.96 | 1e-31 | 130 |
| LLPS-Dio-1671 | Dipodomys ordii | 40.96 | 1e-31 | 130 |
| LLPS-Fud-0947 | Fukomys damarensis | 40.96 | 8e-32 | 130 |
| LLPS-Maf-2685 | Macaca fascicularis | 40.96 | 1e-31 | 130 |
| LLPS-Aon-1830 | Aotus nancymaae | 40.96 | 1e-31 | 129 |
| LLPS-Eqc-3627 | Equus caballus | 40.96 | 1e-31 | 130 |
| LLPS-Caf-4518 | Canis familiaris | 40.96 | 1e-31 | 130 |
| LLPS-Rhb-3791 | Rhinopithecus bieti | 40.96 | 1e-31 | 130 |
| LLPS-Orc-1493 | Oryctolagus cuniculus | 40.96 | 1e-31 | 130 |
| LLPS-Man-3994 | Macaca nemestrina | 40.96 | 1e-31 | 130 |
| LLPS-Cap-4605 | Cavia porcellus | 40.43 | 5e-31 | 128 |
| LLPS-Cas-1813 | Carlito syrichta | 39.89 | 3e-26 | 114 |
| LLPS-Ere-0878 | Erinaceus europaeus | 37.69 | 4e-42 | 153 |
| LLPS-Mod-3694 | Monodelphis domestica | 34.92 | 2e-34 | 134 |