LLPS-Hos-2333
LGALS7B
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| P-body | "...Comparing protein relative abundances between the sorted and pre-sorted fractions, we identified 125 proteins as significantly enriched in P-bodies." | HEK293 cells | 28965817 |
▼ FUNCTION
| Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000314980.4 | ENSP00000313571.3 |
| UniProt | P47929, LEG7_HUMAN, Q6IB87 | |
| GeneBank | BC073743, BC042911, CR456917, CH471126, U06643, L07769, BC061588 | EAW56817.1, AAA67899.1, AAH73743.1, EAW56818.1, AAA86820.1, AAH42911.2, CAG33198.1, AAH61588.1 |
| RefSeq | NM_001042507.3, NM_002307.3 | NP_001035972.1, NP_002298.1 |
| Entrez | 653499 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSNVPHKSSL PEGIRPGTVL RIRGLVPPNA SRFHVNLLCG EEQGSDAALH FNPRLDTSEV 60 61 VFNSKEQGSW GREERGPGVP FQRGQPFEVL IIASDDGFKA VVGDAQYHHF RHRLPLARVR 120 121 LVEVGGDVQL DSVRIF 136 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCCAACG TCCCCCACAA GTCCTCACTG CCCGAGGGCA TCCGCCCTGG CACGGTGCTG 60 61 AGAATTCGCG GCTTGGTTCC TCCCAATGCC AGCAGGTTCC ATGTAAACCT GCTGTGCGGG 120 121 GAGGAGCAGG GCTCCGATGC CGCCCTGCAT TTCAACCCCC GGCTGGACAC GTCGGAGGTG 180 181 GTCTTCAACA GCAAGGAGCA AGGCTCCTGG GGCCGCGAGG AGCGCGGGCC GGGCGTTCCT 240 241 TTCCAGCGCG GGCAGCCCTT CGAGGTGCTC ATCATCGCGT CAGACGACGG CTTCAAGGCC 300 301 GTGGTTGGGG ACGCCCAGTA CCACCACTTC CGCCACCGCC TGCCGCTGGC GCGCGTGCGC 360 361 CTGGTGGAGG TGGGCGGGGA CGTGCAGCTG GACTCCGTGA GGATCTTCTG A 411 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Extracellular exosome | |
Cellular Component | Extracellular space | |
Cellular Component | Nucleus | |
Molecular Function | Carbohydrate binding | |
Biological Process | Apoptotic process | |
Biological Process | Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | CellMarker | RaftProt | ||
| Localization | ||||
| COMPARTMENTS | NLSdb | |||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Gog-3255 | Gorilla gorilla | 100.0 | 2e-94 | 276 |
| LLPS-Nol-4671 | Nomascus leucogenys | 98.53 | 2e-93 | 273 |
| LLPS-Poa-2837 | Pongo abelii | 98.53 | 3e-93 | 272 |
| LLPS-Pap-0478 | Pan paniscus | 98.53 | 1e-93 | 273 |
| LLPS-Paa-2683 | Papio anubis | 98.53 | 2e-93 | 273 |
| LLPS-Mam-0402 | Macaca mulatta | 97.79 | 3e-93 | 273 |
| LLPS-Mal-4017 | Mandrillus leucophaeus | 97.79 | 2e-92 | 270 |
| LLPS-Rhb-3366 | Rhinopithecus bieti | 97.06 | 4e-93 | 272 |
| LLPS-Cea-3402 | Cercocebus atys | 97.06 | 2e-91 | 268 |
| LLPS-Caj-3631 | Callithrix jacchus | 96.32 | 6e-92 | 269 |
| LLPS-Maf-3407 | Macaca fascicularis | 96.32 | 1e-90 | 266 |
| LLPS-Man-2849 | Macaca nemestrina | 95.59 | 7e-91 | 266 |
| LLPS-Aon-4145 | Aotus nancymaae | 94.12 | 5e-90 | 264 |
| LLPS-Pat-2362 | Pan troglodytes | 88.97 | 2e-80 | 240 |
| LLPS-Chs-1952 | Chlorocebus sabaeus | 88.97 | 3e-81 | 242 |
| LLPS-Loa-2944 | Loxodonta africana | 80.6 | 1e-75 | 228 |
| LLPS-Ict-0879 | Ictidomys tridecemlineatus | 79.26 | 6e-77 | 231 |
| LLPS-Cas-2367 | Carlito syrichta | 77.94 | 3e-73 | 222 |
| LLPS-Mum-4461 | Mus musculus | 77.94 | 3e-75 | 227 |
| LLPS-Otg-3250 | Otolemur garnettii | 76.47 | 4e-75 | 226 |
| LLPS-Caf-0172 | Canis familiaris | 76.3 | 3e-73 | 222 |
| LLPS-Sus-4083 | Sus scrofa | 76.19 | 8e-55 | 174 |
| LLPS-Mea-3085 | Mesocricetus auratus | 74.81 | 4e-69 | 211 |
| LLPS-Aim-1709 | Ailuropoda melanoleuca | 74.44 | 8e-68 | 209 |
| LLPS-Myl-3651 | Myotis lucifugus | 73.88 | 3e-71 | 217 |
| LLPS-Bot-0807 | Bos taurus | 73.88 | 5e-69 | 213 |
| LLPS-Ran-4220 | Rattus norvegicus | 72.79 | 6e-70 | 213 |
| LLPS-Mup-3756 | Mustela putorius furo | 72.59 | 3e-70 | 214 |
| LLPS-Ova-2523 | Ovis aries | 72.39 | 6e-69 | 211 |
| LLPS-Fec-4154 | Felis catus | 72.32 | 3e-55 | 176 |
| LLPS-Orc-0961 | Oryctolagus cuniculus | 72.06 | 2e-66 | 204 |
| LLPS-Eqc-4534 | Equus caballus | 71.85 | 4e-66 | 204 |
| LLPS-Urm-3002 | Ursus maritimus | 69.17 | 1e-50 | 165 |
| LLPS-Fud-3318 | Fukomys damarensis | 66.32 | 3e-40 | 136 |
| LLPS-Ora-1010 | Ornithorhynchus anatinus | 66.18 | 2e-64 | 199 |
| LLPS-Cap-3302 | Cavia porcellus | 65.44 | 2e-62 | 194 |
| LLPS-Mod-3903 | Monodelphis domestica | 64.18 | 4e-61 | 191 |
| LLPS-Tut-1704 | Tursiops truncatus | 49.26 | 2e-39 | 135 |
| LLPS-Ere-0879 | Erinaceus europaeus | 48.15 | 3e-42 | 143 |
| LLPS-Fia-0299 | Ficedula albicollis | 39.86 | 1e-18 | 84.0 |
| LLPS-Sah-3480 | Sarcophilus harrisii | 37.9 | 5e-20 | 85.5 |
| LLPS-Tag-0556 | Taeniopygia guttata | 37.68 | 7e-19 | 84.3 |
| LLPS-Orl-1972 | Oryzias latipes | 37.4 | 5e-15 | 74.7 |
| LLPS-Gaga-1831 | Gallus gallus | 36.3 | 3e-18 | 82.4 |
| LLPS-Pes-0911 | Pelodiscus sinensis | 36.3 | 2e-17 | 80.5 |
| LLPS-Anp-0614 | Anas platyrhynchos | 36.03 | 3e-18 | 82.0 |
| LLPS-Meg-0690 | Meleagris gallopavo | 35.51 | 3e-19 | 85.5 |
| LLPS-Anc-4011 | Anolis carolinensis | 33.33 | 4e-15 | 73.9 |